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Volumn 11, Issue 1, 2014, Pages 1-19

Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies

Author keywords

Cell cycle; Energy metabolism; Glutaminolysis; Glycolysis; Mitochondria biogenesis

Indexed keywords

FATTY ACID; GLUCOSE; GLUTAMINE;

EID: 84897935083     PISSN: 20953941     EISSN: None     Source Type: Journal    
DOI: 10.7497/j.issn.2095-3941.2014.01.001     Document Type: Review
Times cited : (403)

References (184)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation. Cell 2011;144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer
    • Yeung S J, Pan J, Lee M H. Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci 2008;65:3981-3999.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.H.3
  • 3
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R J, Lum J J, Hatzivassiliou G, Thompson C B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008;7:11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 4
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis R J, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 2007;104:19345-19350.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6
  • 7
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M G, Cantley L C, Thompson C B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 9
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise D R, DeBerardinis R J, Mancuso A, Sayed N, Zhang X Y, Pfeiffer H K, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008;105:18782-18787.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18782-18787
    • Wise, D.R.1    DeBerardinis, R.J.2    Mancuso, A.3    Sayed, N.4    Zhang, X.Y.5    Pfeiffer, H.K.6
  • 10
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: a new therapeutic target in cancer
    • Wise D R, Thompson C B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci 2010;35:427-433.
    • (2010) Trends Biochem Sci , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 11
    • 0032905924 scopus 로고    scopus 로고
    • c-Myc target genes involved in cell growth, apoptosis, and metabolism
    • Dang C V. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999;19:1-11.
    • (1999) Mol Cell Biol , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 12
    • 70350247869 scopus 로고    scopus 로고
    • MYC, microRNAs and glutamine addiction in cancers
    • Dang C V. MYC, microRNAs and glutamine addiction in cancers. Cell Cycle 2009;8:3243-3245.
    • (2009) Cell Cycle , vol.8 , pp. 3243-3245
    • Dang, C.V.1
  • 13
    • 77958492734 scopus 로고    scopus 로고
    • Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?
    • Dang C V. Glutaminolysis: supplying carbon or nitrogen or both for cancer cells? Cell Cycle 2010;9:3884-3886.
    • (2010) Cell Cycle , vol.9 , pp. 3884-3886
    • Dang, C.V.1
  • 14
    • 76249110471 scopus 로고    scopus 로고
    • Rethinking the Warburg effect with Myc micromanaging glutamine metabolism
    • Dang C V. Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 2010;70:859-862.
    • (2010) Cancer Res , vol.70 , pp. 859-862
    • Dang, C.V.1
  • 15
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang C V, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 2009;15:6479-6483.
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 16
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang C V, Semenza G L. Oncogenic alterations of metabolism. Trends Biochem Sci 1999;24:68-72.
    • (1999) Trends Biochem Sci , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 17
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward P S, Thompson C B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012;21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 18
    • 0000459772 scopus 로고
    • Ueber den Stoffwechsel der Tumoren
    • (German). Reprinted in English in the book On metabolism of tumors by O. Warburg, Publisher: Constable, London, 1930.
    • Warburg O, Posener K, Negelein E. Ueber den Stoffwechsel der Tumoren. Biochemische Zeitschrift 1924;152:319-344 (German). Reprinted in English in the book On metabolism of tumors by O. Warburg, Publisher: Constable, London, 1930.
    • (1924) Biochemische Zeitschrift , vol.152 , pp. 319-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 19
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956;124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 20
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956;123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 21
    • 55949123655 scopus 로고    scopus 로고
    • The interplay between MYC and HIF in the Warburg effect
    • Dang C V. The interplay between MYC and HIF in the Warburg effect. Ernst Schering Found Symp Proc 2007;4:35-53.
    • (2007) Ernst Schering Found Symp Proc , vol.4 , pp. 35-53
    • Dang, C.V.1
  • 22
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis R J, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010;29:313-324.
    • (2010) Oncogene , vol.29 , pp. 313-324
    • Deberardinis, R.J.1    Cheng, T.2
  • 23
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu P P, Sabatini D M. Cancer cell metabolism: Warburg and beyond. Cell 2008;134:703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 24
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: a recipe for cancer growth
    • Jones RG, Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009;23:537-548.
    • (2009) Genes Dev , vol.23 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 26
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • Denko N C. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008;8:705-713.
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 27
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 2004;64:2627-2633.
    • (2004) Cancer Res , vol.64 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 28
    • 43049139541 scopus 로고    scopus 로고
    • p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    • Kawauchi K, Araki K, Tobiume K, Tanaka N. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 2008;10:611-618.
    • (2008) Nat Cell Biol , vol.10 , pp. 611-618
    • Kawauchi, K.1    Araki, K.2    Tobiume, K.3    Tanaka, N.4
  • 31
    • 81455128226 scopus 로고    scopus 로고
    • Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
    • Draoui N, Feron O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech 2011;4:727-732.
    • (2011) Dis Model Mech , vol.4 , pp. 727-732
    • Draoui, N.1    Feron, O.2
  • 32
    • 75149178349 scopus 로고    scopus 로고
    • Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation
    • Kennedy K M, Dewhirst M W. Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol 2010;6:127-148.
    • (2010) Future Oncol , vol.6 , pp. 127-148
    • Kennedy, K.M.1    Dewhirst, M.W.2
  • 33
    • 57449115616 scopus 로고    scopus 로고
    • Tumor metabolism: cancer cells give and take lactate
    • Semenza G L. Tumor metabolism: cancer cells give and take lactate. J Clin Invest 2008;118:3835-3837.
    • (2008) J Clin Invest , vol.118 , pp. 3835-3837
    • Semenza, G.L.1
  • 34
    • 77956419439 scopus 로고    scopus 로고
    • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    • Bonuccelli G, Tsirigos A, Whitaker-Menezes D, Pavlides S, Pestell R G, Chiavarina B, et al. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010;9:3506-3514.
    • (2010) Cell Cycle , vol.9 , pp. 3506-3514
    • Bonuccelli, G.1    Tsirigos, A.2    Whitaker-Menezes, D.3    Pavlides, S.4    Pestell, R.G.5    Chiavarina, B.6
  • 35
    • 79954537559 scopus 로고    scopus 로고
    • Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    • Martinez-Outschoorn U E, Prisco M, Ertel A, Tsirigos A, Lin Z, Pavlides S, et al. Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle 2011;10:1271-1286.
    • (2011) Cell Cycle , vol.10 , pp. 1271-1286
    • Martinez-Outschoorn, U.E.1    Prisco, M.2    Ertel, A.3    Tsirigos, A.4    Lin, Z.5    Pavlides, S.6
  • 37
    • 33750619348 scopus 로고    scopus 로고
    • Glucose metabolism and cancer
    • Shaw R J. Glucose metabolism and cancer. Curr Opin Cell Biol 2006;18:598-608.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 598-608
    • Shaw, R.J.1
  • 38
    • 14744284637 scopus 로고    scopus 로고
    • Multifaceted roles of glycolytic enzymes
    • Kim J W, Dang C V. Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 2005;30:142-150.
    • (2005) Trends Biochem Sci , vol.30 , pp. 142-150
    • Kim, J.W.1    Dang, C.V.2
  • 39
    • 79959588949 scopus 로고    scopus 로고
    • Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells
    • Sandulache V C, Ow T J, Pickering C R, Frederick M J, Zhou G, Fokt I, et al. Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer 2011;117:2926-2938.
    • (2011) Cancer , vol.117 , pp. 2926-2938
    • Sandulache, V.C.1    Ow, T.J.2    Pickering, C.R.3    Frederick, M.J.4    Zhou, G.5    Fokt, I.6
  • 40
  • 41
    • 64749116346 scopus 로고    scopus 로고
    • c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang T C, Lee Y S, Kita K, Ochi T, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009;458:762-765.
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6
  • 42
  • 43
    • 77958478353 scopus 로고    scopus 로고
    • Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells
    • Meng M, Chen S, Lao T, Liang D, Sang N. Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells. Cell Cycle 2010;9:3921-3932.
    • (2010) Cell Cycle , vol.9 , pp. 3921-3932
    • Meng, M.1    Chen, S.2    Lao, T.3    Liang, D.4    Sang, N.5
  • 44
    • 84863486244 scopus 로고    scopus 로고
    • The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate
    • Riganti C, Gazzano E, Polimeni M, Aldieri E, Ghigo D. The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med 2012;53:421-436.
    • (2012) Free Radic Biol Med , vol.53 , pp. 421-436
    • Riganti, C.1    Gazzano, E.2    Polimeni, M.3    Aldieri, E.4    Ghigo, D.5
  • 45
    • 0026780928 scopus 로고
    • Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia
    • Jonas S K, Benedetto C, Flatman A, Hammond R H, Micheletti L, Riley C, et al. Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia. Br J Cancer 1992;66:185-191.
    • (1992) Br J Cancer , vol.66 , pp. 185-191
    • Jonas, S.K.1    Benedetto, C.2    Flatman, A.3    Hammond, R.H.4    Micheletti, L.5    Riley, C.6
  • 47
    • 65649120706 scopus 로고    scopus 로고
    • Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29
    • Vizán P, Alcarraz-Vizán G, Díaz-Moralli S, Solovjeva O N, Frederiks W M, Cascante M. Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. Int J Cancer 2009;124:2789-2796.
    • (2009) Int J Cancer , vol.124 , pp. 2789-2796
    • Vizán, P.1    Alcarraz-Vizán, G.2    Díaz-Moralli, S.3    Solovjeva, O.N.4    Frederiks, W.M.5    Cascante, M.6
  • 48
    • 79952280229 scopus 로고    scopus 로고
    • p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 2011;13:310-316.
    • (2011) Nat Cell Biol , vol.13 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3    Mancuso, A.4    Gao, X.5    Wu, M.6
  • 49
    • 3042547565 scopus 로고    scopus 로고
    • Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells
    • Gao L, Mejías R, Echevarría M, López-Barneo J. Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells. FEBS Lett 2004;569:256-260.
    • (2004) FEBS Lett , vol.569 , pp. 256-260
    • Gao, L.1    Mejías, R.2    Echevarría, M.3    López-Barneo, J.4
  • 50
    • 77957573766 scopus 로고    scopus 로고
    • Resveratrol treatment induces redox stress in red blood cells: a possible role of caspase 3 in metabolism and anion transport
    • Galtieri A, Tellone E, Ficarra S, Russo A, Bellocco E, Barreca D, et al. Resveratrol treatment induces redox stress in red blood cells: a possible role of caspase 3 in metabolism and anion transport. Biol Chem 2010;391:1057-1065.
    • (2010) Biol Chem , vol.391 , pp. 1057-1065
    • Galtieri, A.1    Tellone, E.2    Ficarra, S.3    Russo, A.4    Bellocco, E.5    Barreca, D.6
  • 51
    • 0034161904 scopus 로고    scopus 로고
    • Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells
    • Boros L G, Torday J S, Lim S, Bassilian S, Cascante M, Lee W N. Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res 2000;60:1183-1185.
    • (2000) Cancer Res , vol.60 , pp. 1183-1185
    • Boros, L.G.1    Torday, J.S.2    Lim, S.3    Bassilian, S.4    Cascante, M.5    Lee, W.N.6
  • 52
    • 0033917915 scopus 로고    scopus 로고
    • Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation
    • Cascante M, Centelles J J, Veech R L, Lee W N, Boros L G. Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. Nutr Cancer 2000;36:150-154.
    • (2000) Nutr Cancer , vol.36 , pp. 150-154
    • Cascante, M.1    Centelles, J.J.2    Veech, R.L.3    Lee, W.N.4    Boros, L.G.5
  • 53
    • 33344456073 scopus 로고    scopus 로고
    • Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
    • Langbein S, Zerilli M, Zur Hausen A, Staiger W, Rensch-Boschert K, Lukan N, et al. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer 2006;94:578-585.
    • (2006) Br J Cancer , vol.94 , pp. 578-585
    • Langbein, S.1    Zerilli, M.2    Zur Hausen, A.3    Staiger, W.4    Rensch-Boschert, K.5    Lukan, N.6
  • 54
    • 0034717224 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract: potential role of the pentose phosphate pathways
    • Porter S N, Howarth G S, Butler R N. Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract: potential role of the pentose phosphate pathways. Eur J Pharmacol 2000;397:1-9.
    • (2000) Eur J Pharmacol , vol.397 , pp. 1-9
    • Porter, S.N.1    Howarth, G.S.2    Butler, R.N.3
  • 56
    • 60849114962 scopus 로고    scopus 로고
    • A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stress
    • Li D, Zhu Y, Tang Q, Lu H, Li H, Yang Y, et al. A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stress. Cancer Biother Radiopharm 2009;24:81-90.
    • (2009) Cancer Biother Radiopharm , vol.24 , pp. 81-90
    • Li, D.1    Zhu, Y.2    Tang, Q.3    Lu, H.4    Li, H.5    Yang, Y.6
  • 57
    • 4344624553 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis
    • Fico A, Paglialunga F, Cigliano L, Abrescia P, Verde P, Martini G, et al. Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis. Cell Death Differ 2004;11:823-831.
    • (2004) Cell Death Differ , vol.11 , pp. 823-831
    • Fico, A.1    Paglialunga, F.2    Cigliano, L.3    Abrescia, P.4    Verde, P.5    Martini, G.6
  • 58
    • 0036277102 scopus 로고    scopus 로고
    • Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production
    • Pias E K, Aw T Y. Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production. FASEB J 2002;16:781-790.
    • (2002) FASEB J , vol.16 , pp. 781-790
    • Pias, E.K.1    Aw, T.Y.2
  • 59
    • 79551580561 scopus 로고    scopus 로고
    • ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    • Cosentino C, Grieco D, Costanzo V. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J 2011;30:546-555.
    • (2011) EMBO J , vol.30 , pp. 546-555
    • Cosentino, C.1    Grieco, D.2    Costanzo, V.3
  • 60
    • 0035100719 scopus 로고    scopus 로고
    • DNA damage and apoptosis in mononuclear cells from glucose-6-phosphate dehydrogenase-deficient patients (G6PD Aachen variant) after UV irradiation
    • Efferth T, Fabry U, Osieka R. DNA damage and apoptosis in mononuclear cells from glucose-6-phosphate dehydrogenase-deficient patients (G6PD Aachen variant) after UV irradiation. J Leukoc Biol 2001;69:340-342.
    • (2001) J Leukoc Biol , vol.69 , pp. 340-342
    • Efferth, T.1    Fabry, U.2    Osieka, R.3
  • 61
    • 33645812852 scopus 로고    scopus 로고
    • Effects of small molecules on chaperone-mediated autophagy
    • Finn P F, Mesires N T, Vine M, Dice J F. Effects of small molecules on chaperone-mediated autophagy. Autophagy 2005;1:141-145.
    • (2005) Autophagy , vol.1 , pp. 141-145
    • Finn, P.F.1    Mesires, N.T.2    Vine, M.3    Dice, J.F.4
  • 62
    • 0041355256 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis
    • Leopold J A, Walker J, Scribner A W, Voetsch B, Zhang Y Y, Loscalzo A J, et al. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J Biol Chem 2003;278:32100-6.
    • (2003) J Biol Chem , vol.278 , pp. 32100-32106
    • Leopold, J.A.1    Walker, J.2    Scribner, A.W.3    Voetsch, B.4    Zhang, Y.Y.5    Loscalzo, A.J.6
  • 63
    • 66349107721 scopus 로고    scopus 로고
    • Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells
    • Pan S, World C J, Kovacs C J, Berk B C. Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Arterioscler Thromb Vasc Biol 2009;29:895-901.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 895-901
    • Pan, S.1    World, C.J.2    Kovacs, C.J.3    Berk, B.C.4
  • 64
    • 80052708782 scopus 로고    scopus 로고
    • Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
    • Polimeni M, Voena C, Kopecka J, Riganti C, Pescarmona G, Bosia A, et al. Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity. Biochem J 2011;439:141-149.
    • (2011) Biochem J , vol.439 , pp. 141-149
    • Polimeni, M.1    Voena, C.2    Kopecka, J.3    Riganti, C.4    Pescarmona, G.5    Bosia, A.6
  • 65
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondria and cancer
    • Wallace D C. Mitochondria and cancer. Nat Rev Cancer 2012;12:685-698.
    • (2012) Nat Rev Cancer , vol.12 , pp. 685-698
    • Wallace, D.C.1
  • 66
    • 0030728737 scopus 로고    scopus 로고
    • Diminished tumorigenic phenotype after depletion of mitochondrial DNA
    • Cavalli L R, Varella-Garcia M, Liang B C. Diminished tumorigenic phenotype after depletion of mitochondrial DNA. Cell Growth Differ 1997;8:1189-1198.
    • (1997) Cell Growth Differ , vol.8 , pp. 1189-1198
    • Cavalli, L.R.1    Varella-Garcia, M.2    Liang, B.C.3
  • 67
    • 0021966704 scopus 로고
    • Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts
    • Desjardins P, Frost E, Morais R. Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts. Mol Cell Biol 1985;5:1163-1169.
    • (1985) Mol Cell Biol , vol.5 , pp. 1163-1169
    • Desjardins, P.1    Frost, E.2    Morais, R.3
  • 68
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
    • King M P, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989;246:500-503.
    • (1989) Science , vol.246 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 69
    • 58149299283 scopus 로고    scopus 로고
    • mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft
    • Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak P K, et al. mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. BMC Genomics 2008;9:521.
    • (2008) BMC Genomics , vol.9 , pp. 521
    • Magda, D.1    Lecane, P.2    Prescott, J.3    Thiemann, P.4    Ma, X.5    Dranchak, P.K.6
  • 70
    • 0028107856 scopus 로고
    • Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA
    • Morais R, Zinkewich-Péotti K, Parent M, Wang H, Babai F, Zollinger M. Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA. Cancer Res 1994;54:3889-3896.
    • (1994) Cancer Res , vol.54 , pp. 3889-3896
    • Morais, R.1    Zinkewich-Péotti, K.2    Parent, M.3    Wang, H.4    Babai, F.5    Zollinger, M.6
  • 72
    • 21744442902 scopus 로고    scopus 로고
    • Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis
    • Li F, Wang Y, Zeller K I, Potter J J, Wonsey D R, O'Donnell K A, et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 2005;25:6225-6234.
    • (2005) Mol Cell Biol , vol.25 , pp. 6225-6234
    • Li, F.1    Wang, Y.2    Zeller, K.I.3    Potter, J.J.4    Wonsey, D.R.5    O'Donnell, K.A.6
  • 73
    • 84863837081 scopus 로고    scopus 로고
    • Lipid metabolism in cancer
    • Santos C R, Schulze A. Lipid metabolism in cancer. FEBS J 2012;279:2610-2623.
    • (2012) FEBS J , vol.279 , pp. 2610-2623
    • Santos, C.R.1    Schulze, A.2
  • 74
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes G, Thomas A, weinhouse S. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 1953;13:27-29.
    • (1953) Cancer Res , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 76
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • Menendez J A, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007;7:763-777.
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 77
    • 0034715909 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia
    • Li J N, Mahmoud M A, Han W F, Ripple M, Pizer E S. Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia. Exp Cell Res 2000;261:159-165.
    • (2000) Exp Cell Res , vol.261 , pp. 159-165
    • Li, J.N.1    Mahmoud, M.A.2    Han, W.F.3    Ripple, M.4    Pizer, E.S.5
  • 79
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • Yoon S, Lee M Y, Park S W, Moon J S, Koh Y K, Ahn Y H, et al. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem 2007;282:26122-26131.
    • (2007) J Biol Chem , vol.282 , pp. 26122-26131
    • Yoon, S.1    Lee, M.Y.2    Park, S.W.3    Moon, J.S.4    Koh, Y.K.5    Ahn, Y.H.6
  • 80
    • 39549117982 scopus 로고    scopus 로고
    • Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
    • Furuta E, Pai S K, Zhan R, Bandyopadhyay S, Watabe M, Mo Y Y, et al. Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res 2008;68:1003-1011.
    • (2008) Cancer Res , vol.68 , pp. 1003-1011
    • Furuta, E.1    Pai, S.K.2    Zhan, R.3    Bandyopadhyay, S.4    Watabe, M.5    Mo, Y.Y.6
  • 81
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer D E, Hatzivassiliou G, Zhao F, Andreadis C, Thompson C B. ATP citrate lyase is an important component of cell growth and transformation. Oncogene 2005;24:6314-6322.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 83
    • 34548580317 scopus 로고    scopus 로고
    • Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
    • Beckers A, Organe S, Timmermans L, Scheys K, Peeters A, Brusselmans K, et al. Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res 2007;67:8180-8187.
    • (2007) Cancer Res , vol.67 , pp. 8180-8187
    • Beckers, A.1    Organe, S.2    Timmermans, L.3    Scheys, K.4    Peeters, A.5    Brusselmans, K.6
  • 84
    • 40949096164 scopus 로고    scopus 로고
    • Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells
    • Accioly M T, Pacheco P, Maya-Monteiro C M, Carrossini N, Robbs B K, Oliveira S S, et al. Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer Res 2008;68:1732-1740.
    • (2008) Cancer Res , vol.68 , pp. 1732-1740
    • Accioly, M.T.1    Pacheco, P.2    Maya-Monteiro, C.M.3    Carrossini, N.4    Robbs, B.K.5    Oliveira, S.S.6
  • 85
    • 34347369084 scopus 로고    scopus 로고
    • Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
    • Konstantinopoulos P A, Karamouzis M V, Papavassiliou A G. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat Rev Drug Discov 2007;6:541-555.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 541-555
    • Konstantinopoulos, P.A.1    Karamouzis, M.V.2    Papavassiliou, A.G.3
  • 87
    • 33947594969 scopus 로고    scopus 로고
    • Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study
    • Kornblau S M, Banker D E, Stirewalt D, Shen D, Lemker E, Verstovsek S, et al. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study. Blood 2007;109:2999-3006.
    • (2007) Blood , vol.109 , pp. 2999-3006
    • Kornblau, S.M.1    Banker, D.E.2    Stirewalt, D.3    Shen, D.4    Lemker, E.5    Verstovsek, S.6
  • 88
    • 51549085692 scopus 로고    scopus 로고
    • Chemoembolization combined with pravastatin improves survival in patients with hepatocellular carcinoma
    • Graf H, Jüngst C, Straub G, Dogan S, Hoffmann R T, Jakobs T, et al. Chemoembolization combined with pravastatin improves survival in patients with hepatocellular carcinoma. Digestion 2008;78:34-38.
    • (2008) Digestion , vol.78 , pp. 34-38
    • Graf, H.1    Jüngst, C.2    Straub, G.3    Dogan, S.4    Hoffmann, R.T.5    Jakobs, T.6
  • 89
    • 80053557393 scopus 로고    scopus 로고
    • Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway
    • Kodach L L, Jacobs R J, Voorneveld P W, Wildenberg M E, Verspaget H W, van Wezel T, et al. Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway. Gut 2011;60:1544-1553.
    • (2011) Gut , vol.60 , pp. 1544-1553
    • Kodach, L.L.1    Jacobs, R.J.2    Voorneveld, P.W.3    Wildenberg, M.E.4    Verspaget, H.W.5    Van Wezel, T.6
  • 90
    • 0036864411 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
    • Horton J D. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans 2002;30:1091-1095.
    • (2002) Biochem Soc Trans , vol.30 , pp. 1091-1095
    • Horton, J.D.1
  • 91
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    • Hardie D G. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007;8:774-785.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 92
    • 63249089044 scopus 로고    scopus 로고
    • Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation
    • Shamma A, Takegami Y, Miki T, Kitajima S, Noda M, Obara T, et al. Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell 2009;15:255-269.
    • (2009) Cancer Cell , vol.15 , pp. 255-269
    • Shamma, A.1    Takegami, Y.2    Miki, T.3    Kitajima, S.4    Noda, M.5    Obara, T.6
  • 94
    • 84861101004 scopus 로고    scopus 로고
    • An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway
    • Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, et al. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov 2011;1:442-456.
    • (2011) Cancer Discov , vol.1 , pp. 442-456
    • Guo, D.1    Reinitz, F.2    Youssef, M.3    Hong, C.4    Nathanson, D.5    Akhavan, D.6
  • 95
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • Samuel V T, Shulman G I. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 97
    • 77956230328 scopus 로고    scopus 로고
    • Defining the pathway to insulin-like growth factor system targeting in cancer
    • Rosenzweig S A, Atreya H S. Defining the pathway to insulin-like growth factor system targeting in cancer. Biochem Pharmacol 2010;80:1115-1124.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1115-1124
    • Rosenzweig, S.A.1    Atreya, H.S.2
  • 99
    • 64749108996 scopus 로고    scopus 로고
    • Tumours with PI3K activation are resistant to dietary restriction
    • Kalaany N Y, Sabatini D M. Tumours with PI3K activation are resistant to dietary restriction. Nature 2009;458:725-731.
    • (2009) Nature , vol.458 , pp. 725-731
    • Kalaany, N.Y.1    Sabatini, D.M.2
  • 100
    • 0346725865 scopus 로고    scopus 로고
    • Caloric restriction and insulin-like growth factors in aging and cancer
    • Sell Ch. Caloric restriction and insulin-like growth factors in aging and cancer. Horm Metab Res 2003;35:705-711.
    • (2003) Horm Metab Res , vol.35 , pp. 705-711
    • Sell, Ch.1
  • 101
    • 84875465199 scopus 로고    scopus 로고
    • Cancer metabolism: fatty acid oxidation in the limelight
    • Carracedo A, Cantley L C, Pandolfi P P. Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer 2013;13:227-232.
    • (2013) Nat Rev Cancer , vol.13 , pp. 227-232
    • Carracedo, A.1    Cantley, L.C.2    Pandolfi, P.P.3
  • 102
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: connecting autophagy and lipid metabolism
    • Singh R, Cuervo A M. Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol 2012;2012:282041.
    • (2012) Int J Cell Biol , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 103
    • 84867877340 scopus 로고    scopus 로고
    • The NAD metabolome - a key determinant of cancer cell biology
    • Chiarugi A, Dölle C, Felici R, Ziegler M. The NAD metabolome - a key determinant of cancer cell biology. Nat Rev Cancer 2012;12:741-752.
    • (2012) Nat Rev Cancer , vol.12 , pp. 741-752
    • Chiarugi, A.1    Dölle, C.2    Felici, R.3    Ziegler, M.4
  • 104
    • 79955601028 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
    • Pike LS, Smift A L, Croteau N J, Ferrick D A, Wu M. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta 2011;1807:726-734.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 726-734
    • Pike, L.S.1    Smift, A.L.2    Croteau, N.J.3    Ferrick, D.A.4    Wu, M.5
  • 106
    • 33645730667 scopus 로고    scopus 로고
    • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 2006;12:446-451.
    • (2006) Nat Med , vol.12 , pp. 446-451
    • Ito, K.1    Hirao, A.2    Arai, F.3    Takubo, K.4    Matsuoka, S.5    Miyamoto, K.6
  • 107
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004;431:997-1002.
    • (2004) Nature , vol.431 , pp. 997-1002
    • Ito, K.1    Hirao, A.2    Arai, F.3    Matsuoka, S.4    Takubo, K.5    Hamaguchi, I.6
  • 108
    • 84863763440 scopus 로고    scopus 로고
    • AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    • Jeon S M, Chandel N S, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012;485:661-665.
    • (2012) Nature , vol.485 , pp. 661-665
    • Jeon, S.M.1    Chandel, N.S.2    Hay, N.3
  • 109
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova M M, Shaw R J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011;13:1016-1023.
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 110
    • 14544272384 scopus 로고    scopus 로고
    • Phosphorylation of PPARs: from molecular characterization to physiological relevance
    • Diradourian C, Girard J, Pégorier J P. Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 2005;87:33-38.
    • (2005) Biochimie , vol.87 , pp. 33-38
    • Diradourian, C.1    Girard, J.2    Pégorier, J.P.3
  • 111
    • 79956326256 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
    • Zaugg K, Yao Y, Reilly P T, Kannan K, Kiarash R, Mason J, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 2011;25:1041-1051.
    • (2011) Genes Dev , vol.25 , pp. 1041-1051
    • Zaugg, K.1    Yao, Y.2    Reilly, P.T.3    Kannan, K.4    Kiarash, R.5    Mason, J.6
  • 112
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • Schafer Z T, Grassian A R, Song L, Jiang Z, Gerhart-Hines Z, Irie H Y, et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009;461:109-113.
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1    Grassian, A.R.2    Song, L.3    Jiang, Z.4    Gerhart-Hines, Z.5    Irie, H.Y.6
  • 114
    • 20044393093 scopus 로고    scopus 로고
    • tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1
    • Giordano A, Calvani M, Petillo O, Grippo P, Tuccillo F, Melone M A, et al. tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1. Cell Death Differ 2005;12:603-613.
    • (2005) Cell Death Differ , vol.12 , pp. 603-613
    • Giordano, A.1    Calvani, M.2    Petillo, O.3    Grippo, P.4    Tuccillo, F.5    Melone, M.A.6
  • 115
    • 0031584852 scopus 로고    scopus 로고
    • Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2
    • Paumen M B, Ishida Y, Han H, Muramatsu M, Eguchi Y, Tsujimoto Y, et al. Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Biochem Biophys Res Commun 1997;231:523-525.
    • (1997) Biochem Biophys Res Commun , vol.231 , pp. 523-525
    • Paumen, M.B.1    Ishida, Y.2    Han, H.3    Muramatsu, M.4    Eguchi, Y.5    Tsujimoto, Y.6
  • 116
    • 74949089659 scopus 로고    scopus 로고
    • Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
    • Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest 2010;120:142-156.
    • (2010) J Clin Invest , vol.120 , pp. 142-156
    • Samudio, I.1    Harmancey, R.2    Fiegl, M.3    Kantarjian, H.4    Konopleva, M.5    Korchin, B.6
  • 117
    • 62749187786 scopus 로고    scopus 로고
    • Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors
    • Vickers A E. Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors. Toxicol Pathol 2009;37:78-88.
    • (2009) Toxicol Pathol , vol.37 , pp. 78-88
    • Vickers, A.E.1
  • 118
    • 48549088300 scopus 로고    scopus 로고
    • The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation
    • Samudio I, Fiegl M, McQueen T, Clise-Dwyer K, Andreeff M. The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res 2008;68:5198-5205.
    • (2008) Cancer Res , vol.68 , pp. 5198-5205
    • Samudio, I.1    Fiegl, M.2    Mcqueen, T.3    Clise-Dwyer, K.4    Andreeff, M.5
  • 120
    • 79951507755 scopus 로고    scopus 로고
    • Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
    • Kurhanewicz J, Vigneron D B, Brindle K, Chekmenev E Y, Comment A, Cunningham C H, et al. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia 2011;13:81-97.
    • (2011) Neoplasia , vol.13 , pp. 81-97
    • Kurhanewicz, J.1    Vigneron, D.B.2    Brindle, K.3    Chekmenev, E.Y.4    Comment, A.5    Cunningham, C.H.6
  • 121
    • 36049025517 scopus 로고    scopus 로고
    • Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer
    • Nahmias C, Carlson E R, Duncan L D, Blodgett T M, Kennedy J, Long M J, et al. Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer. J Oral Maxillofac Surg 2007;65:2524-2535.
    • (2007) J Oral Maxillofac Surg , vol.65 , pp. 2524-2535
    • Nahmias, C.1    Carlson, E.R.2    Duncan, L.D.3    Blodgett, T.M.4    Kennedy, J.5    Long, M.J.6
  • 123
    • 33750294785 scopus 로고    scopus 로고
    • PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT
    • Talbot J N, Gutman F, Fartoux L, Grange J D, Ganne N, Kerrou K, et al. PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT. Eur J Nucl Med Mol Imaging 2006;33:1285-1289.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , pp. 1285-1289
    • Talbot, J.N.1    Gutman, F.2    Fartoux, L.3    Grange, J.D.4    Ganne, N.5    Kerrou, K.6
  • 124
    • 33751418560 scopus 로고    scopus 로고
    • Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation
    • Kubota K, Furumoto S, Iwata R, Fukuda H, Kawamura K, Ishiwata K. Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation. Ann Nucl Med 2006;20:527-533.
    • (2006) Ann Nucl Med , vol.20 , pp. 527-533
    • Kubota, K.1    Furumoto, S.2    Iwata, R.3    Fukuda, H.4    Kawamura, K.5    Ishiwata, K.6
  • 125
    • 77950560590 scopus 로고    scopus 로고
    • Detection of local, regional, and distant recurrence in patients with psa relapse after external-beam radiotherapy using (11)C-choline positron emission tomography
    • Breeuwsma A J, Pruim J, van den Bergh A C, Leliveld A M, Nijman R J, Dierckx R A, et al. Detection of local, regional, and distant recurrence in patients with psa relapse after external-beam radiotherapy using (11)C-choline positron emission tomography. Int J Radiat Oncol Biol Phys 2010;77:160-164.
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , pp. 160-164
    • Breeuwsma, A.J.1    Pruim, J.2    Van den Bergh, A.C.3    Leliveld, A.M.4    Nijman, R.J.5    Dierckx, R.A.6
  • 126
    • 70349645988 scopus 로고    scopus 로고
    • Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniques
    • Piert M, Park H, Khan A, Siddiqui J, Hussain H, Chenevert T, et al. Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniques. J Nucl Med 2009;50:1585-1593.
    • (2009) J Nucl Med , vol.50 , pp. 1585-1593
    • Piert, M.1    Park, H.2    Khan, A.3    Siddiqui, J.4    Hussain, H.5    Chenevert, T.6
  • 127
    • 66349098351 scopus 로고    scopus 로고
    • Molecular imaging of proliferation in vivo: positron emission tomography with [18F]fluorothymidine
    • Buck A K, Herrmann K, Shen C, Dechow T, Schwaiger M, Wester H J. Molecular imaging of proliferation in vivo: positron emission tomography with [18F]fluorothymidine. Methods 2009;48:205-215.
    • (2009) Methods , vol.48 , pp. 205-215
    • Buck, A.K.1    Herrmann, K.2    Shen, C.3    Dechow, T.4    Schwaiger, M.5    Wester, H.J.6
  • 128
    • 34748835270 scopus 로고    scopus 로고
    • Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours
    • Buchmann I, Henze M, Engelbrecht S, Eisenhut M, Runz A, Schäfer M, et al. Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2007;34:1617-1626.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1617-1626
    • Buchmann, I.1    Henze, M.2    Engelbrecht, S.3    Eisenhut, M.4    Runz, A.5    Schäfer, M.6
  • 129
    • 84875796822 scopus 로고    scopus 로고
    • 18F-FES and 18F-FDG PET for differential diagnosis and quantitative evaluation of mesenchymal uterine tumors: correlation with immunohistochemical analysis
    • Zhao Z, Yoshida Y, Kurokawa T, Kiyono Y, Mori T, Okazawa H. 18F-FES and 18F-FDG PET for differential diagnosis and quantitative evaluation of mesenchymal uterine tumors: correlation with immunohistochemical analysis. J Nucl Med 2013;54:499-506.
    • (2013) J Nucl Med , vol.54 , pp. 499-506
    • Zhao, Z.1    Yoshida, Y.2    Kurokawa, T.3    Kiyono, Y.4    Mori, T.5    Okazawa, H.6
  • 130
    • 33746576145 scopus 로고    scopus 로고
    • Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?
    • Haubner R. Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis? Eur J Nucl Med Mol Imaging 2006;33 Suppl 1:54-63.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , Issue.SUPPL.1 , pp. 54-63
    • Haubner, R.1
  • 131
    • 33750940935 scopus 로고    scopus 로고
    • Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography
    • Wagner B, Anton M, Nekolla S G, Reder S, Henke J, Seidl S, et al. Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography. J Am Coll Cardiol 2006;48:2107-2115.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 2107-2115
    • Wagner, B.1    Anton, M.2    Nekolla, S.G.3    Reder, S.4    Henke, J.5    Seidl, S.6
  • 132
    • 35348933212 scopus 로고    scopus 로고
    • Potential value of MR spectroscopic imaging for the radiosurgical management of patients with recurrent high-grade gliomas
    • Chuang C F, Chan A A, Larson D, Verhey L J, McDermott M, Nelson S J, et al. Potential value of MR spectroscopic imaging for the radiosurgical management of patients with recurrent high-grade gliomas. Technol Cancer Res Treat 2007;6:375-382.
    • (2007) Technol Cancer Res Treat , vol.6 , pp. 375-382
    • Chuang, C.F.1    Chan, A.A.2    Larson, D.3    Verhey, L.J.4    Mcdermott, M.5    Nelson, S.J.6
  • 135
    • 55649089391 scopus 로고    scopus 로고
    • MRI and (1)H MRS of the breast: presence of a choline peak as malignancy marker is related to K21 value of the tumor in patients with invasive ductal carcinoma
    • Geraghty P R, van den Bosch M A, Spielman D M, Hunjan S, Birdwell R L, Fong K J, et al. MRI and (1)H MRS of the breast: presence of a choline peak as malignancy marker is related to K21 value of the tumor in patients with invasive ductal carcinoma. Breast J 2008;14:574-580.
    • (2008) Breast J , vol.14 , pp. 574-580
    • Geraghty, P.R.1    Van den Bosch, M.A.2    Spielman, D.M.3    Hunjan, S.4    Birdwell, R.L.5    Fong, K.J.6
  • 136
    • 33750383279 scopus 로고    scopus 로고
    • Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions
    • Glunde K, Ackerstaff E, Mori N, Jacobs M A, Bhujwalla Z M. Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Mol Pharm 2006;3:496-506.
    • (2006) Mol Pharm , vol.3 , pp. 496-506
    • Glunde, K.1    Ackerstaff, E.2    Mori, N.3    Jacobs, M.A.4    Bhujwalla, Z.M.5
  • 139
    • 23844457954 scopus 로고    scopus 로고
    • In vivo magnetic resonance spectroscopy in cancer
    • Gillies R J, Morse D L. In vivo magnetic resonance spectroscopy in cancer. Annu Rev Biomed Eng 2005;7:287-326.
    • (2005) Annu Rev Biomed Eng , vol.7 , pp. 287-326
    • Gillies, R.J.1    Morse, D.L.2
  • 140
    • 33646691063 scopus 로고    scopus 로고
    • In vivo research in astrocytoma cell proliferation with 1H-magnetic resonance spectroscopy: correlation with histopathology and immunohistochemistry
    • Chen J, Huang S L, Li T, Chen X L. In vivo research in astrocytoma cell proliferation with 1H-magnetic resonance spectroscopy: correlation with histopathology and immunohistochemistry. Neuroradiology 2006;48:312-318.
    • (2006) Neuroradiology , vol.48 , pp. 312-318
    • Chen, J.1    Huang, S.L.2    Li, T.3    Chen, X.L.4
  • 141
    • 13244279646 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy of brain tumors correlated with pathology
    • Magalhaes A, Godfrey W, Shen Y, Hu J, Smith W. Proton magnetic resonance spectroscopy of brain tumors correlated with pathology. Acad Radiol 2005;12:51-57.
    • (2005) Acad Radiol , vol.12 , pp. 51-57
    • Magalhaes, A.1    Godfrey, W.2    Shen, Y.3    Hu, J.4    Smith, W.5
  • 142
    • 34047202785 scopus 로고    scopus 로고
    • Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas
    • McKnight T R, Lamborn K R, Love T D, Berger M S, Chang S, Dillon W P, et al. Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas. J Neurosurg 2007;106:660-666.
    • (2007) J Neurosurg , vol.106 , pp. 660-666
    • McKnight, T.R.1    Lamborn, K.R.2    Love, T.D.3    Berger, M.S.4    Chang, S.5    Dillon, W.P.6
  • 143
    • 33845735110 scopus 로고    scopus 로고
    • Cerebral blood volume measurements and proton MR spectroscopy in grading of oligodendroglial tumors
    • Spampinato M V, Smith J K, Kwock L, Ewend M, Grimme J D, Camacho D L, et al. Cerebral blood volume measurements and proton MR spectroscopy in grading of oligodendroglial tumors. AJR Am J Roentgenol 2007;188:204-212.
    • (2007) AJR Am J Roentgenol , vol.188 , pp. 204-212
    • Spampinato, M.V.1    Smith, J.K.2    Kwock, L.3    Ewend, M.4    Grimme, J.D.5    Camacho, D.L.6
  • 147
    • 83455170880 scopus 로고    scopus 로고
    • Full-length human glutaminase in complex with an allosteric inhibitor
    • DeLaBarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, et al. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 2011;50:10764-10770.
    • (2011) Biochemistry , vol.50 , pp. 10764-10770
    • DeLaBarre, B.1    Gross, S.2    Fang, C.3    Gao, Y.4    Jha, A.5    Jiang, F.6
  • 148
  • 149
    • 84855453655 scopus 로고    scopus 로고
    • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
    • Le A, Lane A N, Hamaker M, Bose S, Gouw A, Barbi J, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012;15:110-121.
    • (2012) Cell Metab , vol.15 , pp. 110-121
    • Le, A.1    Lane, A.N.2    Hamaker, M.3    Bose, S.4    Gouw, A.5    Barbi, J.6
  • 150
    • 77953286130 scopus 로고    scopus 로고
    • Evaluation of thieno[3, 2-b]pyrrole[3, 2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase
    • Jiang J K, Boxer M B, Vander Heiden M G, Shen M, Skoumbourdis A P, Southall N, et al. Evaluation of thieno[3, 2-b]pyrrole[3, 2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett 2010;20:3387-3393.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 3387-3393
    • Jiang, J.K.1    Boxer, M.B.2    Vander Heiden, M.G.3    Shen, M.4    Skoumbourdis, A.P.5    Southall, N.6
  • 151
    • 84885589840 scopus 로고    scopus 로고
    • PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
    • Israelsen W J, Dayton T L, Davidson S M, Fiske B P, Hosios A M, Bellinger G, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 2013;155:397-409.
    • (2013) Cell , vol.155 , pp. 397-409
    • Israelsen, W.J.1    Dayton, T.L.2    Davidson, S.M.3    Fiske, B.P.4    Hosios, A.M.5    Bellinger, G.6
  • 152
    • 0242694902 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells
    • Zhou W, Simpson P J, McFadden J M, et al. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res 2003;63:7330-7337.
    • (2003) Cancer Res , vol.63 , pp. 7330-7337
    • Zhou, W.1    Simpson, P.J.2    McFadden, J.M.3
  • 154
    • 80053923216 scopus 로고    scopus 로고
    • Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors
    • Morris J C, Chiche J, Grellier C, Lopez M, Bornaghi L F, Maresca A, et al. Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J Med Chem 2011;54:6905-6918.
    • (2011) J Med Chem , vol.54 , pp. 6905-6918
    • Morris, J.C.1    Chiche, J.2    Grellier, C.3    Lopez, M.4    Bornaghi, L.F.5    Maresca, A.6
  • 155
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: upstream and downstream of cancer metabolism
    • Semenza G L. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 2010;20:51-56.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 156
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza G L. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 157
    • 33751091519 scopus 로고    scopus 로고
    • The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma
    • Fang J, Quinones Q J, Holman T L, Morowitz M J, Wang Q, Zhao H, et al. The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol 2006;70:2108-2115.
    • (2006) Mol Pharmacol , vol.70 , pp. 2108-2115
    • Fang, J.1    Quinones, Q.J.2    Holman, T.L.3    Morowitz, M.J.4    Wang, Q.5    Zhao, H.6
  • 159
  • 160
    • 79954603194 scopus 로고    scopus 로고
    • Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
    • Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang K Y, et al. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci 2011;102:1007-1013.
    • (2011) Cancer Sci , vol.102 , pp. 1007-1013
    • Izumi, H.1    Takahashi, M.2    Uramoto, H.3    Nakayama, Y.4    Oyama, T.5    Wang, K.Y.6
  • 162
    • 78650722178 scopus 로고    scopus 로고
    • Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?
    • Papandreou I, Goliasova T, Denko N C. Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm? Int J Cancer 2011;128:1001-1008.
    • (2011) Int J Cancer , vol.128 , pp. 1001-1008
    • Papandreou, I.1    Goliasova, T.2    Denko, N.C.3
  • 163
    • 33846002728 scopus 로고    scopus 로고
    • A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    • Bonnet S, Archer S L, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007;11:37-51.
    • (2007) Cancer Cell , vol.11 , pp. 37-51
    • Bonnet, S.1    Archer, S.L.2    Allalunis-Turner, J.3    Haromy, A.4    Beaulieu, C.5    Thompson, R.6
  • 164
    • 76649126249 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    • Le A, Cooper C R, Gouw A M, Dinavahi R, Maitra A, Deck L M, et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 2010;107:2037-2042.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2037-2042
    • Le, A.1    Cooper, C.R.2    Gouw, A.M.3    Dinavahi, R.4    Maitra, A.5    Deck, L.M.6
  • 165
    • 33847353815 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose
    • Maher J C, Wangpaichitr M, Savaraj N, Kurtoglu M, Lampidis T J. Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol Cancer Ther 2007;6:732-741.
    • (2007) Mol Cancer Ther , vol.6 , pp. 732-741
    • Maher, J.C.1    Wangpaichitr, M.2    Savaraj, N.3    Kurtoglu, M.4    Lampidis, T.J.5
  • 166
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano H, Martin D S, Xu R H, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006;25:4633-4646.
    • (2006) Oncogene , vol.25 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 167
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw R J, Lamia K A, Vasquez D, Koo S H, Bardeesy N, Depinho R A, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005;310:1642-1646.
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 169
    • 33746592505 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin: Response to Farooki and Schneider
    • Bowker S L, Majumdar S R, Veugelers P, Johnson J A. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin: Response to Farooki and Schneider. Diabetes Care 2006;29:1990-1991.
    • (2006) Diabetes Care , vol.29 , pp. 1990-1991
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 170
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch H A, Iliopoulos D, Tsichlis P N, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009;69:7507-7511.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 171
    • 74949117339 scopus 로고    scopus 로고
    • Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer
    • Dahabreh I J, Linardou H, Siannis F, Kosmidis P, Bafaloukos D, Murray S. Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2010;16:291-303.
    • (2010) Clin Cancer Res , vol.16 , pp. 291-303
    • Dahabreh, I.J.1    Linardou, H.2    Siannis, F.3    Kosmidis, P.4    Bafaloukos, D.5    Murray, S.6
  • 173
    • 34347402459 scopus 로고    scopus 로고
    • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    • Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 2007;178:93-105.
    • (2007) J Cell Biol , vol.178 , pp. 93-105
    • Yuneva, M.1    Zamboni, N.2    Oefner, P.3    Sachidanandam, R.4    Lazebnik, Y.5
  • 174
    • 70349331678 scopus 로고    scopus 로고
    • Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
    • Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009;325:1555-1559.
    • (2009) Science , vol.325 , pp. 1555-1559
    • Yun, J.1    Rago, C.2    Cheong, I.3    Pagliarini, R.4    Angenendt, P.5    Rajagopalan, H.6
  • 175
    • 38349183620 scopus 로고    scopus 로고
    • Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
    • Clem B, Telang S, Clem A, Yalcin A, Meier J, Simmons A, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther 2008;7:110-120.
    • (2008) Mol Cancer Ther , vol.7 , pp. 110-120
    • Clem, B.1    Telang, S.2    Clem, A.3    Yalcin, A.4    Meier, J.5    Simmons, A.6
  • 176
    • 0033773575 scopus 로고    scopus 로고
    • Engineering the substrate specificity of Escherichia coli asparaginase. II. Selective reduction of glutaminase activity by amino acid replacements at position 248
    • Derst C, Henseling J, Röhm K H. Engineering the substrate specificity of Escherichia coli asparaginase. II. Selective reduction of glutaminase activity by amino acid replacements at position 248. Protein Sci 2000;9:2009-2017.
    • (2000) Protein Sci , vol.9 , pp. 2009-2017
    • Derst, C.1    Henseling, J.2    Röhm, K.H.3
  • 177
    • 0001068795 scopus 로고
    • The effect of arginase on the retardation of tumour growth
    • Bach S J, Swaine D. The effect of arginase on the retardation of tumour growth. Br J Cancer 1965;19:379-386.
    • (1965) Br J Cancer , vol.19 , pp. 379-386
    • Bach, S.J.1    Swaine, D.2
  • 178
    • 39149099417 scopus 로고    scopus 로고
    • Arginine deiminase, a potential anti-tumor drug
    • Ni Y, Schwaneberg U, Sun Z H. Arginine deiminase, a potential anti-tumor drug. Cancer Lett 2008;261:1-11.
    • (2008) Cancer Lett , vol.261 , pp. 1-11
    • Ni, Y.1    Schwaneberg, U.2    Sun, Z.H.3
  • 179
    • 0010438308 scopus 로고
    • Dual requirement of Walker carcinosarcoma 256 in vitro for asparagine and glutamine
    • Neuman R E, Mccoy T A. Dual requirement of Walker carcinosarcoma 256 in vitro for asparagine and glutamine. Science 1956;124:124-125.
    • (1956) Science , vol.124 , pp. 124-125
    • Neuman, R.E.1    Mccoy, T.A.2
  • 180
    • 0020617998 scopus 로고
    • Glutamine metabolism in lymphocytes of the rat
    • Ardawi M S, Newsholme E A. Glutamine metabolism in lymphocytes of the rat. Biochem J 1983;212:835-842.
    • (1983) Biochem J , vol.212 , pp. 835-842
    • Ardawi, M.S.1    Newsholme, E.A.2
  • 181
    • 70949092805 scopus 로고    scopus 로고
    • Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE
    • Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, et al. Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PLoS One 2009;4:e7897.
    • (2009) PLoS One , vol.4
    • Bruzzone, S.1    Fruscione, F.2    Morando, S.3    Ferrando, T.4    Poggi, A.5    Garuti, A.6
  • 182
    • 38149105811 scopus 로고    scopus 로고
    • The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
    • Holen K, Saltz L B, Hollywood E, Burk K, Hanauske A R. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs 2008;26:45-51.
    • (2008) Invest New Drugs , vol.26 , pp. 45-51
    • Holen, K.1    Saltz, L.B.2    Hollywood, E.3    Burk, K.4    Hanauske, A.R.5
  • 184
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang C V. Links between metabolism and cancer. Genes Dev 2012;26:877-890.
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1


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