Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells

Cancer Research

Volumn 68, Issue 6, 2008, Pages 1732-1740

  Accioly, Maria T ^a   Pacheco, Patricia ^b   Maya Monteiro, Clarissa M ^b   Carrossini, Nina ^a   Robbs, Bruno K ^a   Oliveira, Silvia S ^a   Kaufmann, Cristiane ^a   Morgado Diaz, José A ^a   Bozza, Patricia T ^b   Viola, João P B ^a  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; FATTY ACID SYNTHASE INHIBITOR; ICOSANOID; LIPID; PROSTAGLANDIN E2;

ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; COLON ADENOCARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOLOCALIZATION; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STAINING;

4-BUTYROLACTONE; ADENOCARCINOMA; ASPIRIN; CACO-2 CELLS; CELL GROWTH PROCESSES; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; DINOPROSTONE; HCT116 CELLS; HT29 CELLS; HUMANS; LIPID METABOLISM; ORGANELLES; SUBCELLULAR FRACTIONS;

EID: 40949096164     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1999     Document Type: Article

References (54)

1. Swinnen JV, Brusselmans K, Verhoeven G. Increased lipogenesis in cancer cells: newplayers, novel targets. Curr Opin Clin Nutr Metab Care 2006;9:358-65.
2. Kuhajda FP. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 2006;66:5977-80.
3. Tauchi-Sato K, Ozeki S, Houjou T, et al. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 2002;277:44507-12.
4. Murphy DJ. The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 2001;40:325-438.
5. Bozza PT, Melo RC, Bandeira-Melo C. Leukocyte lipid bodies regulation and function: contribution to allergy and host defense. Pharmacol Ther 2007;113:30-49.
6. Brasaemle DL, Barber T, Wolins NE, et al. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 1997;38:2249-63.
7. Heid HW, Moll R, Schwetlick I, et al.. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 1998;294:309-21.
8. Fujimoto T, Kogo H, Ishiguro K, et al. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J Cell Biol 2001;152:1079-85.
9. Pol A, Luetterforst R, Lindsay M, et al. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 2001;152:1057-70.
10. Liu P, Ying Y, Zhao Y, et al. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem 2004;279:3787-92.
11. Brasaemle DL, Dolios G, Shapiro L, Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-1 adipocytes. J Biol Chem 2004;279:46835-42.
12. Wan HC, Melo RC, Jin Z, et al. Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies. FASEB J 2007;21:167-78.
13. Dvorak AM, Weller PF, Harvey VS, et al. Ultrastructural localization of prostaglandin endoperoxide synthase (cyclooxygenase) to isolated, purified fractions of guinea pig peritoneal macrophage and line 10 hepatocarcinoma cell lipid bodies. Int Arch Allergy Immunol 1993;101:136-42.
14. Bozza PT, Yu W, Penrose JF, et al. Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. J Exp Med 1997;186:909-20.
15. Yu W, Bozza PT, Tzizik DM, et al. Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies. Am J Pathol 1998;152:759-69.
16. Yu W, Cassara J, Weller PF. Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood 2000;95:1078-85.
17. Chen JS, Greenberg AS, Wang SM. Oleic acid-induced PKC isozyme translocation in RAW 264.7 macrophages. J Cell Biochem 2002;86:784-91.
18. Dvorak AM, Dvorak HF, Peters SP, et al. Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. J Immunol 1983;131:2965-76.
19. Cao Y, Pearman AT, Zimmerman GA, et al. Intracellular unesterified arachidonic acid signals apoptosis. Proc Natl Acad Sci U S A 2000;97:11280-5.
20. Cao Y, Dave KB, Doan TP, et al. Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. Cancer Res 2001;61:8429-34.
21. Sano H, Kawahito Y, Wilder RL, et al. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 1995;55:3785-9.
22. Eberhart CE, Coffey RJ, Radhika A, et al. Upregulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994;107:1183-8.
23. Kargman SL, O'Neill GP, Vickers PJ, et al. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res 1995;55:2556-9.
24. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000;69:145-82.
25. 2. Gut 1994;35:675-8.
26. 2 levels and lymphocyte subsets in portal venous drainage of colorectal cancers. Am J Surg 1994;167:264-7.
27. Ulrich CM, Bigler J, Potter JD. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer 2006;6:130-40.
28. Cha YI, DuBois RN. NSAIDs and cancer prevention: targets downstream of COX-2. Annu Rev Med 2007;58:239-52.
29. Bozza PT, Payne JL, Morham SG, et al. Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. Proc Natl Acad Sci U S A 1996;93:11091-6.
30. Pacheco P, Bozza FA, Gomes RN, et al. Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism. J Immunol 2002;169:6498-506.
31. Bandeira-Melo C, Phoofolo M, Weller PF. Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. J Biol Chem 2001;276:22779-87.
32. D'Avila H, Melo RC, Parreira GG, et al. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 2006;176:3087-97.
33. Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
34. Angermuller S, Fahimi HD. Imidazole-buffered osmium tetroxide: an excellent stain for visualization of lipids in transmission electron microscopy. Histochem J 1982;14:823-35.
35. Samuelsson B, Morgenstern R, Jakobsson PJ. Membrane prostaglandin e synthase-1: a novel therapeutic target. Pharmacol Rev 2007;59:207-24.
36. Cao Y, Prescott SM. Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 2002;190:279-86.
37. Bozza PT, Pacheco P, Yu W, et al. NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation. Prostaglandins Leukot Essent Fatty Acids 2002;67:237-44.
38. Rashid A, Pizer ES, Moga M, et al. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol 1997;150:201-8.
39. Visca P, Alo PL, Del Nonno F, et al. Immunohistochemical expression of fatty acid synthase, apoptoticregulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. Clin Cancer Res 1999;5:4111-8.
40. Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci U S A 2000;97:3450-4.
41. Zhou W, Simpson PJ, McFadden JM, et al. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res 2003;63:7330-7.
42. De Schrijver E, Brusselmans K, Heyns W, et al. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 2003;63:3799-804.
43. Schmid B, Rippmann JF, Tadayyon M, et al. Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochem Biophys Res Commun 2005;328:1073-82.
44. Sheng H, Shao J, Dixon DA, et al. Transforming growth factor-β1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem 2000;275:6628-35.
45. Jess T, Gamborg M, Matzen P, et al. Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol 2005;100:2724-9.
46. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420:860-7.
47. Beil WJ, Weller PF, Peppercorn MA, et al. Ultrastructural immunogold localization of subcellular sites of TNF-α in colonic Crohn's disease. J Leukoc Biol 1995;58:284-98.
48. Brasaemle DL. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis. J Lipid Res 2007;48:2547-59.
49. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995;83:493-501.
50. Sheng H, Shao J, Morrow JD, et al. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 1998;58:362-6.
51. Sheng H, Shao J, Washington MK, et al. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem 2001;276:18075-81.
52. Cohen AW, Razani B, Schubert W, et al. Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes 2004;53:1261-70.
53. Yao M, Huang Y, Shioi K, et al. Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma. Clin Cancer Res 2007;13:152-60.
54. Yao M, Tabuchi H, Nagashima Y, et al. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol 2005;205:377-87