Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 14, 2003, Pages 8514-8519

  Lehnardt, Seija ^a   Massillon, Leon ^a   Follett, Pamela ^a   Jensen, Frances E ^a   Ratan, Rajiv ^a   Rosenberg, Paul A ^a   Volpe, Joseph J ^a   Vartanian, Timothy ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Infection; Lipopolysaccharide; Microglia; Neuronal injury

Indexed keywords

LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL LOSS; CENTRAL NERVOUS SYSTEM; IMMUNOSTIMULATION; MICROGLIA; MOUSE; NERVE CELL; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD14; APOPTOSIS; BYSTANDER EFFECT; CEREBRAL CORTEX; CHICK EMBRYO; COCULTURE TECHNIQUES; GANGLIA, SPINAL; HYPOXIA-ISCHEMIA, BRAIN; IMMUNITY, NATURAL; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICROGLIA; NERVE DEGENERATION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

ANIMALIA;

EID: 0037477629     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1432609100     Document Type: Article

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