Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 3, 2006, Pages

  Ohata, Hiroto ^a   Cao, Suyi ^a   Koehler, Raymond C ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Carbon monoxide; Cerebral circulation; Cyclooxygenase; Epoxygenase; Neurovascular coupling; Nitric oxide

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ALLOXAZINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ARACHIDONIC ACID; BICUCULLINE; CYCLOOXYGENASE 2; ENZYME INHIBITOR; HEME OXYGENASE; KAINIC ACID; KAINIC ACID RECEPTOR; MESOPORPHYRIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID; N METHYLSULFONYL 6 (2 PROPARGYLOXYPHENYL)HEXANAMIDE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERIOLE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG RESPONSE; ENZYME ACTIVITY; EXPERIMENTAL MODEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE; VASODILATATION; ANIMAL; DRUG ANTAGONISM; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY; PIA MATER; TIME; VASCULARIZATION; WISTAR RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ARTERIOLES; HEME OXYGENASE (DECYCLIZING); MALE; PIA MATER; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; TIME FACTORS; VASODILATION;

EID: 33748456081     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00757.2005     Document Type: Article

References (54)

1. Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, and Harder DR. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke 27: 971-979, 1996.
2. 2 adenosine receptors in cultured cortical astrocytes. Br J Pharmacol 141: 935-942, 2004.
3. Appleton SD, Chretien ML, McLaughlin BE, Vreman HJ, Stevenson DK, Brien JF, Nakatsu K, Maurice DH, and Marks GS. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab Dispos 27: 1214-1219, 1999.
4. 2-adrenergic agonist dexmedetomidine in the rat. Am J Physiol Heart Circ Physiol 272: H2547-H2556, 1997.
5. Beart PM, Sheehan KAM, and Manallack DT. Absence of N-methyl-D-aspartate receptors on ovine cerebral microvessels. J Cereb Blood Flow Metab 8: 879-882, 1988.
6. Bhardwaj A, Northington FJ, Carhuapoma JR, Falck JR, Harder DR, Traystman RJ, and Koehler RC. P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. Am J Physiol Heart Circ Physiol 279: H1616-H1624, 2000.
7. Bhardwaj A, Northington FJ, Ichord RN, Hanley DF, Traystman RJ, and Koehler RC. Characterization of ionotropic glutamate receptor-mediated nitric oxide production in vivo in rats. Stroke 28: 850-857, 1997.
8. 2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol 47: 801-814, 1994.
9. Christopherson KS, Hillier BJ, Lim WA, and Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 274: 27467-27473, 1999.
10. Coney AM and Marshall JM. Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. J Physiol 509: 507-518, 1998.
11. Craig CG and White TD. N-methyl-D-aspartate- and non-N-methyl-D- aspartate-evoked adenosine release from rat cortical slices: distinct purinergic sources and mechanisms of release. J Neurochem 60: 1073-1080, 1993.
12. Curran-Everett D. Multiple comparisons: philosophies and illustrations. Am J Physiol Regul Integr Comp Physiol 279: R1-R8, 2000.
13. Dirnagl U, Niwa K, Lindauer U, and Villringer A. Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. Am J Physiol Heart Circ Physiol 267: H296-H301, 1994.
14. Faraci FM and Breese KR. Nitric oxide mediates vasodilation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res 72: 476-480, 1993.
15. Faraci FM, Breese KR, and Heistad DD. Responses of cerebral arterioles to kainate. Stroke 25: 2080-2084, 1994.
16. Faraci FM and Brian JE Jr. 7-Nitroindazole inhibits brain nitric oxide synthase and cerebral vasodilation in response to N-methyl-D-aspartate. Stroke 26: 2172-2176, 1995.
17. Filosa JA, Bonev AD, and Nelson MT. Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circ Res 95: E73-E81, 2004.
18. Hirata T, Koehler RC, Kawaguchi T, Brusilow SW, and Traystman RJ. Impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depends on glutamine synthesis. Stroke 27: 729-736, 1996.
19. +- and glutamate-evoked release of endogenous adenosine from rat cortical slices. J Neurochem 54: 256-265, 1990.
20. Ibayashi S, Ngai AC, Meno JR, and Winn HR. Effects of topical adenosine analogs and forskolin on rat pial arterioles in vivo. J Cereb Blood Flow Metab 11: 72-76, 1991.
21. Iliff JJ, D'Ambrosio R, Ngai AC, and Winn HR. Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. Am J Physiol Heart Circ Physiol 284: H1631-H1637, 2003.
22. Irikura K, Maynard KI, and Moskowitz MA. Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation. J Cereb Blood Flow Metab 14: 45-48, 1994.
23. + channels. Circ Res 97: 805-812, 2005.
24. s proteins in type-1 cerebellar astrocytes. Glia 26: 119-128, 1999.
25. Leffler CW, Nasjletti A, Yu C, Johnson RA, Fedinec AL, and Walker N. Carbon monoxide and cerebral microvascular tone in newborn pigs. Am J Physiol Heart Circ Physiol 276: H1641-H1646, 1999.
26. 2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Circ Res 76: 242-251, 1995.
27. Meng W, Tobin JR, and Busija DW. Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors. Stroke 26: 857-863, 1995.
28. Meno JR, Crum AV, and Winn HR. Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. Am J Physiol Heart Circ Physiol 281: H2018-H2027, 2001.
29. Montecot C, Seylaz J, and Pinard E. Carbon monoxide regulates cerebral blood flow in epileptic seizures but not in hypercapnia. Neuroreport 9: 2341-2346, 1998.
30. Morley P, Small DL, Murray CL, Mealing GA, Poulter MO, Durkin JP, and Stanimirovic DB. Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells. J Cereb Blood Flow Metab 18: 396-406, 1998.
31. Ngai AC, Coyne EF, Meno JR, West GA, and Winn HR. Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles. Am J Physiol Heart Circ Physiol 280: H2329-H2335, 2001.
32. Ngai AC and Winn HR. Effects of adenosine and its analogues on isolated intracerebral arterioles. Extraluminal and intraluminal application. Circ Res 73: 448-457, 1993.
33. Niwa K, Araki E, Morham SG, Ross ME, and Iadecola C. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci 20: 763-770, 2000.
34. Niwa K, Haensel C, Ross ME, and Iadecola C. Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation. Circ Res 88: 600-608, 2001.
35. Norup Nielsen A and Lauritzen M. Coupling and uncoupling of activity-dependent increases of neuronal activity and blood flow in rat somatosensory cortex. J Physiol 533: 773-785, 2001.
36. Ongini E, Dionisotti S, Gessi S, Irenius E, and Fredholm BB. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 359: 7-10, 1999.
37. 2a adenosine receptor. Mol Pharmacol 48: 970-974, 1995.
38. Parfenova H, Fedinec A, and Leffler CW. Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase. J Cereb Blood Flow Metab 23: 190-197, 2003.
39. Parfenova H, Neff RA III, Alonso JS, Shlopov BV, Jamal CN, Sarkisova SA, and Leffler CW. Cerebral vascular endothelial heme oxygenase: expression, localization, and activation by glutamate. Am J Physiol Cell Physiol 281: C1954-C1963, 2001.
40. Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, and Koehler RC. Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Am J Physiol Heart Circ Physiol 283: H2029-H2037, 2002.
41. Peng X, Zhang C, Alkayed NJ, Harder DR, and Koehler RC. Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats. J Cereb Blood Flow Metab 24: 509-517, 2004.
42. Pilitsis JG and Kimelberg HK. Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes. Brain Res 798: 294-303, 1998.
43. 2a selective adenosine receptor antagonist. Br J Pharmacol 115: 1096-1102, 1995.
44. Pourcyrous M, Bada HS, Parfenova H, Daley ML, Korones SB, and Leffler CW. Cerebrovasodilatory contribution of endogenous carbon monoxide during seizures in newborn pigs. Pediatr Res 51: 579-585, 2002.
45. Robinson JS, Fedinec AL, and Leffler CW. Role of carbon monoxide in glutamate receptor-induced dilation of newborn pig pial arterioles. Am J Physiol Heart Circ Physiol 282: H2371-H2376, 2002.
46. 2B receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol 278: H339-H344, 2000.
47. Sinha AK, Azevedo R, Chi OZ, and Weiss HR. Down-regulation of AMPA glutamate receptors reduces cerebrocortical metabolic response to stimulation. Neurochem Res 29: 1425-1430, 2004.
48. Stein-Behrens BA, Elliott EM, Miller CA, Schilling JW, Newcombe R, and Sapolsky RM. Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus. J Neurochem 58: 1730-1735, 1992.
49. Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, and Nedergaard M. Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 9: 260-267, 2006.
50. Verma A, Hirsch DJ, Glatt CE, Ronnett GV, and Snyder SH. Carbon monoxide: a putative neural messenger. Science 259: 381-384, 1993.
51. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, and Schwartzman ML. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther 284: 966-973, 1998.
52. 2+ sensitivity of α-subunits. Am J Physiol Heart Circ Physiol 286: H610-H618, 2004.
53. Yang G, Chen G, Ebner TJ, and Iadecola C. Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats. Am J Physiol Regul Integr Comp Physiol 277: R1760-R1770, 1999.
54. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, and Carmignoto G. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 6: 43-50, 2003.