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Volumn 13, Issue 4, 2012, Pages 267-278

Neuroprotective mechanisms of hypothermia in brain ischaemia

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; APOPTOSIS INDUCING FACTOR; AQUAPORIN 4; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; DEATH RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FREE RADICAL; GLUTAMATE RECEPTOR 2; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 84858706456     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3174     Document Type: Review
Times cited : (467)

References (126)
  • 1
    • 0023554153 scopus 로고
    • Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury
    • This study was the first to show that relatively small decreases in temperature resulted in remarkable neuroprotection and led to a resurgence of interest in the field of therapeutic hypothermia
    • Busto, R. et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J. Cereb. Blood Flow Metab. 7, 729-738 (1987). This study was the first to show that relatively small decreases in temperature resulted in remarkable neuroprotection and led to a resurgence of interest in the field of therapeutic hypothermia.
    • (1987) J. Cereb. Blood Flow Metab. , vol.7 , pp. 729-738
    • Busto, R.1
  • 2
    • 0037148929 scopus 로고    scopus 로고
    • Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    • Bernard, S. A. et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N. Engl. J. Med. 346, 557-563 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 557-563
    • Bernard, S.A.1
  • 3
    • 0037148926 scopus 로고    scopus 로고
    • Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
    • The Hypothermia after Cardiac Arrest Study Group References 2 and 3 are prospective clinical studies that showed that mild hypothermia improved neurological outcomes in victims of cardiac arrest
    • The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346, 549-556 (2002). References 2 and 3 are prospective clinical studies that showed that mild hypothermia improved neurological outcomes in victims of cardiac arrest.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 549-556
  • 4
    • 13844321255 scopus 로고    scopus 로고
    • Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial
    • A clinical trial of selective head cooling that showed improvement in neurological outcomes in some neonates with hypoxic ischaemic encephalopathy
    • Gluckman, P. D. et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365, 663-670 (2005). A clinical trial of selective head cooling that showed improvement in neurological outcomes in some neonates with hypoxic ischaemic encephalopathy.
    • (2005) Lancet , vol.365 , pp. 663-670
    • Gluckman, P.D.1
  • 5
    • 26444452073 scopus 로고    scopus 로고
    • Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    • A clinical trial of whole body cooling that showed improvement in neurological outcomes in some neonates with hypoxic ischaemic encephalopathy
    • Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med. 353, 1574-1584 (2005). A clinical trial of whole body cooling that showed improvement in neurological outcomes in some neonates with hypoxic ischaemic encephalopathy.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1574-1584
    • Shankaran, S.1
  • 6
    • 11144235526 scopus 로고    scopus 로고
    • Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs
    • Nozari, A. et al. Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs. J. Trauma 57, 1266-1275 (2004).
    • (2004) J. Trauma , vol.57 , pp. 1266-1275
    • Nozari, A.1
  • 7
    • 72949098569 scopus 로고    scopus 로고
    • The evidence for hypothermia as a neuroprotectant in traumatic brain injury
    • Dietrich, W. D. & Bramlett, H. M. The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics 7, 43-50 (2010).
    • (2010) Neurotherapeutics , vol.7 , pp. 43-50
    • Dietrich, W.D.1    Bramlett, H.M.2
  • 8
    • 62649129002 scopus 로고    scopus 로고
    • Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia
    • Dietrich, W. D., Atkins, C. M. & Bramlett, H. M. Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia. J. Neurotrauma 26, 301-312 (2009).
    • (2009) J. Neurotrauma , vol.26 , pp. 301-312
    • Dietrich, W.D.1    Atkins, C.M.2    Bramlett, H.M.3
  • 9
    • 0030220884 scopus 로고    scopus 로고
    • An automated system for regulating brain temperature in awake and freely moving rodents
    • Colbourne, F., Sutherland, G. R. & Auer, R. N. An automated system for regulating brain temperature in awake and freely moving rodents. J. Neurosci. Methods 67, 185-190 (1996).
    • (1996) J. Neurosci. Methods , vol.67 , pp. 185-190
    • Colbourne, F.1    Sutherland, G.R.2    Auer, R.N.3
  • 10
    • 34548491610 scopus 로고    scopus 로고
    • Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis
    • This paper provided a systematic review and meta-analysis of the evidence for efficacy of hypothermia in animal models of ischaemic stroke based on more than 100 publications
    • van der Worp, H. B., Sena, E. S., Donnan, G. A., Howells, D. W. & Macleod, M. R. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain 130, 3063-3074 (2007). This paper provided a systematic review and meta-analysis of the evidence for efficacy of hypothermia in animal models of ischaemic stroke based on more than 100 publications.
    • (2007) Brain , vol.130 , pp. 3063-3074
    • Van Der Worp, H.B.1    Sena, E.S.2    Donnan, G.A.3    Howells, D.W.4    Macleod, M.R.5
  • 11
    • 2542566701 scopus 로고    scopus 로고
    • Therapeutic hypothermia for acute ischemic stroke: What do laboratory studies teach us?
    • Krieger, D. W. & Yenari, M. A. Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us? Stroke 35, 1482-1489 (2004).
    • (2004) Stroke , vol.35 , pp. 1482-1489
    • Krieger, D.W.1    Yenari, M.A.2
  • 12
    • 54049103618 scopus 로고    scopus 로고
    • Metabolic downregulation: A key to successful neuroprotection?
    • This paper reviews how therapeutic hypothermia and ischaemic preconditioning, which are both widely studied models of neuroprotection in the laboratory, have moved from basic science studies to clinical studies
    • Yenari, M., Kitagawa, K., Lyden, P. & Perez-Pinzon, M. Metabolic downregulation: a key to successful neuroprotection? Stroke 39, 2910-2917 (2008). This paper reviews how therapeutic hypothermia and ischaemic preconditioning, which are both widely studied models of neuroprotection in the laboratory, have moved from basic science studies to clinical studies.
    • (2008) Stroke , vol.39 , pp. 2910-2917
    • Yenari, M.1    Kitagawa, K.2    Lyden, P.3    Perez-Pinzon, M.4
  • 13
    • 0033508013 scopus 로고    scopus 로고
    • Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats
    • This study demonstrated remarkable and durable neuroprotection by therapeutic cooling in a global cerebral ischaemia model, even when cooling was started as late as 6 h from ischaemia onset
    • Colbourne, F., Li, H. & Buchan, A. M. Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 19, 742-749 (1999). This study demonstrated remarkable and durable neuroprotection by therapeutic cooling in a global cerebral ischaemia model, even when cooling was started as late as 6 h from ischaemia onset.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 742-749
    • Colbourne, F.1    Li, H.2    Buchan, A.M.3
  • 14
    • 0034859356 scopus 로고    scopus 로고
    • Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: Neurological outcome and infarct size
    • Maier, C. M., Sun, G. H., Kunis, D., Yenari, M. A. &Steinberg, G. K. Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size. J. Neurosurg. 94, 90-96 (2001).
    • (2001) J. Neurosurg. , vol.94 , pp. 90-96
    • Maier, C.M.1    Sun, G.H.2    Kunis, D.3    Yenari, M.A.4    Steinberg, G.K.5
  • 16
    • 0038029401 scopus 로고    scopus 로고
    • Effects of hypothermia on energy metabolism in mammalian central nervous system
    • Erecinska, M., Thoresen, M. & Silver, I. A. Effects of hypothermia on energy metabolism in mammalian central nervous system. J. Cereb. Blood Flow Metab. 23, 513-530 (2003).
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 513-530
    • Erecinska, M.1    Thoresen, M.2    Silver, I.A.3
  • 18
    • 36249003722 scopus 로고    scopus 로고
    • General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage
    • This paper provides a comprehensive description of the protective mechanisms of hypothermia from laboratory data to facilitate clinical translation of therapeutic hypothermia
    • Zhao, H., Steinberg, G. K. & Sapolsky, R. M. General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage. J. Cereb. Blood Flow Metab. 27, 1879-1894 (2007). This paper provides a comprehensive description of the protective mechanisms of hypothermia from laboratory data to facilitate clinical translation of therapeutic hypothermia.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 1879-1894
    • Zhao, H.1    Steinberg, G.K.2    Sapolsky, R.M.3
  • 19
    • 0033600277 scopus 로고    scopus 로고
    • The changing landscape of ischaemic brain injury mechanisms
    • Lee, J. M., Zipfel, G. J. & Choi, D. W. The changing landscape of ischaemic brain injury mechanisms. Nature 399, A7-A14 (1999).
    • (1999) Nature , vol.399
    • Lee, J.M.1    Zipfel, G.J.2    Choi, D.W.3
  • 20
    • 0037418299 scopus 로고    scopus 로고
    • Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia
    • Colbourne, F., Grooms, S. Y., Zukin, R. S., Buchan, A. M. & Bennett, M. V. Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia. Proc. Natl Acad. Sci. USA 100, 2906-2910 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2906-2910
    • Colbourne, F.1    Grooms, S.Y.2    Zukin, R.S.3    Buchan, A.M.4    Bennett, M.V.5
  • 22
    • 0027231086 scopus 로고
    • Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats
    • Dietrich, W. D., Busto, R., Alonso, O., Globus, M. Y. &Ginsberg, M. D. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 13, 541-549 (1993).
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 541-549
    • Dietrich, W.D.1    Busto, R.2    Alonso, O.3    Globus, M.Y.4    Ginsberg, M.D.5
  • 23
    • 0028980652 scopus 로고
    • Biphasic expression of the fos and jun families of transcription factors following transient forebrain ischaemia in the rat. Effect of hypothermia
    • Kamme, F., Campbell, K. & Wieloch, T. Biphasic expression of the fos and jun families of transcription factors following transient forebrain ischaemia in the rat. Effect of hypothermia. Eur. J. Neurosci. 7, 2007-2016 (1995).
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 2007-2016
    • Kamme, F.1    Campbell, K.2    Wieloch, T.3
  • 24
    • 67649666795 scopus 로고    scopus 로고
    • Hypothermia enhances heat-shock protein 70 production in ischemic brains
    • Terao, Y. et al. Hypothermia enhances heat-shock protein 70 production in ischemic brains. Neuroreport 20, 745-749 (2009).
    • (2009) Neuroreport , vol.20 , pp. 745-749
    • Terao, Y.1
  • 25
    • 0031038430 scopus 로고    scopus 로고
    • Characterization of hypothermia-induced cellular stress response in mouse tissues
    • Cullen, K. E. & Sarge, K. D. Characterization of hypothermia-induced cellular stress response in mouse tissues. J. Biol. Chem. 272, 1742-1746 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 1742-1746
    • Cullen, K.E.1    Sarge, K.D.2
  • 26
    • 29744466461 scopus 로고    scopus 로고
    • Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection
    • Yenari, M. A. et al. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann. NY Acad. Sci. 1053, 74-83 (2005).
    • (2005) Ann. NY Acad. Sci. , vol.1053 , pp. 74-83
    • Yenari, M.A.1
  • 27
    • 0029622509 scopus 로고
    • The effect of hypothermia on induction of heat shock protein (HSP)-72 in ischemic brain
    • Kumar, K., Wu, X., Evans, A. T. & Marcoux, F. The effect of hypothermia on induction of heat shock protein (HSP)-72 in ischemic brain. Metab. Brain Dis. 10, 283-291 (1995).
    • (1995) Metab. Brain Dis. , vol.10 , pp. 283-291
    • Kumar, K.1    Wu, X.2    Evans, A.T.3    Marcoux, F.4
  • 28
    • 0036139651 scopus 로고    scopus 로고
    • Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade
    • Xu, L., Yenari, M. A., Steinberg, G. K. & Giffard, R. G. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J. Cereb. Blood Flow Metab. 22, 21-28 (2002).
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 21-28
    • Xu, L.1    Yenari, M.A.2    Steinberg, G.K.3    Giffard, R.G.4
  • 29
    • 77954957348 scopus 로고    scopus 로고
    • The microRNAs and stroke: No need to be coded to be counted
    • Vemuganti, R. The microRNAs and stroke: no need to be coded to be counted. Transl. Stroke Res. 1, 158-160 (2010).
    • (2010) Transl. Stroke Res. , vol.1 , pp. 158-160
    • Vemuganti, R.1
  • 30
    • 85027950214 scopus 로고    scopus 로고
    • Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats
    • This paper demonstrated that several miRNAs are also extremely temperature sensitive (in addition to many well-known temperature-sensitive mRNAs)
    • Truettner, J. S., Alonso, O. F., Bramlett, H. M. &Dietrich, W. D. Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats. J. Cereb. Blood Flow Metab. 31, 1897-1907 (2011). This paper demonstrated that several miRNAs are also extremely temperature sensitive (in addition to many well-known temperature-sensitive mRNAs).
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1897-1907
    • Truettner, J.S.1    Alonso, O.F.2    Bramlett, H.M.3    Dietrich, W.D.4
  • 31
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D. R. & Reed, J. C. Mitochondria and apoptosis. Science 281, 1309-1312 (1998).
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 32
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A. & Dixit, V. M. Death receptors: signaling and modulation. Science 281, 1305-1308 (1998).
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 33
    • 34249777567 scopus 로고    scopus 로고
    • Therapeutic hypothermia: Neuroprotective mechanisms
    • Liu, L. & Yenari, M. A. Therapeutic hypothermia: neuroprotective mechanisms. Front. Biosci. 12, 816-825 (2007).
    • (2007) Front. Biosci. , vol.12 , pp. 816-825
    • Liu, L.1    Yenari, M.A.2
  • 34
    • 3843146318 scopus 로고    scopus 로고
    • Protein kinase C δ mediates cerebral reperfusion injury in vivo
    • Bright, R. et al. Protein kinase C δ mediates cerebral reperfusion injury in vivo. J. Neurosci. 24, 6880-6888 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 6880-6888
    • Bright, R.1
  • 35
    • 18944383054 scopus 로고    scopus 로고
    • Protein kinase C δ cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation
    • Raval, A. P. et al. Protein kinase C δ cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. J. Cereb. Blood Flow Metab. 25, 730-741 (2005).
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 730-741
    • Raval, A.P.1
  • 36
    • 69549126148 scopus 로고    scopus 로고
    • The protective effect of early hypothermia on PTEN phosphorylation correlates with free radical inhibition in rat stroke
    • Lee, S. M., Zhao, H., Maier, C. M. & Steinberg, G. K. The protective effect of early hypothermia on PTEN phosphorylation correlates with free radical inhibition in rat stroke. J. Cereb. Blood Flow Metab. 29, 1589-1600 (2009).
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1589-1600
    • Lee, S.M.1    Zhao, H.2    Maier, C.M.3    Steinberg, G.K.4
  • 37
    • 33846614162 scopus 로고    scopus 로고
    • εPKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model
    • Shimohata, T., Zhao, H. & Steinberg, G. K. εPKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. Stroke 38, 375-380 (2007).
    • (2007) Stroke , vol.38 , pp. 375-380
    • Shimohata, T.1    Zhao, H.2    Steinberg, G.K.3
  • 38
    • 0033562658 scopus 로고    scopus 로고
    • CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
    • Martin-Villalba, A. et al. CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J. Neurosci. 19, 3809-3817 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 3809-3817
    • Martin-Villalba, A.1
  • 39
    • 0034666684 scopus 로고    scopus 로고
    • Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia
    • Rosenbaum, D. M. et al. Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia. J. Neurosci. Res. 61, 686-692 (2000).
    • (2000) J. Neurosci. Res. , vol.61 , pp. 686-692
    • Rosenbaum, D.M.1
  • 40
    • 51649094117 scopus 로고    scopus 로고
    • FasL shedding is reduced by hypothermia in experimental stroke
    • Liu, L. et al. FasL shedding is reduced by hypothermia in experimental stroke. J. Neurochem. 106, 541-550 (2008).
    • (2008) J. Neurochem. , vol.106 , pp. 541-550
    • Liu, L.1
  • 41
    • 20344373695 scopus 로고    scopus 로고
    • Multiple roles for MMPs and TIMPs in cerebral ischemia
    • Cunningham, L. A., Wetzel, M. & Rosenberg, G. A. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 50, 329-339 (2005).
    • (2005) Glia , vol.50 , pp. 329-339
    • Cunningham, L.A.1    Wetzel, M.2    Rosenberg, G.A.3
  • 42
    • 0033576645 scopus 로고    scopus 로고
    • The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
    • Powell, W. C., Fingleton, B., Wilson, C. L., Boothby, M. & Matrisian, L. M. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr. Biol. 9, 1441-1447 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 1441-1447
    • Powell, W.C.1    Fingleton, B.2    Wilson, C.L.3    Boothby, M.4    Matrisian, L.M.5
  • 43
    • 1442299254 scopus 로고    scopus 로고
    • Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia
    • Hamann, G. F. et al. Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia. Stroke 35, 764-769 (2004).
    • (2004) Stroke , vol.35 , pp. 764-769
    • Hamann, G.F.1
  • 44
    • 25444527207 scopus 로고    scopus 로고
    • Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke
    • Lee, J. E., Yoon, Y. J., Moseley, M. E. & Yenari, M. A. Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke. J. Neurosurg. 103, 289-297 (2005).
    • (2005) J. Neurosurg. , vol.103 , pp. 289-297
    • Lee, J.E.1    Yoon, Y.J.2    Moseley, M.E.3    Yenari, M.A.4
  • 45
    • 27544505259 scopus 로고    scopus 로고
    • Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats
    • Truettner, J. S., Alonso, O. F. & Dalton Dietrich, W. Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats. J. Cereb. Blood Flow Metab. 25, 1505-1516 (2005).
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 1505-1516
    • Truettner, J.S.1    Alonso, O.F.2    Dalton Dietrich, W.3
  • 46
    • 0043158751 scopus 로고    scopus 로고
    • Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia
    • Wagner, S. et al. Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia. Brain Res. 984, 63-75 (2003).
    • (2003) Brain Res. , vol.984 , pp. 63-75
    • Wagner, S.1
  • 47
    • 0036137197 scopus 로고    scopus 로고
    • Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke
    • Yenari, M. A. et al. Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke. J. Cereb. Blood Flow Metab. 22, 29-38 (2002).
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 29-38
    • Yenari, M.A.1
  • 48
    • 0033521741 scopus 로고    scopus 로고
    • Molecular characterization of mitochondrial apoptosis-inducing factor
    • Susin, S. A. et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446 (1999).
    • (1999) Nature , vol.397 , pp. 441-446
    • Susin, S.A.1
  • 49
    • 34548840827 scopus 로고    scopus 로고
    • Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion
    • Zhao, H. et al. Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion. J. Neurosurg. 107, 636-641 (2007).
    • (2007) J. Neurosurg. , vol.107 , pp. 636-641
    • Zhao, H.1
  • 50
    • 79151485699 scopus 로고    scopus 로고
    • PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway
    • Shi, G. D. et al. PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway. Biochem. Biophys. Res. Commun. 404, 941-945 (2011).
    • (2011) Biochem. Biophys. Res. Commun. , vol.404 , pp. 941-945
    • Shi, G.D.1
  • 51
    • 17944404963 scopus 로고    scopus 로고
    • Delayed hypothermia preferentially increases expression of brain-derived neurotrophic factor exon III in rat hippocampus after asphyxial cardiac arrest
    • Vosler, P. S., Logue, E. S., Repine, M. J. & Callaway, C. W. Delayed hypothermia preferentially increases expression of brain-derived neurotrophic factor exon III in rat hippocampus after asphyxial cardiac arrest. Brain Res. Mol. Brain Res. 135, 21-29 (2005).
    • (2005) Brain Res. Mol. Brain Res. , vol.135 , pp. 21-29
    • Vosler, P.S.1    Logue, E.S.2    Repine, M.J.3    Callaway, C.W.4
  • 52
    • 0036301345 scopus 로고    scopus 로고
    • Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation
    • D'Cruz, B. J. et al. Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. J. Cereb. Blood Flow Metab. 22, 843-851 (2002).
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 843-851
    • D'Cruz, B.J.1
  • 53
    • 4444234326 scopus 로고    scopus 로고
    • Regional changes in glial cell line-derived neurotrophic factor after cardiac arrest and hypothermia in rats
    • Schmidt, K. M., Repine, M. J., Hicks, S. D., DeFranco, D. B. & Callaway, C. W. Regional changes in glial cell line-derived neurotrophic factor after cardiac arrest and hypothermia in rats. Neurosci. Lett. 368, 135-139 (2004).
    • (2004) Neurosci. Lett. , vol.368 , pp. 135-139
    • Schmidt, K.M.1    Repine, M.J.2    Hicks, S.D.3    DeFranco, D.B.4    Callaway, C.W.5
  • 54
    • 0032506612 scopus 로고    scopus 로고
    • The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat
    • Boris-Moller, F., Kamme, F. & Wieloch, T. The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. Brain Res. Mol. Brain Res. 63, 163-173 (1998).
    • (1998) Brain Res. Mol. Brain Res. , vol.63 , pp. 163-173
    • Boris-Moller, F.1    Kamme, F.2    Wieloch, T.3
  • 55
    • 0034048006 scopus 로고    scopus 로고
    • Hypothermia differentially increases extracellular signal-regulated kinase and stress-activated protein kinase/c-Jun terminal kinase activation in the hippocampus during reperfusion after asphyxial cardiac arrest
    • Hicks, S. D., Parmele, K. T., DeFranco, D. B., Klann, E. & Callaway, C. W. Hypothermia differentially increases extracellular signal-regulated kinase and stress-activated protein kinase/c-Jun terminal kinase activation in the hippocampus during reperfusion after asphyxial cardiac arrest. Neuroscience 98, 677-685 (2000).
    • (2000) Neuroscience , vol.98 , pp. 677-685
    • Hicks, S.D.1    Parmele, K.T.2    DeFranco, D.B.3    Klann, E.4    Callaway, C.W.5
  • 57
    • 0035426040 scopus 로고    scopus 로고
    • Hypothermia enhances bcl-2 expression and protects against oxidative stress-induced cell death in Chinese hamster ovary cells
    • Slikker, W., Desai, V. G., Duhart, H., Feuers, R. &Imam, S. Z. Hypothermia enhances bcl-2 expression and protects against oxidative stress-induced cell death in Chinese hamster ovary cells. Free Radic. Biol. Med. 31, 405-411 (2001).
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 405-411
    • Slikker, W.1    Desai, V.G.2    Duhart, H.3    Feuers, R.4    Imam, S.Z.5
  • 58
    • 0035500995 scopus 로고    scopus 로고
    • Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia
    • Zhang, Z., Sobel, R. A., Cheng, D., Steinberg, G. K. &Yenari, M. A. Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia. Brain Res. Mol. Brain Res. 95, 75-85 (2001).
    • (2001) Brain Res. Mol. Brain Res. , vol.95 , pp. 75-85
    • Zhang, Z.1    Sobel, R.A.2    Cheng, D.3    Steinberg, G.K.4    Yenari, M.A.5
  • 59
    • 27144446140 scopus 로고    scopus 로고
    • Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats
    • Zhao, H. et al. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J. Neurosci. 25, 9794-9806 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 9794-9806
    • Zhao, H.1
  • 60
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • Wang, Q., Tang, X. N. & Yenari, M. A. The inflammatory response in stroke. J. Neuroimmunol. 184, 53-68 (2007).
    • (2007) J. Neuroimmunol. , vol.184 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 61
    • 78549247765 scopus 로고    scopus 로고
    • The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia
    • Ceulemans, A. G. et al. The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. J. Neuroinflammation 7, 74 (2010).
    • (2010) J. Neuroinflammation , vol.7 , pp. 74
    • Ceulemans, A.G.1
  • 62
    • 77956579125 scopus 로고    scopus 로고
    • Whole body hypothermia and oxidative stress in babies with hypoxic-ischemic brain injury
    • Perrone, S. et al. Whole body hypothermia and oxidative stress in babies with hypoxic-ischemic brain injury. Pediatr. Neurol. 43, 236-240 (2010).
    • (2010) Pediatr. Neurol. , vol.43 , pp. 236-240
    • Perrone, S.1
  • 63
    • 0037095686 scopus 로고    scopus 로고
    • Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation
    • Han, H. S., Qiao, Y., Karabiyikoglu, M., Giffard, R. G. &Yenari, M. A. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J. Neurosci. 22, 3921-3928 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 3921-3928
    • Han, H.S.1    Qiao, Y.2    Karabiyikoglu, M.3    Giffard, R.G.4    Yenari, M.A.5
  • 64
    • 0141530958 scopus 로고    scopus 로고
    • Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation
    • Deng, H., Han, H. S., Cheng, D., Sun, G. H. & Yenari, M. A. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke 34, 2495-2501 (2003).
    • (2003) Stroke , vol.34 , pp. 2495-2501
    • Deng, H.1    Han, H.S.2    Cheng, D.3    Sun, G.H.4    Yenari, M.A.5
  • 65
    • 77949445034 scopus 로고    scopus 로고
    • Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation
    • Meybohm, P. et al. Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation. Crit. Care 14, R21 (2010).
    • (2010) Crit. Care , vol.14
    • Meybohm, P.1
  • 66
    • 64249155625 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-3αplays a key role in the inflammatory cascade in rat focal cerebral ischemia
    • Terao, Y. et al. Macrophage inflammatory protein-3αplays a key role in the inflammatory cascade in rat focal cerebral ischemia. Neurosci. Res. 64, 75-82 (2009).
    • (2009) Neurosci. Res. , vol.64 , pp. 75-82
    • Terao, Y.1
  • 67
    • 46349104658 scopus 로고    scopus 로고
    • IL-10 production is reduced by hypothermia but augmented by hyperthermia in rat microglia
    • Matsui, T. & Kakeda, T. IL-10 production is reduced by hypothermia but augmented by hyperthermia in rat microglia. J. Neurotrauma 25, 709-715 (2008).
    • (2008) J. Neurotrauma , vol.25 , pp. 709-715
    • Matsui, T.1    Kakeda, T.2
  • 68
    • 23744490946 scopus 로고    scopus 로고
    • The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat
    • Truettner, J. S., Suzuki, T. & Dietrich, W. D. The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Brain Res. Mol. Brain Res. 138, 124-134 (2005).
    • (2005) Brain Res. Mol. Brain Res. , vol.138 , pp. 124-134
    • Truettner, J.S.1    Suzuki, T.2    Dietrich, W.D.3
  • 69
    • 33744984395 scopus 로고    scopus 로고
    • Influence of hypothermia on post-ischemic inflammation: Role of nuclear factor kappa B (NFκB)
    • Yenari, M. A. & Han, H. S. Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFκB). Neurochem. Int. 49, 164-169 (2006).
    • (2006) Neurochem. Int. , vol.49 , pp. 164-169
    • Yenari, M.A.1    Han, H.S.2
  • 71
    • 58149522103 scopus 로고    scopus 로고
    • Inflammation and NFκB activation is decreased by hypothermia following global cerebral ischemia
    • Webster, C. M. et al. Inflammation and NFκB activation is decreased by hypothermia following global cerebral ischemia. Neurobiol. Dis. 33, 301-312 (2009).
    • (2009) Neurobiol. Dis. , vol.33 , pp. 301-312
    • Webster, C.M.1
  • 72
    • 0033979815 scopus 로고    scopus 로고
    • Roles of nuclear factor κB in neuronal survival and plasticity
    • Mattson, M. P., Culmsee, C., Yu, Z. & Camandola, S. Roles of nuclear factor κB in neuronal survival and plasticity. J. Neurochem. 74, 443-456 (2000).
    • (2000) J. Neurochem. , vol.74 , pp. 443-456
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.3    Camandola, S.4
  • 73
    • 34548556073 scopus 로고    scopus 로고
    • Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells
    • Schmitt, K. R. et al. Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells. J. Neuroimmunol. 189, 7-16 (2007).
    • (2007) J. Neuroimmunol. , vol.189 , pp. 7-16
    • Schmitt, K.R.1
  • 74
    • 79955069098 scopus 로고    scopus 로고
    • Mild hypothermia attenuates intercellular adhesion molecule-1 induction via activation of extracellular signal-regulated kinase-1/2 in a focal cerebral ischemia model
    • Choi, J. S. et al. Mild hypothermia attenuates intercellular adhesion molecule-1 induction via activation of extracellular signal-regulated kinase-1/2 in a focal cerebral ischemia model. Stroke Res. Treat. 2011, 846716 (2011).
    • (2011) Stroke Res. Treat. , vol.2011 , pp. 846716
    • Choi, J.S.1
  • 75
    • 0024996707 scopus 로고
    • The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia
    • Dietrich, W. D., Busto, R., Halley, M. & Valdes, I. The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia. J. Neuropathol. Exp. Neurol. 49, 486-497 (1990).
    • (1990) J. Neuropathol. Exp. Neurol. , vol.49 , pp. 486-497
    • Dietrich, W.D.1    Busto, R.2    Halley, M.3    Valdes, I.4
  • 76
    • 45449105179 scopus 로고    scopus 로고
    • Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats
    • Kawanishi, M. et al. Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats. J. Stroke Cerebrovasc. Dis. 17, 187-195 (2008).
    • (2008) J. Stroke Cerebrovasc. Dis. , vol.17 , pp. 187-195
    • Kawanishi, M.1
  • 77
    • 33646699334 scopus 로고    scopus 로고
    • The influence of hypothermia on outcome after intracerebral hemorrhage in rats
    • MacLellan, C. L., Davies, L. M., Fingas, M. S. &Colbourne, F. The influence of hypothermia on outcome after intracerebral hemorrhage in rats. Stroke 37, 1266-1270 (2006).
    • (2006) Stroke , vol.37 , pp. 1266-1270
    • MacLellan, C.L.1    Davies, L.M.2    Fingas, M.S.3    Colbourne, F.4
  • 78
    • 79953286438 scopus 로고    scopus 로고
    • Combinational therapy using hypothermia and the immunophilin ligand FK506 to target altered pial arteriolar reactivity, axonal damage, and blood-brain barrier dysfunction after traumatic brain injury in rat
    • Oda, Y., Gao, G., Wei, E. P. & Povlishock, J. T. Combinational therapy using hypothermia and the immunophilin ligand FK506 to target altered pial arteriolar reactivity, axonal damage, and blood-brain barrier dysfunction after traumatic brain injury in rat. J. Cereb. Blood Flow Metab. 31, 1143-1154 (2011).
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1143-1154
    • Oda, Y.1    Gao, G.2    Wei, E.P.3    Povlishock, J.T.4
  • 79
    • 7744223842 scopus 로고    scopus 로고
    • A two-hour window for hypothermic modulation of early events that impact delayed opening of the rat blood-brain barrier after ischemia
    • Preston, E. & Webster, J. A two-hour window for hypothermic modulation of early events that impact delayed opening of the rat blood-brain barrier after ischemia. Acta Neuropathol. 108, 406-412 (2004).
    • (2004) Acta Neuropathol. , vol.108 , pp. 406-412
    • Preston, E.1    Webster, J.2
  • 80
    • 37349030729 scopus 로고    scopus 로고
    • Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: Effects on BBB breakdown and MMP expression in the acute and subacute phase
    • Nagel, S. et al. Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase. Brain Res. 1188, 198-206 (2008).
    • (2008) Brain Res. , vol.1188 , pp. 198-206
    • Nagel, S.1
  • 81
    • 63149103495 scopus 로고    scopus 로고
    • Effect of mild hypothermia on blood brain barrier disruption induced by oleic acid in rats
    • Lee, K. M., Jang, J. H., Park, J. S., Kim, D. S. & Han, H. S. Effect of mild hypothermia on blood brain barrier disruption induced by oleic acid in rats. Genes Genomics 31, 89-98 (2009).
    • (2009) Genes Genomics , vol.31 , pp. 89-98
    • Lee, K.M.1    Jang, J.H.2    Park, J.S.3    Kim, D.S.4    Han, H.S.5
  • 82
    • 67349280915 scopus 로고    scopus 로고
    • Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia
    • Baumann, E., Preston, E., Slinn, J. & Stanimirovic, D. Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia. Brain Res. 1269, 185-197 (2009).
    • (2009) Brain Res. , vol.1269 , pp. 185-197
    • Baumann, E.1    Preston, E.2    Slinn, J.3    Stanimirovic, D.4
  • 83
    • 36249003924 scopus 로고    scopus 로고
    • The effect of moderate hypothermia in acute ischemic stroke on pericyte migration: An ultrastructural study
    • Duz, B., Oztas, E., Erginay, T., Erdogan, E. & Gonul, E. The effect of moderate hypothermia in acute ischemic stroke on pericyte migration: an ultrastructural study. Cryobiology 55, 279-284 (2007).
    • (2007) Cryobiology , vol.55 , pp. 279-284
    • Duz, B.1    Oztas, E.2    Erginay, T.3    Erdogan, E.4    Gonul, E.5
  • 84
    • 0033966090 scopus 로고    scopus 로고
    • Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
    • Manley, G. T. et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Med. 6, 159-163 (2000).
    • (2000) Nature Med. , vol.6 , pp. 159-163
    • Manley, G.T.1
  • 85
    • 33646040095 scopus 로고    scopus 로고
    • Effect of local mild hypothermia on expression of aquaporin-4 following intracerebral hemorrhage in rats
    • in Chinese
    • Dai, D. W. et al. Effect of local mild hypothermia on expression of aquaporin-4 following intracerebral hemorrhage in rats. Zhonghua Yi Xue Za Zhi 86, 906-910 (2006) (in Chinese).
    • (2006) Zhonghua Yi Xue Za Zhi , vol.86 , pp. 906-910
    • Dai, D.W.1
  • 86
    • 4544228367 scopus 로고    scopus 로고
    • Cerebral cortical aquaporin-4 expression in brain edema following cardiac arrest in rats
    • Xiao, F. et al. Cerebral cortical aquaporin-4 expression in brain edema following cardiac arrest in rats. Acad. Emerg. Med. 11, 1001-1007 (2004).
    • (2004) Acad. Emerg. Med. , vol.11 , pp. 1001-1007
    • Xiao, F.1
  • 87
    • 33746458373 scopus 로고    scopus 로고
    • Effect of therapeutic moderate hypothermia on multi-drug resistance protein 1-mediated transepithelial transport of drugs
    • Jin, J. S. et al. Effect of therapeutic moderate hypothermia on multi-drug resistance protein 1-mediated transepithelial transport of drugs. Neurol. Med. Chir. 46, 321-327 (2006).
    • (2006) Neurol. Med. Chir. , vol.46 , pp. 321-327
    • Jin, J.S.1
  • 88
    • 68549099646 scopus 로고    scopus 로고
    • Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia
    • This is a comprehensive study of therapeutic hypothermia in a brain haemorrhage model
    • Fingas, M., Penner, M., Silasi, G. & Colbourne, F. Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia. Exp. Neurol. 219, 156-162 (2009). This is a comprehensive study of therapeutic hypothermia in a brain haemorrhage model.
    • (2009) Exp. Neurol. , vol.219 , pp. 156-162
    • Fingas, M.1    Penner, M.2    Silasi, G.3    Colbourne, F.4
  • 89
    • 77955174248 scopus 로고    scopus 로고
    • Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage
    • Kollmar, R. et al. Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage. Stroke 41, 1684-1689 (2010).
    • (2010) Stroke , vol.41 , pp. 1684-1689
    • Kollmar, R.1
  • 90
    • 70350447423 scopus 로고    scopus 로고
    • Coagulopathy by hypothermia and acidosis: Mechanisms of thrombin generation and fibrinogen availability
    • Martini, W. Z. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. J. Trauma 67, 202-209 (2009).
    • (2009) J. Trauma , vol.67 , pp. 202-209
    • Martini, W.Z.1
  • 91
    • 33846117829 scopus 로고    scopus 로고
    • The effects of hypothermia on fibrinogen metabolism and coagulation function in swine
    • Martini, W. Z. The effects of hypothermia on fibrinogen metabolism and coagulation function in swine. Metabolism 56, 214-221 (2007).
    • (2007) Metabolism , vol.56 , pp. 214-221
    • Martini, W.Z.1
  • 92
    • 72749107866 scopus 로고    scopus 로고
    • Forebrain neurogenesis after focal ischemic and traumatic brain injury
    • Kernie, S. G. & Parent, J. M. Forebrain neurogenesis after focal ischemic and traumatic brain injury. Neurobiol. Dis. 37, 267-274 (2010).
    • (2010) Neurobiol. Dis. , vol.37 , pp. 267-274
    • Kernie, S.G.1    Parent, J.M.2
  • 93
    • 77956521284 scopus 로고    scopus 로고
    • Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke
    • Font, M. A., Arboix, A. & Krupinski, J. Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke. Curr. Cardiol. Rev. 6, 238-244 (2010).
    • (2010) Curr. Cardiol. Rev. , vol.6 , pp. 238-244
    • Font, M.A.1    Arboix, A.2    Krupinski, J.3
  • 94
    • 78649993950 scopus 로고    scopus 로고
    • Neurogenesis in the aged and neurodegenerative brain
    • Shruster, A., Melamed, E. & Offen, D. Neurogenesis in the aged and neurodegenerative brain. Apoptosis 15, 1415-1421 (2010).
    • (2010) Apoptosis , vol.15 , pp. 1415-1421
    • Shruster, A.1    Melamed, E.2    Offen, D.3
  • 95
    • 78650665522 scopus 로고    scopus 로고
    • Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus
    • Jinno, S. Decline in adult neurogenesis during aging follows a topographic pattern in the mouse hippocampus. J. Comp. Neurol. 519, 451-466 (2011).
    • (2011) J. Comp. Neurol. , vol.519 , pp. 451-466
    • Jinno, S.1
  • 96
    • 33748313450 scopus 로고    scopus 로고
    • A decrease of cell proliferation by hypothermia in the hippocampus of the neonatal rat
    • Kanagawa, T. et al. A decrease of cell proliferation by hypothermia in the hippocampus of the neonatal rat. Brain Res. 1111, 36-40 (2006).
    • (2006) Brain Res. , vol.1111 , pp. 36-40
    • Kanagawa, T.1
  • 97
    • 79953674463 scopus 로고    scopus 로고
    • Post-ischemic hypothermia promotes generation of neural cells and reduces apoptosis by Bcl-2 in the striatum of neonatal rat brain
    • Xiong, M. et al. Post-ischemic hypothermia promotes generation of neural cells and reduces apoptosis by Bcl-2 in the striatum of neonatal rat brain. Neurochem. Int. 58, 625-633 (2011).
    • (2011) Neurochem. Int. , vol.58 , pp. 625-633
    • Xiong, M.1
  • 98
    • 77957329905 scopus 로고    scopus 로고
    • Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding protein
    • Saito, K. et al. Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding protein. Brain Res. 1358, 20-29 (2010).
    • (2010) Brain Res. , vol.1358 , pp. 20-29
    • Saito, K.1
  • 99
    • 79961011455 scopus 로고    scopus 로고
    • Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia
    • This paper showed that prolonged hypothermia positively interacts with post-ischaemic repair processes, such as neurogenesis, resulting in improved functional outcome
    • Silasi, G. & Colbourne, F. Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia. J. Cereb. Blood Flow Metab. 31, 1725-1735 (2011). This paper showed that prolonged hypothermia positively interacts with post-ischaemic repair processes, such as neurogenesis, resulting in improved functional outcome.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1725-1735
    • Silasi, G.1    Colbourne, F.2
  • 100
    • 70350707920 scopus 로고    scopus 로고
    • Mild hypothermia has no long-term impact on postischemic neurogenesis in rats
    • Lasarzik, I. et al. Mild hypothermia has no long-term impact on postischemic neurogenesis in rats. Anesth. Analg. 109, 1632-1639 (2009).
    • (2009) Anesth. Analg. , vol.109 , pp. 1632-1639
    • Lasarzik, I.1
  • 101
    • 79960083902 scopus 로고    scopus 로고
    • Oligodendrocyte vulnerability following traumatic brain injury in rats
    • Lotocki, G. et al. Oligodendrocyte vulnerability following traumatic brain injury in rats. Neurosci. Lett. 499, 143-148 (2011).
    • (2011) Neurosci. Lett. , vol.499 , pp. 143-148
    • Lotocki, G.1
  • 102
    • 84858706830 scopus 로고    scopus 로고
    • Oligodendrocyte vulnerability following traumatic brain injury in rats: Effect of moderate hypothermia
    • Lotocki, G. et al. Oligodendrocyte vulnerability following traumatic brain injury in rats: effect of moderate hypothermia. Therapeutic Hypothermia and Temperature Management 1, 43-51 (2011).
    • (2011) Therapeutic Hypothermia and Temperature Management , vol.1 , pp. 43-51
    • Lotocki, G.1
  • 103
    • 78049443518 scopus 로고    scopus 로고
    • Hypothermia-induced increase of oligodendrocyte precursor cells: Possible involvement of plasmalemmal voltage-dependent anion channel 1
    • Imada, S. et al. Hypothermia-induced increase of oligodendrocyte precursor cells: possible involvement of plasmalemmal voltage-dependent anion channel 1. J. Neurosci. Res. 88, 3457-3466 (2010).
    • (2010) J. Neurosci. Res. , vol.88 , pp. 3457-3466
    • Imada, S.1
  • 104
    • 33846211826 scopus 로고    scopus 로고
    • The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep
    • Bennet, L. et al. The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep. J. Physiol. 578, 491-506 (2007).
    • (2007) J. Physiol. , vol.578 , pp. 491-506
    • Bennet, L.1
  • 105
    • 0032250227 scopus 로고    scopus 로고
    • Hypothermia causes a reversible, p53-mediated cell cycle arrest in cultured fibroblasts
    • Matijasevic, Z., Snyder, J. E. & Ludlum, D. B. Hypothermia causes a reversible, p53-mediated cell cycle arrest in cultured fibroblasts. Oncol. Res. 10, 605-610 (1998).
    • (1998) Oncol. Res. , vol.10 , pp. 605-610
    • Matijasevic, Z.1    Snyder, J.E.2    Ludlum, D.B.3
  • 106
    • 80052858407 scopus 로고    scopus 로고
    • Stem cells in stroke repair: Current success & future prospects
    • Gopurappilly, R. et al. Stem cells in stroke repair: current success & future prospects. CNS Neurol. Disord. Drug Targets 10, 741-756 (2011).
    • (2011) CNS Neurol. Disord. Drug Targets , vol.10 , pp. 741-756
    • Gopurappilly, R.1
  • 107
    • 77957376758 scopus 로고    scopus 로고
    • Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic
    • Li, L. et al. Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic. Glia 58, 1610-1619 (2010).
    • (2010) Glia , vol.58 , pp. 1610-1619
    • Li, L.1
  • 108
    • 79955747773 scopus 로고    scopus 로고
    • The unusual response of serotonergic neurons after CNS injury: Lack of axonal dieback and enhanced sprouting within the inhibitory environment of the glial scar
    • Hawthorne, A. L. et al. The unusual response of serotonergic neurons after CNS injury: lack of axonal dieback and enhanced sprouting within the inhibitory environment of the glial scar. J. Neurosci. 31, 5605-5616 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 5605-5616
    • Hawthorne, A.L.1
  • 109
    • 20344394152 scopus 로고    scopus 로고
    • Neuroprotective role of astrocytes in cerebral ischemia: Focus on ischemic preconditioning
    • Trendelenburg, G. & Dirnagl, U. Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia 50, 307-320 (2005).
    • (2005) Glia , vol.50 , pp. 307-320
    • Trendelenburg, G.1    Dirnagl, U.2
  • 110
    • 34447528731 scopus 로고    scopus 로고
    • Effect of mild hypothermia on angiogenesis in rats with focal cerebral ischemia
    • Xie, Y. C., Li, C. Y., Li, T., Nie, D. Y. & Ye, F. Effect of mild hypothermia on angiogenesis in rats with focal cerebral ischemia. Neurosci. Lett. 422, 87-90 (2007).
    • (2007) Neurosci. Lett. , vol.422 , pp. 87-90
    • Xie, Y.C.1    Li, C.Y.2    Li, T.3    Nie, D.Y.4    Ye, F.5
  • 111
    • 79955034788 scopus 로고    scopus 로고
    • Body cooling ameliorating spinal cord injury
    • may be neurogenesis-, anti-inflammation- and angiogenesis-associated in rats.
    • Kao, C. H., Chio, C. C., Lin, M. T. & Yeh, C. H. Body cooling ameliorating spinal cord injury may be neurogenesis-, anti-inflammation- and angiogenesis-associated in rats. J. Trauma 70, 885-893 (2011).
    • (2011) J. Trauma , vol.70 , pp. 885-893
    • Kao, C.H.1    Chio, C.C.2    Lin, M.T.3    Yeh, C.H.4
  • 112
    • 78650819783 scopus 로고    scopus 로고
    • Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats
    • Kuo, J. R. et al. Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats. J. Trauma 69, 1467-1472 (2010).
    • (2010) J. Trauma , vol.69 , pp. 1467-1472
    • Kuo, J.R.1
  • 113
    • 79955531477 scopus 로고    scopus 로고
    • A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke
    • Navarro-Sobrino, M. et al. A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke. Atherosclerosis 216, 205-211 (2011).
    • (2011) Atherosclerosis , vol.216 , pp. 205-211
    • Navarro-Sobrino, M.1
  • 114
    • 2642569472 scopus 로고    scopus 로고
    • Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and
    • may be compromised by angiogenesis.
    • Manoonkitiwongsa, P. S., Schultz, R. L., McCreery, D. B., Whitter, E. F. & Lyden, P. D. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis. J. Cereb. Blood Flow Metab. 24, 693-702 (2004).
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 693-702
    • Manoonkitiwongsa, P.S.1    Schultz, R.L.2    McCreery, D.B.3    Whitter, E.F.4    Lyden, P.D.5
  • 115
    • 77953208308 scopus 로고    scopus 로고
    • Hypothermia-induced neurite outgrowth is mediated by tumor necrosis factor-α
    • Schmitt, K. R. et al. Hypothermia-induced neurite outgrowth is mediated by tumor necrosis factor-α. Brain Pathol. 20, 771-779 (2010).
    • (2010) Brain Pathol. , vol.20 , pp. 771-779
    • Schmitt, K.R.1
  • 116
    • 34548044662 scopus 로고    scopus 로고
    • S100B modulates IL-6 release and cytotoxicity from hypothermic brain cells and inhibits hypothermia-induced axonal outgrowth
    • Schmitt, K. R. et al. S100B modulates IL-6 release and cytotoxicity from hypothermic brain cells and inhibits hypothermia-induced axonal outgrowth. Neurosci. Res. 59, 168-173 (2007).
    • (2007) Neurosci. Res. , vol.59 , pp. 168-173
    • Schmitt, K.R.1
  • 117
    • 77956182588 scopus 로고    scopus 로고
    • Effect of therapeutic mild hypothermia on the genomics of the hippocampus after moderate traumatic brain injury in rats
    • Feng, J. F. et al. Effect of therapeutic mild hypothermia on the genomics of the hippocampus after moderate traumatic brain injury in rats. Neurosurgery 67, 730-742 (2010).
    • (2010) Neurosurgery , vol.67 , pp. 730-742
    • Feng, J.F.1
  • 118
    • 0034894973 scopus 로고    scopus 로고
    • Complications and treatment of mild hypothermia
    • Sessler, D. I. Complications and treatment of mild hypothermia. Anesthesiology 95, 531-543 (2001).
    • (2001) Anesthesiology , vol.95 , pp. 531-543
    • Sessler, D.I.1
  • 119
    • 0031916611 scopus 로고    scopus 로고
    • Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: An in vitro study in hippocampal slices
    • Frerichs, K. U. & Hallenbeck, J. M. Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: an in vitro study in hippocampal slices. J. Cereb. Blood Flow Metab. 18, 168-175 (1998).
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 168-175
    • Frerichs, K.U.1    Hallenbeck, J.M.2
  • 120
    • 67651184052 scopus 로고    scopus 로고
    • Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel
    • Dave, K. R. et al. Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel. J. Neurochem. 110, 1170-1179 (2009).
    • (2009) J. Neurochem. , vol.110 , pp. 1170-1179
    • Dave, K.R.1
  • 121
    • 4644308998 scopus 로고    scopus 로고
    • Hypoxia tolerance in mammalian heterotherms
    • Drew, K. L. et al. Hypoxia tolerance in mammalian heterotherms. J. Exp. Biol. 207, 3155-3162 (2004).
    • (2004) J. Exp. Biol. , vol.207 , pp. 3155-3162
    • Drew, K.L.1
  • 122
    • 79951824325 scopus 로고    scopus 로고
    • Hibernation in black bears: Independence of metabolic suppression from body temperature
    • Toien, O. et al. Hibernation in black bears: independence of metabolic suppression from body temperature. Science 331, 906-909 (2011).
    • (2011) Science , vol.331 , pp. 906-909
    • Toien, O.1
  • 123
    • 34447323567 scopus 로고    scopus 로고
    • Effect of gene expression by therapeutic hypothermia in cerebral ischemia
    • This review covers the spectrum of gene expression changes resulting from hypothermia, including temperature-sensitive RNAs
    • Han, H. S. & Yenari, M. A. Effect of gene expression by therapeutic hypothermia in cerebral ischemia. Future Neurol. 2, 435-440 (2007). This review covers the spectrum of gene expression changes resulting from hypothermia, including temperature-sensitive RNAs.
    • (2007) Future Neurol. , vol.2 , pp. 435-440
    • Han, H.S.1    Yenari, M.A.2
  • 124
    • 66449098776 scopus 로고    scopus 로고
    • Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs
    • Al-Fageeh, M. B. & Smales, C. M. Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs. RNA 15, 1164-1176 (2009).
    • (2009) RNA , vol.15 , pp. 1164-1176
    • Al-Fageeh, M.B.1    Smales, C.M.2
  • 125
    • 77955983291 scopus 로고    scopus 로고
    • Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain
    • Liu, A., Zhang, Z., Li, A. & Xue, J. Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain. Brain Res. 1347, 104-110 (2010).
    • (2010) Brain Res. , vol.1347 , pp. 104-110
    • Liu, A.1    Zhang, Z.2    Li, A.3    Xue, J.4
  • 126
    • 33646047404 scopus 로고    scopus 로고
    • Cirp protects against tumor necrosis factor-á-induced apoptosis via activation of extracellular signal-regulated kinase
    • Sakurai, T. et al. Cirp protects against tumor necrosis factor-á-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim. Biophys. Acta 1763, 290-295 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1763 , pp. 290-295
    • Sakurai, T.1


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