메뉴 건너뛰기




Volumn 110, Issue 43, 2013, Pages

Phagocytosis executes delayed neuronal death after focal brain ischemia

Author keywords

Neuroinflammation; Phagoptosis

Indexed keywords

ENDOTHELIN 1; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTADHERIN; METHANOL EXTRACTION RESIDUE; PHOSPHATIDYLSERINE; PROTEIN TYROSINE KINASE;

EID: 84886434703     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308679110     Document Type: Article
Times cited : (265)

References (57)
  • 1
    • 43249116466 scopus 로고    scopus 로고
    • A new penumbra: Transitioning from injury into repair after stroke
    • Lo EH (2008) A new penumbra: Transitioning from injury into repair after stroke. Nat Med 14(5):497-500.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 497-500
    • Lo, E.H.1
  • 2
    • 77955919765 scopus 로고    scopus 로고
    • Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis
    • Karl JM, Alaverdashvili M, Cross AR, Whishaw IQ (2010) Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis. Neuroscience 170(1):123-137.
    • (2010) Neuroscience , vol.170 , Issue.1 , pp. 123-137
    • Karl, J.M.1    Alaverdashvili, M.2    Cross, A.R.3    Whishaw, I.Q.4
  • 3
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola C, Anrather J (2011) The immunology of stroke: From mechanisms to translation. Nat Med 17(7):796-808.
    • (2011) Nat Med , vol.17 , Issue.7 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 4
    • 84859717206 scopus 로고    scopus 로고
    • Innate immunity in the central nervous system
    • Ransohoff RM, Brown MA (2012) Innate immunity in the central nervous system. J Clin Invest 122(4):1164-1171.
    • (2012) J Clin Invest , vol.122 , Issue.4 , pp. 1164-1171
    • Ransohoff, R.M.1    Brown, M.A.2
  • 5
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: An essential link between degeneration and regeneration. Brain 132(Pt 2):288-295.
    • (2009) Brain , vol.132 , Issue.PART 2 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 6
    • 0038723231 scopus 로고    scopus 로고
    • "Recruitment signals" from apoptotic cells: Invitation to a quiet meal
    • Ravichandran KS (2003) "Recruitment signals" from apoptotic cells: Invitation to a quiet meal. Cell 113(7):817-820.
    • (2003) Cell , vol.113 , Issue.7 , pp. 817-820
    • Ravichandran, K.S.1
  • 7
    • 61449208877 scopus 로고    scopus 로고
    • Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: Role in macrophage recognition and engulfment
    • JitkaewS, Witasp E, Zhang S, Kagan VE, Fadeel B (2009) Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: Role in macrophage recognition and engulfment. J Leukoc Biol 85(3):427-437.
    • (2009) J Leukoc Biol , vol.85 , Issue.3 , pp. 427-437
    • Jitkaew, S.1    Witasp, E.2    Zhang, S.3    Kagan, V.E.4    Fadeel, B.5
  • 8
    • 34247235049 scopus 로고    scopus 로고
    • Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation
    • Tyurina YY, et al. (2007) Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: Implications for the resolution of inflammation. J Biol Chem 282(11):8498-8509.
    • (2007) J Biol Chem , vol.282 , Issue.11 , pp. 8498-8509
    • Tyurina, Y.Y.1
  • 9
    • 84863141913 scopus 로고    scopus 로고
    • MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation
    • Fricker M, et al. (2012) MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. J Neurosci 32(8):2657-2666.
    • (2012) J Neurosci , vol.32 , Issue.8 , pp. 2657-2666
    • Fricker, M.1
  • 10
    • 79955008182 scopus 로고    scopus 로고
    • Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    • Neher JJ, et al. (2011) Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol 186(8):4973-4983.
    • (2011) J Immunol , vol.186 , Issue.8 , pp. 4973-4983
    • Neher, J.J.1
  • 11
    • 81155154302 scopus 로고    scopus 로고
    • Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia
    • Neniskyte U, Neher JJ, Brown GC (2011) Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia. J Biol Chem 286(46):39904-39913.
    • (2011) J Biol Chem , vol.286 , Issue.46 , pp. 39904-39913
    • Neniskyte, U.1    Neher, J.J.2    Brown, G.C.3
  • 12
    • 84862334971 scopus 로고    scopus 로고
    • Primary phagocytosis of neurons by inflamed microglia: Potential roles in neurodegeneration
    • Neher JJ, Neniskyte U, Brown GC (2012) Primary phagocytosis of neurons by inflamed microglia: Potential roles in neurodegeneration. Front Pharmacol 3:27.
    • (2012) Front Pharmacol , vol.3 , pp. 27
    • Neher, J.J.1    Neniskyte, U.2    Brown, G.C.3
  • 13
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama R, et al. (2002) Identification of a factor that links apoptotic cells to phagocytes. Nature 417(6885):182-187.
    • (2002) Nature , vol.417 , Issue.6885 , pp. 182-187
    • Hanayama, R.1
  • 14
    • 0035837323 scopus 로고    scopus 로고
    • Phagocytosis and clearance of apoptotic cells is mediated by MER
    • Scott RS, et al. (2001) Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411(6834):207-211.
    • (2001) Nature , vol.411 , Issue.6834 , pp. 207-211
    • Scott, R.S.1
  • 15
    • 43449096015 scopus 로고    scopus 로고
    • Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases
    • Grommes C, et al. (2008) Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases. J Neuroimmune Pharmacol 3(2):130-140.
    • (2008) J Neuroimmune Pharmacol , vol.3 , Issue.2 , pp. 130-140
    • Grommes, C.1
  • 16
    • 14644411712 scopus 로고    scopus 로고
    • A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells
    • Wu Y, Singh S, Georgescu MM, Birge RB (2005) A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci 118(Pt 3):539-553.
    • (2005) J Cell Sci , vol.118 , Issue.PART 3 , pp. 539-553
    • Wu, Y.1    Singh, S.2    Georgescu, M.M.3    Birge, R.B.4
  • 17
    • 2442623202 scopus 로고    scopus 로고
    • Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin v
    • Mari C, et al. (2004) Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V. Eur J Nucl Med Mol Imaging 31(5):733-739.
    • (2004) Eur J Nucl Med Mol Imaging , vol.31 , Issue.5 , pp. 733-739
    • Mari, C.1
  • 18
    • 69949158152 scopus 로고    scopus 로고
    • The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells
    • Shao WH, Zhen Y, Eisenberg RA, Cohen PL (2009) The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clin Immunol 133(1):138-144.
    • (2009) Clin Immunol , vol.133 , Issue.1 , pp. 138-144
    • Shao, W.H.1    Zhen, Y.2    Eisenberg, R.A.3    Cohen, P.L.4
  • 19
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • Hanayama R, et al. (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304(5674):1147-1150.
    • (2004) Science , vol.304 , Issue.5674 , pp. 1147-1150
    • Hanayama, R.1
  • 20
    • 55849085357 scopus 로고    scopus 로고
    • MFG-E8 regulates microglial phagocytosis of apoptotic neurons
    • Fuller AD, Van Eldik LJ (2008) MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol 3(4):246-256.
    • (2008) J Neuroimmune Pharmacol , vol.3 , Issue.4 , pp. 246-256
    • Fuller, A.D.1    Van Eldik, L.J.2
  • 21
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Immunological Genome Consortium
    • Gautier EL, et al.; Immunological Genome Consortium (2012) Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol 13(11):1118-1128.
    • (2012) Nat Immunol , vol.13 , Issue.11 , pp. 1118-1128
    • Gautier, E.L.1
  • 22
    • 45549108475 scopus 로고    scopus 로고
    • Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    • Binder MD, et al. (2008) Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. J Neurosci 28(20):5195-5206.
    • (2008) J Neurosci , vol.28 , Issue.20 , pp. 5195-5206
    • Binder, M.D.1
  • 23
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • Ransohoff RM, Perry VH (2009) Microglial physiology: Unique stimuli, specialized responses. Annu Rev Immunol 27:119-145.
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 24
    • 0344305375 scopus 로고    scopus 로고
    • Focal lesions in the rat central nervous system induced by endothelin-1
    • Hughes PM, et al. (2003) Focal lesions in the rat central nervous system induced by endothelin-1. J Neuropathol Exp Neurol 62(12):1276-1286.
    • (2003) J Neuropathol Exp Neurol , vol.62 , Issue.12 , pp. 1276-1286
    • Hughes, P.M.1
  • 25
    • 0026571078 scopus 로고
    • Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat
    • Fuxe K, et al. (1992) Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat. Exp Brain Res 88(1):131-139.
    • (1992) Exp Brain Res , vol.88 , Issue.1 , pp. 131-139
    • Fuxe, K.1
  • 26
    • 34548127060 scopus 로고    scopus 로고
    • Neurogenesis associated with endothelininduced cortical infarction in the mouse
    • Wang Y, Jin K, Greenberg DA (2007) Neurogenesis associated with endothelininduced cortical infarction in the mouse. Brain Res 1167:118-122.
    • (2007) Brain Res , vol.1167 , pp. 118-122
    • Wang, Y.1    Jin, K.2    Greenberg, D.A.3
  • 27
    • 34249852075 scopus 로고    scopus 로고
    • Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
    • Durukan A, Tatlisumak T (2007) Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav 87(1):179-197.
    • (2007) Pharmacol Biochem Behav , vol.87 , Issue.1 , pp. 179-197
    • Durukan, A.1    Tatlisumak, T.2
  • 28
    • 1842553440 scopus 로고
    • Stimulated macrophages express a new glycoprotein receptor reactive with Griffonia simplicifolia I-B4 isolectin
    • Maddox DE, Shibata S, Goldstein IJ (1982) Stimulated macrophages express a new glycoprotein receptor reactive with Griffonia simplicifolia I-B4 isolectin. Proc Natl Acad Sci USA 79(1):166-170.
    • (1982) Proc Natl Acad Sci USA , vol.79 , Issue.1 , pp. 166-170
    • Maddox, D.E.1    Shibata, S.2    Goldstein, I.J.3
  • 29
    • 0031025503 scopus 로고    scopus 로고
    • Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion
    • Zhang Z, Chopp M, Powers C (1997) Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion. Brain Res 744(2):189-198.
    • (1997) Brain Res , vol.744 , Issue.2 , pp. 189-198
    • Zhang, Z.1    Chopp, M.2    Powers, C.3
  • 30
    • 21044455286 scopus 로고    scopus 로고
    • Lactadherin promotes VEGF-dependent neovascularization
    • Silvestre JS, et al. (2005) Lactadherin promotes VEGF-dependent neovascularization. Nat Med 11(5):499-506.
    • (2005) Nat Med , vol.11 , Issue.5 , pp. 499-506
    • Silvestre, J.S.1
  • 31
    • 34247894107 scopus 로고    scopus 로고
    • Evidence of a role for lactadherin in Alzheimer's disease
    • Boddaert J, et al. (2007) Evidence of a role for lactadherin in Alzheimer's disease. Am J Pathol 170(3):921-929.
    • (2007) Am J Pathol , vol.170 , Issue.3 , pp. 921-929
    • Boddaert, J.1
  • 32
    • 0034163837 scopus 로고    scopus 로고
    • Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
    • D'Cruz PM, et al. (2000) Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9(4):645-651.
    • (2000) Hum Mol Genet , vol.9 , Issue.4 , pp. 645-651
    • D'Cruz, P.M.1
  • 33
    • 77955487488 scopus 로고    scopus 로고
    • The science of stroke: Mechanisms in search of treatments
    • Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: Mechanisms in search of treatments. Neuron 67(2):181-198.
    • (2010) Neuron , vol.67 , Issue.2 , pp. 181-198
    • Moskowitz, M.A.1    Lo, E.H.2    Iadecola, C.3
  • 34
    • 0026522027 scopus 로고
    • The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke
    • Buchan AM, Slivka A, Xue D (1992) The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke. Brain Res 574(1-2):171-177.
    • (1992) Brain Res , vol.574 , Issue.1-2 , pp. 171-177
    • Buchan, A.M.1    Slivka, A.2    Xue, D.3
  • 35
    • 0035371472 scopus 로고    scopus 로고
    • In vitro model of microglial deramification: Ramified microglia transform into amoeboid phagocytes following addition of brain cell membranes to microglia-astrocyte cocultures
    • Bohatschek M, Kloss CU, Kalla R, Raivich G (2001) In vitro model of microglial deramification: Ramified microglia transform into amoeboid phagocytes following addition of brain cell membranes to microglia-astrocyte cocultures. J Neurosci Res 64(5):508-522.
    • (2001) J Neurosci Res , vol.64 , Issue.5 , pp. 508-522
    • Bohatschek, M.1    Kloss, C.U.2    Kalla, R.3    Raivich, G.4
  • 36
    • 77649184973 scopus 로고    scopus 로고
    • Microglia: Biology and pathology
    • Graeber MB, Streit WJ (2010) Microglia: Biology and pathology. Acta Neuropathol 119(1):89-105.
    • (2010) Acta Neuropathol , vol.119 , Issue.1 , pp. 89-105
    • Graeber, M.B.1    Streit, W.J.2
  • 37
    • 76749086068 scopus 로고    scopus 로고
    • Molecular mechanisms of late apoptotic/necrotic cell clearance
    • Poon IK, Hulett MD, Parish CR (2010) Molecular mechanisms of late apoptotic/necrotic cell clearance. Cell Death Differ 17(3):381-397.
    • (2010) Cell Death Differ , vol.17 , Issue.3 , pp. 381-397
    • Poon, I.K.1    Hulett, M.D.2    Parish, C.R.3
  • 38
    • 84864322419 scopus 로고    scopus 로고
    • Eaten alive! Cell death by primary phagocytosis: 'Phagoptosis'
    • Brown GC, Neher JJ (2012) Eaten alive! Cell death by primary phagocytosis: 'Phagoptosis'. Trends Biochem Sci 37(8):325-332.
    • (2012) Trends Biochem Sci , vol.37 , Issue.8 , pp. 325-332
    • Brown, G.C.1    Neher, J.J.2
  • 39
    • 79955953536 scopus 로고    scopus 로고
    • Mechanism for phosphatidylserinedependent erythrophagocytosis in mouse liver
    • Lee SJ, Park SY, Jung MY, Bae SM, Kim IS (2011) Mechanism for phosphatidylserinedependent erythrophagocytosis in mouse liver. Blood 117(19):5215-5223.
    • (2011) Blood , vol.117 , Issue.19 , pp. 5215-5223
    • Lee, S.J.1    Park, S.Y.2    Jung, M.Y.3    Bae, S.M.4    Kim, I.S.5
  • 40
    • 0027958313 scopus 로고
    • Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages
    • Lagasse E, Weissman IL (1994) bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 179(3):1047-1052.
    • (1994) J Exp Med , vol.179 , Issue.3 , pp. 1047-1052
    • Lagasse, E.1    Weissman, I.L.2
  • 41
    • 0035849886 scopus 로고    scopus 로고
    • Phagocytosis promotes programmed cell death in C. Elegans
    • Reddien PW, Cameron S, Horvitz HR (2001) Phagocytosis promotes programmed cell death in C. elegans. Nature 412(6843):198-202.
    • (2001) Nature , vol.412 , Issue.6843 , pp. 198-202
    • Reddien, P.W.1    Cameron, S.2    Horvitz, H.R.3
  • 42
    • 0035849895 scopus 로고    scopus 로고
    • Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
    • Hoeppner DJ, Hengartner MO, Schnabel R (2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 412(6843):202-206.
    • (2001) Nature , vol.412 , Issue.6843 , pp. 202-206
    • Hoeppner, D.J.1    Hengartner, M.O.2    Schnabel, R.3
  • 43
    • 78650512821 scopus 로고    scopus 로고
    • Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans
    • Neukomm LJ, et al. (2011) Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nat Cell Biol 13(1):79-86.
    • (2011) Nat Cell Biol , vol.13 , Issue.1 , pp. 79-86
    • Neukomm, L.J.1
  • 44
    • 42549152012 scopus 로고    scopus 로고
    • Role of C. Elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry
    • Darland-Ransom M, et al. (2008) Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science 320(5875):528-531.
    • (2008) Science , vol.320 , Issue.5875 , pp. 528-531
    • Darland-Ransom, M.1
  • 45
    • 37049037061 scopus 로고    scopus 로고
    • Apoptotic PS to phagocyte TIM-4: Eat me
    • Savill J, Gregory C (2007) Apoptotic PS to phagocyte TIM-4: Eat me. Immunity 27(6): 830-832.
    • (2007) Immunity , vol.27 , Issue.6 , pp. 830-832
    • Savill, J.1    Gregory, C.2
  • 46
    • 2942650183 scopus 로고    scopus 로고
    • Delayed shrinkage of the brain after ischemic stroke: Preliminary observations with voxel-guided morphometry
    • KraemerM, et al. (2004) Delayed shrinkage of the brain after ischemic stroke: Preliminary observations with voxel-guided morphometry. J Neuroimaging 14(3):265-272.
    • (2004) J Neuroimaging , vol.14 , Issue.3 , pp. 265-272
    • Kraemer, M.1
  • 47
    • 84856509033 scopus 로고    scopus 로고
    • Atrophy of spared gray matter tissue predicts poorer motor recovery and rehabilitation response in chronic stroke
    • Gauthier LV, Taub E, Mark VW, Barghi A, Uswatte G (2012) Atrophy of spared gray matter tissue predicts poorer motor recovery and rehabilitation response in chronic stroke. Stroke 43(2):453-457.
    • (2012) Stroke , vol.43 , Issue.2 , pp. 453-457
    • Gauthier, L.V.1    Taub, E.2    Mark, V.W.3    Barghi, A.4    Uswatte, G.5
  • 48
    • 33645845142 scopus 로고    scopus 로고
    • Phosphatidylserine recognition by phagocytes: A view to a kill
    • Wu Y, Tibrewal N, Birge RB (2006) Phosphatidylserine recognition by phagocytes: A view to a kill. Trends Cell Biol 16(4):189-197.
    • (2006) Trends Cell Biol , vol.16 , Issue.4 , pp. 189-197
    • Wu, Y.1    Tibrewal, N.2    Birge, R.B.3
  • 49
    • 78650059543 scopus 로고    scopus 로고
    • Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages
    • Eken C, et al. (2010) Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages. J Biol Chem 285(51): 39914-39921.
    • (2010) J Biol Chem , vol.285 , Issue.51 , pp. 39914-39921
    • Eken, C.1
  • 50
    • 84874604501 scopus 로고    scopus 로고
    • MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury
    • Deroide N, et al. (2013) MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury. J Clin Invest 123(3):1176-1181.
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 1176-1181
    • Deroide, N.1
  • 51
    • 84855939217 scopus 로고    scopus 로고
    • Recombinant human MFG-E8 attenuates cerebral ischemic injury: Its role in anti-inflammation and anti-apoptosis
    • Cheyuo C, et al. (2012) Recombinant human MFG-E8 attenuates cerebral ischemic injury: Its role in anti-inflammation and anti-apoptosis. Neuropharmacology 62(2):890-900.
    • (2012) Neuropharmacology , vol.62 , Issue.2 , pp. 890-900
    • Cheyuo, C.1
  • 52
    • 79954579638 scopus 로고    scopus 로고
    • Stroke and the immune system: From pathophysiology to new therapeutic strategies
    • Macrez R, et al. (2011) Stroke and the immune system: From pathophysiology to new therapeutic strategies. Lancet Neurol 10(5):471-480.
    • (2011) Lancet Neurol , vol.10 , Issue.5 , pp. 471-480
    • Macrez, R.1
  • 53
    • 79952586998 scopus 로고    scopus 로고
    • Inflammation and reactive oxygen/nitrogen species in glial/neuronal cultures
    • Neher JJ, Brown GC, Kinsner-Ovaskainen A, Bal-Price A (2010) Inflammation and reactive oxygen/nitrogen species in glial/neuronal cultures. Neuromethods 56:331-347.
    • (2010) Neuromethods , vol.56 , pp. 331-347
    • Neher, J.J.1    Brown, G.C.2    Kinsner-Ovaskainen, A.3    Bal-Price, A.4
  • 54
    • 0038205804 scopus 로고    scopus 로고
    • Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury
    • Gupta R, Singh M, Sharma A (2003) Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. Pharmacol Res 48(2):209-215.
    • (2003) Pharmacol Res , vol.48 , Issue.2 , pp. 209-215
    • Gupta, R.1    Singh, M.2    Sharma, A.3
  • 55
    • 0036093430 scopus 로고    scopus 로고
    • MRI evaluation and functional assessment of brain injury after hypoxic ischemia in neonatal mice
    • Adén U, et al. (2002) MRI evaluation and functional assessment of brain injury after hypoxic ischemia in neonatal mice. Stroke 33(5):1405-1410.
    • (2002) Stroke , vol.33 , Issue.5 , pp. 1405-1410
    • Adén, U.1
  • 56
    • 33749472615 scopus 로고    scopus 로고
    • The stairway: A novel behavioral test detecting sensomotoric stroke deficits in rats
    • Boltze J, et al. (2006) The stairway: A novel behavioral test detecting sensomotoric stroke deficits in rats. Artif Organs 30(10):756-763.
    • (2006) Artif Organs , vol.30 , Issue.10 , pp. 756-763
    • Boltze, J.1
  • 57
    • 0026101797 scopus 로고
    • The "staircase test": A measure of independent forelimb reaching and grasping abilities in rats
    • Montoya CP, Campbell-Hope LJ, Pemberton KD, Dunnett SB (1991) The "staircase test": A measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods 36(2-3):219-228.
    • (1991) J Neurosci Methods , vol.36 , Issue.2-3 , pp. 219-228
    • Montoya, C.P.1    Campbell-Hope, L.J.2    Pemberton, K.D.3    Dunnett, S.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.