Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6905-6918

  Morris, Jason C ^a   Chiche, Johanna ^c   Grellier, Caroline ^a   Lopez, Marie ^a   Bornaghi, Laurent F ^a   Maresca, Alfonso ^b   Supuran, Claudiu T ^b   Pouysségur, Jacques ^c   Poulsen, Sally Ann ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,2',3,3',4',6,6' HEPTA O ACETYL S PROPYNYL 1 THIO BETA DEXTRO MALTOSIDE; 2,3,4,6 TETRA O ACETYL PROPYNYL 1 THIO BETA DEXTRO GALACTOPYRANOSIDE; 2,3,4,6 TETRA O ACETYL PROPYNYL 1 THIO BETA DEXTRO GLUCOPYRANOSIDE; 4 [4 [(2',2'',3',3'',4'',6',6'' HEPTA O ACETYL BETA MALTOSYL)SULFONYLMETHYL] 1H 1,2,3 TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [4 [(2',2'',3',3'',4'',6',6'' HEPTA O ACETYL BETA MALTOSYL)SULFONYLMETHYL] 5 IODO 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',2'',3',3'',4',6',6'' HEPTA O ACETYL BETA MALTOSIDE) THIOMETHYL] 5 IODO 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) THIOMETHYL] 5 IODO 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL)SULFONYLMETHYL] 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL)SULFONYLMETHYL] 5 IODO H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL)THIOMETHYL] 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) SULFONYLMETHYL]1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) THIOMETHYL] 5 IODO 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(2',3',4',6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)THIOMETHYL] 1H 1,2,3 TRIAZOL 1 YL] BENZENESULFONAMIDE; 4 [4 [(BETA DEXTRO GLUCOPYRANOSYL)THIOMETHYL] 5 IODO 1H 1,2,3 TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 AZIDOBENZENE SULFONAMIDE; ANTINEOPLASTIC AGENT; CARBOHYDRATE; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CATALYSIS; CELL HYPOXIA; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; COMPETITIVE INHIBITION; CONJUGATION; CONTROLLED STUDY; DRUG STRUCTURE; IMMUNOBLOTTING; NONHUMAN; OXIDATION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TUMOR MICROENVIRONMENT; UPREGULATION;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL HYPOXIA; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CLICK CHEMISTRY; DRUG SCREENING ASSAYS, ANTITUMOR; GLUCOSIDES; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; SULFONAMIDES;

EID: 80053923216     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200892s     Document Type: Article

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