p53: new roles in metabolism

Trends in Cell Biology

Volumn 17, Issue 6, 2007, Pages 286-291

  Bensaad, Karim ^a   Vousden, Karen H ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTIOXIDANT; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C OXIDASE; GLUTATHIONE; HYDROGEN PEROXIDE; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

AGING; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL DEATH; DNA REPAIR; ENERGY METABOLISM; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TUMOR SUPPRESSOR GENE;

AGING; ANIMALS; CELL RESPIRATION; ENERGY METABOLISM; HUMANS; NEOPLASMS; OXIDATIVE STRESS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34249681337     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2007.04.004     Document Type: Review

References (67)

1. Vogelstein B., et al. Surfing the p53 network. Nature 408 (2000) 307-310
2. Vousden K.H. Outcomes of p53 activation - spoilt for choice. J. Cell Sci. 119 (2006) 5015-5020
3. Liu G., and Chen X. Regulation of the p53 transcriptional activity. J. Cell Biochem. 97 (2006) 448-458
4. Bensaad K., and Vousden K.H. Savior and slayer: the two faces of p53. Nat. Med. 11 (2005) 1278-1279
5. Sablina A.A., et al. The antioxidant function of the p53 tumor suppressor gene. Nat. Med. 11 (2005) 1306-1313
6. Stambolsky P., et al. Regulation of AIF expression by p53. Cell Death Differ. 13 (2006) 2140-2149
7. Bensaad K., et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126 (2006) 107-120
8. Rozan L.M., and El-Deiry W.S. p53 downstream target genes and tumor suppression: a classical view in evolution. Cell Death Differ. 14 (2007) 3-9
9. Fei P., et al. Tissue-specific induction of p53 targets in vivo. Cancer Res. 62 (2002) 7316-7327
10. Cawley S., et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116 (2004) 499-509
11. Wei C.-L., et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 124 (2006) 207-219
12. Hardie D.G. The AMP-activated protein kinase pathway - new players upstream and donwstream. J. Cell Sci. 117 (2004) 5479-5487
13. Jones R.G., et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18 (2005) 283-293
14. Imamura K., et al. Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem. Biophys. Res. Com. 287 (2001) 562-567
15. Feng Z., et al. The coordinate regulation of the p53 nd mTOR pathways in cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 8204-8209
16. Shaw R.J. Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18 (2006) 598-608
17. Matoba S., et al. p53 regulates mitochondrial respiration. Science 312 (2006) 1650-1653
18. Kondoh H., et al. Glycolytic enzymes can modulate cellular lifespan. Cancer Res. 65 (2005) 177-185
19. Polyak K., et al. A model for p53-induced apoptosis. Nature 389 (1997) 300-305
20. Rivera A., and Maxwell S.A. The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J. Biol. Chem. 280 (2005) 29346-29354
21. Faraonio R., et al. p53 supresses the Nrf2-dependent transcription of antioxidant response genes. J. Biol. Chem. 281 (2006) 39776-39784
22. Johnson T.M., et al. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 11848-11852
23. Li P.-F., et al. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO J. 18 (1999) 6027-6036
24. Martindale J.L., and Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell. Physiol. 192 (2002) 1-15
25. Budanov A.V., et al. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304 (2004) 596-600
26. Tan M., et al. Transcriptional activation of the human glutathione peroxidase promoter by p53. J. Biol. Chem. 274 (1999) 12061-12066
27. Yoon K.A., et al. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J. Hum. Genet. 49 (2004) 134-140
28. Buettner V.L., et al. Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system. Mutat. Res. 379 (1997) 13-20
29. Burr K.L., et al. p53 deficiency does not affect mutation rates in the mouse germline. Oncogene 24 (2005) 4315-4318
30. Pelicano H., et al. Glycolysis inhibition for anticancer treatment. Oncogene 25 (2006) 4633-4646
31. Tian W.N., et al. Importance of glucose-6-phosphate dehydrogenase activity in cell death. Am. J. Physiol. 276 (1999) C1121-C1131
32. Brand K.A., and Hermfisse U. Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species. FASEB J. 11 (1997) 388-395
33. Golden T.R., and Hinerfeld D.A. Oxidative stress and aging: beyond correlation. Aging Cell 1 (2002) 117-123
34. Tyner S.D., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
35. Maier B., et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18 (2004) 306-319
36. Mendrysa S.M., and Perry M.E. Tumor suppression by p53 without accelerated aging: just enough of a good thing?. Cell Cycle 5 (2006) 714-717
37. Poyurovsky M.V., and Prives C. Unleashing the power of p53: lessons from mice and men. Genes Dev. 20 (2006) 125-131
38. Garcia-Cao I., et al. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21 (2002) 6225-6235
39. Mendrysa S.M., et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev. 20 (2006) 16-21
40. Mathea A., et al. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev. 18 (2006) 2736-2746
41. Bauer J.H., et al. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 (2005) 2063-2068
42. Murray-Zmijewski F., et al. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ. 13 (2006) 962-972
43. Pietsch E.C., et al. Polymorphisms in the p53 pathway. Oncogene 25 (2006) 1602-1611
44. van Heemst D., et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40 (2005) 11-15
45. Haupt S., and Haupt Y. Importance of p53 for cancer onset and therapy. Anticancer Drugs 17 (2006) 725-732
46. Garber K. Energy deregulation: licensing tumors to grow. Science 312 (2006) 1158-1159
47. Ko Y.H., et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem. Biophys. Res. Commun. 324 (2004) 269-275
48. Mathupala S.P., et al. Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25 (2006) 4777-4786
49. Fantin V.R., et al. Attenuation of LDH-A expression uncovers a link between glycolysis, micochondrial physiology, and tumor maintenance. Cancer Cell 9 (2006) 425-434
50. + channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer cell growth. Cancer Cell 11 (2007) 37-51
51. Ramsey M.R., and Sharpless N.E. ROS as a tumor suppressor?. Nat. Cell Biol. 8 (2006) 1213-1214
52. Kim J.-W., and Dang C.V. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 66 (2006) 8927-8930
53. Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis. Nat. Rev. Cancer 4 (2004) 891-899
54. Bui T., and Thomson C.B. Cancer's sweet tooth. Cancer Cell 9 (2006) 419-420
55. Plas D.R., and Thompson C.B. Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24 (2005) 7435-7442
56. Shim H., et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 6658-6663
57. Osthus R.C., et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J. Biol. Chem. 275 (2000) 21797-21800
58. King A., et al. Succinate dehydrogenase and fumerate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 25 (2006) 4675-4682
59. Brahimi-Horn C., and Pouyssegur J. The role of the hypoxia-inducible factor in tumor metabolism, growth and invasion. Bull. Cancer 93 (2006) E73-E80
60. An W.G., et al. Stabilization of wild-type by hypoxia-inducible factor 1α. Nature 392 (1998) 405-408
61. Ravi R., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev. 14 (2000) 34-44
62. Sanchez-Puig N., et al. Binding of natively unfolded HIF-1α ODD domain to p53. Mol. Cell 17 (2005) 11-21
63. Roe J.-S., et al. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol. Cell 22 (2006) 395-405
64. Fels D.R., and Koumenis C. HIF-1α and p53: the ODD couple?. Trends Biochem. Sci. 30 (2005) 426-429
65. Halliwell B. Oxidative stress and cancer: have we moved forward?. Biochem. J. 401 (2007) 1-11
66. Takahashi A., et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat. Cell Biol. 8 (2006) 1291-1297
67. Kondoh H., et al. Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization. Histol. Histopathol. 22 (2007) 85-90