-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
3
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol, W. H., Bounds, P. L. & Dang, C. V. Otto Warburg's contributions to current concepts of cancer metabolism. Nature Rev. Cancer 11, 325-337 (2011).
-
(2011)
Nature Rev. Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
4
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk, H. R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233 (2008).
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
-
5
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale, J. W. et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genet. 43, 869-874 (2011).
-
(2011)
Nature Genet.
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
-
6
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden, M. G. et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 329, 1492-1499 (2010).
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
-
7
-
-
84869077946
-
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
-
Hitosugi, T. et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22, 585-600 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 585-600
-
-
Hitosugi, T.1
-
8
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis, R. J. et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl Acad. Sci. USA 104, 19345-19350 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19345-19350
-
-
Deberardinis, R.J.1
-
9
-
-
77955281020
-
Glutamine addiction: A new therapeutic target in cancer
-
Wise, D. R. & Thompson, C. B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 35, 427-433 (2010).
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 427-433
-
-
Wise, D.R.1
Thompson, C.B.2
-
10
-
-
84859768059
-
Lipophagy: Connecting autophagy and lipid metabolism
-
Singh, R. & Cuervo, A. M. Lipophagy: connecting autophagy and lipid metabolism. Int. J. Cell Biol. 2012, 282041 (2012).
-
(2012)
Int. J. Cell Biol.
, vol.2012
, pp. 282041
-
-
Singh, R.1
Cuervo, A.M.2
-
11
-
-
69949101473
-
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
-
Schafer, Z. T. et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461, 109-113 (2009).
-
(2009)
Nature
, vol.461
, pp. 109-113
-
-
Schafer, Z.T.1
-
12
-
-
84865959001
-
A metabolic prosurvival role for PML in breast cancer
-
Carracedo, A. et al. A metabolic prosurvival role for PML in breast cancer. J. Clin. Invest. 122, 3088-3100 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3088-3100
-
-
Carracedo, A.1
-
13
-
-
79956326256
-
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
-
Zaugg, K. et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 25, 1041-1051 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 1041-1051
-
-
Zaugg, K.1
-
14
-
-
84862280420
-
Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition
-
Carrasco, P. et al. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J. Biol. Chem. 287, 21224-21232 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 21224-21232
-
-
Carrasco, P.1
-
15
-
-
84867746022
-
Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism
-
Lee, J. & Wolfgang, M. J. Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 13, 23 (2012).
-
(2012)
BMC Biochem.
, vol.13
, Issue.23
-
-
Lee, J.1
Wolfgang, M.J.2
-
16
-
-
43749088942
-
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
-
Sierra, A. Y. et al. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J. Biol. Chem. 283, 6878-6885 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 6878-6885
-
-
Sierra, A.Y.1
-
17
-
-
74949089659
-
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
-
Samudio, I. et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J. Clin. Invest. 120, 142-156 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 142-156
-
-
Samudio, I.1
-
18
-
-
20044393093
-
TBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl- CoA-independent inhibition of carnitine palmitoyltransferase-1
-
Giordano, A. et al. tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl- CoA-independent inhibition of carnitine palmitoyltransferase-1. Cell Death Differ. 12, 603-613 (2005).
-
(2005)
Cell Death Differ.
, Issue.12
, pp. 603-613
-
-
Giordano, A.1
-
19
-
-
0031584852
-
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase i with Bcl-2. Biochem
-
Paumen, M. B. et al. Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Biochem. Biophys. Res. Commun. 231, 523-525 (1997).
-
(1997)
Biophys. Res. Commun.
, vol.231
, pp. 523-525
-
-
Paumen, M.B.1
-
20
-
-
62749187786
-
Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors
-
Vickers, A. E. Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors. Toxicol. Pathol. 37, 78-88 (2009).
-
(2009)
Toxicol. Pathol.
, vol.37
, pp. 78-88
-
-
Vickers, A.E.1
-
21
-
-
48549088300
-
The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation
-
Samudio, I., Fiegl, M., McQueen, T., Clise-Dwyer, K. & Andreeff, M. The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res. 68, 5198-5205 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 5198-5205
-
-
Samudio, I.1
Fiegl, M.2
McQueen, T.3
Clise-Dwyer, K.4
Andreeff, M.5
-
22
-
-
20144382754
-
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
-
Monti, S. et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 105, 1851-1861 (2005).
-
(2005)
Blood
, vol.105
, pp. 1851-1861
-
-
Monti, S.1
-
23
-
-
84867595989
-
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
-
Caro, P. et al. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell 22, 547-560 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 547-560
-
-
Caro, P.1
-
24
-
-
84868632060
-
A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
-
Ito, K. et al. A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nature Med. 18, 1350-1358 (2012).
-
(2012)
Nature Med.
, vol.18
, pp. 1350-1358
-
-
Ito, K.1
-
25
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
Gan, B. et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468, 701-704 (2011).
-
(2011)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
-
26
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
Gurumurthy, S. et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468, 659-663 (2011).
-
(2011)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
-
27
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
Nakada, D., Saunders, T. L. & Morrison, S. J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468, 653-658 (2011).
-
(2011)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
28
-
-
84872169944
-
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
-
Knobloch, M. et al. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature 493, 226-230 (2013).
-
(2013)
Nature
, vol.493
, pp. 226-230
-
-
Knobloch, M.1
-
29
-
-
84867878045
-
Cancer stem cell definitions and terminology: The devil is in the details
-
Valent, P. et al. Cancer stem cell definitions and terminology: the devil is in the details. Nature Rev. Cancer 12, 767-775 (2012).
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 767-775
-
-
Valent, P.1
-
30
-
-
84867877340
-
The NAD metabolome-a key determinant of cancer cell biology
-
Chiarugi, A., Dolle, C., Felici, R. & Ziegler, M. The NAD metabolome-a key determinant of cancer cell biology. Nature Rev. Cancer 12, 741-752 (2012).
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 741-752
-
-
Chiarugi, A.1
Dolle, C.2
Felici, R.3
Ziegler, M.4
-
31
-
-
79955601028
-
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
-
Pike, L. S., Smift, A. L., Croteau, N. J., Ferrick, D. A. & Wu, M. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim. Biophys. Acta 1807, 726-734 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 726-734
-
-
Pike, L.S.1
Smift, A.L.2
Croteau, N.J.3
Ferrick, D.A.4
Wu, M.5
-
32
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
Jeon, S. M., Chandel, N. S. & Hay, N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 485, 661-665 (2012).
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
33
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova, M. M. & Shaw, R. J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biol. 13, 1016-1023 (2011).
-
(2011)
Nature Cell Biol.
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
34
-
-
14544272384
-
Phosphorylation of PPARs: From molecular characterization to physiological relevance
-
Diradourian, C., Girard, J. & Pegorier, J. P. Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 87, 33-38 (2005).
-
(2005)
Biochimie
, vol.87
, pp. 33-38
-
-
Diradourian, C.1
Girard, J.2
Pegorier, J.P.3
-
35
-
-
34848867521
-
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
-
Hosokawa, K. et al. Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem. Biophys. Res. Commun. 363, 578-583 (2007).
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.363
, pp. 578-583
-
-
Hosokawa, K.1
-
36
-
-
33645730667
-
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
-
Ito, K. et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nature Med. 12, 446-451 (2006).
-
(2006)
Nature Med.
, vol.12
, pp. 446-451
-
-
Ito, K.1
-
37
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito, K. et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997-1002 (2004).
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
-
38
-
-
81255157465
-
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
-
Nieman, K. M. et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Med. 17, 1498-1503 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 1498-1503
-
-
Nieman, K.M.1
-
39
-
-
0034652297
-
The subcellular localization of acetyl-CoA carboxylase 2
-
Abu-Elheiga, L. et al. The subcellular localization of acetyl-CoA carboxylase 2. Proc. Natl Acad. Sci. USA 97, 1444-1449 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 1444-1449
-
-
Abu-Elheiga, L.1
-
40
-
-
34547800233
-
A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: The ERGO (etomoxir for the recovery of glucose oxidation)
-
Holubarsch, C. J. et al. A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study. Clin. Sci. (Lond.) 113, 205-212 (2007).
-
(2007)
Study. Clin. Sci. (Lond.)
, vol.113
, pp. 205-212
-
-
Holubarsch, C.J.1
-
41
-
-
0034678082
-
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
-
Kantor, P. F., Lucien, A., Kozak, R. & Lopaschuk, G. D. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 86, 580-588 (2000).
-
(2000)
Circ. Res.
, vol.86
, pp. 580-588
-
-
Kantor, P.F.1
Lucien, A.2
Kozak, R.3
Lopaschuk, G.D.4
-
42
-
-
53349097796
-
Ranolazine for chronic stable angina
-
Nash, D. T. & Nash, S. D. Ranolazine for chronic stable angina. Lancet 372, 1335-1341 (2008).
-
(2008)
Lancet
, vol.372
, pp. 1335-1341
-
-
Nash, D.T.1
Nash, S.D.2
|