High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

Experimental Neurology

Volumn 254, Issue , 2014, Pages 109-120

  Evans, Teresa A ^a   Barkauskas, Deborah S ^a   Myers, Jay T ^a   Hare, Elisabeth G ^a   You, Jing Qiang ^a   Ransohoff, Richard M ^b   Huang, Alex Y ^a   Silver, Jerry ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c 2109 Adelbert Road ^*  (United States)

Author keywords

Axonal dieback; Bone marrow chimera mice; CCR2; CX3CR1; Macrophages; Microglia; Monocytes; Retraction bulb; Spinal cord injury; Two photon microscopy

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CX3CR1; GREEN FLUORESCENT PROTEIN; THY 1 ANTIGEN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXONAL INJURY; CELL INTERACTION; CELL MOTILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; IN VIVO STUDY; MACROPHAGE MIGRATION; MALE; MICROGLIA; MOLECULAR MECHANICS; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RADIATION CHIMERA; REGULATORY MECHANISM; SPINAL CORD INJURY;

AXONAL DIEBACK; BONE MARROW CHIMERA MICE; CCR2; CX3CR1; MACROPHAGES; MICROGLIA; MONOCYTES; RETRACTION BULB; SPINAL CORD INJURY; TWO-PHOTON MICROSCOPY;

ANIMALS; AXONS; BONE MARROW TRANSPLANTATION; CELL COMMUNICATION; FEMALE; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MICROSCOPY; MONOCYTES; NERVE CRUSH; PHAGOCYTOSIS; RECEPTORS, CCR2; RECEPTORS, CHEMOKINE; SCIATIC NERVE; SPINAL CORD INJURIES; TRANSPLANTATION CHIMERA;

EID: 84896689625     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.01.013     Document Type: Article

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