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Volumn 13, Issue 4, 2013, Pages 227-232

Cancer metabolism: Fatty acid oxidation in the limelight

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE I; ETOMOXIR; FATTY ACID SYNTHASE; FENOFIBRATE; GLUCOSE; GLUTAMINE; METFORMIN; OXFENICINE; PERHEXILINE; PHENFORMIN; RANOLAZINE; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; TRIMETAZIDINE; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

EID: 84875465199     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3483     Document Type: Article
Times cited : (974)

References (42)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 3
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol, W. H., Bounds, P. L. & Dang, C. V. Otto Warburg's contributions to current concepts of cancer metabolism. Nature Rev. Cancer 11, 325-337 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 4
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk, H. R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233 (2008).
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1
  • 5
    • 80052258995 scopus 로고    scopus 로고
    • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
    • Locasale, J. W. et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genet. 43, 869-874 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 869-874
    • Locasale, J.W.1
  • 6
    • 77956674635 scopus 로고    scopus 로고
    • Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    • Vander Heiden, M. G. et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 329, 1492-1499 (2010).
    • (2010) Science , vol.329 , pp. 1492-1499
    • Vander Heiden, M.G.1
  • 7
    • 84869077946 scopus 로고    scopus 로고
    • Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
    • Hitosugi, T. et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22, 585-600 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 585-600
    • Hitosugi, T.1
  • 8
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis, R. J. et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl Acad. Sci. USA 104, 19345-19350 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1
  • 9
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: A new therapeutic target in cancer
    • Wise, D. R. & Thompson, C. B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 35, 427-433 (2010).
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 10
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: Connecting autophagy and lipid metabolism
    • Singh, R. & Cuervo, A. M. Lipophagy: connecting autophagy and lipid metabolism. Int. J. Cell Biol. 2012, 282041 (2012).
    • (2012) Int. J. Cell Biol. , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 11
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • Schafer, Z. T. et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461, 109-113 (2009).
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1
  • 12
    • 84865959001 scopus 로고    scopus 로고
    • A metabolic prosurvival role for PML in breast cancer
    • Carracedo, A. et al. A metabolic prosurvival role for PML in breast cancer. J. Clin. Invest. 122, 3088-3100 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3088-3100
    • Carracedo, A.1
  • 13
    • 79956326256 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
    • Zaugg, K. et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 25, 1041-1051 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 1041-1051
    • Zaugg, K.1
  • 14
    • 84862280420 scopus 로고    scopus 로고
    • Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition
    • Carrasco, P. et al. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J. Biol. Chem. 287, 21224-21232 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 21224-21232
    • Carrasco, P.1
  • 15
    • 84867746022 scopus 로고    scopus 로고
    • Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism
    • Lee, J. & Wolfgang, M. J. Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 13, 23 (2012).
    • (2012) BMC Biochem. , vol.13 , Issue.23
    • Lee, J.1    Wolfgang, M.J.2
  • 16
    • 43749088942 scopus 로고    scopus 로고
    • CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
    • Sierra, A. Y. et al. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J. Biol. Chem. 283, 6878-6885 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 6878-6885
    • Sierra, A.Y.1
  • 17
    • 74949089659 scopus 로고    scopus 로고
    • Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
    • Samudio, I. et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J. Clin. Invest. 120, 142-156 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 142-156
    • Samudio, I.1
  • 18
    • 20044393093 scopus 로고    scopus 로고
    • TBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl- CoA-independent inhibition of carnitine palmitoyltransferase-1
    • Giordano, A. et al. tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl- CoA-independent inhibition of carnitine palmitoyltransferase-1. Cell Death Differ. 12, 603-613 (2005).
    • (2005) Cell Death Differ. , Issue.12 , pp. 603-613
    • Giordano, A.1
  • 19
    • 0031584852 scopus 로고    scopus 로고
    • Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase i with Bcl-2. Biochem
    • Paumen, M. B. et al. Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Biochem. Biophys. Res. Commun. 231, 523-525 (1997).
    • (1997) Biophys. Res. Commun. , vol.231 , pp. 523-525
    • Paumen, M.B.1
  • 20
    • 62749187786 scopus 로고    scopus 로고
    • Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors
    • Vickers, A. E. Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors. Toxicol. Pathol. 37, 78-88 (2009).
    • (2009) Toxicol. Pathol. , vol.37 , pp. 78-88
    • Vickers, A.E.1
  • 21
    • 48549088300 scopus 로고    scopus 로고
    • The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation
    • Samudio, I., Fiegl, M., McQueen, T., Clise-Dwyer, K. & Andreeff, M. The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res. 68, 5198-5205 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 5198-5205
    • Samudio, I.1    Fiegl, M.2    McQueen, T.3    Clise-Dwyer, K.4    Andreeff, M.5
  • 22
    • 20144382754 scopus 로고    scopus 로고
    • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
    • Monti, S. et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 105, 1851-1861 (2005).
    • (2005) Blood , vol.105 , pp. 1851-1861
    • Monti, S.1
  • 23
    • 84867595989 scopus 로고    scopus 로고
    • Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
    • Caro, P. et al. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell 22, 547-560 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 547-560
    • Caro, P.1
  • 24
    • 84868632060 scopus 로고    scopus 로고
    • A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
    • Ito, K. et al. A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nature Med. 18, 1350-1358 (2012).
    • (2012) Nature Med. , vol.18 , pp. 1350-1358
    • Ito, K.1
  • 25
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan, B. et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468, 701-704 (2011).
    • (2011) Nature , vol.468 , pp. 701-704
    • Gan, B.1
  • 26
    • 78649851511 scopus 로고    scopus 로고
    • The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
    • Gurumurthy, S. et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468, 659-663 (2011).
    • (2011) Nature , vol.468 , pp. 659-663
    • Gurumurthy, S.1
  • 27
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada, D., Saunders, T. L. & Morrison, S. J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468, 653-658 (2011).
    • (2011) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 28
    • 84872169944 scopus 로고    scopus 로고
    • Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
    • Knobloch, M. et al. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature 493, 226-230 (2013).
    • (2013) Nature , vol.493 , pp. 226-230
    • Knobloch, M.1
  • 29
    • 84867878045 scopus 로고    scopus 로고
    • Cancer stem cell definitions and terminology: The devil is in the details
    • Valent, P. et al. Cancer stem cell definitions and terminology: the devil is in the details. Nature Rev. Cancer 12, 767-775 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 767-775
    • Valent, P.1
  • 30
    • 84867877340 scopus 로고    scopus 로고
    • The NAD metabolome-a key determinant of cancer cell biology
    • Chiarugi, A., Dolle, C., Felici, R. & Ziegler, M. The NAD metabolome-a key determinant of cancer cell biology. Nature Rev. Cancer 12, 741-752 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 741-752
    • Chiarugi, A.1    Dolle, C.2    Felici, R.3    Ziegler, M.4
  • 31
    • 79955601028 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
    • Pike, L. S., Smift, A. L., Croteau, N. J., Ferrick, D. A. & Wu, M. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim. Biophys. Acta 1807, 726-734 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 726-734
    • Pike, L.S.1    Smift, A.L.2    Croteau, N.J.3    Ferrick, D.A.4    Wu, M.5
  • 32
    • 84863763440 scopus 로고    scopus 로고
    • AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    • Jeon, S. M., Chandel, N. S. & Hay, N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 485, 661-665 (2012).
    • (2012) Nature , vol.485 , pp. 661-665
    • Jeon, S.M.1    Chandel, N.S.2    Hay, N.3
  • 33
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova, M. M. & Shaw, R. J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biol. 13, 1016-1023 (2011).
    • (2011) Nature Cell Biol. , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 34
    • 14544272384 scopus 로고    scopus 로고
    • Phosphorylation of PPARs: From molecular characterization to physiological relevance
    • Diradourian, C., Girard, J. & Pegorier, J. P. Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 87, 33-38 (2005).
    • (2005) Biochimie , vol.87 , pp. 33-38
    • Diradourian, C.1    Girard, J.2    Pegorier, J.P.3
  • 35
    • 34848867521 scopus 로고    scopus 로고
    • Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
    • Hosokawa, K. et al. Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem. Biophys. Res. Commun. 363, 578-583 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.363 , pp. 578-583
    • Hosokawa, K.1
  • 36
    • 33645730667 scopus 로고    scopus 로고
    • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    • Ito, K. et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nature Med. 12, 446-451 (2006).
    • (2006) Nature Med. , vol.12 , pp. 446-451
    • Ito, K.1
  • 37
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • Ito, K. et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997-1002 (2004).
    • (2004) Nature , vol.431 , pp. 997-1002
    • Ito, K.1
  • 38
    • 81255157465 scopus 로고    scopus 로고
    • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • Nieman, K. M. et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Med. 17, 1498-1503 (2011).
    • (2011) Nature Med. , vol.17 , pp. 1498-1503
    • Nieman, K.M.1
  • 39
    • 0034652297 scopus 로고    scopus 로고
    • The subcellular localization of acetyl-CoA carboxylase 2
    • Abu-Elheiga, L. et al. The subcellular localization of acetyl-CoA carboxylase 2. Proc. Natl Acad. Sci. USA 97, 1444-1449 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 1444-1449
    • Abu-Elheiga, L.1
  • 40
    • 34547800233 scopus 로고    scopus 로고
    • A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: The ERGO (etomoxir for the recovery of glucose oxidation)
    • Holubarsch, C. J. et al. A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study. Clin. Sci. (Lond.) 113, 205-212 (2007).
    • (2007) Study. Clin. Sci. (Lond.) , vol.113 , pp. 205-212
    • Holubarsch, C.J.1
  • 41
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • Kantor, P. F., Lucien, A., Kozak, R. & Lopaschuk, G. D. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 86, 580-588 (2000).
    • (2000) Circ. Res. , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 42
    • 53349097796 scopus 로고    scopus 로고
    • Ranolazine for chronic stable angina
    • Nash, D. T. & Nash, S. D. Ranolazine for chronic stable angina. Lancet 372, 1335-1341 (2008).
    • (2008) Lancet , vol.372 , pp. 1335-1341
    • Nash, D.T.1    Nash, S.D.2


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