Traumatic Injury to the Immature Brain: Inflammation, Oxidative Injury, and Iron-Mediated Damage as Potential Therapeutic Targets

NeuroRx

Volumn 3, Issue 2, 2006, Pages 143-153

  Potts, Mathew B ^a   Koh, Seong Eun ^a   Whetstone, William D ^a   Walker, Breset A ^a   Yoneyama, Tomoko ^a   Claus, Catherine P ^a   Manvelyan, Hovhannes M ^a   Noble Haeusslein, Linda J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

immature brain; inflammation; iron; oxidative damage; Traumatic brain injury

Indexed keywords

2,2' BIPYRIDINE; 2,3 DIHYDROXYBENZOIC ACID; 21 AMINOSTEROID; ANTIOXIDANT; CHEMOKINE; CYTOKINE; DEFEROXAMINE; DEXANABINOL; EBSELEN; GLUTATHIONE PEROXIDASE; IBUPROFEN; INDOMETACIN; IRON; MELATONIN; MINOCYCLINE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRONE DERIVATIVE; NITROXIDE DERIVATIVE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SUPEROXIDE DISMUTASE; TIRILAZAD; TOCOPHEROL;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BONE DISEASE; BONE GROWTH; BRAIN DAMAGE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN MATURATION; CALCIUM CELL LEVEL; CELL DEATH; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COGNITION; CONVALESCENCE; CYTOTOXICITY; DEVELOPMENTAL DISORDER; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; ENCEPHALITIS; ENZYME ACTIVITY; ENZYME INHIBITION; EXCITOTOXICITY; HEAD INJURY; HUMAN; IRON CHELATION; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PATHOGENESIS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; STROKE; SUBARACHNOID HEMORRHAGE; TOOTH DISCOLORATION; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; BRAIN INJURY; CHILD; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; REVIEW;

ANIMALS; BRAIN; BRAIN INJURIES; CHILD; ENCEPHALITIS; HUMANS; IRON; OXIDATIVE STRESS;

EID: 33646140345     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1016/j.nurx.2006.01.006     Document Type: Article

References (146)

1. Langlois J., Rutland-Brown W., and Thomas K. Traumatic brain injury in the United States. Emergency department visits, hospitalizations, and deaths (2004), Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Atlanta (GA)
2. Mazzola C.A., and Adelson P.D. Critical care management of head trauma in children. Crit Care Med 30 (2002) S393-S401
3. Costeff H., Groswasser Z., and Goldstein R. Long-term follow-up review of 31 children with severe closed head trauma. J Neurosurg 73 (1990) 684-687
4. Salmond C.H., and Sahakian B.J. Cognitive outcome in traumatic brain injury survivors. Curr Opin Crit Care 11 (2005) 111-116
5. Levin H.S., Aldrich E.F., Saydjari C., Eisenberg H.M., Foulkes M.A., Bellefleur M., et al. Severe head injury in children. experience of the Traumatic Coma Data Bank. Neurosurgery 31 (1992) 435-443 discussion 443-434
6. Khoshyomn S., and Tranmer B.I. Diagnosis and management of pediatric closed head injury. Semin Pediatr Surg 13 (2004) 80-86
7. Adelson P.D., Clyde B., Kochanek P.M., Wisniewski S.R., Marion D.W., and Yonas H. Cerebrovascular response in infants and young children following severe traumatic brain injury. a preliminary report. Pediatr Neurosurg 26 (1997) 200-207
8. Koskiniemi M., Kyykka T., Nybo T., and Jarho L. Long-term outcome after severe brain injury in preschoolers is worse than expected. Arch Pediatr Adolesc Med 149 (1995) 249-254
9. Bittigau P., Sifringer M., Felderhoff-Mueser U., and Ikonomidou C. Apoptotic neurodegeneration in the context of traumatic injury to the developing brain. Exp Toxicol Pathol 56 (2004) 83-89
10. Adelson P.D., Bratton S.L., Carney N.A., Chesnut R.M., du Coudray H.E., Goldstein B., et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Pediatr Crit Care Med 4 (2003) S2-S75
11. Carmody D.P., Dunn S.M., Boddie-Willis A.S., DeMarco J.K., and Lewis M. A quantitative measure of myelination development in infants, using MR images. Neuroradiology 46 (2004) 781-786
12. Koizumi H. The concept of 'developing the brain'. a new natural science for learning and education. Brain Dev 26 (2004) 434-441
13. Haynes R.L., Borenstein N.S., Desilva T.M., Folkerth R.D., Liu L.G., Volpe J.J., et al. Axonal development in the cerebral white matter of the human fetus and infant. J Comp Neurol 484 (2005) 156-167
14. Chambers I.R., Jones P.A., Lo T.Y., Forsyth R.J., Fulton B., Andrews P.J., et al. Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury. J Neurol Neurosurg Psychiatry (2005)
15. Durkin M.S., Olsen S., Barlow B., Virella A., and Connolly Jr. E.S. The epidemiology of urban pediatric neurological trauma. evaluation of, and implications for, injury prevention programs. Neurosurgery 42 (1998) 300-310
16. Pigula F.A., Wald S.L., Shackford S.R., and Vane D.W. The effect of hypotension and hypoxia on children with severe head injuries. J Pediatr Surg 28 (1993) 310-316 discussion 315-316
17. Natale J.E., Joseph J.G., Helfaer M.A., and Shaffner D.H. Early hyperthermia after traumatic brain injury in children. risk factors, influence on length of stay, and effect on short-term neurologic status. Crit Care Med 28 (2000) 2608-2615
18. Ylvisaker M., Adelson P.D., Braga L.W., Burnett S.M., Glang A., Feeney T., et al. Rehabilitation and ongoing support after pediatric TBI. twenty years of progress. J Head Trauma Rehabil 20 (2005) 95-109
19. Bayir H., Kochanek P.M., and Clark R.S. Traumatic brain injury in infants and children. mechanisms of secondary damage and treatment in the intensive care unit. Crit Care Clin 19 (2003) 529-549
20. Kreutzberg G. Microglia. a sensor for pathological events in the CNS. Trends in Neuroscience 19 (1996) 312-318
21. Gao H.-M., and Hong J.-S. Critical role of microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neuroscience 23 (2002) 6181-6187
22. Hudome S., Palmer C., Roberts R.L., Mauger D., Housman C., and Towfighi J. The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res 41 (1997) 607-616
23. Kawabata K., Hagio T., and Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 451 (2002) 1-10
24. Lee W., and Downey G. Leukocyte elastase. physiological functions and role in acute lung injury. Am J Respir Crit Care Med 164 (2001) 896-904
25. Owen C., and Campbell E. The cell biology of leukocyte-mediated proteolysis. J Leukoc Biol 1999 Feb;65(2):137-50 65 (1999) 137-150
26. DeWitt D.S., and Prough D.S. Traumatic cerebral vascular injury. the effects of concussive brain injury on the cerebral vasculature. J Neurotrauma 20 (2003) 795-825
27. Morganti-Kossmann M.C., Rancan M., Stahel P.F., and Kossmann T. Inflammatory response in acute traumatic brain injury. a double-edged sword. Curr Opin Crit Care 8 (2002) 101-105
28. Rothwall N. Interleukin-1 and neuronal injury. mechanisms, modification, and therapeutic potential. Brain, Behavior, and Immunity 17 (2003) 152-157
29. Sherwood E.R., and Prough D.S. Interleukin-8, neuroinflammation, and secondary brain injury. Crit Care Med 28 (2000) 1221-1223
30. Shohami E., Bass R., Wallach D., Yamin A., and Gallily R. Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury. J Cereb Blood Flow Metab 16 (1996) 378-384
31. Scherbel U., Raghupathi R., Nakamura M., Saatman K.E., Trojanowski J.Q., Neugebauer E., et al. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc Natl Acad Sci U S A 96 (1999) 8721-8726
32. Toulmond S., and Rothwell N.J. Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res 671 (1995) 261-266
33. DeKosky S.T., Styren S.D., O'Malley M.E., Goss J.R., Kochanek P., Marion D., et al. Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain. Ann Neurol 39 (1996) 123-127
34. Yang K., Mu X.S., and Hayes R.L. Increased cortical nuclear factor-kappa B (NF-kappa B) DNA binding activity after traumatic brain injury in rats. Neurosci Lett 197 (1995) 101-104
35. Nonaka M., Chen X.H., Pierce J.E., Leoni M.J., McIntosh T.K., Wolf J.A., et al. Prolonged activation of NF-kappaB following traumatic brain injury in rats. J Neurotrauma 16 (1999) 1023-1034
36. Bell M.J., Kochanek P.M., Doughty L.A., Carcillo J.A., Adelson P.D., Clark R.S., et al. Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 14 (1997) 451-457
37. Bell M.J., Kochanek P.M., Doughty L.A., Carcillo J.A., Adelson P.D., Clark R.S., et al. Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock. Acta Neurochir Suppl (Wien) 70 (1997) 96-97
38. Bajetto A., and Bonavai R. Characterization of chemokines and their receptors in the central nervous system. physiopathological implications. S.B,G.S. J Neurochem. 82 (2002) 1311-1329
39. Bell M.D., Taub D.D., and Perry V.H. Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines. Neuroscience 74 (1996) 283-292
40. Whalen M.J., Carlos T.M., Kochanek P.M., Wisniewski S.R., Bell M.J., Clark R.S., et al. Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit Care Med 28 (2000) 929-934
41. Vane J.R., and Botting R.M. Mechanism of action of antiinflammatory drugs. Int J Tissue React 20 (1998) 3-15
42. Willard L.B., Hauss-Wegrzyniak B., Danysz W., and Wenk G.L. The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition. Exp Brain Res 134 (2000) 58-65
43. Dunon D., Piali L., and Imhof B. To stick or not to stick. the new leukocyte homing paradigm. Curr Opin Cell Biol 8 (1996) 714-723
44. Whalen M.J., Carlos T.M., Dixon C.E., Schiding J.K., Clark R.S., Baum E., et al. Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1. assessment of histopathologic and functional outcome. J Neurotrauma 16 (1999) 299-309
45. Knoblach S., and Faden A.I. Administration of either anti-intercellular adhesion molecule-1 or a nonspecific control antibody improves recovery after traumatic brain injury in the rat. J Neurotrauma 19 (2002) 1039-1049
46. Balabanov R., Goldman H., Murphy S., Pellizon G., Owen C., Rafols J., et al. Endothelial cell activation following moderate traumatic brain injury. Neurol Res 23 (2001) 175-182
47. Whalen M.J., Carlos T.M., Kochanek P.M., Wisniewski S.R., Bell M.J., Carcillo J.A., et al. Soluble adhesion molecules in CSF are increased in children with severe head injury. J Neurotrauma 15 (1998) 777-787
48. Lawson L.J., and Perry V.H. The unique characteristics of inflammatory responses in mouse brain are acquired during postnatal development. Eur J Neurosci 7 (1995) 1584-1595
49. Anthony D.C., Bolton S.J., Fearn S., and Perry V.H. Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats. Brain 120 Pt 3 (1997) 435-444
50. Anthony D., Dempster R., Fearn S., Clements J., Wells G., Perry V.H., et al. CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown. Curr Biol 8 (1998) 923-926
51. Yrjanheikki J., Tikka T., Keinanen R., Goldsteins G., Chan P.H., and Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. PNAS 96 (1999) 13496-13500
52. Tikka T., Fiebich B., Goldsteins G., Keinanen R., and Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neuroscience 21 (2001) 2580-2588
53. Popovic N., Schubart A., Goetz B., Zhang S., Linington C., and Duncan I.D. Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol 51 (2002) 215-223
54. Thomas M., Le W.D., and Jankovic J. Minocycline and other tetracycline derivatives. a neuroprotective strategy in Parkinson's disease and Huntington's disease. Clin Neuropharmacol 26 (2003) 18-23
55. Zhu S., Stavrovskaya I.G., Drozda M., Kim B.Y., Ona V., Li M., et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417 (2002) 74-78
56. Saccani S., Pantano S., and Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 3 (2002) 69-75
57. Sanchez Mejia R., Ona V., Li M., and Friedlander R.M. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 48 (2001) 1293-1298
58. Arvin K.L., Han B.H., Du Y., Lin S.Z., Paul S.M., and Holtzman D.M. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 52 (2002) 54-61
59. Fox C., Dingman A., Derugin N., Wendland M.F., Manabat C., Ji S., et al. Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 25 (2005) 1138-1149
60. Kontos H.A., and Wei E.P. Superoxide production in experimental brain injury. J Neurosurg 64 (1986) 803-807
61. Hall E.D., and Braughler J.M. Free radicals in CNS injury. Res Publ Assoc Res Nerv Ment Dis 71 (1993) 81-105
62. Smith S.L., Andrus P.K., Zhang J.R., and Hall E.D. Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J Neurotrauma 11 (1994) 393-404
63. Lewen A., Matz P., and Chan P.H. Free radical pathways in CNS injury. J Neurotrauma 17 (2000) 871-890
64. Shohami E., Beit-Yannai E., Horowitz M., and Kohen R. Oxidative stress in closed-head injury. brain antioxidant capacity as an indicator of functional outcome. J Cereb Blood Flow Metab 17 (1997) 1007-1019
65. Warner D.S., Sheng H., and Batinic-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol 207 (2004) 3221-3231
66. Lifshitz J., Sullivan P.G., Hovda D.A., Wieloch T., and McIntosh T.K. Mitochondrial damage and dysfunction in traumatic brain injury. Mitochondrion 4 (2004) 705-713
67. Dietrich W.D., Chatzipanteli K., Vitarbo E., Wada K., and Kinoshita K. The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma. Acta Neurochir Suppl 89 (2004) 69-74
68. Feuerstein G.Z., Wang X., and Barone F.C. Inflammatory gene expression in cerebral ischemia and trauma. Potential new therapeutic targets. Ann N Y Acad Sci 825 (1997) 179-193
69. Floyd R.A., and Carney J.M. Age influence on oxidative events during brain ischemia/reperfusion. Arch Gerontol Geriatr 12 (1991) 155-177
70. Bayir H., Kagan V.E., Tyurina Y.Y., Tyurin V., Ruppel R.A., Adelson P.D., et al. Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Res 51 (2002) 571-578
71. Sheldon R.A., Jiang X., Francisco C., Christen S., Vexler Z.S., Tauber M.G., et al. Manipulation of antioxidant pathways in neonatal murine brain. Pediatr Res 56 (2004) 656-662
72. Natale J.E., Knight J.B., Cheng Y., Rome J.E., and Gallo V. Metallothionein I and II mitigate age-dependent secondary brain injury. J Neurosci Res 78 (2004) 303-314
73. Mavelli I., Rigo A., Federico R., Ciriolo M.R., and Rotilio G. Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain. Biochem J 204 (1982) 535-540
74. Mikawa S., Kinouchi H., Kamii H., Gobbel G.T., Chen S.F., Carlson E., et al. Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice. J Neurosurg 85 (1996) 885-891
75. McIntosh T.K., Juhler M., and Wieloch T. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury. 1998. J Neurotrauma 15 (1998) 731-769
76. Kinouchi H., Epstein C.J., Mizui T., Carlson E., Chen S.F., and Chan P.H. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc Natl Acad Sci U S A 88 (1991) 11158-11162
77. Ditelberg J.S., Sheldon R.A., Epstein C.J., and Ferriero D.M. Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice. Pediatr Res 39 (1996) 204-208
78. Fullerton H.J., Ditelberg J.S., Chen S.F., Sarco D.P., Chan P.H., Epstein C.J., et al. Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol 44 (1998) 357-364
79. Mischel R.E., Kim Y.S., Sheldon R.A., and Ferriero D.M. Hydrogen peroxide is selectively toxic to immature murine neurons in vitro. Neurosci Lett 231 (1997) 17-20
80. Lewen A., Fujimura M., Sugawara T., Matz P., Copin J.C., and Chan P.H. Oxidative stress-dependent release of mitochondrial cytochrome c after traumatic brain injury. J Cereb Blood Flow Metab 21 (2001) 914-920
81. Sheng H., Bart R.D., Oury T.D., Pearlstein R.D., Crapo J.D., and Warner D.S. Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neuroscience 88 (1999) 185-191
82. Sheng H., Kudo M., Mackensen G.B., Pearlstein R.D., Crapo J.D., and Warner D.S. Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia. Exp Neurol 163 (2000) 392-398
83. Sheng H., Brady T.C., Pearlstein R.D., Crapo J.D., and Warner D.S. Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. Neurosci Lett 267 (1999) 13-16
84. Hamm R.J., Temple M.D., Pike B.R., and Ellis E.F. The effect of postinjury administration of polyethylene glycol-conjugated superoxide dismutase (pegorgotein, Dismutec) or lidocaine on behavioral function following fluid-percussion brain injury in rats. J Neurotrauma 13 (1996) 325-332
85. Yunoki M., Kawauchi M., Ukita N., Noguchi Y., Nishio S., Ono Y., et al. Effects of lecithinized superoxide dismutase on traumatic brain injury in rats. J Neurotrauma 14 (1997) 739-746
86. Yunoki M., Kawauchi M., Ukita N., Sugiura T., and Ohmoto T. Effects of lecithinized superoxide dismutase on neuronal cell loss in CA3 hippocampus after traumatic brain injury in rats. Surg Neurol 59 (2003) 156-160 discussion 160-151
87. Kesner R.P., Lee I., and Gilbert P. A behavioral assessment of hippocampal function based on a subregional analysis. Rev Neurosci 15 (2004) 333-351
88. Marklund S.L., Westman N.G., Lundgren E., and Roos G. Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res 42 (1982) 1955-1961
89. Fan P., Yamauchi T., Noble L.J., and Ferriero D.M. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma 20 (2003) 437-445
90. Royo N.C., Shimizu S., Schouten J.W., Stover J.F., and McIntosh T.K. Pharmacology of traumatic brain injury. Curr Opin Pharmacol 3 (2003) 27-32
91. Marklund N., Clausen F., McIntosh T.K., and Hillered L. Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat. J Neurotrauma 18 (2001) 821-832
92. Hall E.D., Yonkers P.A., McCall J.M., and Braughler J.M. Effects of the 21-aminosteroid U74006F on experimental head injury in mice. J Neurosurg 68 (1988) 456-461
93. McIntosh T.K., Thomas M., Smith D., and Banbury M. The novel 21-aminosteroid U74006F attenuates cerebral edema and improves survival after brain injury in the rat. J Neurotrauma 9 (1992) 33-46
94. Sanada T., Nakamura T., Nishimura M.C., Isayama K., and Pitts L.H. Effect of U74006F on neurologic function and brain edema after fluid percussion injury in rats. J Neurotrauma 10 (1993) 65-71
95. Mathew P., Bullock R., Teasdale G., and McCulloch J. Changes in local microvascular permeability and in the effect of intervention with 21-aminosteroid (Tirilazad) in a new experimental model of focal cortical injury in the rat. J Neurotrauma 13 (1996) 465-472
96. Wei E.P., Kontos H.A., Dietrich W.D., Povlishock J.T., and Ellis E.F. Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. Circ Res 48 (1981) 95-103
97. Hall E.D. Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice. comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase. Cent Nerv Syst Trauma 2 (1985) 75-83
98. Kim H.J., Levasseur J.E., Patterson Jr. J.L., Jackson G.F., Madge G.E., and Povlishock J.T. Effect of indomethacin pretreatment on acute mortality in experimental brain injury. J Neurosurg 71 (1989) 565-572
99. Jafarian-Tehrani M., Louin G., Royo N.C., Besson V.C., Bohme G.A., Plotkine M., et al. 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats. Nitric Oxide 12 (2005) 61-69
100. Clifton G.L., Lyeth B.G., Jenkins L.W., Taft W.C., DeLorenzo R.J., and Hayes R.L. Effect of D, alpha-tocopheryl succinate and polyethylene glycol on performance tests after fluid percussion brain injury. J Neurotrauma 6 (1989) 71-81
101. Inci S., Ozcan O.E., and Kilinc K. Time-level relationship for lipid peroxidation and the protective effect of alpha-tocopherol in experimental mild and severe brain injury. Neurosurgery 43 (1998) 330-335 discussion 335-336
102. Beit-Yannai E., Zhang R., Trembovler V., Samuni A., and Shohami E. Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat. Brain Res 717 (1996) 22-28
103. Zhang R., Shohami E., Beit-Yannai E., Bass R., Trembovler V., and Samuni A. Mechanism of brain protection by nitroxide radicals in experimental model of closed-head injury. Free Radic Biol Med 24 (1998) 332-340
104. Sarrafzadeh A.S., Thomale U.W., Kroppenstedt S.N., and Unterberg A.W. Neuroprotective effect of melatonin on cortical impact injury in the rat. Acta Neurochir (Wien) 142 (2000) 1293-1299
105. Ozdemir D., Tugyan K., Uysal N., Sonmez U., Sonmez A., Acikgoz O., et al. Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats. Neurosci Lett 385 (2005) 234-239
106. Shohami E., Novikov M., and Bass R. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res 674 (1995) 55-62
107. Nadler V., Biegon A., Beit-Yannai E., Adamchik J., and Shohami E. 45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211. Brain Res 685 (1995) 1-11
108. Aoyama N., Katayama Y., Kawamata T., Maeda T., Mori T., Yamamoto T., et al. Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat. Brain Res 934 (2002) 117-124
109. Xiong Y., Peterson P.L., Muizelaar J.P., and Lee C.P. Amelioration of mitochondrial function by a novel antioxidant U-101033E following traumatic brain injury in rats. J Neurotrauma 14 (1997) 907-917
110. Wada K., Alonso O.F., Busto R., Panetta J., Clemens J.A., Ginsberg M.D., et al. Early treatment with a novel inhibitor of lipid peroxidation (LY341122) improves histopathological outcome after moderate fluid percussion brain injury in rats. Neurosurgery 45 (1999) 601-608
111. Hall E.D., Andrus P.K., Smith S.L., Fleck T.J., Scherch H.M., Lutzke B.S., et al. Pyrrolopyrimidines. novel brain-penetrating antioxidants with neuroprotective activity in brain injury and ischemia models. J Pharmacol Exp Ther 281 (1997) 895-904
112. Muizelaar J.P., Marmarou A., Young H.F., Choi S.C., Wolf A., Schneider R.L., et al. Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase. a phase II trial. J Neurosurg 78 (1993) 375-382
113. Young B., Runge J.W., Waxman K.S., Harrington T., Wilberger J., Muizelaar J.P., et al. Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial. Jama 276 (1996) 538-543
114. Marshall L.F., Maas A.I., Marshall S.B., Bricolo A., Fearnside M., Iannotti F., et al. A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. J Neurosurg 89 (1998) 519-525
115. Knoller N., Levi L., Shoshan I., Reichenthal E., Razon N., Rappaport Z.H., et al. Dexanabinol (HU-211) in the treatment of severe closed head injury. a randomized, placebo-controlled, phase II clinical trial. Crit Care Med 30 (2002) 548-554
116. Yamaguchi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., et al., Ebselen Study Group. Ebselen in acute ischemic stroke. a placebo-controlled, double-blind clinical trial. Stroke 29 (1998) 12-17
117. Saito I., Asano T., Sano K., Takakura K., Abe H., Yoshimoto T., et al. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 42 (1998) 269-277 discussion 277-268
118. Ogawa A., Yoshimoto T., Kikuchi H., Sano K., Saito I., Yamaguchi T., et al. Ebselen in acute middle cerebral artery occlusion. a placebo-controlled, double-blind clinical trial. Cerebrovasc Dis 9 (1999) 112-118
119. Chang E.F., Claus C.P., Vreman H.J., Wong R.J., and Noble-Haeusslein L.J. Heme regulation in traumatic brain injury. relevance to the adult and developing brain. J Cereb Blood Flow Metab (2005)
120. Connor J.R., Menzies S.L., Burdo J.R., and Boyer P.J. Iron and iron management proteins in neurobiology. Pediatr Neurol 25 (2001) 118-129
121. Roskams A.J., and Connor J.R. Iron, transferrin, and ferritin in the rat brain during development and aging. J Neurochem 63 (1994) 709-716
122. Berger H.M., Mumby S., and Gutteridge J.M. Ferrous ions detected in iron-overloaded cord blood plasma from preterm and term babies. implications for oxidative stress. Free Radic Res 22 (1995) 555-559
123. Gutteridge J.M., Mumby S., Koizumi M., and Taniguchi N. "Free" iron in neonatal plasma activates aconitase. evidence for biologically reactive iron. Biochem Biophys Res Commun 229 (1996) 806-809
124. Gutteridge J.M. Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage. Clin Sci (Lond) 82 (1992) 315-320
125. Dietrich R.B., and Bradley Jr. W.G. Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children. Radiology 168 (1988) 203-206
126. Cheepsunthorn P., Palmer C., Menzies S., Roberts R.L., and Connor J.R. Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains. J Comp Neurol 431 (2001) 382-396
127. Palmer C., Menzies S.L., Roberts R.L., Pavlick G., and Connor J.R. Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat. J Neurosci Res 56 (1999) 60-71
128. Kondo Y., Ogawa N., Asanuma M., Ota Z., and Mori A. Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain. J Cereb Blood Flow Metab 15 (1995) 216-226
129. Fredriksson A., Schroder N., Eriksson P., Izquierdo I., and Archer T. Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice. Toxicol Appl Pharmacol 159 (1999) 25-30
130. Connor J.R., and Menzies S.L. Relationship of iron to oligodendrocytes and myelination. Glia 17 (1996) 83-93
131. Connor J.R., Pavlick G., Karli D., Menzies S.L., and Palmer C. A histochemical study of iron-positive cells in the developing rat brain. J Comp Neurol 355 (1995) 111-123
132. Ikeda Y., Ikeda K., and Long D.M. Comparative study of different iron-chelating agents in cold-induced brain edema. Neurosurgery 24 (1989) 820-824
133. Regan R.F., and Rogers B. Delayed treatment of hemoglobin neurotoxicity. J Neurotrauma 20 (2003) 111-120
134. Bergeron M., Gidday J.M., Yu A.Y., Semenza G.L., Ferriero D.M., and Sharp F.R. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48 (2000) 285-296
135. Hamrick S.E., McQuillen P.S., Jiang X., Mu D., Madan A., and Ferriero D.M. A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection. Neurosci Lett 379 (2005) 96-100
136. Long D.A., Ghosh K., Moore A.N., Dixon C.E., and Dash P.K. Deferoxamine improves spatial memory performance following experimental brain injury in rats. Brain Res 717 (1996) 109-117
137. Panter S.S., Braughler J.M., and Hall E.D. Dextran-coupled deferoxamine improves outcome in a murine model of head injury. J Neurotrauma 9 (1992) 47-53
138. Nakamura T., Keep R.F., Hua Y., Schallert T., Hoff J.T., and Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg 100 (2004) 672-678
139. Groenendaal F., Shadid M., McGowan J.E., Mishra O.P., and van Bel F. Effects of deferoxamine, a chelator of free iron, on NA(+), K(+)-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs. Pediatr Res 48 (2000) 560-564
140. Peeters-Scholte C., Braun K., Koster J., Kops N., Blomgren K., Buonocore G., et al. Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia. Pediatr Res 54 (2003) 516-522
141. Pettus E.H., Wright D.W., Stein D.G., and Hoffman S.W. Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res 1049 (2005) 112-119
142. He J., Evans C.O., Hoffman S.W., Oyesiku N.M., and Stein D.G. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol 189 (2004) 404-412
143. Truettner J.S., Suzuki T., and Dietrich W.D. The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Brain Res Mol Brain Res 138 (2005) 124-134
144. Lynch J.R., Wang H., Mace B., Leinenweber S., Warner D.S., Bennett E.R., et al. A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. Exp Neurol 192 (2005) 109-116
145. Marklund N., Keck C., Hoover R., Soltesz K., Millard M., LeBold D., et al. Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin -6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat. Restor Neurol Neurosci 23 (2005) 31-42
146. Gopez J.J., Yue H., Vasudevan R., Malik A.S., Fogelsanger L.N., Lewis S., et al. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery 56 (2005) 590-604