Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 2 58-2, 2005, Pages

  Gidday, Jeffrey M ^a,b   Gasche, Yvan G ^c,e   Copin, Jean C ^c,e   Shah, Aarti R ^a   Perez, Ronald S ^a   Shapiro, Steven D ^d   Chan, Pak H ^e   Park, T S ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial cells; Inflammation; Mice; Stroke; Vascular permeability

Indexed keywords

GELATINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL ADHESION; CHIMERA; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME RELEASE; GENE DELETION; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE; MOUSE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPERFUSION; STROKE;

ANIMALS; BLOOD CELL COUNT; BLOOD VESSELS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CELL ADHESION; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; COLLAGEN TYPE IV; ENDOTHELIUM, VASCULAR; HEMODYNAMIC PROCESSES; INFLAMMATION MEDIATORS; ISCHEMIC ATTACK, TRANSIENT; LEUKOCYTES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; NERVOUS SYSTEM DISEASES; NEUTROPHIL INFILTRATION;

EID: 23744437416     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01275.2004     Document Type: Article

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