-
1
-
-
0000459772
-
On the metabolism of carcinoma cells
-
Warburg, O., Posener, K. & Negelein, E. On the metabolism of carcinoma cells. Biochem. Z. 152, 309-344 (1924).
-
(1924)
Biochem. Z
, vol.152
, pp. 309-344
-
-
Warburg, O.1
Posener, K.2
Negelein, E.3
-
2
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R.A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein, B. & Kinzler, K.W. Cancer genes and the pathways they control. Nat. Med. 10, 789-799 (2004).
-
(2004)
Nat. Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
4
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M.G., Cantley, L.C. & Thompson, C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
5
-
-
43749083041
-
Brick by brick: Metabolism and tumor cell growth
-
DeBerardinis, R.J., Sayed, N., Ditsworth, D. & Thompson, C.B. Brick by brick: metabolism and tumor cell growth. Curr. Opin. Genet. Dev. 18, 54-61 (2008).
-
(2008)
Curr. Opin. Genet. Dev
, vol.18
, pp. 54-61
-
-
Deberardinis, R.J.1
Sayed, N.2
Ditsworth, D.3
Thompson, C.B.4
-
6
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu, P.P. & Sabatini, D.M. Cancer cell metabolism: Warburg and beyond. Cell 134, 703-707 (2008).
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
7
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou, D. et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat. Chem. Biol. 8, 839-847 (2012).
-
(2012)
Nat. Chem. Biol
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
-
8
-
-
84855453655
-
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
-
Le, A. et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 15, 110-121 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 110-121
-
-
Le, A.1
-
9
-
-
78651339534
-
NCBI GEO: Archive for functional genomics data sets-10 years on
-
Barrett, T. et al. NCBI GEO: archive for functional genomics data sets-10 years on. Nucleic Acids Res. 39, D1005-D1010 (2011).
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Barrett, T.1
-
10
-
-
58149204055
-
ArrayExpress update-from an archive of functional genomics experiments to the atlas of gene expression
-
Parkinson, H. et al. ArrayExpress update-from an archive of functional genomics experiments to the atlas of gene expression. Nucleic Acids Res. 37, D868-D872 (2009).
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Parkinson, H.1
-
11
-
-
75549090213
-
KEGG for representation and analysis of molecular networks involving diseases and drugs
-
Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M. & Hirakawa, M. KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 38, D355-D360 (2010).
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Kanehisa, M.1
Goto, S.2
Furumichi, M.3
Tanabe, M.4
Hirakawa, M.5
-
12
-
-
77955199853
-
Measuring gene expression divergence: The distance to keep
-
Glazko, G. & Mushegian, A. Measuring gene expression divergence: the distance to keep. Biol. Direct 5, 51 (2010).
-
(2010)
Biol. Direct
, vol.5
, pp. 51
-
-
Glazko, G.1
Mushegian, A.2
-
13
-
-
14844326483
-
Computational prediction of human metabolic pathways from the complete human genome
-
Romero, P. et al. Computational prediction of human metabolic pathways from the complete human genome. Genome Biol. 6, R2 (2005).
-
(2005)
Genome Biol
, vol.6
-
-
Romero, P.1
-
14
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol, W.H., Bounds, P.L. & Dang, C.V. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 11, 325-337 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
15
-
-
0027054926
-
Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility
-
Smith, C.A., Moss, J.E., Gough, A.C., Spurr, N.K. & Wolf, C.R. Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility. Environ. Health Perspect. 98, 107-112 (1992).
-
(1992)
Environ. Health Perspect
, vol.98
, pp. 107-112
-
-
Smith, C.A.1
Moss, J.E.2
Gough, A.C.3
Spurr, N.K.4
Wolf, C.R.5
-
16
-
-
43749116210
-
Implication of xenobiotic metabolizing enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma
-
Khedhaier, A. et al. Implication of xenobiotic metabolizing enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma. BMC Cancer 8, 109 (2008).
-
(2008)
BMC Cancer
, vol.8
, pp. 109
-
-
Khedhaier, A.1
-
17
-
-
0842288337
-
Inferring cellular networks using probabilistic graphical models
-
Friedman, N. Inferring cellular networks using probabilistic graphical models. Science 303, 799-805 (2004).
-
(2004)
Science
, vol.303
, pp. 799-805
-
-
Friedman, N.1
-
18
-
-
33846400424
-
Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles
-
Faith, J.J. et al. Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. PLoS Biol. 5, e8 (2007).
-
(2007)
PLoS Biol
, vol.5
-
-
Faith, J.J.1
-
19
-
-
46749121459
-
Causes and consequences of increased glucose metabolism of cancers
-
Gillies, R.J., Robey, I. & Gatenby, R.A. Causes and consequences of increased glucose metabolism of cancers. J. Nucl. Med. 49 (suppl. 2), 24S-42S (2008).
-
(2008)
J. Nucl. Med
, vol.49
, Issue.SUPPL. 2
-
-
Gillies, R.J.1
Robey, I.2
Gatenby, R.A.3
-
21
-
-
33846910173
-
Global reconstruction of the human metabolic network based on genomic and bibliomic data
-
Duarte, N.C. et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc. Natl. Acad. Sci. USA 104, 1777-1782 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 1777-1782
-
-
Duarte, N.C.1
-
22
-
-
0004026407
-
-
5th edn., W.H. Freeman, New York
-
Lehninger, A.L., Nelson, D.L. & Cox, M.M. Lehninger Principles of Biochemistry, 5th edn. (W.H. Freeman, New York, 2008).
-
(2008)
Lehninger Principles of Biochemistry
-
-
Lehninger, A.L.1
Nelson, D.L.2
Cox, M.M.3
-
23
-
-
70349240206
-
Tumor cell energy metabolism and its common features with yeast metabolism
-
Diaz-Ruiz, R., Uribe-Carvajal, S., Devin, A. & Rigoulet, M. Tumor cell energy metabolism and its common features with yeast metabolism. Biochim. Biophys. Acta 1796, 252-265 (2009).
-
(2009)
Biochim. Biophys. Acta
, vol.1796
, pp. 252-265
-
-
Diaz-Ruiz, R.1
Uribe-Carvajal, S.2
Devin, A.3
Rigoulet, M.4
-
24
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk, H.R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233 (2008).
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
-
25
-
-
3242798360
-
Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology
-
Walenta, S., Schroeder, T. & Mueller-Klieser, W. Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Curr. Med. Chem. 11, 2195-2204 (2004).
-
(2004)
Curr. Med. Chem
, vol.11
, pp. 2195-2204
-
-
Walenta, S.1
Schroeder, T.2
Mueller-Klieser, W.3
-
26
-
-
33744994567
-
Glutathione in cancer biology and therapy
-
Estrela, J.M., Ortega, A. & Obrador, E. Glutathione in cancer biology and therapy. Crit. Rev. Clin. Lab. Sci. 43, 143-181 (2006).
-
(2006)
Crit. Rev. Clin. Lab. Sci
, vol.43
, pp. 143-181
-
-
Estrela, J.M.1
Ortega, A.2
Obrador, E.3
-
27
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao, P. et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458, 762-765 (2009).
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
-
28
-
-
79957774646
-
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
-
Cheng, T. et al. Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proc. Natl. Acad. Sci. USA 108, 8674-8679 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 8674-8679
-
-
Cheng, T.1
-
29
-
-
0028327047
-
Alteration of aldolase isozymes in serum and tissues of patients with cancer and other diseases
-
Asaka, M. et al. Alteration of aldolase isozymes in serum and tissues of patients with cancer and other diseases. J. Clin. Lab. Anal. 8, 144-148 (1994).
-
(1994)
J. Clin. Lab. Anal
, vol.8
, pp. 144-148
-
-
Asaka, M.1
-
30
-
-
0028359507
-
Human aldolase C: Characterization of the recombinant enzyme expressed in Escherichia coli
-
Kusakabe, T., Motoki, K. & Hori, K. Human aldolase C: characterization of the recombinant enzyme expressed in Escherichia coli. J. Biochem. 115, 1172-1177 (1994).
-
(1994)
J. Biochem
, vol.115
, pp. 1172-1177
-
-
Kusakabe, T.1
Motoki, K.2
Hori, K.3
-
31
-
-
33746291023
-
Increased lipogenesis in cancer cells: New players, novel targets
-
Swinnen, J.V., Brusselmans, K. & Verhoeven, G. Increased lipogenesis in cancer cells: new players, novel targets. Curr. Opin. Clin. Nutr. Metab. Care 9, 358-365 (2006).
-
(2006)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.9
, pp. 358-365
-
-
Swinnen, J.V.1
Brusselmans, K.2
Verhoeven, G.3
-
32
-
-
0036674190
-
Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells
-
Costello, L.C. & Franklin, R.B. Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells. Horm. Metab. Res. 34, 417-424 (2002).
-
(2002)
Horm. Metab. Res
, vol.34
, pp. 417-424
-
-
Costello, L.C.1
Franklin, R.B.2
-
33
-
-
0021106559
-
A comparative study of citrate efflux from mitochondria of oleaginous and non-oleaginous yeasts
-
Evans, C.T., Scragg, A.H. & Ratledge, C. A comparative study of citrate efflux from mitochondria of oleaginous and non-oleaginous yeasts. Eur. J. Biochem. 130, 195-204 (1983).
-
(1983)
Eur. J. Biochem
, vol.130
, pp. 195-204
-
-
Evans, C.T.1
Scragg, A.H.2
Ratledge, C.3
-
34
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo, C.M. et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380-384 (2012).
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
-
35
-
-
77956265489
-
IDH mutations in glioma and acute myeloid leukemia
-
Dang, L., Jin, S. & Su, S.M. IDH mutations in glioma and acute myeloid leukemia. Trends Mol. Med. 16, 387-397 (2010).
-
(2010)
Trends Mol. Med
, vol.16
, pp. 387-397
-
-
Dang, L.1
Jin, S.2
Su, S.M.3
-
36
-
-
79955755461
-
Inborn and acquired metabolic defects in cancer
-
Frezza, C., Pollard, P.J. & Gottlieb, E. Inborn and acquired metabolic defects in cancer. J. Mol. Med. 89, 213-220 (2011).
-
(2011)
J. Mol. Med
, vol.89
, pp. 213-220
-
-
Frezza, C.1
Pollard, P.J.2
Gottlieb, E.3
-
37
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009).
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
-
38
-
-
78149466021
-
IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders
-
Zou, Y. et al. IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders. Biochem. Biophys. Res. Commun. 402, 378-383 (2010).
-
(2010)
Biochem. Biophys. Res. Commun
, vol.402
, pp. 378-383
-
-
Zou, Y.1
-
39
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs, J.S. et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8, 143-153 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
-
40
-
-
33947520506
-
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF
-
Koivunen, P. et al. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 282, 4524-4532 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 4524-4532
-
-
Koivunen, P.1
-
41
-
-
34047255064
-
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
-
Hewitson, K.S. et al. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J. Biol. Chem. 282, 3293-3301 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 3293-3301
-
-
Hewitson, K.S.1
-
42
-
-
2142744836
-
Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer
-
Habano, W. et al. Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer. Oncol. Rep. 10, 1375-1380 (2003).
-
(2003)
Oncol. Rep
, vol.10
, pp. 1375-1380
-
-
Habano, W.1
-
43
-
-
80053385552
-
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion
-
Bass, A.J. et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat. Genet. 43, 964-968 (2011).
-
(2011)
Nat. Genet
, vol.43
, pp. 964-968
-
-
Bass, A.J.1
-
44
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood, L.D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113 (2007).
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
-
45
-
-
0037069467
-
Analysis of optimality in natural and perturbed metabolic networks
-
Segre, D., Vitkup, D. & Church, G.M. Analysis of optimality in natural and perturbed metabolic networks. Proc. Natl. Acad. Sci. USA 99, 15112-15117 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 15112-15117
-
-
Segre, D.1
Vitkup, D.2
Church, G.M.3
-
46
-
-
0347694776
-
Cancer metabolism: Facts, fantasy, and fiction
-
Zu, X.L. & Guppy, M. Cancer metabolism: facts, fantasy, and fiction. Biochem. Biophys. Res. Commun. 313, 459-465 (2004).
-
(2004)
Biochem. Biophys. Res. Commun
, vol.313
, pp. 459-465
-
-
Zu, X.L.1
Guppy, M.2
-
47
-
-
2542610720
-
Preprocessing of oligonucleotide array data
-
author reply 658
-
Wu, Z. & Irizarry, R.A. Preprocessing of oligonucleotide array data. Nat. Biotechnol. 22, 656-658, author reply 658 (2004).
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 656-658
-
-
Wu, Z.1
Irizarry, R.A.2
-
48
-
-
4544341015
-
Linear models and empirical Bayes methods for assessing differential expression in microarray experiments
-
Smyth, G.K. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, e3 (2004).
-
(2004)
Stat. Appl. Genet. Mol. Biol
, vol.3
-
-
Smyth, G.K.1
-
49
-
-
0001677717
-
Controlling the false discovery rate - A practical and powerful approach to multiple testing
-
Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J. Roy. Stat. Soc. B Met. 57, 289-300 (1995).
-
(1995)
J. Roy. Stat. Soc. B Met
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
50
-
-
64749094310
-
The cancer genome
-
Stratton, M.R., Campbell, P.J. & Futreal, P.A. The cancer genome. Nature 458, 719-724 (2009).
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
|