메뉴 건너뛰기




Volumn 67, Issue 17, 2007, Pages 8180-8187

Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; PALMITIC ACID; POLYKETIDE; SORAPHEN A; UNCLASSIFIED DRUG;

EID: 34548580317     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0389     Document Type: Article
Times cited : (263)

References (47)
  • 2
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: New application of an old pathway
    • Kuhajda FP. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 2006;66:5977-80.
    • (2006) Cancer Res , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 4
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum LZ, Witters LA, Pasternack GR, Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997;3:2115-20.
    • (1997) Clin Cancer Res , vol.3 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 5
    • 0033814153 scopus 로고    scopus 로고
    • Selective activation of the fatty acid synthesis pathway in human prostate cancer
    • Swinnen JV, Vanderhoydonc F, Elgamal AA, et al. Selective activation of the fatty acid synthesis pathway in human prostate cancer. Int J Cancer 2000;88:176-9.
    • (2000) Int J Cancer , vol.88 , pp. 176-179
    • Swinnen, J.V.1    Vanderhoydonc, F.2    Elgamal, A.A.3
  • 6
    • 0033808261 scopus 로고    scopus 로고
    • The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung
    • Piyathilake CJ, Frost AR, Manne U, et al. The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 2000;31:1068-73.
    • (2000) Hum Pathol , vol.31 , pp. 1068-1073
    • Piyathilake, C.J.1    Frost, A.R.2    Manne, U.3
  • 7
    • 0036497907 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
    • Swinnen JV, Roskams T, Joniau S, et al. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer 2002;98:19-22.
    • (2002) Int J Cancer , vol.98 , pp. 19-22
    • Swinnen, J.V.1    Roskams, T.2    Joniau, S.3
  • 8
    • 0034002793 scopus 로고    scopus 로고
    • Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
    • Kuhajda FP. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 2000;16:202-8.
    • (2000) Nutrition , vol.16 , pp. 202-208
    • Kuhajda, F.P.1
  • 10
    • 0029971427 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer
    • Pizer ES, Wood FD, Heine HS, Romantsev FE, Pasternack GR, Kuhajda FP. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res 1996;56:1189-93.
    • (1996) Cancer Res , vol.56 , pp. 1189-1193
    • Pizer, E.S.1    Wood, F.D.2    Heine, H.S.3    Romantsev, F.E.4    Pasternack, G.R.5    Kuhajda, F.P.6
  • 11
    • 0032532655 scopus 로고    scopus 로고
    • Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    • Pizer ES, Chrest FJ, DiGiuseppe JA, Han WF. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 1998;58:4611-5.
    • (1998) Cancer Res , vol.58 , pp. 4611-4615
    • Pizer, E.S.1    Chrest, F.J.2    DiGiuseppe, J.A.3    Han, W.F.4
  • 13
    • 0035866378 scopus 로고    scopus 로고
    • Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53
    • Li JN, Gorospe M, Chrest FJ, et al. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 2001;61:1493-9.
    • (2001) Cancer Res , vol.61 , pp. 1493-1499
    • Li, J.N.1    Gorospe, M.2    Chrest, F.J.3
  • 14
    • 0041337028 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells
    • Brusselmans K, De Schrijver E, Heyns W, Verhoeven G, Swinnen JV. Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int J Cancer 2003;106:856-62.
    • (2003) Int J Cancer , vol.106 , pp. 856-862
    • Brusselmans, K.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 15
    • 1542720382 scopus 로고    scopus 로고
    • Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
    • Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res 2004;64:2070-5.
    • (2004) Cancer Res , vol.64 , pp. 2070-2075
    • Kridel, S.J.1    Axelrod, F.2    Rozenkrantz, N.3    Smith, J.W.4
  • 16
    • 0038418257 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
    • De Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 2003;63:3799-804.
    • (2003) Cancer Res , vol.63 , pp. 3799-3804
    • De Schrijver, E.1    Brusselmans, K.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 18
    • 0029777452 scopus 로고    scopus 로고
    • Identification of a second human acetyl-CoA carboxylase gene
    • Widmer J, Fassihi KS, Schlichter SC, et al. Identification of a second human acetyl-CoA carboxylase gene. Biochem J 1996;316:915-22.
    • (1996) Biochem J , vol.316 , pp. 915-922
    • Widmer, J.1    Fassihi, K.S.2    Schlichter, S.C.3
  • 19
    • 33947100984 scopus 로고    scopus 로고
    • Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
    • Carretero J, Medina PP, Blanco R, et al. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene 2007;26:1616-25.
    • (2007) Oncogene , vol.26 , pp. 1616-1625
    • Carretero, J.1    Medina, P.P.2    Blanco, R.3
  • 20
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw RJ, Kosmatka M, Bardeesy N, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004;101:3329-35.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3
  • 21
    • 33645646867 scopus 로고    scopus 로고
    • BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase
    • Moreau K, Dizin E, Ray H, et al. BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. J Biol Chem 2006;281:3172-81.
    • (2006) J Biol Chem , vol.281 , pp. 3172-3181
    • Moreau, K.1    Dizin, E.2    Ray, H.3
  • 22
    • 0037015671 scopus 로고    scopus 로고
    • BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains
    • Magnard C, Bachelier R, Vincent A, et al. BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. Oncogene 2002;21:6729-39.
    • (2002) Oncogene , vol.21 , pp. 6729-6739
    • Magnard, C.1    Bachelier, R.2    Vincent, A.3
  • 23
    • 0034650757 scopus 로고    scopus 로고
    • Malonylcoenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
    • Pizer ES, Thupari J, Han WF, et al. Malonylcoenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 2000;60:213-8.
    • (2000) Cancer Res , vol.60 , pp. 213-218
    • Pizer, E.S.1    Thupari, J.2    Han, W.F.3
  • 24
    • 0034806134 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity
    • Thupari JN, Pinn ML, Kuhajda FP. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun 2001;285:217-23.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 217-223
    • Thupari, J.N.1    Pinn, M.L.2    Kuhajda, F.P.3
  • 25
    • 23044482013 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the acetyl-CoA-carboxylase-a gene induces growth inhibition and apoptosis of prostate cancer cells
    • Brusselmans K, De Schrijver E, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-a gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 2005;65:6719-25.
    • (2005) Cancer Res , vol.65 , pp. 6719-6725
    • Brusselmans, K.1    De Schrijver, E.2    Verhoeven, G.3    Swinnen, J.V.4
  • 26
    • 33744808464 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase a is essential to breast cancer cell survival
    • Chajes V, Cambot M, Moreau K, Lenoir GM, Joulin V. Acetyl-CoA carboxylase a is essential to breast cancer cell survival. Cancer Res 2006;66:5287-94.
    • (2006) Cancer Res , vol.66 , pp. 5287-5294
    • Chajes, V.1    Cambot, M.2    Moreau, K.3    Lenoir, G.M.4    Joulin, V.5
  • 27
    • 84988075033 scopus 로고
    • Isolation and structure elucidation of soraphen A1, a novel antifungal macrolide from Sorangium cellulosum
    • Bedorf N, Schomburg D, Gerth K, Reichenbach H, Höfle G. Isolation and structure elucidation of soraphen A1, a novel antifungal macrolide from Sorangium cellulosum. Liebigs Ann Chem 1993;1017-21.
    • (1993) Liebigs Ann Chem , pp. 1017-1021
    • Bedorf, N.1    Schomburg, D.2    Gerth, K.3    Reichenbach, H.4    Höfle, G.5
  • 28
    • 0028154083 scopus 로고
    • The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Soraphen A1 a: fermentation, isolation, biological properties
    • Gerth K, Bedorf N, Irschik H, Hofle G, Reichenbach H. The soraphens: a family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Soraphen A1 a: fermentation, isolation, biological properties. J Antibiot (Tokyo) 1994;47:23-31.
    • (1994) J Antibiot (Tokyo) , vol.47 , pp. 23-31
    • Gerth, K.1    Bedorf, N.2    Irschik, H.3    Hofle, G.4    Reichenbach, H.5
  • 29
    • 0002970751 scopus 로고
    • Inhibition of fungal acetyl-CoA carboxylase: A novel target discovered with the myxobacterial compound soraphen
    • Dixon GK, Copping LG, Hollomon DW, editors, Oxford: BIOS Scientific Publishers Ltd
    • Pridzun L, Sasse F, Reichenbach H. Inhibition of fungal acetyl-CoA carboxylase: A novel target discovered with the myxobacterial compound soraphen. In: Dixon GK, Copping LG, Hollomon DW, editors. Antifungal agents. Oxford: BIOS Scientific Publishers Ltd.; 1995. p. 99-109.
    • (1995) Antifungal agents , pp. 99-109
    • Pridzun, L.1    Sasse, F.2    Reichenbach, H.3
  • 30
    • 0028040134 scopus 로고
    • Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A
    • Vahlensieck HF, Pridzun L, Reichenbach H, Hinnen A. Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A. Curr Genet 1994;25:95-100.
    • (1994) Curr Genet , vol.25 , pp. 95-100
    • Vahlensieck, H.F.1    Pridzun, L.2    Reichenbach, H.3    Hinnen, A.4
  • 31
    • 10944226843 scopus 로고    scopus 로고
    • A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product
    • Shen Y, Volrath SL, Weatherly SC, Elich TD, Tong L. A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Mol Cell 2004;16:881-91.
    • (2004) Mol Cell , vol.16 , pp. 881-891
    • Shen, Y.1    Volrath, S.L.2    Weatherly, S.C.3    Elich, T.D.4    Tong, L.5
  • 32
    • 2642540877 scopus 로고    scopus 로고
    • Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain
    • Weatherly SC, Volrath SL, Elich TD. Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain. Biochem J 2004;380:105-10.
    • (2004) Biochem J , vol.380 , pp. 105-110
    • Weatherly, S.C.1    Volrath, S.L.2    Elich, T.D.3
  • 33
    • 0029743674 scopus 로고    scopus 로고
    • Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP
    • Swinnen JV, Van Veldhoven PP, Esquenet M, Heyns W, Verhoeven G. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 1996;137:4468-74.
    • (1996) Endocrinology , vol.137 , pp. 4468-4474
    • Swinnen, J.V.1    Van Veldhoven, P.P.2    Esquenet, M.3    Heyns, W.4    Verhoeven, G.5
  • 34
    • 0024296459 scopus 로고
    • Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells
    • Van Veldhoven PP, Bell RM. Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells. Biochim Biophys Acta 1988;959:185-96.
    • (1988) Biochim Biophys Acta , vol.959 , pp. 185-196
    • Van Veldhoven, P.P.1    Bell, R.M.2
  • 35
    • 0032502911 scopus 로고    scopus 로고
    • Enzymatic quantitation of cholesterol esters in lipid extracts
    • Van Veldhoven PP, Meyhi E, Mannaerts GP. Enzymatic quantitation of cholesterol esters in lipid extracts. Anal Biochem 1998;258:152-5.
    • (1998) Anal Biochem , vol.258 , pp. 152-155
    • Van Veldhoven, P.P.1    Meyhi, E.2    Mannaerts, G.P.3
  • 36
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-8.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 37
    • 0028836002 scopus 로고
    • Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles
    • Biederbick A, Kern HF, Elsasser HP. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 1995;66:3-14.
    • (1995) Eur J Cell Biol , vol.66 , pp. 3-14
    • Biederbick, A.1    Kern, H.F.2    Elsasser, H.P.3
  • 38
    • 0033997045 scopus 로고    scopus 로고
    • The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe
    • Niemann A, Takatsuki A, Elsasser HP. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe. J Histochem Cytochem 2000;48:251-8.
    • (2000) J Histochem Cytochem , vol.48 , pp. 251-258
    • Niemann, A.1    Takatsuki, A.2    Elsasser, H.P.3
  • 39
    • 0034757896 scopus 로고    scopus 로고
    • A novel assay to study autophagy: Regulation of autophagosome vacuole size by amino acid deprivation
    • Munafo DB, Colombo MI. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J Cell Sci 2001;114:3619-29.
    • (2001) J Cell Sci , vol.114 , pp. 3619-3629
    • Munafo, D.B.1    Colombo, M.I.2
  • 40
    • 0021164209 scopus 로고
    • Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria
    • Kiorpes TC, Hoerr D, Ho W, Weaner LE, Inman MG, Tutwiler GF. Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. J Biol Chem 1984;259:9750-5.
    • (1984) J Biol Chem , vol.259 , pp. 9750-9755
    • Kiorpes, T.C.1    Hoerr, D.2    Ho, W.3    Weaner, L.E.4    Inman, M.G.5    Tutwiler, G.F.6
  • 41
    • 0344838439 scopus 로고    scopus 로고
    • Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
    • Swinnen JV, Van Veldhoven PP, Timmermans L, et al. Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun 2003;302:898-903.
    • (2003) Biochem Biophys Res Commun , vol.302 , pp. 898-903
    • Swinnen, J.V.1    Van Veldhoven, P.P.2    Timmermans, L.3
  • 42
    • 0032053210 scopus 로고    scopus 로고
    • Androgens and the control of lipid metabolism in human prostate cancer cells
    • Swinnen JV, Verhoeven G. Androgens and the control of lipid metabolism in human prostate cancer cells. J Steroid Biochem Mol Biol 1998;65:191-198.
    • (1998) J Steroid Biochem Mol Biol , vol.65 , pp. 191-198
    • Swinnen, J.V.1    Verhoeven, G.2
  • 43
    • 0021715781 scopus 로고
    • Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid
    • Halvorson DL, McCune SA. Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid. Lipids 1984;19:851-856.
    • (1984) Lipids , vol.19 , pp. 851-856
    • Halvorson, D.L.1    McCune, S.A.2
  • 44
    • 0022351343 scopus 로고
    • Reciprocal effects of 5-(tetradecyloxy)-2-furoic acid on fatty acid oxidation
    • Otto DA, Chatzidakis C, Kasziba E, Cook GA. Reciprocal effects of 5-(tetradecyloxy)-2-furoic acid on fatty acid oxidation. Arch Biochem Biophys 1985;242:23-31.
    • (1985) Arch Biochem Biophys , vol.242 , pp. 23-31
    • Otto, D.A.1    Chatzidakis, C.2    Kasziba, E.3    Cook, G.A.4
  • 45
    • 18144396604 scopus 로고    scopus 로고
    • Treating the metabolic syndrome: Acetyl-CoA carboxylase inhibition
    • Harwood HJ, Jr. Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition. Expert Opin Ther Targets 2005;9:267-81.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 267-281
    • Harwood Jr., H.J.1
  • 46
    • 33747589441 scopus 로고    scopus 로고
    • Spot 14: A marker of aggressive breast cancer and a potential therapeutic target
    • Kinlaw WB, Quinn JL, Wells WA, Roser-Jones C, Moncur JT. Spot 14: A marker of aggressive breast cancer and a potential therapeutic target. Endocrinology 2006;147:4048-55.
    • (2006) Endocrinology , vol.147 , pp. 4048-4055
    • Kinlaw, W.B.1    Quinn, J.L.2    Wells, W.A.3    Roser-Jones, C.4    Moncur, J.T.5
  • 47
    • 3042619469 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome
    • Harwood HJ, Jr. Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome. Curr Opin Investig Drugs 2004;5:283-9.
    • (2004) Curr Opin Investig Drugs , vol.5 , pp. 283-289
    • Harwood Jr., H.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.