The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

Investigational New Drugs

Volumn 26, Issue 1, 2008, Pages 45-51

  Holen, Kyle ^a   Saltz, Leonard B ^b   Hollywood, Ellen ^b   Burk, Konrad ^c   Hanauske, Axel Rainer ^d  

^a UNIVERSITY OF WISCONSIN   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c ClinDescience GmbH   (Germany)

^d DEPARTMENT OF CARDIOLOGY   (Germany)

Author keywords

NAD; Nicotinamide; Pharmacokinetics; Phase I; VEGF

Indexed keywords

ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; FK 866; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; FATIGUE; FEMALE; HUMAN; HYPERGLYCEMIA; HYPOALBUMINEMIA; LYMPHOCYTOPENIA; MALE; MAXIMUM TOLERATED DOSE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; SOLID TUMOR; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ACRYLAMIDES; ADULT; AGED; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATIGUE; FEMALE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NAD; NAUSEA; NEOPLASMS; NEUTROPENIA; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PIPERIDINES; THROMBOCYTOPENIA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VOMITING;

EID: 38149105811     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-007-9083-2     Document Type: Article

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