Role for matrix metalloproteinase 9 after focal cerebral ischemia: Effects of gene knockout and enzyme inhibition with BB-94

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 12, 2000, Pages 1681-1689

  Asahi, Minoru ^a   Asahi, Kazuko ^a   Jung, Jae Chang ^b   Del Zoppo, Gregory J ^c   Fini, M Elizabeth ^b   Lo, Eng H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Extracellular matrix; Gene knockout; Mouse; Neuroprotection; Proteolysis; Stroke

Indexed keywords

BATIMASTAT; GELATINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; KNOCKOUT GENE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZYMOGRAPHY;

EID: 0033638508     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200012000-00007     Document Type: Article

References (39)

1. Role of mitogen activated protein kinases in ischemia and reperfusion injury
2. MEK1 protein kinase inhibition protects against damage from focal cerebral ischemia
3. Expression of c-los and c-jun family genes after focal cerebral ischemia
4. Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin
5. Role of oxidants in ischemic brain damage
6. Matrix metalloproteinases degrade myelin basic protein
7. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
8. Plasminogen activators and matrix metalloproteinases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system
9. Regulation of matrix metalloproteinase gene expression
10. Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury
11. Early appearance of activated MMP-9 after focal cerebral ischemia in mice
12. Processing of tumor necrosis factor alpha by metalloproteinase
13. Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis
14. Regulation of matrix metalloproteinase expression in astrocytes, microgila and neurons
15. Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes
16. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia
17. Secretion of metalloproteinases by stimulated capillary endothelial cells: Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors
18. Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor
19. Effect of brain edema on infarct volume in a focal ischemia model in rats
20. The matrix metalloproteinase inhibitor BB-94 retards human breast cancer tumor growth but not acites formation in nude mice
21. Regulation of cell surface APO-I/Fas (CD95) ligand expression by metalloproteases
22. Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodeling cornea
23. Curcuminoids inhibit the angiogenic response stimulated by FGF-2 including expression of matrix metalloproteinase gelatinase B
24. Overexpression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold induced brain trauma
25. Matrix metalloproteinases in cerebrovascular disease
26. Matrix metalloproteinases: A minireview
27. Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes
28. High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells
29. Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in mouse CNS in normal and inflammatory states
30. Borrelia burgdorferi induces matrix metalloproteinases by neural cultures
31. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats
32. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
33. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat
34. MMP-9 is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
35. Effects of matrix metalloproteinase 9 gene knockout on morphological and motor outcomes after traumatic brain injury
36. Fibrin deposition in tissues from endotoxin treated mice correlates with decreases in the expression of urokinase type but not tissue type plasminogen activator
37. Localization of metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
38. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
39. Neuronal matrix metalloproteinase 2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan