Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

Genes and Development

Volumn 25, Issue 10, 2011, Pages 1041-1051

  Zaugg, Kathrin ^a,b,c,d,e   Yao, Yi ^c,m   Reilly, Patrick T ^a,f   Kannan, Karuppiah ^g   Kiarash, Reza ^c   Mason, Jacqueline ^c   Huang, Ping ^c   Sawyer, Suzanne K ^h   Fuerth, Benjamin ^h   Faubert, Brandon ^c   Kalliomäki, Tuula ^a,b,c,d   Elia, Andrew ^a,b,c,d   Luo, Xunyi ^c   Nadeem, Vincent ⁱ   Bungard, David ^g   Yalavarthi, Sirseesha ^g   Growney, Joseph D ^a,b,c,d   Wakeham, Andrew ^c   Moolani, Yasmin ^a   Silvester, Jennifer ^h   Ten, Annick You ^h   Bakker, Walbert ^a   Tsuchihara, Katsuya ^c   Berger, Shelley L ^a,b,c,d   Hill, Richard P ^a,b,c,d   Jones, Russell G ^h   Tsao, Ming ^c   Robinson, Murray O ^g   Thompson, Craig B ^j,k,l   Pan, Guohua ^c,m   Mak, Tak W ^a,b,c,m   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^g AVEO ONCOLOGY   (United States)

^h MCGILL UNIVERSITY   (Canada)

ⁱ WISTAR INSTITUTE   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

^k UNIVERSITY OF PENNSYLVANIA   (United States)

^l UTRECHT UNIVERSITY   (Netherlands)

^m NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

more..

Author keywords

Cpt1C; Fatty acid homeostasis; Metabolic stress; Rapamycin resistance; Xenograft tumors

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 1C; FATTY ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; RAPAMYCIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENERGY YIELD; ENZYME ACTIVATION; FATTY ACID OXIDATION; GENE EXPRESSION; GENETIC CORRELATION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; HYPOXIA; LUNG TUMOR; METABOLIC STRESS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; STARVATION; STRESS; TUMOR CELL; TUMOR GROWTH; TUMOR RESISTANCE; TUMOR XENOGRAFT; UPREGULATION;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANOXIA; APOPTOSIS; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; LUNG NEOPLASMS; MICE; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

MAMMALIA; MURINAE;

EID: 79956326256     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1987211     Document Type: Article

References (33)

1. Brown JM, Wilson WR. 2004. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4: 437-447.
2. Buck E, Eyzaguirre A, Brown E, Petti F, McCormack S, Haley JD, Iwata KK, Gibson NW, Griffin G. 2006. Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther 5: 2676-2684.
3. Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL. 2010. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329: 1201-1205.
4. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. 1998. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501.
5. Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. 2007. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67: 6745-6752.
6. Gatenby RA, Gillies RJ. 2004. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 4: 891-899.
7. Guy CT, Cardiff RD, Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12: 954-961.
8. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. 2008. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30: 214-226.
9. Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, Bulyk M, Tsichlis PN, Shirley Liu X, Struhl K. 2010. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17: 348-361.
10. Hui CC, Joyner AL. 1993. A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 3: 241-246.
11. Ide T, Brown-Endres L, Chu K, Ongusaha PP, Ohtsuka T, El-Deiry WS, Aaronson SA, Lee SW. 2009. GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell 36: 379-392.
12. Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18: 283-293.
13. Kerner J, Hoppel C. 2000. Fatty acid import into mitochondria. Biochim Biophys Acta 1486: 1-17.
14. Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M, Viollet B. 2006. 59-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 26: 5336-5347.
15. Liu Y. 2006. Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis 9: 230-234.
16. Maglione JE, Moghanaki D, Young LJ, Manner CK, Ellies LG, Joseph SO, Nicholson B, Cardiff RD, MacLeod CL. 2001. Transgenic Polyoma middle-T mice model premalignant mammary disease. Cancer Res 61: 8298-8305.
17. Menendez JA, Lupu R. 2007. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7: 763-777.
18. Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. 2010. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140: 49-61.
19. Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, et al. 2002. Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol 22: 3509-3517.
20. Pan JG, Mak TW. 2007. Metabolic targeting as an anticancer strategy: dawn of a new era?. Sci STKE 2007: pe14. doi: 10.1126/stke.3812007pe14.
21. Pelicano H, Martin DS, Xu RH, Huang P. 2006. Glycolysis inhibition for anticancer treatment. Oncogene 25: 4633-4646.
22. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al. 2000. Molecular portraits of human breast tumours. Nature 406: 747-752.
23. Plas DR, Thompson CB. 2005. Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24: 7435-7442.
24. Price N, van der Leij F, Jackson V, Corstorphine C, Thomson R, Sorensen A, Zammit V. 2002. A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics 80: 433-442.
25. Ramsay RR, Zammit VA. 2004. Carnitine acyltransferases and their influence on CoA pools in health and disease. Mol Aspects Med 25: 475-493.
26. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Shaw RJ. 2006. Glucose metabolism and cancer. Curr Opin Cell Biol 18: 598-608.
28. Sierra AY, Gratacos E, Carrasco P, Clotet J, Urena J, Serra D, Asins G, Hegardt FG, Casals N. 2008. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J Biol Chem 283: 6878-6885.
29. Skinnider BF, Elia AJ, Gascoyne RD, Trumper LH, von Bonin F, Kapp U, Patterson B, Snow BE, Mak TW. 2001. Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 97: 250-255.
30. Swinnen JV, Brusselmans K, Verhoeven G. 2006. Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care 9: 358-365.
31. Wolfgang MJ, Kurama T, Dai Y, Suwa A, Asaumi M, Matsumoto S, Cha SH, Shimokawa T, Lane MD. 2006. The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci 103: 7282-7287.
32. Wolfgang MJ, Cha SH, Millington DS, Cline G, Shulman GI, Suwa A, Asaumi M, Kurama T, Shimokawa T, Lane MD. 2008. Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem 105: 1550-1559.
33. Yamashita Y, Kumabe T, Cho YY, Watanabe M, Kawagishi J, Yoshimoto T, Fujino T, Kang MJ, Yamamoto TT. 2000. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Oncogene 19: 5919-5925.