Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

Biochemical Journal

Volumn 439, Issue 1, 2011, Pages 141-149

  Polimeni, Manuela ^a   Voena, Claudia ^a   Kopecka, Joanna ^a   Riganti, Chiara ^a   Pescarmona, Gianpiero ^a   Bosia, Amalia ^a   Ghigo, Dario ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Doxorubicin; Glucose 6 phosphate dehydrogenase (G6PD); Glutathione (GSH); Multidrug resistance (MDR); Pentose phosphate pathway (PPP)

Indexed keywords

6 AMINONICOTINAMIDE; DOXORUBICIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; PRASTERONE;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HT29; COLON CANCER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLUCOSEPHOSPHATE DEHYDROGENASE; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 80052708782     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20102016     Document Type: Article

References (45)

1. Simon, S. M. and Schindler, M. (1994) Cell biological mechanisms of multidrug resistance in tumors. Proc. Natl. Acad. Sci. U.S.A. 91, 3497-3504
2. Gottesman, M. M., Fojo, T. and Bates, S. E. (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48-58
3. Baird, R. D. and Kaye, S. (2003) Drug resistance reversal: are we getting closer? Eur. J. Cancer 39, 2450-2461 (Pubitemid 37340159)
4. Bonadonna, G. and Monfardini, S. (1969) Cardiac toxicity of daunorubicin. Lancet 1, 837
5. Sau, A., Pellizzari Tregno, F., Valentino, F., Federici, G. and Caccuri, A. M. (2010) Glutathione transferases and development of new principles to overcome drug resistance. Arch. Biochem. Biophys. 500, 116-122
6. Morrow, C. S., Peklak-Scott, C., Bishwokarma, B., Kute, T. E., Smitherman, P. K. and Townsend, A. J. (2006) Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol. Pharmacol. 69, 1499-1505
7. Kuo, M. T. (2009) Redox regulation of multidrug resistance in cancer chemotherapy. Antioxid. Redox Signaling 11, 99-134
8. Estrela, J. M., Ortega, A. and Obrador, E. (2006) Glutathione in cancer biology and therapy. Crit. Rev. Clin. Lab. Sci. 43, 143-181
9. Kruh, G. D., Zeng, H., Rea, P. A., Liu, G., Chen, Z. S., Lee, K. and Belinsky, M. G. (2001) MRP subfamily transporters and resistance to anticancer agents. J. Bioenerg. Biomembr. 33, 493-501
10. Riganti, C., Miraglia, E., Viarisio, D., Costamagna, C., Pescarmona, G., Ghigo, D. and Bosia, A. (2005) Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res. 65, 516-525
11. Riganti, C., Aldieri, E., Bergandi, L., Fenoglio, I., Costamagna, C., Fubini, B., Bosia, A. and Ghigo, D. (2002) Crocidolite asbestos inhibits pentose phosphate pathway and glucose 6-phospate dehydrogenase activity in human lung epithelial cells. Free Radical Biol. Med. 32, 938-949
12. Polimeni, M., Gazzano, E., Ghiazza, M., Fenoglio, I., Bosia, A., Fubini, B. and Ghigo, D. (2008) Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages. Chem. Res. Toxicol. 21, 888-894
13. Ellman, G. L. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70-77
14. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
15. Voena, C., Conte, C., Ambrogio, C., Boeri Erba, E., Boccalatte, F., Mohammed, S., Jensen, O. N., Palestro, G., Inghirami, G. and Chiarle, R. (2007) The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. Cancer Res. 67, 4278-4286 (Pubitemid 46815075)
16. Mimnaugh, E. G., Trush, M. A., Bhatnagar, M. and Gram, T. E. (1985) Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin. Biochem. Pharmacol. 34, 847-856
17. Wefers, H. and Sies, H. (1983) Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity. Arch. Biochem. Biophys. 224, 568-578
18. Schwartz, A. G. and Pashko, L. L. (2004) Dehydroepiandrosterone, glucose 6-phosphate dehydrogenase, and longevity. Ageing Res. Rev. 3, 171-187
19. Jiang, Y., Miyazaki, T., Honda, A., Hirayama, T., Yoshida, S., Tanaka, N. and Matsuzaki, Y. (2005) Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone. J. Gastroenterol. 40, 490-497 (Pubitemid 40823284)
20. Miraglia, E., Lussiana, C., Viarisio, D., Racca, C., Cipriani, A., Gazzano, E., Bosia, A., Revelli, A. and Ghigo, D. (2010) The pentose phosphate pathway plays an essential role in supporting human sperm capacitation. Fertil. Steril. 93, 2437-2440
21. Walker, D. L., Reid, J. M., Svingen, P. A., Rios, R., Covey, J. M., Alley, M. C., Hollingshead, M. G., Budihardjo, I. I., Eckdahl, S., Boerner, S. A. et al. (1999) Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent. Biochem. Pharmacol. 58, 1057-1066
22. Budihardjo, I. I., Boerner, S. A., Eckdahl, S., Svingen, P. A., Rios, R., Ames, M. M. and Kaufmann, S. H. (2000) Effect of 6-aminonicotinamide and other protein synthesis inhibitors on formation of platinum-DNA adducts and cisplatin sensitivity. Mol. Pharmacol. 57, 529-538
23. Doublier, S., Riganti, C., Voena, C., Costamagna, C., Aldieri, E., Pescarmona, G., Ghigo, D. and Bosia, A. (2008) RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells. Mol. Cancer Res. 6, 1607-1620
24. Riganti, C., Aldieri, E., Bergandi, L., Tomatis, M., Fenoglio, I., Costamagna, C., Fubini, B., Bosia, A. and Ghigo, D. (2003) Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells. Toxicol. Appl. Pharmacol. 193, 106-115
25. Bast, A., Kaiserova, H., den Hartog, G. J. M., Haenen, G. R. M. M. and van der Vijgh, V. J. F. (2007) Protectors against doxorubicin-induced cardiotoxicity: flavonoids. Cell. Biol. Toxicol. 23, 39-47
26. Bryant, J., Picot, J., Baxter, L., Levitt, G., Sullivan, I. and Clegg, A. (2007) Clinical and costeffectiveness of cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review. Br. J. Cancer 96, 226-230 (Pubitemid 46160626)
27. Borst, P., Evers, R., Kool, M. and Wijnholds, J. (2000) A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92, 1295-1302
28. Homolya, L., Váradi, A. and Sarkadi, B. (2003) Multidrug resistance-associated proteins: export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors 17, 103-114 (Pubitemid 37267146)
29. Singhal, S. S., Yadav, S., Roth, C. and Singhal, J. (2009) RLIP76: a novel glutathione-conjugate and multi-drug transporter. Biochem. Pharmacol. 77, 761-769
30. Ferretti, A., Chen, L. L., Di Vito, M., Barca, S., Tombesi, M., Cianfriglia, M., Bozzi, A., Strom, R. and Podo, F. (1993) Pentose phosphate pathway alterations in multi-drug resistant leukemic T-cells: 31P NMR and enzymatic studies. Anticancer Res. 13, 867-872 (Pubitemid 23247428)
31. Lafleur, M. V. and Retèl, J. (1993) Contrasting effects of SH-compounds on oxidative DNA damage: repair and increase of damage. Mutat. Res. 295, 1-10
32. Ban, N., Takahashi, Y., Takayama, T., Kura, T., Katahira, T., Sakamaki, S. and Niitsu, Y. (1996) Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adryamicin, cisplatin, melphalan, and etoposide. Cancer Res. 56, 3577-3582 (Pubitemid 26251655)
33. Fojo, T. and Bates, S. (2003) Strategies for reversing drug resistance. Oncogene 22, 7512-7523 (Pubitemid 37487173)
34. Spolarics, Z. (1998) Endotoxemia, pentose cycle, and the oxidant/antioxidant balance in the hepatic sinusoid. J. Leukocyte Biol. 63, 534-541
35. Simunek, T., Sterba, M., Popelova, O., Adamcova, M., Hrdina, R. and Gersl, V. (2009) Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol. Rep. 61, 154-171
36. Minotti, G., Menna, P., Salvatorelli, E., Cairo, G. and Gianni, L. (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 56, 185-229
37. Wallace, K. B. (2007) Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis. Cardiovasc. Toxicol. 7, 101-107
38. Yeh, G. C., Occhipinti, S. J., Cowan, K. H., Chabner, B. A. and Myers, C. E. (1987) Adryamicin resistance in human tumor cells associated with marked alterations in the regulation of the hexose monophosphate shunt and its response to oxidant stress. Cancer Res. 47, 5994-5999
39. Yu, D. S., Chang, S. Y. and Ma, C. P. (1997) The correlation of membranous glycoprotein-gp-170, cytoplasmic glutathione and glucose-6-phosphate dehydrogenase levels with multidrug resistance in transitional cell carcinoma cell lines of the urinary tract. J. Urol. 157, 727-731
40. Lutzky, J., Astor, M. B., Taub, R. N., Baker, M. A., Bhalla, K., Gervasoni, Jr, J. E., Rosado, M., Stewart, V., Krishna, S. and Hindenburg, A. A. (1989) Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells. Cancer Res. 49, 4120-4125
41. Akan, I., Akan, S., Akca, H., Savas, B. and Ozben, T. (2005) Multidrug resistance-associated protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and buthionine sulfoximine. Cancer Cell Int. 5, 22-29
42. Gessner, T., Vaughan, L. A., Beehler, B. C., Bartels, C. J. and Baker, R. M. (1990) Elevated pentose cycle and glucuronyltransferase in daunorubicin-resistant P388 cells. Cancer Res. 50, 3921-3927
43. Fanciulli, M., Bruno, T., Castiglione, S., Del Carlo, C., Paggi, M. G. and Floridi, A. (1993) Glucose metabolism in adryamicin-sensitive and -resistant LoVo human colon carcinoma cells. Oncol. Res. 5, 357-362
44. Miccadei, S., Fanciulli, M., Bruno, T., Paggi, M. G. and Floridi, A. (1996) Energy metabolism of adryamicin-sensitive and -resistant Erlich ascites tumor cells. Oncol. Res. 8, 27-35
45. Lai, G. M., Moscow, J. A., Alvarez, M. G., Fojo, A. T. and Bates, S. E. (1991) Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines. Int. J. Cancer 49, 688-695