Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury

Molecular Brain Research

Volumn 85, Issue 1-2, 2000, Pages 114-122

  Satake, Kotaro ^a   Matsuyama, Yukihiro ^a   Kamiya, Mitsuhiro ^a   Kawakami, Hiroshi ^a   Iwata, Hisashi ^a   Adachi, Kayo ^b   Kiuchi, Kazutoshi ^b,c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RIKEN   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

Apoptosis; iNOS; Macrophage; Spinal cord

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL POPULATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; NICK END LABELING; NONHUMAN; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY;

ANIMALS; APOPTOSIS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IN SITU NICK-END LABELING; MACROPHAGES; MALE; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD INJURIES;

EID: 0034727873     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00253-9     Document Type: Article

References (53)

1. Regulation of nitric oxide synthase activity in cortical slices by excitatory amino acids and calcium
2. Surgery of experimental lesions of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report
3. Remarks on the histopathological changes in the spinal cord due to impact. An experimental study
4. The cerebral perivascular cells. Advances in Anatomy
5. In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: Involvement of other cytokines
6. HIV-1 gp120 produces DNA fragmentation in the cerebral cortex of rat
7. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
8. NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: A chemist's perspective
9. Inducible nitric oxide synthase activity of cloned murine microglial cells
10. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
11. The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3
12. The microvasculature in transitory traumatic paraplegia. An electron microscopic study in the monkey
13. Experimental neurobiology of central nervous system trauma
14. Enhancement of nitric oxide production from activated macrophages by a purified form of ginsenoside (Rg1)
15. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
16. Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma
17. Transitory expression of NADPH diaphorase (NOS) in axonal swellings after spinal cord injury
18. Roles of nitric oxide in compression injury or rat spinal cord
19. Induction and its spread of apoptosis in rat spinal cord after mechanical trauma
20. Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells
21. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases
22. The pathophysiology of spinal cord injury and its clinical implications
23. Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord, apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord
24. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
25. Neuronal and glial apoptosis after yraumatic spinal cord injury
26. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
27. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
28. Nitric oxide: A possible etiologic factor in spinal cord cavitation
29. Expression of inducible nitric oxide synthase by neurons following exposure to endotoxin and cytokine
30. The discovery of nitric oxide as the endogenous nitrovasodilator
31. Identification of microglia in light and electron microscopy
32. Morphological studies on neuroglia. I. Electron microscopic identification of silver-impregnated glial cells
33. Synthesis of nitric oxide in CNS glial cells
34. Microglial conditioned medium promotes survival and development of cultured mesencephalic neurons from embryonic rat brain
35. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats
36. Differential expression of MHC class II antigen in the contused rat spinal cord
37. Activated macropharge/microglial cells can promote the regeneration of sensory axons into the injured spinal cord
38. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth
39. MRC OX-43: A monoclonal antibody which reacts with all vascular endothelium in the rat except that of brain capillaries
40. A requirement for the intercellular messenger nitric oxide in long-term potentiation
41. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum
42. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats
43. A comparison of the regeneration potential of dorsal root fibers into gray or white matter of the adult rat spinal cord
44. Microglial NO induces delayed neuronal death following acute injury in the striatum
45. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
46. Update on the pathophysiology and pathology of acute spinal cord injury
47. NADPH-diaphorase activity in activated astrocytes represents inducible nitric oxide synthase
48. Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation
49. Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes
50. Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry
51. Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury
52. Time course of NOS expression and neuronal death in Clarke's nucleus following traumatic injury in adult rat spinal cord
53. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury