Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A2A receptors

American Journal of Pathology

Volumn 160, Issue 6, 2002, Pages 2009-2018

  Montesinos, M Carmen ^a   Desai, Avani ^a   Chen, Jiang Fan ^b   Yee, Herman ^a   Schwarzschild, Michael A ^b   Fink, J Stephen ^b   Cronstein, Bruce N ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; BLOOD CLOTTING FACTOR 8;

ADOLESCENT; ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRAVASATION; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; TISSUE INJURY; WOUND HEALING;

EID: 0036087210     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61151-0     Document Type: Article

References (52)

1. Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors
2. Cyclopentyladenosine improves cell proliferation, wound healing, and hair growth
3. Adenosine and hypoxia stimulate proliferation and migration of endothelial cells
4. Functional evidence for the presence of adenosine A2-receptors in cultured coronary endothelial cells
5. Adenosine stimulates proliferation of human endothelial cells in culture
6. Characterization of the adenosine receptor in microvascular coronary endothelial cells
7. Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine
8. Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors
9. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
10. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells
11. Adenosine stimulation of DNA synthesis in human endothelial cells
12. Adenosine stimulates canine retinal microvascular endothelial cell migration and tube formation
13. Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells
14. Hypoxia-induced angiogenesis in chick chorioallantoic membranes: A role for adenosine
15. 5′ nucleotidase and adenosine during retinal vasculogenesis and oxygen-induced retinopathy
16. Localization of aden osine A2a receptor in retinal development and oxygen-induced retinopathy
17. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation
18. Role of P1 receptors in inflammation
19. Adenosine: A physiological modulator of superoxide anion generation by human neutrophils
20. Adenosine: A physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils
21. Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors
22. Adenosine and its receptors during inflammation
23. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice
24. The antiinflammatory mechanism of methotrexate: Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation
25. Tumor angiogenesis as a prognostic predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence
26. Prospective study of intratumoral microvessel density, p53 expression
27. Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer
28. Adenosine A2a receptors increase arterial endothelial cell nitric oxide
29. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart
30. Adenosine and ATP: Progress in their receptors' structures and functions
31. Presence of both A1 and A2a adenosine receptors in human cells and their interaction
32. Adenine nucleotides modulate epithelial wound healing in vitro
33. Stimulatory effects of dibutyryl cyclic adenosine monophosphate on cytokine production by keratinocytes and fibroblasts
34. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: Involvement of A2 purinergic receptor subtypes
35. Adenosine and adenine nucleotides inhibit the autonomous and epidermal growth factor-mediated proliferation of cultured human keratinocytes
36. Fcgamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy: A1 receptors are stimulatory and A2 receptors are inhibitory
37. The adenosine/neutrophil paradox resolved. Human neutrophils possess both A1 and A2 receptors which promote chemotaxis and inhibit O2-generation, respectively
38. Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure
39. Interstitial transudate purines in normoxic and hypoxic immature and mature rabbit hearts
40. Adenosine. A homeostatic metabolite in cardiac energy metabolism
41. Cardiac adenosine production is linked to myocardial pO2
42. Adenine nucleotide release from isolated perfused guinea pig hearts and extracellular formation of adenosine
43. Turnover of adenosine in plasma of human and dog blood
44. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase-mediated conversion of adenine nucleotides
45. Attenuation of ecto-5′-nucleotidase activity and adenosine release in activated human polymorphonuclear leukocytes
46. Role of activation of protein kinase C in the infarct size-limiting effect of ischemic preconditioning through activation of ecto-5′-nucleotidase
47. Activation of ecto-5′-nucleotidase by protein kinase C and its role in ischaemic tolerance in the canine heart
48. The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat
49. The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine
50. The antiinflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites
51. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
52. Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: Adenosine-dependent and adenosine-independent mechanisms