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Volumn 30, Issue 2, 2015, Pages 381-392

The role of the microglia in acute CNS injury

Author keywords

Brain; Inflammation; Microglia; Spinal cord; Stroke; Trauma

Indexed keywords

ANIMAL; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR ACCIDENT; HUMAN; INJURIES; MICROGLIA; PATHOLOGY;

EID: 84896689074     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-014-9531-6     Document Type: Review
Times cited : (106)

References (164)
  • 1
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • COI: 1:CAS:528:DC%2BD2sXhtlKltLbP, PID: 18026097
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 10(12):1538–1543. doi:10.1038/nn2014
    • (2007) Nat Neurosci , vol.10 , Issue.12 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 3
    • 79958022133 scopus 로고    scopus 로고
    • The microglial-motoneuron dialogue in ALS
    • COI: 1:CAS:528:DC%2BC3MXhtFCqsLnN, PID: 21842586
    • Appel SH, Zhao W, Beers DR, Henkel JS (2011) The microglial-motoneuron dialogue in ALS. Acta Myol 30(1):4–8
    • (2011) Acta Myol , vol.30 , Issue.1 , pp. 4-8
    • Appel, S.H.1    Zhao, W.2    Beers, D.R.3    Henkel, J.S.4
  • 4
    • 79958255054 scopus 로고    scopus 로고
    • Molecular pathophysiology of cerebral hemorrhage: secondary brain injury
    • PID: 21527759
    • Aronowski J, Zhao X (2011) Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke 42(6):1781–1786. doi:10.1161/STROKEAHA.110.596718
    • (2011) Stroke , vol.42 , Issue.6 , pp. 1781-1786
    • Aronowski, J.1    Zhao, X.2
  • 5
    • 0033638508 scopus 로고    scopus 로고
    • Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94
    • COI: 1:CAS:528:DC%2BD3cXptVegur4%3D, PID: 11129784
    • Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH (2000) Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab 20(12):1681–1689. doi:10.1097/00004647-200012000-00007
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.12 , pp. 1681-1689
    • Asahi, M.1    Asahi, K.2    Jung, J.C.3    del Zoppo, G.J.4    Fini, M.E.5    Lo, E.H.6
  • 6
    • 1642358379 scopus 로고    scopus 로고
    • Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats
    • COI: 1:CAS:528:DC%2BD2cXivVCit7o%3D, PID: 15009633
    • Bao F, Chen Y, Dekaban GA, Weaver LC (2004) Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats. J Neurochem 88(6):1335–1344
    • (2004) J Neurochem , vol.88 , Issue.6 , pp. 1335-1344
    • Bao, F.1    Chen, Y.2    Dekaban, G.A.3    Weaver, L.C.4
  • 7
    • 24144485411 scopus 로고    scopus 로고
    • Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats
    • COI: 1:CAS:528:DC%2BD2MXpvF2qu70%3D, PID: 15992367
    • Bao F, Dekaban GA, Weaver LC (2005) Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats. J Neurochem 94(5):1361–1373. doi:10.1111/j.1471-4159.2005.03280.x
    • (2005) J Neurochem , vol.94 , Issue.5 , pp. 1361-1373
    • Bao, F.1    Dekaban, G.A.2    Weaver, L.C.3
  • 8
    • 0033104019 scopus 로고    scopus 로고
    • Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
    • COI: 1:CAS:528:DyaK1MXhtlCrtL8%3D, PID: 10024357
    • Batchelor PE, Liberatore GT, Wong JY, Porritt MJ, Frerichs F, Donnan GA, Howells DW (1999) Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J Neurosci 19(5):1708–1716
    • (1999) J Neurosci , vol.19 , Issue.5 , pp. 1708-1716
    • Batchelor, P.E.1    Liberatore, G.T.2    Wong, J.Y.3    Porritt, M.J.4    Frerichs, F.5    Donnan, G.A.6    Howells, D.W.7
  • 9
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
    • COI: 1:CAS:528:DyaK28XntFymtrc%3D, PID: 8944624
    • Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271(5 Pt 1):C1424–C1437
    • (1996) Am J Physiol , vol.271 , pp. 1424-1437
    • Beckman, J.S.1    Koppenol, W.H.2
  • 10
    • 0036939246 scopus 로고    scopus 로고
    • CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury
    • COI: 1:CAS:528:DC%2BD38XjtlSgu74%3D, PID: 12012085
    • Beschorner R, Nguyen TD, Gozalan F, Pedal I, Mattern R, Schluesener HJ, Meyermann R, Schwab JM (2002a) CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury. Acta Neuropathol 103(6):541–549. doi:10.1007/s00401-001-0503-7
    • (2002) Acta Neuropathol , vol.103 , Issue.6 , pp. 541-549
    • Beschorner, R.1    Nguyen, T.D.2    Gozalan, F.3    Pedal, I.4    Mattern, R.5    Schluesener, H.J.6    Meyermann, R.7    Schwab, J.M.8
  • 11
    • 0036093401 scopus 로고    scopus 로고
    • Infiltrating CD14+ monocytes and expression of CD14 by activated parenchymal microglia/macrophages contribute to the pool of CD14+ cells in ischemic brain lesions
    • COI: 1:CAS:528:DC%2BD38XjvVaqt7o%3D, PID: 12020962
    • Beschorner R, Schluesener HJ, Gozalan F, Meyermann R, Schwab JM (2002b) Infiltrating CD14+ monocytes and expression of CD14 by activated parenchymal microglia/macrophages contribute to the pool of CD14+ cells in ischemic brain lesions. J Neuroimmunol 126(1–2):107–115
    • (2002) J Neuroimmunol , vol.126 , Issue.1-2 , pp. 107-115
    • Beschorner, R.1    Schluesener, H.J.2    Gozalan, F.3    Meyermann, R.4    Schwab, J.M.5
  • 12
    • 0028331346 scopus 로고
    • Effects of silica on the outcome from experimental spinal cord injury: implication of macrophages in secondary tissue damage
    • COI: 1:CAS:528:DyaK2cXkvVSisLw%3D, PID: 8052418
    • Blight AR (1994) Effects of silica on the outcome from experimental spinal cord injury: implication of macrophages in secondary tissue damage. Neuroscience 60(1):263–273
    • (1994) Neuroscience , vol.60 , Issue.1 , pp. 263-273
    • Blight, A.R.1
  • 13
    • 69249101175 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
    • COI: 1:CAS:528:DC%2BD1MXhtFWju7fO, PID: 19670441
    • Byrnes KR, Stoica B, Riccio A, Pajoohesh-Ganji A, Loane DJ, Faden AI (2009) Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol 66(1):63–74. doi:10.1002/ana.21673
    • (2009) Ann Neurol , vol.66 , Issue.1 , pp. 63-74
    • Byrnes, K.R.1    Stoica, B.2    Riccio, A.3    Pajoohesh-Ganji, A.4    Loane, D.J.5    Faden, A.I.6
  • 14
    • 59349113948 scopus 로고    scopus 로고
    • Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
    • COI: 1:CAS:528:DC%2BD1MXhsFKrtbc%3D, PID: 18621108
    • Candelario-Jalil E, Yang Y, Rosenberg GA (2009) Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 158(3):983–994. doi:10.1016/j.neuroscience.2008.06.025
    • (2009) Neuroscience , vol.158 , Issue.3 , pp. 983-994
    • Candelario-Jalil, E.1    Yang, Y.2    Rosenberg, G.A.3
  • 15
    • 77952997178 scopus 로고    scopus 로고
    • Control of macrophage activation and function by PPARs
    • COI: 1:CAS:528:DC%2BC3cXmsFyisro%3D, PID: 20508200
    • Chawla A (2010) Control of macrophage activation and function by PPARs. Circ Res 106(10):1559–1569. doi:10.1161/CIRCRESAHA.110.216523
    • (2010) Circ Res , vol.106 , Issue.10 , pp. 1559-1569
    • Chawla, A.1
  • 16
    • 67649852282 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion
    • COI: 1:CAS:528:DC%2BD1MXnvVyit7g%3D, PID: 19417757
    • Chen H, Song YS, Chan PH (2009) Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J Cereb Blood Flow Metab 29(7):1262–1272. doi:10.1038/jcbfm.2009.47
    • (2009) J Cereb Blood Flow Metab , vol.29 , Issue.7 , pp. 1262-1272
    • Chen, H.1    Song, Y.S.2    Chan, P.H.3
  • 17
    • 56849129516 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice
    • PID: 18947400
    • Clausen BH, Lambertsen KL, Babcock AA, Holm TH, Dagnaes-Hansen F, Finsen B (2008) Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflammation 5:46. doi:10.1186/1742-2094-5-46
    • (2008) J Neuroinflammation , vol.5 , pp. 46
    • Clausen, B.H.1    Lambertsen, K.L.2    Babcock, A.A.3    Holm, T.H.4    Dagnaes-Hansen, F.5    Finsen, B.6
  • 18
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • PID: 19655259
    • Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4(4):399–418. doi:10.1007/s11481-009-9164-4
    • (2009) J Neuroimmune Pharmacol , vol.4 , Issue.4 , pp. 399-418
    • Colton, C.A.1
  • 19
    • 0032752147 scopus 로고    scopus 로고
    • IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-alpha, TGF-beta1 and blood-brain barrier function
    • COI: 1:CAS:528:DyaK1MXntlentL4%3D, PID: 10580806
    • Csuka E, Morganti-Kossmann MC, Lenzlinger PM, Joller H, Trentz O, Kossmann T (1999) IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-alpha, TGF-beta1 and blood-brain barrier function. J Neuroimmunol 101(2):211–221
    • (1999) J Neuroimmunol , vol.101 , Issue.2 , pp. 211-221
    • Csuka, E.1    Morganti-Kossmann, M.C.2    Lenzlinger, P.M.3    Joller, H.4    Trentz, O.5    Kossmann, T.6
  • 20
    • 0034601386 scopus 로고    scopus 로고
    • Cell activation and inflammatory response following traumatic axonal injury in the rat
    • COI: 1:STN:280:DC%2BD3M%2FmvFSnug%3D%3D, PID: 10943727
    • Csuka E, Hans VH, Ammann E, Trentz O, Kossmann T, Morganti-Kossmann MC (2000) Cell activation and inflammatory response following traumatic axonal injury in the rat. Neuroreport 11(11):2587–2590
    • (2000) Neuroreport , vol.11 , Issue.11 , pp. 2587-2590
    • Csuka, E.1    Hans, V.H.2    Ammann, E.3    Trentz, O.4    Kossmann, T.5    Morganti-Kossmann, M.C.6
  • 22
    • 0035086799 scopus 로고    scopus 로고
    • Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family
    • COI: 1:CAS:528:DC%2BD3MXitlSnurY%3D, PID: 11241283
    • Daws MR, Lanier LL, Seaman WE, Ryan JC (2001) Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol 31(3):783–791. doi:10.1002/1521-4141(200103)31:3<783::AID-IMMU783>3.0.CO;2-U
    • (2001) Eur J Immunol , vol.31 , Issue.3 , pp. 783-791
    • Daws, M.R.1    Lanier, L.L.2    Seaman, W.E.3    Ryan, J.C.4
  • 23
    • 0038784517 scopus 로고    scopus 로고
    • Pattern recognition by TREM-2: binding of anionic ligands
    • COI: 1:CAS:528:DC%2BD3sXltFymt7o%3D, PID: 12847223
    • Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE (2003) Pattern recognition by TREM-2: binding of anionic ligands. J Immunol 171(2):594–599
    • (2003) J Immunol , vol.171 , Issue.2 , pp. 594-599
    • Daws, M.R.1    Sullam, P.M.2    Niemi, E.C.3    Chen, T.T.4    Tchao, N.K.5    Seaman, W.E.6
  • 24
    • 33846591479 scopus 로고    scopus 로고
    • Microglial activation and matrix protease generation during focal cerebral ischemia
    • PID: 17261708
    • del Zoppo GJ, Milner R, Mabuchi T, Hung S, Wang X, Berg GI, Koziol JA (2007) Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke 38(2 Suppl):646–651. doi:10.1161/01.STR.0000254477.34231.cb
    • (2007) Stroke , vol.38 , Issue.2 , pp. 646-651
    • del Zoppo, G.J.1    Milner, R.2    Mabuchi, T.3    Hung, S.4    Wang, X.5    Berg, G.I.6    Koziol, J.A.7
  • 26
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • COI: 1:CAS:528:DyaK1MXlsVygtrk%3D, PID: 10441299
    • Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22(9):391–397
    • (1999) Trends Neurosci , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 27
    • 16944366731 scopus 로고    scopus 로고
    • Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities
    • COI: 1:CAS:528:DyaK2sXksVSgtb8%3D, PID: 9204916
    • Donovan FM, Pike CJ, Cotman CW, Cunningham DD (1997) Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 17(14):5316–5326
    • (1997) J Neurosci , vol.17 , Issue.14 , pp. 5316-5326
    • Donovan, F.M.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 28
    • 84858072878 scopus 로고    scopus 로고
    • Comparison of polarization properties of human adult microglia and blood-derived macrophages
    • PID: 22290798
    • Durafourt BA, Moore CS, Zammit DA, Johnson TA, Zaguia F, Guiot MC, Bar-Or A, Antel JP (2012) Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia 60(5):717–727. doi:10.1002/glia.22298
    • (2012) Glia , vol.60 , Issue.5 , pp. 717-727
    • Durafourt, B.A.1    Moore, C.S.2    Zammit, D.A.3    Johnson, T.A.4    Zaguia, F.5    Guiot, M.C.6    Bar-Or, A.7    Antel, J.P.8
  • 29
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • COI: 1:STN:280:DyaK2czls1ansg%3D%3D, PID: 8075816
    • Dusart I, Schwab ME (1994) Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 6(5):712–724
    • (1994) Eur J Neurosci , vol.6 , Issue.5 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 30
    • 0031957224 scopus 로고    scopus 로고
    • Microglia, scavenger receptors, and the pathogenesis of Alzheimer’s disease
    • PID: 9562474
    • El Khoury J, Hickman SE, Thomas CA, Loike JD, Silverstein SC (1998) Microglia, scavenger receptors, and the pathogenesis of Alzheimer’s disease. Neurobiol Aging 19(1 Suppl):S81–S84
    • (1998) Neurobiol Aging , vol.19 , Issue.1 , pp. 81-84
    • El Khoury, J.1    Hickman, S.E.2    Thomas, C.A.3    Loike, J.D.4    Silverstein, S.C.5
  • 31
    • 84885292635 scopus 로고    scopus 로고
    • Rotenone induces neuronal death by microglial phagocytosis of neurons
    • COI: 1:CAS:528:DC%2BC3sXhsFOgsrzJ, PID: 23789887
    • Emmrich JV, Hornik TC, Neher JJ, Brown GC (2013) Rotenone induces neuronal death by microglial phagocytosis of neurons. FEBS J 280(20):5030–5038. doi:10.1111/febs.12401
    • (2013) FEBS J , vol.280 , Issue.20 , pp. 5030-5038
    • Emmrich, J.V.1    Hornik, T.C.2    Neher, J.J.3    Brown, G.C.4
  • 32
    • 0033937484 scopus 로고    scopus 로고
    • Dynamics of microglial activation after human traumatic brain injury are revealed by delayed expression of macrophage-related proteins MRP8 and MRP14
    • COI: 1:CAS:528:DC%2BD3cXmtFSnurc%3D, PID: 10965802
    • Engel S, Schluesener H, Mittelbronn M, Seid K, Adjodah D, Wehner HD, Meyermann R (2000) Dynamics of microglial activation after human traumatic brain injury are revealed by delayed expression of macrophage-related proteins MRP8 and MRP14. Acta Neuropathol 100(3):313–322
    • (2000) Acta Neuropathol , vol.100 , Issue.3 , pp. 313-322
    • Engel, S.1    Schluesener, H.2    Mittelbronn, M.3    Seid, K.4    Adjodah, D.5    Wehner, H.D.6    Meyermann, R.7
  • 33
    • 84896689625 scopus 로고    scopus 로고
    • High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury
    • Evans TA, Barkauskas DS, Myers JT, Hare EG, You JQ, Ransohoff RM, Huang AY, Silver J (2014) High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Exp Neurol 254C:109–120. doi:10.1016/j.expneurol.2014.01.013
    • (2014) Exp Neurol , vol.254C , pp. 109-120
    • Evans, T.A.1    Barkauskas, D.S.2    Myers, J.T.3    Hare, E.G.4    You, J.Q.5    Ransohoff, R.M.6    Huang, A.Y.7    Silver, J.8
  • 34
    • 0029960060 scopus 로고    scopus 로고
    • Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS
    • COI: 1:CAS:528:DyaK28XhvVKrtbg%3D, PID: 8965649
    • Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK (1996) Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res Mol Brain Res 36(2):287–291
    • (1996) Brain Res Mol Brain Res , vol.36 , Issue.2 , pp. 287-291
    • Fan, L.1    Young, P.R.2    Barone, F.C.3    Feuerstein, G.Z.4    Smith, D.H.5    McIntosh, T.K.6
  • 36
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
    • COI: 1:CAS:528:DyaK1MXmt1aquro%3D, PID: 10493720
    • Fitch MT, Doller C, Combs CK, Landreth GE, Silver J (1999) Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 19(19):8182–8198
    • (1999) J Neurosci , vol.19 , Issue.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Landreth, G.E.4    Silver, J.5
  • 37
    • 72449204160 scopus 로고    scopus 로고
    • Does neuroinflammation fan the flame in neurodegenerative diseases?
    • PID: 19917131
    • Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG (2009) Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4:47. doi:10.1186/1750-1326-4-47
    • (2009) Mol Neurodegener , vol.4 , pp. 47
    • Frank-Cannon, T.C.1    Alto, L.T.2    McAlpine, F.E.3    Tansey, M.G.4
  • 38
    • 33845220750 scopus 로고    scopus 로고
    • Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo
    • COI: 1:CAS:528:DC%2BD28Xht12qsL7O, PID: 17084034
    • Fujimoto S, Katsuki H, Ohnishi M, Takagi M, Kume T, Akaike A (2007) Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo. Neuroscience 144(2):694–701. doi:10.1016/j.neuroscience.2006.09.049
    • (2007) Neuroscience , vol.144 , Issue.2 , pp. 694-701
    • Fujimoto, S.1    Katsuki, H.2    Ohnishi, M.3    Takagi, M.4    Kume, T.5    Akaike, A.6
  • 39
    • 77952887297 scopus 로고    scopus 로고
    • Unravelling mononuclear phagocyte heterogeneity
    • COI: 1:CAS:528:DC%2BC3cXlvFOkurY%3D, PID: 20467425
    • Geissmann F, Gordon S, Hume DA, Mowat AM, Randolph GJ (2010) Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol 10(6):453–460. doi:10.1038/nri2784
    • (2010) Nat Rev Immunol , vol.10 , Issue.6 , pp. 453-460
    • Geissmann, F.1    Gordon, S.2    Hume, D.A.3    Mowat, A.M.4    Randolph, G.J.5
  • 40
    • 7944233053 scopus 로고    scopus 로고
    • Long-term intracerebral inflammatory response after traumatic brain injury
    • COI: 1:STN:280:DC%2BD2crmvFGgtw%3D%3D, PID: 15542269
    • Gentleman SM, Leclercq PD, Moyes L, Graham DI, Smith C, Griffin WS, Nicoll JA (2004) Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int 146(2–3):97–104. doi:10.1016/j.forsciint.2004.06.027
    • (2004) Forensic Sci Int , vol.146 , Issue.2-3 , pp. 97-104
    • Gentleman, S.M.1    Leclercq, P.D.2    Moyes, L.3    Graham, D.I.4    Smith, C.5    Griffin, W.S.6    Nicoll, J.A.7
  • 41
    • 23744437416 scopus 로고    scopus 로고
    • Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BD2MXotFaqtbs%3D, PID: 15764676
    • Gidday JM, Gasche YG, Copin JC, Shah AR, Perez RS, Shapiro SD, Chan PH, Park TS (2005) Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol 289(2):H558–H568. doi:10.1152/ajpheart.01275.2004
    • (2005) Am J Physiol Heart Circ Physiol , vol.289 , Issue.2 , pp. 558-568
    • Gidday, J.M.1    Gasche, Y.G.2    Copin, J.C.3    Shah, A.R.4    Perez, R.S.5    Shapiro, S.D.6    Chan, P.H.7    Park, T.S.8
  • 43
    • 0027138139 scopus 로고
    • Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system
    • COI: 1:CAS:528:DyaK2cXltFOitA%3D%3D, PID: 8145296
    • Giulian D, Corpuz M, Chapman S, Mansouri M, Robertson C (1993) Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system. J Neurosci Res 36(6):681–693. doi:10.1002/jnr.490360609
    • (1993) J Neurosci Res , vol.36 , Issue.6 , pp. 681-693
    • Giulian, D.1    Corpuz, M.2    Chapman, S.3    Mansouri, M.4    Robertson, C.5
  • 44
    • 0025096198 scopus 로고
    • Elevation of tumor necrosis factor in head injury
    • COI: 1:STN:280:DyaK3M%2Fjs1SntA%3D%3D, PID: 2229409
    • Goodman JC, Robertson CS, Grossman RG, Narayan RK (1990) Elevation of tumor necrosis factor in head injury. J Neuroimmunol 30(2–3):213–217
    • (1990) J Neuroimmunol , vol.30 , Issue.2-3 , pp. 213-217
    • Goodman, J.C.1    Robertson, C.S.2    Grossman, R.G.3    Narayan, R.K.4
  • 45
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • COI: 1:CAS:528:DC%2BD2MXht1Kntr3N, PID: 16322748
    • Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5(12):953–964. doi:10.1038/nri1733
    • (2005) Nat Rev Immunol , vol.5 , Issue.12 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 46
    • 15944372262 scopus 로고    scopus 로고
    • Activation and assembly of the NADPH oxidase: a structural perspective
    • COI: 1:CAS:528:DC%2BD2MXitVegs7w%3D, PID: 15588255
    • Groemping Y, Rittinger K (2005) Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J 386(Pt 3):401–416. doi:10.1042/BJ20041835
    • (2005) Biochem J , vol.386 , pp. 401-416
    • Groemping, Y.1    Rittinger, K.2
  • 47
    • 21444446874 scopus 로고    scopus 로고
    • Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia
    • PID: 15978027
    • Gunther A, Kuppers-Tiedt L, Schneider PM, Kunert I, Berrouschot J, Schneider D, Rossner S (2005) Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci 21(11):3189–3194. doi:10.1111/j.1460-9568.2005.04151.x
    • (2005) Eur J Neurosci , vol.21 , Issue.11 , pp. 3189-3194
    • Gunther, A.1    Kuppers-Tiedt, L.2    Schneider, P.M.3    Kunert, I.4    Berrouschot, J.5    Schneider, D.6    Rossner, S.7
  • 48
    • 0030054358 scopus 로고    scopus 로고
    • Effects of exogenous transforming growth factor-beta 1 on spinal cord injury in rats
    • COI: 1:CAS:528:DyaK28XlvV2qtw%3D%3D, PID: 8834102
    • Hamada Y, Ikata T, Katoh S, Katoh K, Niwa M, Tsutsumishita Y, Fukuzawa K (1996) Effects of exogenous transforming growth factor-beta 1 on spinal cord injury in rats. Neurosci Lett 203(2):97–100
    • (1996) Neurosci Lett , vol.203 , Issue.2 , pp. 97-100
    • Hamada, Y.1    Ikata, T.2    Katoh, S.3    Katoh, K.4    Niwa, M.5    Tsutsumishita, Y.6    Fukuzawa, K.7
  • 49
    • 0037095686 scopus 로고    scopus 로고
    • Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation
    • COI: 1:CAS:528:DC%2BD38XjvVaiur4%3D, PID: 12019311
    • Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA (2002) Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci 22(10):3921–3928
    • (2002) J Neurosci , vol.22 , Issue.10 , pp. 3921-3928
    • Han, H.S.1    Qiao, Y.2    Karabiyikoglu, M.3    Giffard, R.G.4    Yenari, M.A.5
  • 50
    • 84880099479 scopus 로고    scopus 로고
    • The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage
    • COI: 1:CAS:528:DC%2BC3sXhtlCkt7rI, PID: 23849248
    • Hanafy KA (2013) The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage. J Neuroinflammation 10:83. doi:10.1186/1742-2094-10-83
    • (2013) J Neuroinflammation , vol.10 , pp. 83
    • Hanafy, K.A.1
  • 51
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • COI: 1:CAS:528:DC%2BD2sXht1ajsbbE, PID: 17965659
    • Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10(11):1387–1394. doi:10.1038/nn1997
    • (2007) Nat Neurosci , vol.10 , Issue.11 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 52
    • 0038340422 scopus 로고    scopus 로고
    • Post-traumatic inflammation following spinal cord injury
    • COI: 1:STN:280:DC%2BD3s3ovValtQ%3D%3D, PID: 12815368
    • Hausmann ON (2003) Post-traumatic inflammation following spinal cord injury. Spinal Cord 41(7):369–378. doi:10.1038/sj.sc.3101483
    • (2003) Spinal Cord , vol.41 , Issue.7 , pp. 369-378
    • Hausmann, O.N.1
  • 53
    • 33845259342 scopus 로고    scopus 로고
    • The P2Y12 receptor regulates microglial activation by extracellular nucleotides
    • COI: 1:CAS:528:DC%2BD28Xht1Cns7bN, PID: 17115040
    • Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12):1512–1519. doi:10.1038/nn1805
    • (2006) Nat Neurosci , vol.9 , Issue.12 , pp. 1512-1519
    • Haynes, S.E.1    Hollopeter, G.2    Yang, G.3    Kurpius, D.4    Dailey, M.E.5    Gan, W.B.6    Julius, D.7
  • 54
    • 0033597564 scopus 로고    scopus 로고
    • Long-term intracerebral inflammatory response after experimental focal brain injury in rat
    • COI: 1:STN:280:DyaK1MvivFKgtw%3D%3D, PID: 10501527
    • Holmin S, Mathiesen T (1999) Long-term intracerebral inflammatory response after experimental focal brain injury in rat. Neuroreport 10(9):1889–1891
    • (1999) Neuroreport , vol.10 , Issue.9 , pp. 1889-1891
    • Holmin, S.1    Mathiesen, T.2
  • 55
    • 56949089831 scopus 로고    scopus 로고
    • Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    • COI: 1:CAS:528:DC%2BD1cXht1SgtrzO, PID: 18799667
    • Horn KP, Busch SA, Hawthorne AL, van Rooijen N, Silver J (2008) Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci 28(38):9330–9341. doi:10.1523/JNEUROSCI.2488-08.2008
    • (2008) J Neurosci , vol.28 , Issue.38 , pp. 9330-9341
    • Horn, K.P.1    Busch, S.A.2    Hawthorne, A.L.3    van Rooijen, N.4    Silver, J.5
  • 56
    • 65649114773 scopus 로고    scopus 로고
    • A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
    • COI: 1:CAS:528:DC%2BD1MXlsFyks78%3D, PID: 19302484
    • Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE (2009) A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem 109(4):1144–1156. doi:10.1111/j.1471-4159.2009.06042.x
    • (2009) J Neurochem , vol.109 , Issue.4 , pp. 1144-1156
    • Hsieh, C.L.1    Koike, M.2    Spusta, S.C.3    Niemi, E.C.4    Yenari, M.5    Nakamura, M.C.6    Seaman, W.E.7
  • 57
    • 84868209611 scopus 로고    scopus 로고
    • Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BC38XhsFGqt7nM, PID: 22933588
    • Hu X, Li P, Guo Y, Wang H, Leak RK, Chen S, Gao Y, Chen J (2012) Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 43(11):3063–3070. doi:10.1161/STROKEAHA.112.659656
    • (2012) Stroke , vol.43 , Issue.11 , pp. 3063-3070
    • Hu, X.1    Li, P.2    Guo, Y.3    Wang, H.4    Leak, R.K.5    Chen, S.6    Gao, Y.7    Chen, J.8
  • 58
    • 79959356472 scopus 로고    scopus 로고
    • Direct protection of cultured neurons from ischemia-like injury by minocycline
    • PID: 21267407
    • Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari MA (2010) Direct protection of cultured neurons from ischemia-like injury by minocycline. Anat Cell Biol 43(4):325–331. doi:10.5115/acb.2010.43.4.325
    • (2010) Anat Cell Biol , vol.43 , Issue.4 , pp. 325-331
    • Huang, W.C.1    Qiao, Y.2    Xu, L.3    Kacimi, R.4    Sun, X.5    Giffard, R.G.6    Yenari, M.A.7
  • 59
    • 0028891572 scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
    • COI: 1:CAS:528:DyaK2MXktFWntbw%3D, PID: 7530927
    • Iadecola C, Zhang F, Xu X (1995) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268(1 Pt 2):R286–R292
    • (1995) Am J Physiol , vol.268 , pp. 286-292
    • Iadecola, C.1    Zhang, F.2    Xu, X.3
  • 60
    • 84873497150 scopus 로고    scopus 로고
    • Microglia actively regulate the number of functional synapses
    • COI: 1:CAS:528:DC%2BC3sXivFGlt70%3D, PID: 23393609
    • Ji K, Akgul G, Wollmuth LP, Tsirka SE (2013) Microglia actively regulate the number of functional synapses. PLoS One 8(2):e56293. doi:10.1371/journal.pone.0056293
    • (2013) PLoS One , vol.8 , Issue.2 , pp. 56293
    • Ji, K.1    Akgul, G.2    Wollmuth, L.P.3    Tsirka, S.E.4
  • 61
    • 35649015344 scopus 로고    scopus 로고
    • NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    • COI: 1:CAS:528:DC%2BD2sXhtF2itbnK, PID: 17916764
    • Kahles T, Luedike P, Endres M, Galla HJ, Steinmetz H, Busse R, Neumann-Haefelin T, Brandes RP (2007) NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke 38(11):3000–3006. doi:10.1161/STROKEAHA.107.489765
    • (2007) Stroke , vol.38 , Issue.11 , pp. 3000-3006
    • Kahles, T.1    Luedike, P.2    Endres, M.3    Galla, H.J.4    Steinmetz, H.5    Busse, R.6    Neumann-Haefelin, T.7    Brandes, R.P.8
  • 62
  • 64
    • 84863863921 scopus 로고    scopus 로고
    • Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
    • COI: 1:CAS:528:DC%2BC38XhtV2gtbrM, PID: 22698888
    • Keep RF, Hua Y, Xi G (2012) Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol 11(8):720–731. doi:10.1016/S1474-4422(12)70104-7
    • (2012) Lancet Neurol , vol.11 , Issue.8 , pp. 720-731
    • Keep, R.F.1    Hua, Y.2    Xi, G.3
  • 65
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • COI: 1:CAS:528:DC%2BD1MXhsVSmtrnJ, PID: 19864556
    • Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG (2009) Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 29(43):13435–13444. doi:10.1523/JNEUROSCI.3257-09.2009
    • (2009) J Neurosci , vol.29 , Issue.43 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 66
    • 0031713714 scopus 로고    scopus 로고
    • Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury
    • COI: 1:CAS:528:DyaK1cXmvVWgtro%3D, PID: 9743576
    • Knoblach SM, Faden AI (1998) Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp Neurol 153(1):143–151. doi:10.1006/exnr.1998.6877
    • (1998) Exp Neurol , vol.153 , Issue.1 , pp. 143-151
    • Knoblach, S.M.1    Faden, A.I.2
  • 67
    • 17044364404 scopus 로고    scopus 로고
    • Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice
    • COI: 1:CAS:528:DC%2BD2MXjvVyqur8%3D, PID: 15674236
    • Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx S, Kauppinen RA, Opdenakker G, Koistinaho J (2005) Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice. J Cereb Blood Flow Metab 25(4):460–467. doi:10.1038/sj.jcbfm.9600040
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.4 , pp. 460-467
    • Koistinaho, M.1    Malm, T.M.2    Kettunen, M.I.3    Goldsteins, G.4    Starckx, S.5    Kauppinen, R.A.6    Opdenakker, G.7    Koistinaho, J.8
  • 69
    • 0029028478 scopus 로고
    • The temporal and spatial activation of microglia in fiber tracts undergoing anterograde and retrograde degeneration following spinal cord lesion
    • COI: 1:STN:280:DyaK2Mzls1ahsQ%3D%3D, PID: 7629867
    • Koshinaga M, Whittemore SR (1995) The temporal and spatial activation of microglia in fiber tracts undergoing anterograde and retrograde degeneration following spinal cord lesion. J Neurotrauma 12(2):209–222
    • (1995) J Neurotrauma , vol.12 , Issue.2 , pp. 209-222
    • Koshinaga, M.1    Whittemore, S.R.2
  • 70
    • 17044373214 scopus 로고    scopus 로고
    • Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures
    • COI: 1:CAS:528:DC%2BD2MXjtFyrtL8%3D, PID: 15833361
    • Kremlev SG, Palmer C (2005) Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures. J Neuroimmunol 162(1–2):71–80. doi:10.1016/j.jneuroim.2005.01.010
    • (2005) J Neuroimmunol , vol.162 , Issue.1-2 , pp. 71-80
    • Kremlev, S.G.1    Palmer, C.2
  • 71
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • COI: 1:STN:280:DyaK2s%2FgtVGitg%3D%3D, PID: 8843599
    • Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19(8):312–318
    • (1996) Trends Neurosci , vol.19 , Issue.8 , pp. 312-318
    • Kreutzberg, G.W.1
  • 72
    • 84867213778 scopus 로고    scopus 로고
    • Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention
    • PID: 22728326
    • Kumar A, Loane DJ (2012) Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun 26(8):1191–1201. doi:10.1016/j.bbi.2012.06.008
    • (2012) Brain Behav Immun , vol.26 , Issue.8 , pp. 1191-1201
    • Kumar, A.1    Loane, D.J.2
  • 73
    • 33745761474 scopus 로고    scopus 로고
    • Microglia in cerebral ischemia: molecular actions and interactions
    • COI: 1:CAS:528:DC%2BD28XktlCru7c%3D, PID: 16845890
    • Lai AY, Todd KG (2006) Microglia in cerebral ischemia: molecular actions and interactions. Can J Physiol Pharmacol 84(1):49–59. doi:10.1139/Y05-143
    • (2006) Can J Physiol Pharmacol , vol.84 , Issue.1 , pp. 49-59
    • Lai, A.Y.1    Todd, K.G.2
  • 74
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    • COI: 1:CAS:528:DC%2BD2sXjsVCrtLc%3D, PID: 17344397
    • Lalancette-Hebert M, Gowing G, Simard A, Weng YC, Kriz J (2007) Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci 27(10):2596–2605. doi:10.1523/JNEUROSCI.5360-06.2007
    • (2007) J Neurosci , vol.27 , Issue.10 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Weng, Y.C.4    Kriz, J.5
  • 75
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • COI: 1:CAS:528:DC%2BD2cXitlSnsbY%3D, PID: 15039755
    • Lambeth JD (2004) NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4(3):181–189. doi:10.1038/nri1312
    • (2004) Nat Rev Immunol , vol.4 , Issue.3 , pp. 181-189
    • Lambeth, J.D.1
  • 76
    • 0026552605 scopus 로고
    • Turnover of resident microglia in the normal adult mouse brain
    • COI: 1:STN:280:DyaK383ptlCquw%3D%3D, PID: 1603325
    • Lawson LJ, Perry VH, Gordon S (1992) Turnover of resident microglia in the normal adult mouse brain. Neuroscience 48(2):405–415
    • (1992) Neuroscience , vol.48 , Issue.2 , pp. 405-415
    • Lawson, L.J.1    Perry, V.H.2    Gordon, S.3
  • 77
    • 0037016146 scopus 로고    scopus 로고
    • Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons
    • COI: 1:CAS:528:DC%2BD38XpsFOmsrk%3D, PID: 12488809
    • Lee TH, Kato H, Chen ST, Kogure K, Itoyama Y (2002) Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons. Neuroreport 13(17):2271–2275. doi:10.1097/01.wnr.0000043410.7262
    • (2002) Neuroreport , vol.13 , Issue.17 , pp. 2271-2275
    • Lee, T.H.1    Kato, H.2    Chen, S.T.3    Kogure, K.4    Itoyama, Y.5
  • 78
    • 84899656270 scopus 로고    scopus 로고
    • Transcription-related element gene expression pattern differs between microglia and macrophages during inflammation
    • Lee HT, Kim SK, Kim SH, Kim K, Lim CH, Park J, Roh TY, Kim N, Chai YG (2014) Transcription-related element gene expression pattern differs between microglia and macrophages during inflammation. Inflamm Res. doi:10.1007/s00011-014-0711-y
    • (2014) Inflamm Res
    • Lee, H.T.1    Kim, S.K.2    Kim, S.H.3    Kim, K.4    Lim, C.H.5    Park, J.6    Roh, T.Y.7    Kim, N.8    Chai, Y.G.9
  • 80
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    • COI: 1:CAS:528:DC%2BD3sXlsFGnurw%3D, PID: 12824464
    • Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA, Volpe JJ, Vartanian T (2003) Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A 100(14):8514–8519. doi:10.1073/pnas.1432609100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.14 , pp. 8514-8519
    • Lehnardt, S.1    Massillon, L.2    Follett, P.3    Jensen, F.E.4    Ratan, R.5    Rosenberg, P.A.6    Volpe, J.J.7    Vartanian, T.8
  • 81
    • 0032402337 scopus 로고    scopus 로고
    • Microglia and macrophages are major sources of locally produced transforming growth factor-beta1 after transient middle cerebral artery occlusion in rats
    • COI: 1:STN:280:DyaK1M%2FivF2lsw%3D%3D, PID: 9814824
    • Lehrmann E, Kiefer R, Christensen T, Toyka KV, Zimmer J, Diemer NH, Hartung HP, Finsen B (1998) Microglia and macrophages are major sources of locally produced transforming growth factor-beta1 after transient middle cerebral artery occlusion in rats. Glia 24(4):437–448. doi:10.1002/(SICI)1098-1136(199812)24:4<437::AID-GLIA9>3.0.CO;2-X
    • (1998) Glia , vol.24 , Issue.4 , pp. 437-448
    • Lehrmann, E.1    Kiefer, R.2    Christensen, T.3    Toyka, K.V.4    Zimmer, J.5    Diemer, N.H.6    Hartung, H.P.7    Finsen, B.8
  • 83
    • 30444459031 scopus 로고    scopus 로고
    • The role of inflammation in CNS injury and disease
    • COI: 1:CAS:528:DC%2BD28XisVCnsQ%3D%3D, PID: 16402109
    • Lucas SM, Rothwell NJ, Gibson RM (2006) The role of inflammation in CNS injury and disease. Br J Pharmacol 147(Suppl 1):S232–S240. doi:10.1038/sj.bjp.0706400
    • (2006) Br J Pharmacol , vol.147 , pp. 232-240
    • Lucas, S.M.1    Rothwell, N.J.2    Gibson, R.M.3
  • 84
    • 34250627649 scopus 로고    scopus 로고
    • Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
    • COI: 1:CAS:528:DC%2BD2sXmvVOitrs%3D, PID: 17540348
    • Maeda J, Higuchi M, Inaji M, Ji B, Haneda E, Okauchi T, Zhang MR, Suzuki K, Suhara T (2007) Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res 1157:100–111. doi:10.1016/j.brainres.2007.04.054
    • (2007) Brain Res , vol.1157 , pp. 100-111
    • Maeda, J.1    Higuchi, M.2    Inaji, M.3    Ji, B.4    Haneda, E.5    Okauchi, T.6    Zhang, M.R.7    Suzuki, K.8    Suhara, T.9
  • 85
    • 30744455267 scopus 로고    scopus 로고
    • Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase
    • COI: 1:CAS:528:DC%2BD28Xht1Cnuw%3D%3D, PID: 16393992
    • Mander PK, Jekabsone A, Brown GC (2006) Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase. J Immunol 176(2):1046–1052
    • (2006) J Immunol , vol.176 , Issue.2 , pp. 1046-1052
    • Mander, P.K.1    Jekabsone, A.2    Brown, G.C.3
  • 86
    • 84862176452 scopus 로고    scopus 로고
    • Update on intracerebral hemorrhage
    • Manno EM (2012) Update on intracerebral hemorrhage. Continuum (Minneap Minn) 18(3):598–610. doi:10.1212/01.CON.0000415430.99394.3e
    • (2012) Continuum (Minneap Minn) , vol.18 , Issue.3 , pp. 598-610
    • Manno, E.M.1
  • 87
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • COI: 1:CAS:528:DC%2BD2cXptl2ktbs%3D, PID: 15530839
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25(12):677–686. doi:10.1016/j.it.2004.09.015
    • (2004) Trends Immunol , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 88
    • 0030045798 scopus 로고    scopus 로고
    • Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms
    • COI: 1:STN:280:DyaK28zntlylsA%3D%3D, PID: 8780153
    • McIntosh TK, Smith DH, Meaney DF, Kotapka MJ, Gennarelli TA, Graham DI (1996) Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms. Lab Investig 74(2):315–342
    • (1996) Lab Investig , vol.74 , Issue.2 , pp. 315-342
    • McIntosh, T.K.1    Smith, D.H.2    Meaney, D.F.3    Kotapka, M.J.4    Gennarelli, T.A.5    Graham, D.I.6
  • 90
    • 0032778919 scopus 로고    scopus 로고
    • TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function
    • COI: 1:STN:280:DyaK1MznsVOguw%3D%3D, PID: 10447073
    • Morganti-Kossmann MC, Hans VH, Lenzlinger PM, Dubs R, Ludwig E, Trentz O, Kossmann T (1999) TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function. J Neurotrauma 16(7):617–628
    • (1999) J Neurotrauma , vol.16 , Issue.7 , pp. 617-628
    • Morganti-Kossmann, M.C.1    Hans, V.H.2    Lenzlinger, P.M.3    Dubs, R.4    Ludwig, E.5    Trentz, O.6    Kossmann, T.7
  • 92
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • COI: 1:CAS:528:DC%2BD1cXhsVWlsLfI, PID: 19029990
    • Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8(12):958–969. doi:10.1038/nri2448
    • (2008) Nat Rev Immunol , vol.8 , Issue.12 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 93
    • 33746211119 scopus 로고    scopus 로고
    • Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy
    • COI: 1:CAS:528:DC%2BD28XmvFCmt70%3D, PID: 16849442
    • Nair MG, Guild KJ, Artis D (2006) Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J Immunol 177(3):1393–1399
    • (2006) J Immunol , vol.177 , Issue.3 , pp. 1393-1399
    • Nair, M.G.1    Guild, K.J.2    Artis, D.3
  • 95
    • 84886434703 scopus 로고    scopus 로고
    • Phagocytosis executes delayed neuronal death after focal brain ischemia
    • COI: 1:CAS:528:DC%2BC3sXhslejsb%2FN, PID: 24101459
    • Neher JJ, Emmrich JV, Fricker M, Mander PK, Thery C, Brown GC (2013) Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci U S A 110(43):E4098–E4107. doi:10.1073/pnas.1308679110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.43 , pp. 4098-4107
    • Neher, J.J.1    Emmrich, J.V.2    Fricker, M.3    Mander, P.K.4    Thery, C.5    Brown, G.C.6
  • 96
    • 82555186955 scopus 로고    scopus 로고
    • Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    • COI: 1:CAS:528:DC%2BC3MXhsV2gtr3J, PID: 22101429
    • Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480(7375):104–108. doi:10.1038/nature10653
    • (2011) Nature , vol.480 , Issue.7375 , pp. 104-108
    • Nguyen, K.D.1    Qiu, Y.2    Cui, X.3    Goh, Y.P.4    Mwangi, J.5    David, T.6    Mukundan, L.7    Brombacher, F.8    Locksley, R.M.9    Chawla, A.10
  • 98
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • COI: 1:CAS:528:DC%2BD2MXks1Ciuro%3D, PID: 15831717
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308(5726):1314–1318. doi:10.1126/science.1110647
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 99
    • 84886675646 scopus 로고    scopus 로고
    • Ischemic stroke and neuroprotection
    • PID: 23439855
    • Onwuekwe I, Ezeala-Adikaibe B (2012) Ischemic stroke and neuroprotection. Ann Med Health Sci Res 2(2):186–190. doi:10.4103/2141-9248.105669
    • (2012) Ann Med Health Sci Res , vol.2 , Issue.2 , pp. 186-190
    • Onwuekwe, I.1    Ezeala-Adikaibe, B.2
  • 101
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration
    • PID: 15253803
    • Park E, Velumian AA, Fehlings MG (2004) The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 21(6):754–774. doi:10.1089/0897715041269641
    • (2004) J Neurotrauma , vol.21 , Issue.6 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 102
    • 0042623437 scopus 로고    scopus 로고
    • Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion
    • PID: 12855824
    • Pfefferkorn T, Rosenberg GA (2003) Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke 34(8):2025–2030. doi:10.1161/01.STR.0000083051.93319.28
    • (2003) Stroke , vol.34 , Issue.8 , pp. 2025-2030
    • Pfefferkorn, T.1    Rosenberg, G.A.2
  • 103
    • 0032838089 scopus 로고    scopus 로고
    • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
    • COI: 1:CAS:528:DyaK1MXksFams7o%3D, PID: 10415142
    • Popovich PG, Guan Z, Wei P, Huitinga I, van Rooijen N, Stokes BT (1999) Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 158(2):351–365. doi:10.1006/exnr.1999.7118
    • (1999) Exp Neurol , vol.158 , Issue.2 , pp. 351-365
    • Popovich, P.G.1    Guan, Z.2    Wei, P.3    Huitinga, I.4    van Rooijen, N.5    Stokes, B.T.6
  • 104
    • 0036295056 scopus 로고    scopus 로고
    • The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation
    • COI: 1:STN:280:DC%2BD38zotVaktA%3D%3D, PID: 12125741
    • Popovich PG, Guan Z, McGaughy V, Fisher L, Hickey WF, Basso DM (2002) The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation. J Neuropathol Exp Neurol 61(7):623–633
    • (2002) J Neuropathol Exp Neurol , vol.61 , Issue.7 , pp. 623-633
    • Popovich, P.G.1    Guan, Z.2    McGaughy, V.3    Fisher, L.4    Hickey, W.F.5    Basso, D.M.6
  • 105
    • 33646140345 scopus 로고    scopus 로고
    • Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets
    • COI: 1:CAS:528:DC%2BD28XhtFKqtbfK, PID: 16554253
    • Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ (2006) Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx 3(2):143–153. doi:10.1016/j.nurx.2006.01.006
    • (2006) NeuroRx , vol.3 , Issue.2 , pp. 143-153
    • Potts, M.B.1    Koh, S.E.2    Whetstone, W.D.3    Walker, B.A.4    Yoneyama, T.5    Claus, C.P.6    Manvelyan, H.M.7    Noble-Haeusslein, L.J.8
  • 106
    • 77951039949 scopus 로고    scopus 로고
    • Inflammation and cerebral vasospasm after subarachnoid hemorrhage
    • PID: 20380976
    • Pradilla G, Chaichana KL, Hoang S, Huang J, Tamargo RJ (2010) Inflammation and cerebral vasospasm after subarachnoid hemorrhage. Neurosurg Clin N Am 21(2):365–379. doi:10.1016/j.nec.2009.10.008
    • (2010) Neurosurg Clin N Am , vol.21 , Issue.2 , pp. 365-379
    • Pradilla, G.1    Chaichana, K.L.2    Hoang, S.3    Huang, J.4    Tamargo, R.J.5
  • 108
    • 65449176475 scopus 로고    scopus 로고
    • Intracerebral haemorrhage
    • PID: 19427958
    • Qureshi AI, Mendelow AD, Hanley DF (2009) Intracerebral haemorrhage. Lancet 373(9675):1632–1644. doi:10.1016/S0140-6736(09)60371-8
    • (2009) Lancet , vol.373 , Issue.9675 , pp. 1632-1644
    • Qureshi, A.I.1    Mendelow, A.D.2    Hanley, D.F.3
  • 109
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • COI: 1:CAS:528:DC%2BD1MXlsFSlsbs%3D, PID: 19302036
    • Ransohoff RM, Perry VH (2009) Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 27:119–145. doi:10.1146/annurev.immunol.021908.132528
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 110
    • 0036737795 scopus 로고    scopus 로고
    • Matrix metalloproteinases in neuroinflammation
    • PID: 12203394
    • Rosenberg GA (2002) Matrix metalloproteinases in neuroinflammation. Glia 39(3):279–291. doi:10.1002/glia.10108
    • (2002) Glia , vol.39 , Issue.3 , pp. 279-291
    • Rosenberg, G.A.1
  • 111
    • 0035793934 scopus 로고    scopus 로고
    • Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures
    • COI: 1:CAS:528:DC%2BD3MXht12nt78%3D, PID: 11222998
    • Rosenberg GA, Cunningham LA, Wallace J, Alexander S, Estrada EY, Grossetete M, Razhagi A, Miller K, Gearing A (2001) Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res 893(1–2):104–112
    • (2001) Brain Res , vol.893 , Issue.1-2 , pp. 104-112
    • Rosenberg, G.A.1    Cunningham, L.A.2    Wallace, J.3    Alexander, S.4    Estrada, E.Y.5    Grossetete, M.6    Razhagi, A.7    Miller, K.8    Gearing, A.9
  • 112
    • 0028021564 scopus 로고
    • The presence of tumour necrosis factor in CSF and plasma after severe head injury
    • COI: 1:STN:280:DyaK2M7htVClsQ%3D%3D, PID: 7811406
    • Ross SA, Halliday MI, Campbell GC, Byrnes DP, Rowlands BJ (1994) The presence of tumour necrosis factor in CSF and plasma after severe head injury. Br J Neurosurg 8(4):419–425
    • (1994) Br J Neurosurg , vol.8 , Issue.4 , pp. 419-425
    • Ross, S.A.1    Halliday, M.I.2    Campbell, G.C.3    Byrnes, D.P.4    Rowlands, B.J.5
  • 113
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • COI: 1:CAS:528:DC%2BC3MXhtlGksLzJ, PID: 22025055
    • Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11(11):775–787. doi:10.1038/nri3086
    • (2011) Nat Rev Immunol , vol.11 , Issue.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 114
    • 0033980306 scopus 로고    scopus 로고
    • Important role of membrane-associated CD14 in the induction of IFN-beta and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide
    • COI: 1:CAS:528:DC%2BD3cXlt1Wksw%3D%3D, PID: 10601848
    • Saito S, Matsuura M, Tominaga K, Kirikae T, Nakano M (2000) Important role of membrane-associated CD14 in the induction of IFN-beta and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide. Eur J Biochem 267(1):37–45
    • (2000) Eur J Biochem , vol.267 , Issue.1 , pp. 37-45
    • Saito, S.1    Matsuura, M.2    Tominaga, K.3    Kirikae, T.4    Nakano, M.5
  • 115
    • 0034727873 scopus 로고    scopus 로고
    • Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury
    • COI: 1:CAS:528:DC%2BD3MXnvFKm, PID: 11146113
    • Satake K, Matsuyama Y, Kamiya M, Kawakami H, Iwata H, Adachi K, Kiuchi K (2000) Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury. Brain Res Mol Brain Res 85(1–2):114–122
    • (2000) Brain Res Mol Brain Res , vol.85 , Issue.1-2 , pp. 114-122
    • Satake, K.1    Matsuyama, Y.2    Kamiya, M.3    Kawakami, H.4    Iwata, H.5    Adachi, K.6    Kiuchi, K.7
  • 116
    • 9644307970 scopus 로고    scopus 로고
    • Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
    • PID: 15548205
    • Sessa G, Podini P, Mariani M, Meroni A, Spreafico R, Sinigaglia F, Colonna M, Panina P, Meldolesi J (2004) Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur J Neurosci 20(10):2617–2628. doi:10.1111/j.1460-9568.2004.03729.x
    • (2004) Eur J Neurosci , vol.20 , Issue.10 , pp. 2617-2628
    • Sessa, G.1    Podini, P.2    Mariani, M.3    Meroni, A.4    Spreafico, R.5    Sinigaglia, F.6    Colonna, M.7    Panina, P.8    Meldolesi, J.9
  • 117
    • 33847108114 scopus 로고    scopus 로고
    • Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice
    • COI: 1:CAS:528:DC%2BD2sXitl2nsLo%3D, PID: 17301181
    • Sheehan JJ, Zhou C, Gravanis I, Rogove AD, Wu YP, Bogenhagen DF, Tsirka SE (2007) Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. J Neurosci 27(7):1738–1745. doi:10.1523/JNEUROSCI.4987-06.2007
    • (2007) J Neurosci , vol.27 , Issue.7 , pp. 1738-1745
    • Sheehan, J.J.1    Zhou, C.2    Gravanis, I.3    Rogove, A.D.4    Wu, Y.P.5    Bogenhagen, D.F.6    Tsirka, S.E.7
  • 118
    • 0028364659 scopus 로고
    • Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue
    • COI: 1:CAS:528:DyaK2cXltlWmtr0%3D, PID: 8014208
    • Shohami E, Novikov M, Bass R, Yamin A, Gallily R (1994) Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue. J Cereb Blood Flow Metab 14(4):615–619. doi:10.1038/jcbfm.1994.76
    • (1994) J Cereb Blood Flow Metab , vol.14 , Issue.4 , pp. 615-619
    • Shohami, E.1    Novikov, M.2    Bass, R.3    Yamin, A.4    Gallily, R.5
  • 119
    • 0032830106 scopus 로고    scopus 로고
    • Dual role of tumor necrosis factor alpha in brain injury
    • COI: 1:CAS:528:DyaK1MXmslersrs%3D, PID: 10743503
    • Shohami E, Ginis I, Hallenbeck JM (1999) Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev 10(2):119–130
    • (1999) Cytokine Growth Factor Rev , vol.10 , Issue.2 , pp. 119-130
    • Shohami, E.1    Ginis, I.2    Hallenbeck, J.M.3
  • 120
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28XhvFyjsbs%3D, PID: 16476660
    • Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease. Neuron 49(4):489–502. doi:10.1016/j.neuron.2006.01.022
    • (2006) Neuron , vol.49 , Issue.4 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 121
    • 84860883354 scopus 로고    scopus 로고
    • Systemic administration of LPS worsens delayed deterioration associated with vasospasm after subarachnoid hemorrhage through a myeloid cell-dependent mechanism
    • COI: 1:CAS:528:DC%2BC38XkvVCnt7c%3D, PID: 22090172
    • Smithason S, Moore SK, Provencio JJ (2012) Systemic administration of LPS worsens delayed deterioration associated with vasospasm after subarachnoid hemorrhage through a myeloid cell-dependent mechanism. Neurocrit Care 16(2):327–334. doi:10.1007/s12028-011-9651-3
    • (2012) Neurocrit Care , vol.16 , Issue.2 , pp. 327-334
    • Smithason, S.1    Moore, S.K.2    Provencio, J.J.3
  • 122
    • 67449119394 scopus 로고    scopus 로고
    • The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor
    • COI: 1:CAS:528:DC%2BD1MXosVCmtb0%3D, PID: 19457124
    • Stefano L, Racchetti G, Bianco F, Passini N, Gupta RS, Panina Bordignon P, Meldolesi J (2009) The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem 110(1):284–294. doi:10.1111/j.1471-4159.2009.06130.x
    • (2009) J Neurochem , vol.110 , Issue.1 , pp. 284-294
    • Stefano, L.1    Racchetti, G.2    Bianco, F.3    Passini, N.4    Gupta, R.S.5    Panina Bordignon, P.6    Meldolesi, J.7
  • 123
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • COI: 1:CAS:528:DC%2BD2cXitlCrtb8%3D, PID: 14999069
    • Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W (2004) Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 24(9):2182–2190. doi:10.1523/JNEUROSCI.5275-03.2004
    • (2004) J Neurosci , vol.24 , Issue.9 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6    Ramer, M.S.7    Tetzlaff, W.8
  • 124
    • 0031718663 scopus 로고    scopus 로고
    • Inflammation and glial responses in ischemic brain lesions
    • COI: 1:STN:280:DyaK1cvjtlCjug%3D%3D, PID: 9760699
    • Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56(2):149–171
    • (1998) Prog Neurobiol , vol.56 , Issue.2 , pp. 149-171
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 125
    • 0343953483 scopus 로고    scopus 로고
    • Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats
    • COI: 1:CAS:528:DC%2BD3cXktlKrtLw%3D, PID: 10869807
    • Stover JF, Schoning B, Beyer TF, Woiciechowsky C, Unterberg AW (2000) Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats. Neurosci Lett 288(1):25–28
    • (2000) Neurosci Lett , vol.288 , Issue.1 , pp. 25-28
    • Stover, J.F.1    Schoning, B.2    Beyer, T.F.3    Woiciechowsky, C.4    Unterberg, A.W.5
  • 126
    • 0033496986 scopus 로고    scopus 로고
    • Temporal profile and cellular localization of interleukin-6 protein after focal cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BD3cXks1SntL4%3D, PID: 10566972
    • Suzuki S, Tanaka K, Nogawa S, Nagata E, Ito D, Dembo T, Fukuuchi Y (1999) Temporal profile and cellular localization of interleukin-6 protein after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 19(11):1256–1262. doi:10.1097/00004647-199911000-00010
    • (1999) J Cereb Blood Flow Metab , vol.19 , Issue.11 , pp. 1256-1262
    • Suzuki, S.1    Tanaka, K.2    Nogawa, S.3    Nagata, E.4    Ito, D.5    Dembo, T.6    Fukuuchi, Y.7
  • 127
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • COI: 1:CAS:528:DC%2BD2MXhs1Kmsbk%3D, PID: 15728241
    • Takahashi K, Rochford CD, Neumann H (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 201(4):647–657. doi:10.1084/jem.20041611
    • (2005) J Exp Med , vol.201 , Issue.4 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.2    Neumann, H.3
  • 128
    • 24144490399 scopus 로고    scopus 로고
    • Role of NADPH oxidase in the brain injury of intracerebral hemorrhage
    • COI: 1:CAS:528:DC%2BD2MXpvF2qu78%3D, PID: 16011743
    • Tang J, Liu J, Zhou C, Ostanin D, Grisham MB, Neil Granger D, Zhang JH (2005) Role of NADPH oxidase in the brain injury of intracerebral hemorrhage. J Neurochem 94(5):1342–1350. doi:10.1111/j.1471-4159.2005.03292.x
    • (2005) J Neurochem , vol.94 , Issue.5 , pp. 1342-1350
    • Tang, J.1    Liu, J.2    Zhou, C.3    Ostanin, D.4    Grisham, M.B.5    Neil Granger, D.6    Zhang, J.H.7
  • 129
    • 34547858520 scopus 로고    scopus 로고
    • Apocynin attenuates cerebral infarction after transient focal ischaemia in rats
    • COI: 1:CAS:528:DC%2BD2sXhtVers7fF, PID: 17697529
    • Tang LL, Ye K, Yang XF, Zheng JS (2007) Apocynin attenuates cerebral infarction after transient focal ischaemia in rats. J Int Med Res 35(4):517–522
    • (2007) J Int Med Res , vol.35 , Issue.4 , pp. 517-522
    • Tang, L.L.1    Ye, K.2    Yang, X.F.3    Zheng, J.S.4
  • 130
    • 46549086942 scopus 로고    scopus 로고
    • Apocynin improves outcome in experimental stroke with a narrow dose range
    • COI: 1:CAS:528:DC%2BD1cXnt1enu7c%3D, PID: 18511205
    • Tang XN, Cairns B, Cairns N, Yenari MA (2008) Apocynin improves outcome in experimental stroke with a narrow dose range. Neuroscience 154(2):556–562. doi:10.1016/j.neuroscience.2008.03.090
    • (2008) Neuroscience , vol.154 , Issue.2 , pp. 556-562
    • Tang, X.N.1    Cairns, B.2    Cairns, N.3    Yenari, M.A.4
  • 131
    • 84855360910 scopus 로고    scopus 로고
    • Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke
    • COI: 1:CAS:528:DC%2BC3MXhtlKjtLjJ, PID: 22028221
    • Tang XN, Zheng Z, Giffard RG, Yenari MA (2011) Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke. Ann Neurol 70(4):606–615. doi:10.1002/ana.22476
    • (2011) Ann Neurol , vol.70 , Issue.4 , pp. 606-615
    • Tang, X.N.1    Zheng, Z.2    Giffard, R.G.3    Yenari, M.A.4
  • 132
    • 84863802602 scopus 로고    scopus 로고
    • NADPH oxidase in stroke and cerebrovascular disease
    • COI: 1:CAS:528:DC%2BC38Xhs1ynt7%2FP, PID: 22643077
    • Tang XN, Cairns B, Kim JY, Yenari MA (2012a) NADPH oxidase in stroke and cerebrovascular disease. Neurol Res 34(4):338–345. doi:10.1179/1743132812Y.0000000021
    • (2012) Neurol Res , vol.34 , Issue.4 , pp. 338-345
    • Tang, X.N.1    Cairns, B.2    Kim, J.Y.3    Yenari, M.A.4
  • 133
    • 84865782672 scopus 로고    scopus 로고
    • Bone marrow chimeras in the study of experimental stroke
    • PID: 24323809
    • Tang XN, Zheng Z, Yenari MA (2012b) Bone marrow chimeras in the study of experimental stroke. Transl Stroke Res 3(3):341–347. doi:10.1007/s12975-012-0169-6
    • (2012) Transl Stroke Res , vol.3 , Issue.3 , pp. 341-347
    • Tang, X.N.1    Zheng, Z.2    Yenari, M.A.3
  • 134
    • 84886714373 scopus 로고    scopus 로고
    • Microglial responses after ischemic stroke and intracerebral hemorrhage
    • PID: 24223607
    • Taylor RA, Sansing LH (2013) Microglial responses after ischemic stroke and intracerebral hemorrhage. Clin Dev Immunol 2013:746068. doi:10.1155/2013/746068
    • (2013) Clin Dev Immunol , vol.2013 , pp. 746068
    • Taylor, R.A.1    Sansing, L.H.2
  • 135
    • 0026708978 scopus 로고
    • Brain macrophages: evaluation of microglia and their functions
    • COI: 1:STN:280:DyaK38zks1aitg%3D%3D, PID: 1638276
    • Thomas WE (1992) Brain macrophages: evaluation of microglia and their functions. Brain Res Brain Res Rev 17(1):61–74
    • (1992) Brain Res Brain Res Rev , vol.17 , Issue.1 , pp. 61-74
    • Thomas, W.E.1
  • 136
    • 79961209219 scopus 로고    scopus 로고
    • Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead
    • PID: 21778445
    • Towfighi A, Saver JL (2011) Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke 42(8):2351–2355. doi:10.1161/STROKEAHA.111.621904
    • (2011) Stroke , vol.42 , Issue.8 , pp. 2351-2355
    • Towfighi, A.1    Saver, J.L.2
  • 137
    • 0037102724 scopus 로고    scopus 로고
    • Treatment of spinal cord impact injury in the rat with transforming growth factor-beta
    • COI: 1:CAS:528:DC%2BD38XlsVOqsr8%3D, PID: 12127673
    • Tyor WR, Avgeropoulos N, Ohlandt G, Hogan EL (2002) Treatment of spinal cord impact injury in the rat with transforming growth factor-beta. J Neurol Sci 200(1–2):33–41
    • (2002) J Neurol Sci , vol.200 , Issue.1-2 , pp. 33-41
    • Tyor, W.R.1    Avgeropoulos, N.2    Ohlandt, G.3    Hogan, E.L.4
  • 138
    • 84925946348 scopus 로고    scopus 로고
    • Subarachnoid and intraventricular hemorrhage
    • PID: 22377884
    • Venti M (2012) Subarachnoid and intraventricular hemorrhage. Front Neurol Neurosci 30:149–153. doi:10.1159/000333625
    • (2012) Front Neurol Neurosci , vol.30 , pp. 149-153
    • Venti, M.1
  • 139
    • 33845337987 scopus 로고    scopus 로고
    • Inflammation in adult and neonatal stroke
    • COI: 1:CAS:528:DC%2BD28Xht12ksb3L, PID: 20300490
    • Vexler ZS, Tang XN, Yenari MA (2006) Inflammation in adult and neonatal stroke. Clin Neurosci Res 6(5):293–313
    • (2006) Clin Neurosci Res , vol.6 , Issue.5 , pp. 293-313
    • Vexler, Z.S.1    Tang, X.N.2    Yenari, M.A.3
  • 141
    • 59749083104 scopus 로고    scopus 로고
    • TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia
    • COI: 1:CAS:528:DC%2BD1MXhvFGnsbY%3D, PID: 19111539
    • Walker EJ, Rosenberg GA (2009) TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia. Exp Neurol 216(1):122–131. doi:10.1016/j.expneurol.2008.11.022
    • (2009) Exp Neurol , vol.216 , Issue.1 , pp. 122-131
    • Walker, E.J.1    Rosenberg, G.A.2
  • 142
    • 77956545744 scopus 로고    scopus 로고
    • Preclinical and clinical research on inflammation after intracerebral hemorrhage
    • COI: 1:CAS:528:DC%2BC3cXhsVGntrvO, PID: 20713126
    • Wang J (2010) Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol 92(4):463–477. doi:10.1016/j.pneurobio.2010.08.001
    • (2010) Prog Neurobiol , vol.92 , Issue.4 , pp. 463-477
    • Wang, J.1
  • 143
    • 34250782407 scopus 로고    scopus 로고
    • Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage
    • PID: 17525142
    • Wang J, Dore S (2007a) Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain 130(Pt 6):1643–1652. doi:10.1093/brain/awm095
    • (2007) Brain , vol.130 , pp. 1643-1652
    • Wang, J.1    Dore, S.2
  • 144
    • 34247488271 scopus 로고    scopus 로고
    • Inflammation after intracerebral hemorrhage
    • COI: 1:CAS:528:DC%2BD2sXlvVSktr0%3D, PID: 17033693
    • Wang J, Dore S (2007b) Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab 27(5):894–908. doi:10.1038/sj.jcbfm.9600403
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.5 , pp. 894-908
    • Wang, J.1    Dore, S.2
  • 145
    • 70049112658 scopus 로고    scopus 로고
    • Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice
    • COI: 1:CAS:528:DC%2BD1MXhtFGlur3J, PID: 19646426
    • Wang G, Guo Q, Hossain M, Fazio V, Zeynalov E, Janigro D, Mayberg MR, Namura S (2009) Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice. Brain Res 1294:183–192. doi:10.1016/j.brainres.2009.07.070
    • (2009) Brain Res , vol.1294 , pp. 183-192
    • Wang, G.1    Guo, Q.2    Hossain, M.3    Fazio, V.4    Zeynalov, E.5    Janigro, D.6    Mayberg, M.R.7    Namura, S.8
  • 146
    • 84889084386 scopus 로고    scopus 로고
    • Microglia/macrophage polarization dynamics in white matter after traumatic brain injury
    • COI: 1:CAS:528:DC%2BC3sXhvVOhsr3P, PID: 23942366
    • Wang G, Zhang J, Hu X, Zhang L, Mao L, Jiang X, Liou AK, Leak RK, Gao Y, Chen J (2013) Microglia/macrophage polarization dynamics in white matter after traumatic brain injury. J Cereb Blood Flow Metab 33(12):1864–1874. doi:10.1038/jcbfm.2013.146
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.12 , pp. 1864-1874
    • Wang, G.1    Zhang, J.2    Hu, X.3    Zhang, L.4    Mao, L.5    Jiang, X.6    Liou, A.K.7    Leak, R.K.8    Gao, Y.9    Chen, J.10
  • 147
    • 35548966601 scopus 로고    scopus 로고
    • Evolution of the inflammatory response in the brain following intracerebral hemorrhage and effects of delayed minocycline treatment
    • COI: 1:CAS:528:DC%2BD2sXht1Grs7bF, PID: 17919462
    • Wasserman JK, Zhu X, Schlichter LC (2007) Evolution of the inflammatory response in the brain following intracerebral hemorrhage and effects of delayed minocycline treatment. Brain Res 1180:140–154. doi:10.1016/j.brainres.2007.08.058
    • (2007) Brain Res , vol.1180 , pp. 140-154
    • Wasserman, J.K.1    Zhu, X.2    Schlichter, L.C.3
  • 148
    • 0034726019 scopus 로고    scopus 로고
    • Protective effect of microglial conditioning medium on neuronal damage induced by glutamate
    • COI: 1:CAS:528:DC%2BD3cXkvFSns74%3D, PID: 10899407
    • Watanabe H, Abe H, Takeuchi S, Tanaka R (2000) Protective effect of microglial conditioning medium on neuronal damage induced by glutamate. Neurosci Lett 289(1):53–56
    • (2000) Neurosci Lett , vol.289 , Issue.1 , pp. 53-56
    • Watanabe, H.1    Abe, H.2    Takeuchi, S.3    Tanaka, R.4
  • 149
    • 84881116173 scopus 로고    scopus 로고
    • Microglial P2Y12 deficiency/inhibition protects against brain ischemia
    • COI: 1:CAS:528:DC%2BC3sXht12mtLzN, PID: 23940669
    • Webster CM, Hokari M, McManus A, Tang XN, Ma H, Kacimi R, Yenari MA (2013) Microglial P2Y12 deficiency/inhibition protects against brain ischemia. PLoS One 8(8):e70927. doi:10.1371/journal.pone.0070927
    • (2013) PLoS One , vol.8 , Issue.8 , pp. 70927
    • Webster, C.M.1    Hokari, M.2    McManus, A.3    Tang, X.N.4    Ma, H.5    Kacimi, R.6    Yenari, M.A.7
  • 150
    • 33845742671 scopus 로고    scopus 로고
    • Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury
    • COI: 1:CAS:528:DC%2BD2sXptlertg%3D%3D, PID: 16736051
    • Weston RM, Jones NM, Jarrott B, Callaway JK (2007) Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury. J Cereb Blood Flow Metab 27(1):100–114. doi:10.1038/sj.jcbfm.9600324
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.1 , pp. 100-114
    • Weston, R.M.1    Jones, N.M.2    Jarrott, B.3    Callaway, J.K.4
  • 151
    • 0029121104 scopus 로고
    • Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia
    • COI: 1:CAS:528:DyaK2MXnvV2ksLc%3D, PID: 7477737
    • Wood PL (1995) Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol Res 17(4):242–248
    • (1995) Neurol Res , vol.17 , Issue.4 , pp. 242-248
    • Wood, P.L.1
  • 152
    • 85052610332 scopus 로고    scopus 로고
    • Microglial activation and brain injury after intracerebral hemorrhage
    • COI: 1:STN:280:DC%2BD1cjps1yrtw%3D%3D, PID: 19066084
    • Wu J, Yang S, Xi G, Song S, Fu G, Keep RF, Hua Y (2008) Microglial activation and brain injury after intracerebral hemorrhage. Acta Neurochir Suppl 105:59–65
    • (2008) Acta Neurochir Suppl , vol.105 , pp. 59-65
    • Wu, J.1    Yang, S.2    Xi, G.3    Song, S.4    Fu, G.5    Keep, R.F.6    Hua, Y.7
  • 153
    • 0034646793 scopus 로고    scopus 로고
    • Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death
    • COI: 1:CAS:528:DC%2BD3cXit1Wgtbs%3D, PID: 10754230
    • Xue M, Del Bigio MR (2000) Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death. Neurosci Lett 283(3):230–232
    • (2000) Neurosci Lett , vol.283 , Issue.3 , pp. 230-232
    • Xue, M.1    Del Bigio, M.R.2
  • 154
    • 33749520483 scopus 로고    scopus 로고
    • Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice
    • COI: 1:CAS:528:DC%2BD28XhtVymu77M, PID: 17021183
    • Xue M, Hollenberg MD, Yong VW (2006) Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice. J Neurosci 26(40):10281–10291. doi:10.1523/JNEUROSCI.2806-06.2006
    • (2006) J Neurosci , vol.26 , Issue.40 , pp. 10281-10291
    • Xue, M.1    Hollenberg, M.D.2    Yong, V.W.3
  • 155
    • 78149273251 scopus 로고    scopus 로고
    • Relationship between leukocyte kinetics and behavioral tests changes in the inflammatory process of hemorrhagic stroke recovery
    • PID: 20942593
    • Yabluchanskiy A, Sawle P, Homer-Vanniasinkam S, Green CJ, Motterlini R (2010) Relationship between leukocyte kinetics and behavioral tests changes in the inflammatory process of hemorrhagic stroke recovery. Int J Neurosci 120(12):765–773. doi:10.3109/00207454.2010.523129
    • (2010) Int J Neurosci , vol.120 , Issue.12 , pp. 765-773
    • Yabluchanskiy, A.1    Sawle, P.2    Homer-Vanniasinkam, S.3    Green, C.J.4    Motterlini, R.5
  • 156
    • 84858706456 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of hypothermia in brain ischaemia
    • COI: 1:CAS:528:DC%2BC38Xis1ersL8%3D, PID: 22353781
    • Yenari MA, Han HS (2012) Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci 13(4):267–278. doi:10.1038/nrn3174
    • (2012) Nat Rev Neurosci , vol.13 , Issue.4 , pp. 267-278
    • Yenari, M.A.1    Han, H.S.2
  • 157
    • 33645799230 scopus 로고    scopus 로고
    • Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro
    • PID: 16497985
    • Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG (2006) Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke 37(4):1087–1093. doi:10.1161/01.STR.0000206281.77178.ac
    • (2006) Stroke , vol.37 , Issue.4 , pp. 1087-1093
    • Yenari, M.A.1    Xu, L.2    Tang, X.N.3    Qiao, Y.4    Giffard, R.G.5
  • 158
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
    • COI: 1:CAS:528:DyaK1MXhvFegtw%3D%3D, PID: 9861045
    • Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J (1998) Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A 95(26):15769–15774
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.26 , pp. 15769-15774
    • Yrjanheikki, J.1    Keinanen, R.2    Pellikka, M.3    Hokfelt, T.4    Koistinaho, J.5
  • 159
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • COI: 1:CAS:528:DyaK1MXns1GmurY%3D, PID: 10557349
    • Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J (1999) A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A 96(23):13496–13500
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.23 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 161
    • 0031025503 scopus 로고    scopus 로고
    • Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion
    • COI: 1:CAS:528:DyaK2sXksValug%3D%3D, PID: 9027378
    • Zhang Z, Chopp M, Powers C (1997) Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion. Brain Res 744(2):189–198. doi:10.1016/S0006-8993(96)01085-2
    • (1997) Brain Res , vol.744 , Issue.2 , pp. 189-198
    • Zhang, Z.1    Chopp, M.2    Powers, C.3
  • 162
    • 26444613280 scopus 로고    scopus 로고
    • Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
    • COI: 1:CAS:528:DC%2BD2MXhtVeisbbP, PID: 16166574
    • Zhang N, Komine-Kobayashi M, Tanaka R, Liu M, Mizuno Y, Urabe T (2005) Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 36(10):2220–2225. doi:10.1161/01.STR.0000182241.07096.06
    • (2005) Stroke , vol.36 , Issue.10 , pp. 2220-2225
    • Zhang, N.1    Komine-Kobayashi, M.2    Tanaka, R.3    Liu, M.4    Mizuno, Y.5    Urabe, T.6
  • 163
    • 0034725832 scopus 로고    scopus 로고
    • Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase
    • COI: 1:CAS:528:DC%2BD3cXltlektLg%3D, PID: 10924696
    • Zhao X, Haensel C, Araki E, Ross ME, Iadecola C (2000) Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase. Brain Res 872(1–2):215–218
    • (2000) Brain Res , vol.872 , Issue.1-2 , pp. 215-218
    • Zhao, X.1    Haensel, C.2    Araki, E.3    Ross, M.E.4    Iadecola, C.5
  • 164
    • 33645744014 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in delayed cortical responses after stroke
    • COI: 1:CAS:528:DC%2BD28XjtFKjtb8%3D, PID: 16565723
    • Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH (2006) Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med 12(4):441–445. doi:10.1038/nm1387
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 441-445
    • Zhao, B.Q.1    Wang, S.2    Kim, H.Y.3    Storrie, H.4    Rosen, B.R.5    Mooney, D.J.6    Wang, X.7    Lo, E.H.8


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