-
1
-
-
84894353469
-
Hippocratic writings
-
Hippocrates Chicago IL University of Chicago
-
Hippocrates. Hippocratic Writings. Encyclopedia Britannica. Chicago, IL: University of Chicago; 1955.
-
(1955)
Encyclopedia Britannica
-
-
-
2
-
-
49749212140
-
Coronary heart-disease and physical activity of work
-
contd
-
Morris JN, Heady JA, Raffle PA, Roberts CG, Parks JW. Coronary heart-disease and physical activity of work. Lancet. 1953;265:1053-1057; contd.
-
(1953)
Lancet.
, vol.265
, pp. 1053-1057
-
-
Morris, J.N.1
Heady, J.A.2
Raffle, P.A.3
Roberts, C.G.4
Parks, J.W.5
-
3
-
-
49749214729
-
Coronary heart-disease and physical activity of work
-
concl
-
Morris JN, Heady JA, Raffle PA, Roberts CG, Parks JW. Coronary heart-disease and physical activity of work. Lancet. 1953;265:1111-1120; concl.
-
(1953)
Lancet.
, vol.265
, pp. 1111-1120
-
-
Morris, J.N.1
Heady, J.A.2
Raffle, P.A.3
Roberts, C.G.4
Parks, J.W.5
-
4
-
-
9244222260
-
Endurance running and the evolution of Homo
-
Bramble DM, Lieberman DE. Endurance running and the evolution of Homo. Nature. 2004;432:345-352.
-
(2004)
Nature.
, vol.432
, pp. 345-352
-
-
Bramble, D.M.1
Lieberman, D.E.2
-
5
-
-
79957979015
-
Thermoregulation and endurance running in extinct hominins: Wheelers models revisited
-
Ruxton GD, Wilkinson DM. Thermoregulation and endurance running in extinct hominins: Wheelers models revisited. J Hum Evol. 2011;61:169-175.
-
(2011)
J Hum Evol.
, vol.61
, pp. 169-175
-
-
Ruxton, G.D.1
Wilkinson, D.M.2
-
6
-
-
0033912992
-
The evolution of human skin coloration
-
Jablonski NG, Chaplin G. The evolution of human skin coloration. J Hum Evol. 2000;39:57-106.
-
(2000)
J Hum Evol.
, vol.39
, pp. 57-106
-
-
Jablonski, N.G.1
Chaplin, G.2
-
7
-
-
84873378527
-
Exercise metabolism and the molecular regulation of skeletal muscle adaptation
-
Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17:162-184.
-
(2013)
Cell Metab.
, vol.17
, pp. 162-184
-
-
Egan, B.1
Zierath, J.R.2
-
8
-
-
34548371839
-
The molecular bases of training adaptation
-
Coffey VG, Hawley JA. The molecular bases of training adaptation. Sports Med. 2007;37:737-763.
-
(2007)
Sports Med.
, vol.37
, pp. 737-763
-
-
Coffey, V.G.1
Hawley, J.A.2
-
9
-
-
84862234497
-
Lack of exercise is a major cause of chronic diseases
-
Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143-1211.
-
(2012)
Compr Physiol.
, vol.2
, pp. 1143-1211
-
-
Booth, F.W.1
Roberts, C.K.2
Laye, M.J.3
-
10
-
-
34548264161
-
Activity-dependent signaling pathways controlling muscle diversity and plasticity
-
Schiaffino S, Sandri M, Murgia M. Activity-dependent signaling pathways controlling muscle diversity and plasticity. Physiology (Bethesda). 2007;22:269-278.
-
(2007)
Physiology (Bethesda).
, vol.22
, pp. 269-278
-
-
Schiaffino, S.1
Sandri, M.2
Murgia, M.3
-
11
-
-
84877709562
-
Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness
-
Stuart CA, McCurry MP, Marino A, South MA, Howell ME, Layne AS, Ramsey MW, Stone MH. Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness. J Clin Endocrinol Metab. 2013;98:2027-2036.
-
(2013)
J Clin Endocrinol Metab.
, vol.98
, pp. 2027-2036
-
-
Stuart, C.A.1
McCurry, M.P.2
Marino, A.3
South, M.A.4
Howell, M.E.5
Layne, A.S.6
Ramsey, M.W.7
Stone, M.H.8
-
12
-
-
0030945318
-
Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure
-
Hambrecht R, Fiehn E, Yu J, Niebauer J, Weigl C, Hilbrich L, Adams V, Riede U, Schuler G. Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. J Am Coll Cardiol. 1997;29:1067-1073.
-
(1997)
J Am Coll Cardiol.
, vol.29
, pp. 1067-1073
-
-
Hambrecht, R.1
Fiehn, E.2
Yu, J.3
Niebauer, J.4
Weigl, C.5
Hilbrich, L.6
Adams, V.7
Riede, U.8
Schuler, G.9
-
13
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002;418:797-801.
-
(2002)
Nature.
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
Lowell, B.B.11
Bassel-Duby, R.12
Spiegelman, B.M.13
-
14
-
-
45149108625
-
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
-
Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985). 2008;104:1304-1312.
-
(2008)
J Appl Physiol (1985)
, vol.104
, pp. 1304-1312
-
-
Calvo, J.A.1
Daniels, T.G.2
Wang, X.3
Paul, A.4
Lin, J.5
Spiegelman, B.M.6
Stevenson, S.C.7
Rangwala, S.M.8
-
15
-
-
33845674997
-
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle
-
Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM. The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007;5:35-46.
-
(2007)
Cell Metab.
, vol.5
, pp. 35-46
-
-
Arany, Z.1
Lebrasseur, N.2
Morris, C.3
Smith, E.4
Yang, W.5
Ma, Y.6
Chin, S.7
Spiegelman, B.M.8
-
16
-
-
0642303113
-
Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability
-
Luquet S, Lopez-Soriano J, Holst D, Fredenrich A, Melki J, Rassoulzadegan M, Grimaldi PA. Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB J. 2003;17:2299-2301.
-
(2003)
FASEB J.
, vol.17
, pp. 2299-2301
-
-
Luquet, S.1
Lopez-Soriano, J.2
Holst, D.3
Fredenrich, A.4
Melki, J.5
Rassoulzadegan, M.6
Grimaldi, P.A.7
-
17
-
-
8844276054
-
Regulation of muscle fiber type and running endurance by PPARdelta
-
Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004;2:e294.
-
(2004)
PLoS Biol.
, vol.2
-
-
Wang, Y.X.1
Zhang, C.L.2
Yu, R.T.3
Cho, H.K.4
Nelson, M.C.5
Bayuga-Ocampo, C.R.6
Ham, J.7
Kang, H.8
Evans, R.M.9
-
18
-
-
34548208233
-
The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle
-
Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R, Parker M. The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle. Cell Metab. 2007;6:236-245.
-
(2007)
Cell Metab.
, vol.6
, pp. 236-245
-
-
Seth, A.1
Steel, J.H.2
Nichol, D.3
Pocock, V.4
Kumaran, M.K.5
Fritah, A.6
Mobberley, M.7
Ryder, T.A.8
Rowlerson, A.9
Scott, J.10
Poutanen, M.11
White, R.12
Parker, M.13
-
19
-
-
0034681315
-
Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo
-
Naya FJ, Mercer B, Shelton J, Richardson JA, Williams RS, Olson EN. Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. J Biol Chem. 2000;275:4545-4548.
-
(2000)
J Biol Chem.
, vol.275
, pp. 4545-4548
-
-
Naya, F.J.1
Mercer, B.2
Shelton, J.3
Richardson, J.A.4
Williams, R.S.5
Olson, E.N.6
-
20
-
-
84870204290
-
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN
-
Hasumi H, Baba M, Hasumi Y, Huang Y, Oh H, Hughes RM, Klein ME, Takikita S, Nagashima K, Schmidt LS, Linehan WM. Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst. 2012;104:1750-1764.
-
(2012)
J Natl Cancer Inst.
, vol.104
, pp. 1750-1764
-
-
Hasumi, H.1
Baba, M.2
Hasumi, Y.3
Huang, Y.4
Oh, H.5
Hughes, R.M.6
Klein, M.E.7
Takikita, S.8
Nagashima, K.9
Schmidt, L.S.10
Linehan, W.M.11
-
21
-
-
34848858523
-
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers
-
Potthoff MJ, Wu H, Arnold MA, Shelton JM, Backs J, McAnally J, Richardson JA, Bassel-Duby R, Olson EN. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459-2467.
-
(2007)
J Clin Invest.
, vol.117
, pp. 2459-2467
-
-
Potthoff, M.J.1
Wu, H.2
Arnold, M.A.3
Shelton, J.M.4
Backs, J.5
McAnally, J.6
Richardson, J.A.7
Bassel-Duby, R.8
Olson, E.N.9
-
22
-
-
84871674116
-
IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARdelta, SIRT1, PGC-1alpha, and PGC-1beta expression in male mice
-
Quinn LS, Anderson BG, Conner JD, Wolden-Hanson T. IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARdelta, SIRT1, PGC-1alpha, and PGC-1beta expression in male mice. Endocrinology. 2013;154:232-245
-
(2013)
Endocrinology.
, vol.154
, pp. 232-245
-
-
Quinn, L.S.1
Anderson, B.G.2
Conner, J.D.3
Wolden-Hanson, T.4
-
23
-
-
84869068575
-
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization
-
Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012;53:2610-2619.
-
(2012)
J Lipid Res.
, vol.53
, pp. 2610-2619
-
-
Chao, L.C.1
Wroblewski, K.2
Ilkayeva, O.R.3
Stevens, R.D.4
Bain, J.5
Meyer, G.A.6
Schenk, S.7
Martinez, L.8
Vergnes, L.9
Narkar, V.A.10
Drew, B.G.11
Hong, C.12
Boyadjian, R.13
Hevener, A.L.14
Evans, R.M.15
Reue, K.16
Spencer, M.J.17
Newgard, C.B.18
Tontonoz, P.19
-
24
-
-
49249107662
-
Overexpression of the mitochondrial T3 receptor p43 induces a shift in skeletal muscle fiber types
-
Casas F, Pessemesse L, Grandemange S, Seyer P, Gueguen N, Baris O, Lepourry L, Cabello G, Wrutniak-Cabello C. Overexpression of the mitochondrial T3 receptor p43 induces a shift in skeletal muscle fiber types. PLoS One. 2008;3:e2501.
-
(2008)
PLoS One.
, vol.3
-
-
Casas, F.1
Pessemesse, L.2
Grandemange, S.3
Seyer, P.4
Gueguen, N.5
Baris, O.6
Lepourry, L.7
Cabello, G.8
Wrutniak-Cabello, C.9
-
25
-
-
36348972777
-
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse
-
Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem. 2007;282:32844-32855.
-
(2007)
J Biol Chem.
, vol.282
, pp. 32844-32855
-
-
Hakimi, P.1
Yang, J.2
Casadesus, G.3
Massillon, D.4
Tolentino-Silva, F.5
Nye, C.K.6
Cabrera, M.E.7
Hagen, D.R.8
Utter, C.B.9
Baghdy, Y.10
Johnson, D.H.11
Wilson, D.L.12
Kirwan, J.P.13
Kalhan, S.C.14
Hanson, R.W.15
-
26
-
-
77955873349
-
Oxidative status of muscle is determined by p107 regulation of PGC-1alpha
-
Scimè A, Soleimani VD, Bentzinger CF, Gillespie MA, Le Grand F, Grenier G, Bevilacqua L, Harper ME, Rudnicki MA. Oxidative status of muscle is determined by p107 regulation of PGC-1alpha. J Cell Biol. 2010;190:651-662.
-
(2010)
J Cell Biol.
, vol.190
, pp. 651-662
-
-
Scimè, A.1
Soleimani, V.D.2
Bentzinger, C.F.3
Gillespie, M.A.4
Le Grand, F.5
Grenier, G.6
Bevilacqua, L.7
Harper, M.E.8
Rudnicki, M.A.9
-
27
-
-
84868515579
-
Lack of 2-AR improves exercise capacity and skeletal muscle oxidative phenotype in mice
-
Voltarelli VA, Bacurau AV, Bechara LR, Bueno CR Jr, Bozi LH, Mattos KC, Salemi VM, Brum PC. Lack of 2-AR improves exercise capacity and skeletal muscle oxidative phenotype in mice. Scand J Med Sci Sports. 2012;22:e125-e132.
-
(2012)
Scand J Med Sci Sports.
, vol.22
, pp. 125-132
-
-
Voltarelli, V.A.1
Bacurau, A.V.2
Bechara, L.R.3
Bueno Jr., C.R.4
Bozi, L.H.5
Mattos, K.C.6
Salemi, V.M.7
Brum, P.C.8
-
28
-
-
81055125669
-
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function
-
Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell. 2011;147:827-839.
-
(2011)
Cell.
, vol.147
, pp. 827-839
-
-
Yamamoto, H.1
Williams, E.G.2
Mouchiroud, L.3
Cantó, C.4
Fan, W.5
Downes, M.6
Héligon, C.7
Barish, G.D.8
Desvergne, B.9
Evans, R.M.10
Schoonjans, K.11
Auwerx, J.12
-
29
-
-
79960993380
-
Loss of IL-15 receptor alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles
-
Pistilli EE, Bogdanovich S, Garton F, Yang N, Gulbin JP, Conner JD, Anderson BG, Quinn LS, North K, Ahima RS, Khurana TS. Loss of IL-15 receptor alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles. J Clin Invest. 2011;121:3120-3132.
-
(2011)
J Clin Invest.
, vol.121
, pp. 3120-3132
-
-
Pistilli, E.E.1
Bogdanovich, S.2
Garton, F.3
Yang, N.4
Gulbin, J.P.5
Conner, J.D.6
Anderson, B.G.7
Quinn, L.S.8
North, K.9
Ahima, R.S.10
Khurana, T.S.11
-
30
-
-
0037066459
-
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
-
Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, Williams RS. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science. 2002;296:349-352.
-
(2002)
Science.
, vol.296
, pp. 349-352
-
-
Wu, H.1
Kanatous, S.B.2
Thurmond, F.A.3
Gallardo, T.4
Isotani, E.5
Bassel-Duby, R.6
Williams, R.S.7
-
31
-
-
21244477127
-
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
-
Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005;280:19587-19593.
-
(2005)
J Biol Chem.
, vol.280
, pp. 19587-19593
-
-
Akimoto, T.1
Pohnert, S.C.2
Li, P.3
Zhang, M.4
Gumbs, C.5
Rosenberg, P.B.6
Williams, R.S.7
Yan, Z.8
-
32
-
-
0037979119
-
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice
-
Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD. Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol. 2003;23:4331-4343.
-
(2003)
Mol Cell Biol.
, vol.23
, pp. 4331-4343
-
-
Parsons, S.A.1
Wilkins, B.J.2
Bueno, O.F.3
Molkentin, J.D.4
-
33
-
-
33746328957
-
Signaling pathways in skeletal muscle remodeling
-
Bassel-Duby R, Olson EN. Signaling pathways in skeletal muscle remodeling. Annu Rev Biochem. 2006;75:19-37.
-
(2006)
Annu Rev Biochem.
, vol.75
, pp. 19-37
-
-
Bassel-Duby, R.1
Olson, E.N.2
-
34
-
-
84863992929
-
Impaired calcium calmodulin kinase signaling and muscle adaptation response in the absence of calpain
-
Kramerova I, Kudryashova E, Ermolova N, Saenz A, Jaka O, López De Munain A, Spencer MJ. Impaired calcium calmodulin kinase signaling and muscle adaptation response in the absence of calpain. Hum Mol Genet. 2012;21:3193-3204.
-
(2012)
Hum Mol Genet.
, vol.21
, pp. 3193-3204
-
-
Kramerova, I.1
Kudryashova, E.2
Ermolova, N.3
Saenz, A.4
Jaka, O.5
López De Munain, A.6
Spencer, M.J.7
-
35
-
-
70949087409
-
P38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice
-
Pogozelski AR, Geng T, Li P, Yin X, Lira VA, Zhang M, Chi JT, Yan Z. p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One. 2009;4:e7934.
-
(2009)
PLoS One.
, vol.4
-
-
Pogozelski, A.R.1
Geng, T.2
Li, P.3
Yin, X.4
Lira, V.A.5
Zhang, M.6
Chi, J.T.7
Yan, Z.8
-
36
-
-
74149088545
-
Beta-adrenergic receptor signaling in the heart: Role of CaMKII
-
Grimm M, Brown JH. Beta-adrenergic receptor signaling in the heart: Role of CaMKII. J Mol Cell Cardiol. 2010;48:322-330.
-
(2010)
J Mol Cell Cardiol.
, vol.48
, pp. 322-330
-
-
Grimm, M.1
Brown, J.H.2
-
37
-
-
80053163909
-
AMP-activated protein kinase (AMPK) beta-1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
-
ONeill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jørgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, Kemp BE, Richter EA, Steinberg GR. AMP-activated protein kinase (AMPK) beta-1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci USA. 2011;108:16092-16097.
-
(2011)
Proc Natl Acad Sci U.S.A.
, vol.108
, pp. 16092-16097
-
-
Oneill, H.M.1
Maarbjerg, S.J.2
Crane, J.D.3
Jeppesen, J.4
Jørgensen, S.B.5
Schertzer, J.D.6
Shyroka, O.7
Kiens, B.8
Van Denderen, B.J.9
Tarnopolsky, M.A.10
Kemp, B.E.11
Richter, E.A.12
Steinberg, G.R.13
-
38
-
-
58149099037
-
Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle
-
Garcia-Roves PM, Osler ME, Holmström MH, Zierath JR. Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle. J Biol Chem. 2008;283:35724-35734.
-
(2008)
J Biol Chem.
, vol.283
, pp. 35724-35734
-
-
Garcia-Roves, P.M.1
Osler, M.E.2
Holmström, M.H.3
Zierath, J.R.4
-
39
-
-
4644309036
-
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
-
Barnes BR, Marklund S, Steiler TL, Walter M, Hjälm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, Lindgren K, Abrink M, Stapleton D, Zierath JR, Andersson L. The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem. 2004;279: 38441-38447.
-
(2004)
J Biol Chem.
, vol.279
, pp. 38441-38447
-
-
Barnes, B.R.1
Marklund, S.2
Steiler, T.L.3
Walter, M.4
Hjälm, G.5
Amarger, V.6
Mahlapuu, M.7
Leng, Y.8
Johansson, C.9
Galuska, D.10
Lindgren, K.11
Abrink, M.12
Stapleton, D.13
Zierath, J.R.14
Andersson, L.15
-
40
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458:1056-1060.
-
(2009)
Nature.
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
41
-
-
0028972107
-
Myoglobin O2 desaturation during exercise: Evidence of limited O2 transport
-
Richardson RS, Noyszewski EA, Kendrick KF, Leigh JS, Wagner PD. Myoglobin O2 desaturation during exercise: Evidence of limited O2 transport. J Clin Invest. 1995;96:1916-1926.
-
(1995)
J Clin Invest.
, vol.96
, pp. 1916-1926
-
-
Richardson, R.S.1
Noyszewski, E.A.2
Kendrick, K.F.3
Leigh, J.S.4
Wagner, P.D.5
-
42
-
-
8844276053
-
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance
-
Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004;2:e288.
-
(2004)
PLoS Biol.
, vol.2
-
-
Mason, S.D.1
Howlett, R.A.2
Kim, M.J.3
Olfert, I.M.4
Hogan, M.C.5
McNulty, W.6
Hickey, R.P.7
Wagner, P.D.8
Kahn, C.R.9
Giordano, F.J.10
Johnson, R.S.11
-
43
-
-
36049028935
-
HIF-1alpha in endurance training: Suppression of oxidative metabolism
-
Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson RS. HIF-1alpha in endurance training: Suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol. 2007;293:R2059-R2069.
-
(2007)
Am J Physiol Regul Integr Comp Physiol.
, vol.293
, pp. 2059-2069
-
-
Mason, S.D.1
Rundqvist, H.2
Papandreou, I.3
Duh, R.4
McNulty, W.J.5
Howlett, R.A.6
Olfert, I.M.7
Sundberg, C.J.8
Denko, N.C.9
Poellinger, L.10
Johnson, R.S.11
-
44
-
-
33845596500
-
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
-
Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006;27:728-735.
-
(2006)
Endocr Rev.
, vol.27
, pp. 728-735
-
-
Handschin, C.1
Spiegelman, B.M.2
-
45
-
-
78649508058
-
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity
-
Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab. 2010;12:633-642.
-
(2010)
Cell Metab.
, vol.12
, pp. 633-642
-
-
Zechner, C.1
Lai, L.2
Zechner, J.F.3
Geng, T.4
Yan, Z.5
Rumsey, J.W.6
Collia, D.7
Chen, Z.8
Wozniak, D.F.9
Leone, T.C.10
Kelly, D.P.11
-
46
-
-
84878565172
-
Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle
-
Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep. 2013;3:1449-1456.
-
(2013)
Cell Rep.
, vol.3
, pp. 1449-1456
-
-
Rowe, G.C.1
Patten, I.S.2
Zsengeller, Z.K.3
El-Khoury, R.4
Okutsu, M.5
Bampoh, S.6
Koulisis, N.7
Farrell, C.8
Hirshman, M.F.9
Yan, Z.10
Goodyear, L.J.11
Rustin, P.12
Arany, Z.13
-
47
-
-
77958021516
-
PGC-1 coactivators in cardiac development and disease
-
Rowe GC, Jiang A, Arany Z. PGC-1 coactivators in cardiac development and disease. Circ Res. 2010;107:825-838.
-
(2010)
Circ Res.
, vol.107
, pp. 825-838
-
-
Rowe, G.C.1
Jiang, A.2
Arany, Z.3
-
48
-
-
44649151707
-
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
-
Madrazo JA, Kelly DP. The PPAR trio: Regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol. 2008;44:968-975.
-
(2008)
J Mol Cell Cardiol.
, vol.44
, pp. 968-975
-
-
Madrazo, J.A.1
Kelly, D.P.2
-
49
-
-
42049114034
-
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
-
Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev. 2008;88:611-638.
-
(2008)
Physiol Rev.
, vol.88
, pp. 611-638
-
-
Scarpulla, R.C.1
-
50
-
-
33745815985
-
AMP-activated protein kinase signaling in metabolic regulation
-
Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006;116:1776-1783.
-
(2006)
J Clin Invest.
, vol.116
, pp. 1776-1783
-
-
Long, Y.C.1
Zierath, J.R.2
-
51
-
-
33750724108
-
Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise
-
Winder WW, Taylor EB, Thomson DM. Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise. Med Sci Sports Exerc. 2006;38:1945-1949.
-
(2006)
Med Sci Sports Exerc.
, vol.38
, pp. 1945-1949
-
-
Winder, W.W.1
Taylor, E.B.2
Thomson, D.M.3
-
52
-
-
84858055958
-
Acute exercise remodels promoter methylation in human skeletal muscle
-
Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, OGorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012;15:405-411.
-
(2012)
Cell Metab.
, vol.15
, pp. 405-411
-
-
Barrès, R.1
Yan, J.2
Egan, B.3
Treebak, J.T.4
Rasmussen, M.5
Fritz, T.6
Caidahl, K.7
Krook, A.8
Ogorman, D.J.9
Zierath, J.R.10
-
53
-
-
71549165765
-
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance
-
van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009;17:662-673.
-
(2009)
Dev Cell.
, vol.17
, pp. 662-673
-
-
Van Rooij, E.1
Quiat, D.2
Johnson, B.A.3
Sutherland, L.B.4
Qi, X.5
Richardson, J.A.6
Kelm Jr., R.J.7
Olson, E.N.8
-
54
-
-
66149090410
-
MiRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice
-
Safdar A, Abadi A, Akhtar M, Hettinga BP, Tarnopolsky MA. miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice. PLoS One. 2009;4:e5610.
-
(2009)
PLoS One.
, vol.4
-
-
Safdar, A.1
Abadi, A.2
Akhtar, M.3
Hettinga, B.P.4
Tarnopolsky, M.A.5
-
55
-
-
80051605955
-
Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training
-
Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan SY. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol. 2011;589(pt 16):3983-3994.
-
(2011)
J Physiol.
, vol.589
, Issue.PART 16
, pp. 3983-3994
-
-
Baggish, A.L.1
Hale, A.2
Weiner, R.B.3
Lewis, G.D.4
Systrom, D.5
Wang, F.6
Wang, T.J.7
Chan, S.Y.8
-
56
-
-
77955276502
-
Organellar vs cellular control of mitochondrial dynamics
-
Hyde BB, Twig G, Shirihai OS. Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol. 2010;21:575-581.
-
(2010)
Semin Cell Dev Biol.
, vol.21
, pp. 575-581
-
-
Hyde, B.B.1
Twig, G.2
Shirihai, O.S.3
-
57
-
-
84869030015
-
Fusion and fission: Interlinked processes critical for mitochondrial health
-
Chan DC. Fusion and fission: Interlinked processes critical for mitochondrial health. Annu Rev Genet. 2012;46:265-287.
-
(2012)
Annu Rev Genet.
, vol.46
, pp. 265-287
-
-
Chan, D.C.1
-
58
-
-
0023654783
-
Effects of endurance training on a mitochondrial reticulum in limb skeletal muscle
-
Kirkwood SP, Packer L, Brooks GA. Effects of endurance training on a mitochondrial reticulum in limb skeletal muscle. Arch Biochem Biophys. 1987;255:80-88.
-
(1987)
Arch Biochem Biophys.
, vol.255
, pp. 80-88
-
-
Kirkwood, S.P.1
Packer, L.2
Brooks, G.A.3
-
59
-
-
79954571354
-
The interplay between mitochondrial dynamics and mitophagy
-
Twig G, Shirihai OS. The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011;14:1939-1951.
-
(2011)
Antioxid Redox Signal.
, vol.14
, pp. 1939-1951
-
-
Twig, G.1
Shirihai, O.S.2
-
60
-
-
76749113759
-
Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle
-
Ding H, Jiang N, Liu H, Liu X, Liu D, Zhao F, Wen L, Liu S, Ji LL, Zhang Y. Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle. Biochim Biophys Acta. 2010;1800:250-256.
-
(2010)
Biochim Biophys Acta.
, vol.1800
, pp. 250-256
-
-
Ding, H.1
Jiang, N.2
Liu, H.3
Liu, X.4
Liu, D.5
Zhao, F.6
Wen, L.7
Liu, S.8
Ji, L.L.9
Zhang, Y.10
-
61
-
-
23844494686
-
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise
-
Cartoni R, Léger B, Hock MB, Praz M, Crettenand A, Pich S, Ziltener JL, Luthi F, Dériaz O, Zorzano A, Gobelet C, Kralli A, Russell AP. Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol. 2005;567(pt 1):349-358.
-
(2005)
J Physiol.
, vol.567
, Issue.PART 1
, pp. 349-358
-
-
Cartoni, R.1
Léger, B.2
Hock, M.B.3
Praz, M.4
Crettenand, A.5
Pich, S.6
Ziltener, J.L.7
Luthi, F.8
Dériaz, O.9
Zorzano, A.10
Gobelet, C.11
Kralli, A.12
Russell, A.P.13
-
62
-
-
78649710608
-
Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle
-
Perry CG, Lally J, Holloway GP, Heigenhauser GJ, Bonen A, Spriet LL. Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol. 2010;588(pt 23):4795-4810.
-
(2010)
J Physiol.
, vol.588
, Issue.PART 23
, pp. 4795-4810
-
-
Perry, C.G.1
Lally, J.2
Holloway, G.P.3
Heigenhauser, G.J.4
Bonen, A.5
Spriet, L.L.6
-
63
-
-
77951737783
-
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
-
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010;141:280-289.
-
(2010)
Cell.
, vol.141
, pp. 280-289
-
-
Chen, H.1
Vermulst, M.2
Wang, Y.E.3
Chomyn, A.4
Prolla, T.A.5
McCaffery, J.M.6
Chan, D.C.7
-
64
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
Mizushima N, Komatsu M. Autophagy: Renovation of cells and tissues. Cell. 2011;147:728-741.
-
(2011)
Cell.
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
65
-
-
82855169509
-
Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles
-
Grumati P, Coletto L, Schiavinato A, Castagnaro S, Bertaggia E, Sandri M, Bonaldo P. Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles. Autophagy. 2011;7:1415-1423.
-
(2011)
Autophagy.
, vol.7
, pp. 1415-1423
-
-
Grumati, P.1
Coletto, L.2
Schiavinato, A.3
Castagnaro, S.4
Bertaggia, E.5
Sandri, M.6
Bonaldo, P.7
-
66
-
-
84863393597
-
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
-
He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012;481:511-515.
-
(2012)
Nature.
, vol.481
, pp. 511-515
-
-
He, C.1
Bassik, M.C.2
Moresi, V.3
Sun, K.4
Wei, Y.5
Zou, Z.6
An, Z.7
Loh, J.8
Fisher, J.9
Sun, Q.10
Korsmeyer, S.11
Packer, M.12
May, H.I.13
Hill, J.A.14
Virgin, H.W.15
Gilpin, C.16
Xiao, G.17
Bassel-Duby, R.18
Scherer, P.E.19
Levine, B.20
more..
-
67
-
-
84867249241
-
Exercise induces autophagy in peripheral tissues and in the brain
-
He C, Sumpter R Jr, Levine B. Exercise induces autophagy in peripheral tissues and in the brain. Autophagy. 2012;8:1548-1551.
-
(2012)
Autophagy.
, vol.8
, pp. 1548-1551
-
-
He, C.1
Sumpter Jr., R.2
Levine, B.3
-
68
-
-
80052888751
-
Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle
-
Smuder AJ, Kavazis AN, Min K, Powers SK. Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle. J Appl Physiol (1985). 2011;111:1190-1198.
-
(2011)
J Appl Physiol (1985).
, vol.111
, pp. 1190-1198
-
-
Smuder, A.J.1
Kavazis, A.N.2
Min, K.3
Powers, S.K.4
-
69
-
-
79551510124
-
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1/ATF6 complex
-
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1/ATF6 complex. Cell Metab. 2011;13:160-169.
-
(2011)
Cell Metab.
, vol.13
, pp. 160-169
-
-
Wu, J.1
Ruas, J.L.2
Estall, J.L.3
Rasbach, K.A.4
Choi, J.H.5
Ye, L.6
Boström, P.7
Tyra, H.M.8
Crawford, R.W.9
Campbell, K.P.10
Rutkowski, D.T.11
Kaufman, R.J.12
Spiegelman, B.M.13
-
70
-
-
57649180479
-
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
-
Zwetsloot KA, Westerkamp LM, Holmes BF, Gavin TP. AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise. J Physiol. 2008;586(pt 24):6021-6035.
-
(2008)
J Physiol.
, vol.586
, Issue.PART 24
, pp. 6021-6035
-
-
Zwetsloot, K.A.1
Westerkamp, L.M.2
Holmes, B.F.3
Gavin, T.P.4
-
71
-
-
75849155745
-
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle
-
Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z. The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci USA. 2009;106:21401-21406.
-
(2009)
Proc Natl Acad Sci U.S.A.
, vol.106
, pp. 21401-21406
-
-
Chinsomboon, J.1
Ruas, J.2
Gupta, R.K.3
Thom, R.4
Shoag, J.5
Rowe, G.C.6
Sawada, N.7
Raghuram, S.8
Arany, Z.9
-
72
-
-
84864186432
-
PGC-1 is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle
-
Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. PGC-1 is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle. PLoS One. 2012;7:e41817.
-
(2012)
PLoS One.
, vol.7
-
-
Rowe, G.C.1
El-Khoury, R.2
Patten, I.S.3
Rustin, P.4
Arany, Z.5
-
73
-
-
38949196761
-
PGC-1alpha is not mandatory for exercise-and training-induced adaptive gene responses in mouse skeletal muscle
-
Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H. PGC-1alpha is not mandatory for exercise-and training-induced adaptive gene responses in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2008;294:E463-E474.
-
(2008)
Am J Physiol Endocrinol Metab.
, vol.294
, pp. 463-474
-
-
Leick, L.1
Wojtaszewski, J.F.2
Johansen, S.T.3
Kiilerich, K.4
Comes, G.5
Hellsten, Y.6
Hidalgo, J.7
Pilegaard, H.8
-
74
-
-
39749140405
-
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
-
Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008;451:1008-1012.
-
(2008)
Nature.
, vol.451
, pp. 1008-1012
-
-
Arany, Z.1
Foo, S.Y.2
Ma, Y.3
Ruas, J.L.4
Bommi-Reddy, A.5
Girnun, G.6
Cooper, M.7
Laznik, D.8
Chinsomboon, J.9
Rangwala, S.M.10
Baek, K.H.11
Rosenzweig, A.12
Spiegelman, B.M.13
-
75
-
-
84864283300
-
Muscles, exercise and obesity: Skeletal muscle as a secretory organ
-
Pedersen BK, Febbraio MA. Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8:457-465.
-
(2012)
Nat Rev Endocrinol.
, vol.8
, pp. 457-465
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
76
-
-
55949119252
-
Muscle as an endocrine organ: Focus on muscle-derived interleukin-6
-
Pedersen BK, Febbraio MA. Muscle as an endocrine organ: Focus on muscle-derived interleukin-6. Physiol Rev. 2008;88:1379-1406.
-
(2008)
Physiol Rev.
, vol.88
, pp. 1379-1406
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
77
-
-
33750859187
-
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
-
Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, Prelovsek O, Hohnen-Behrens C, Watt MJ, James DE, Kemp BE, Pedersen BK, Febbraio MA. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes. 2006;55:2688-2697.
-
(2006)
Diabetes.
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
Steinberg, G.R.2
Macaulay, S.L.3
Thomas, W.G.4
Holmes, A.G.5
Ramm, G.6
Prelovsek, O.7
Hohnen-Behrens, C.8
Watt, M.J.9
James, D.E.10
Kemp, B.E.11
Pedersen, B.K.12
Febbraio, M.A.13
-
78
-
-
81255157471
-
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
-
Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, Eppler E, Bouzakri K, Wueest S, Muller YD, Hansen AM, Reinecke M, Konrad D, Gassmann M, Reimann F, Halban PA, Gromada J, Drucker DJ, Gribble FM, Ehses JA, Donath MY. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17:1481-1489.
-
(2011)
Nat Med.
, vol.17
, pp. 1481-1489
-
-
Ellingsgaard, H.1
Hauselmann, I.2
Schuler, B.3
Habib, A.M.4
Baggio, L.L.5
Meier, D.T.6
Eppler, E.7
Bouzakri, K.8
Wueest, S.9
Muller, Y.D.10
Hansen, A.M.11
Reinecke, M.12
Konrad, D.13
Gassmann, M.14
Reimann, F.15
Halban, P.A.16
Gromada, J.17
Drucker, D.J.18
Gribble, F.M.19
Ehses, J.A.20
Donath, M.Y.21
more..
-
79
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius V, Wallenius K, Ahrén B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, Jansson JO. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med. 2002;8:75-79.
-
(2002)
Nat Med.
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
Wallenius, K.2
Ahrén, B.3
Rudling, M.4
Carlsten, H.5
Dickson, S.L.6
Ohlsson, C.7
Jansson, J.O.8
-
80
-
-
69549138878
-
Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimers disease
-
Abbas T, Faivre E, Hölscher C. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimers disease. Behav Brain Res. 2009;205:265-271.
-
(2009)
Behav Brain Res.
, vol.205
, pp. 265-271
-
-
Abbas, T.1
Faivre, E.2
Hölscher, C.3
-
81
-
-
78649745810
-
The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
-
Isacson R, Nielsen E, Dannaeus K, Bertilsson G, Patrone C, Zachrisson O, Wikström L. The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test. Eur J Pharmacol. 2011;650:249-255.
-
(2011)
Eur J Pharmacol.
, vol.650
, pp. 249-255
-
-
Isacson, R.1
Nielsen, E.2
Dannaeus, K.3
Bertilsson, G.4
Patrone, C.5
Zachrisson, O.6
Wikström, L.7
-
82
-
-
84862776702
-
A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature.481:463-468
-
Nature
, vol.481
, pp. 463-468
-
-
Bostrom, P.1
Wu, J.2
Jedrychowski, M.P.3
Korde, A.4
Ye, L.5
Lo, J.C.6
Rasbach, K.A.7
Bostrom, E.A.8
Choi, J.H.9
Long, J.Z.10
Kajimura, S.11
Zingaretti, M.C.12
Vind, B.F.13
Tu, H.14
Cinti, S.15
Hojlund, K.16
Gygi, S.P.17
Spiegelman, B.M.18
-
83
-
-
84873512773
-
Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure
-
Lecker SH, Zavin A, Cao P, Arena R, Allsup K, Daniels KM, Joseph J, Schulze PC, Forman DE. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail. 2012;5:812-818.
-
(2012)
Circ Heart Fail.
, vol.5
, pp. 812-818
-
-
Lecker, S.H.1
Zavin, A.2
Cao, P.3
Arena, R.4
Allsup, K.5
Daniels, K.M.6
Joseph, J.7
Schulze, P.C.8
Forman, D.E.9
-
85
-
-
84877147751
-
Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1-Fndc5 pathway in muscle
-
Shan T, Liang X, Bi P, Kuang S. Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1-Fndc5 pathway in muscle. FASEB J. 2013;27:1981-1989.
-
(2013)
FASEB J.
, vol.27
, pp. 1981-1989
-
-
Shan, T.1
Liang, X.2
Bi, P.3
Kuang, S.4
-
86
-
-
54849438574
-
FGF21 is an Akt-regulated myokine
-
Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K. FGF21 is an Akt-regulated myokine. FEBS Lett. 2008;582:3805-3810.
-
(2008)
FEBS Lett.
, vol.582
, pp. 3805-3810
-
-
Izumiya, Y.1
Bina, H.A.2
Ouchi, N.3
Akasaki, Y.4
Kharitonenkov, A.5
Walsh, K.6
-
87
-
-
84872057896
-
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
-
Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim do H, Hur KY, Kim HK, Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med. 2013;19:83-92.
-
(2013)
Nat Med.
, vol.19
, pp. 83-92
-
-
Kim, K.H.1
Jeong, Y.T.2
Oh, H.3
Kim, S.H.4
Cho, J.M.5
Kim, Y.N.6
Kim, S.S.7
Kim Do, H.8
Hur, K.Y.9
Kim, H.K.10
Ko, T.11
Han, J.12
Kim, H.L.13
Kim, J.14
Back, S.H.15
Komatsu, M.16
Chen, H.17
Chan, D.C.18
Konishi, M.19
Itoh, N.20
Choi, C.S.21
Lee, M.S.22
more..
-
88
-
-
84859488137
-
Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
-
Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012;287:11968-11980.
-
(2012)
J Biol Chem.
, vol.287
, pp. 11968-11980
-
-
Seldin, M.M.1
Peterson, J.M.2
Byerly, M.S.3
Wei, Z.4
Wong, G.W.5
-
89
-
-
77949853820
-
Emerging role of neuregulin as a modulator of muscle metabolism
-
Gumà A, Martínez-Redondo V, López-Soldado I, Cantó C, Zorzano A. Emerging role of neuregulin as a modulator of muscle metabolism. Am J Physiol Endocrinol Metab. 2010;298:E742-E750.
-
(2010)
Am J Physiol Endocrinol Metab.
, vol.298
, pp. 742-750
-
-
Gumà, A.1
Martínez-Redondo, V.2
López-Soldado, I.3
Cantó, C.4
Zorzano, A.5
-
90
-
-
79960209054
-
LIF is a contraction-induced myokine stimulating human myocyte proliferation
-
Broholm C, Laye MJ, Brandt C, Vadalasetty R, Pilegaard H, Pedersen BK, Scheele C. LIF is a contraction-induced myokine stimulating human myocyte proliferation. J Appl Physiol (1985). 2011;111:251-259.
-
(2011)
J Appl Physiol (1985).
, vol.111
, pp. 251-259
-
-
Broholm, C.1
Laye, M.J.2
Brandt, C.3
Vadalasetty, R.4
Pilegaard, H.5
Pedersen, B.K.6
Scheele, C.7
-
91
-
-
67349109400
-
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
-
Matthews VB, Aström MB, Chan MH, Bruce CR, Krabbe KS, Prelovsek O, Akerström T, Yfanti C, Broholm C, Mortensen OH, Penkowa M, Hojman P, Zankari A, Watt MJ, Bruunsgaard H, Pedersen BK, Febbraio MA. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia. 2009;52:1409-1418.
-
(2009)
Diabetologia.
, vol.52
, pp. 1409-1418
-
-
Matthews, V.B.1
Aström, M.B.2
Chan, M.H.3
Bruce, C.R.4
Krabbe, K.S.5
Prelovsek, O.6
Akerström, T.7
Yfanti, C.8
Broholm, C.9
Mortensen, O.H.10
Penkowa, M.11
Hojman, P.12
Zankari, A.13
Watt, M.J.14
Bruunsgaard, H.15
Pedersen, B.K.16
Febbraio, M.A.17
-
92
-
-
77955603289
-
Metabolic signatures of exercise in human plasma
-
Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2011;2:33ra37.
-
(2011)
Sci Transl Med.
, vol.2
, pp. 33-37
-
-
Lewis, G.D.1
Farrell, L.2
Wood, M.J.3
Martinovic, M.4
Arany, Z.5
Rowe, G.C.6
Souza, A.7
Cheng, S.8
McCabe, E.L.9
Yang, E.10
Shi, X.11
Deo, R.12
Roth, F.P.13
Asnani, A.14
Rhee, E.P.15
Systrom, D.M.16
Semigran, M.J.17
Vasan, R.S.18
Carr, S.A.19
Wang, T.J.20
Sabatine, M.S.21
Clish, C.B.22
Gerszten, R.E.23
more..
-
93
-
-
2442649129
-
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
-
He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature. 2004;429:188-193.
-
(2004)
Nature.
, vol.429
, pp. 188-193
-
-
He, W.1
Miao, F.J.2
Lin, D.C.3
Schwandner, R.T.4
Wang, Z.5
Gao, J.6
Chen, J.L.7
Tian, H.8
Ling, L.9
-
94
-
-
77950261397
-
An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81
-
Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 2010;11:311-319.
-
(2010)
Cell Metab.
, vol.11
, pp. 311-319
-
-
Ahmed, K.1
Tunaru, S.2
Tang, C.3
Müller, M.4
Gille, A.5
Sassmann, A.6
Hanson, J.7
Offermanns, S.8
-
95
-
-
84870200989
-
Can exercise teach us how to treat heart disease
-
Mann N, Rosenzweig A. Can exercise teach us how to treat heart disease Circulation. 2012;126:2625-2635.
-
(2012)
Circulation.
, vol.126
, pp. 2625-2635
-
-
Mann, N.1
Rosenzweig, A.2
-
96
-
-
0017813717
-
Alterations in ventricular mass and performance induced by exercise training in man evaluated by echocardiography
-
DeMaria AN, Neumann A, Lee G, Fowler W, Mason DT. Alterations in ventricular mass and performance induced by exercise training in man evaluated by echocardiography. Circulation. 1978;57:237-244.
-
(1978)
Circulation.
, vol.57
, pp. 237-244
-
-
Demaria, A.N.1
Neumann, A.2
Lee, G.3
Fowler, W.4
Mason, D.T.5
-
98
-
-
0037023643
-
Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice
-
Welch S, Plank D, Witt S, Glascock B, Schaefer E, Chimenti S, Andreoli AM, Limana F, Leri A, Kajstura J, Anversa P, Sussman MA. Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ Res. 2002;90:641-648.
-
(2002)
Circ Res.
, vol.90
, pp. 641-648
-
-
Welch, S.1
Plank, D.2
Witt, S.3
Glascock, B.4
Schaefer, E.5
Chimenti, S.6
Andreoli, A.M.7
Limana, F.8
Leri, A.9
Kajstura, J.10
Anversa, P.11
Sussman, M.A.12
-
99
-
-
10744223902
-
The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway
-
McMullen JR, Shioi T, Huang WY, Zhang L, Tarnavski O, Bisping E, Schinke M, Kong S, Sherwood MC, Brown J, Riggi L, Kang PM, Izumo S. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem. 2004;279:4782-4793.
-
(2004)
J Biol Chem.
, vol.279
, pp. 4782-4793
-
-
McMullen, J.R.1
Shioi, T.2
Huang, W.Y.3
Zhang, L.4
Tarnavski, O.5
Bisping, E.6
Schinke, M.7
Kong, S.8
Sherwood, M.C.9
Brown, J.10
Riggi, L.11
Kang, P.M.12
Izumo, S.13
-
100
-
-
33646449520
-
Akt1 is required for physiological cardiac growth
-
DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113:2097-2104.
-
(2006)
Circulation.
, vol.113
, pp. 2097-2104
-
-
Debosch, B.1
Treskov, I.2
Lupu, T.S.3
Weinheimer, C.4
Kovacs, A.5
Courtois, M.6
Muslin, A.J.7
-
101
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002;277:22896-22901.
-
(2002)
J Biol Chem.
, vol.277
, pp. 22896-22901
-
-
Matsui, T.1
Li, L.2
Wu, J.C.3
Cook, S.A.4
Nagoshi, T.5
Picard, M.H.6
Liao, R.7
Rosenzweig, A.8
-
102
-
-
79958792472
-
Exercise protects against myocardial ischemia-reperfusion injury via stimulation of (3)-adrenergic receptors and increased nitric oxide signaling: Role of nitrite and nitrosothiols
-
Calvert JW, Condit ME, Aragón JP, Nicholson CK, Moody BF, Hood RL, Sindler AL, Gundewar S, Seals DR, Barouch LA, Lefer DJ. Exercise protects against myocardial ischemia-reperfusion injury via stimulation of (3)-adrenergic receptors and increased nitric oxide signaling: Role of nitrite and nitrosothiols. Circ Res. 2011;108:1448-1458.
-
(2011)
Circ Res.
, vol.108
, pp. 1448-1458
-
-
Calvert, J.W.1
Condit, M.E.2
Aragón, J.P.3
Nicholson, C.K.4
Moody, B.F.5
Hood, R.L.6
Sindler, A.L.7
Gundewar, S.8
Seals, D.R.9
Barouch, L.A.10
Lefer, D.J.11
-
103
-
-
77950201708
-
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes
-
Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, Macrae CA, Stainier DY, Poss KD. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010;464:601-605.
-
(2010)
Nature.
, vol.464
, pp. 601-605
-
-
Kikuchi, K.1
Holdway, J.E.2
Werdich, A.A.3
Anderson, R.M.4
Fang, Y.5
Egnaczyk, G.F.6
Evans, T.7
Macrae, C.A.8
Stainier, D.Y.9
Poss, K.D.10
-
104
-
-
79952065525
-
Transient regenerative potential of the neonatal mouse heart
-
Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331:1078-1080.
-
(2011)
Science.
, vol.331
, pp. 1078-1080
-
-
Porrello, E.R.1
Mahmoud, A.I.2
Simpson, E.3
Hill, J.A.4
Richardson, J.A.5
Olson, E.N.6
Sadek, H.A.7
-
105
-
-
0015993323
-
Response of the adult newt ventricle to injury
-
Oberpriller JO, Oberpriller JC. Response of the adult newt ventricle to injury. J Exp Zool. 1974;187:249-253.
-
(1974)
J Exp Zool.
, vol.187
, pp. 249-253
-
-
Oberpriller, J.O.1
Oberpriller, J.C.2
-
106
-
-
64249107059
-
Evidence for cardiomyocyte renewal in humans
-
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98-102.
-
(2009)
Science.
, vol.324
, pp. 98-102
-
-
Bergmann, O.1
Bhardwaj, R.D.2
Bernard, S.3
Zdunek, S.4
Barnabé-Heider, F.5
Walsh, S.6
Zupicich, J.7
Alkass, K.8
Buchholz, B.A.9
Druid, H.10
Jovinge, S.11
Frisén, J.12
-
107
-
-
78650472007
-
C/EBP controls exercise-induced cardiac growth and protects against pathological cardiac remodeling
-
Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBP controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010;143:1072-1083.
-
(2010)
Cell.
, vol.143
, pp. 1072-1083
-
-
Boström, P.1
Mann, N.2
Wu, J.3
Quintero, P.A.4
Plovie, E.R.5
Panáková, D.6
Gupta, R.K.7
Xiao, C.8
Macrae, C.A.9
Rosenzweig, A.10
Spiegelman, B.M.11
-
108
-
-
33747384625
-
Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population
-
Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA. Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res. 2006;99:381-388.
-
(2006)
Circ Res.
, vol.99
, pp. 381-388
-
-
Gude, N.1
Muraski, J.2
Rubio, M.3
Kajstura, J.4
Schaefer, E.5
Anversa, P.6
Sussman, M.A.7
-
109
-
-
84875273600
-
Run for your life. at a comfortable speed and not too far
-
OKeefe JH, Lavie CJ. Run for your life. at a comfortable speed and not too far. Heart. 2013;99:516-519.
-
(2013)
Heart.
, vol.99
, pp. 516-519
-
-
Okeefe, J.H.1
Lavie, C.J.2
-
110
-
-
84867158757
-
Cardiovascular damage resulting from chronic excessive endurance exercise
-
Patil HR, OKeefe JH, Lavie CJ, Magalski A, Vogel RA, McCullough PA. Cardiovascular damage resulting from chronic excessive endurance exercise. Mo Med. 2012;109:312-321.
-
(2012)
Mo Med.
, vol.109
, pp. 312-321
-
-
Patil, H.R.1
Okeefe, J.H.2
Lavie, C.J.3
Magalski, A.4
Vogel, R.A.5
McCullough, P.A.6
-
111
-
-
78751625426
-
Marathon rat: Myocardial remodeling in an animal model of vigorous endurance exercise and implications for humans
-
Volders PG. Marathon rat: Myocardial remodeling in an animal model of vigorous endurance exercise and implications for humans. Circulation. 2011;123:5-7.
-
(2011)
Circulation.
, vol.123
, pp. 5-7
-
-
Volders, P.G.1
-
112
-
-
65649084824
-
Relation of vigorous exercise to risk of atrial fibrillation
-
Aizer A, Gaziano JM, Cook NR, Manson JE, Buring JE, Albert CM. Relation of vigorous exercise to risk of atrial fibrillation. Am J Cardiol. 2009;103:1572-1577.
-
(2009)
Am J Cardiol.
, vol.103
, pp. 1572-1577
-
-
Aizer, A.1
Gaziano, J.M.2
Cook, N.R.3
Manson, J.E.4
Buring, J.E.5
Albert, C.M.6
-
113
-
-
84861527673
-
Maximal oxygen consumption is best predicted by measures of cardiac size rather than function in healthy adults
-
La Gerche A, Burns AT, Taylor AJ, Macisaac AI, Heidbüchel H, Prior DL. Maximal oxygen consumption is best predicted by measures of cardiac size rather than function in healthy adults. Eur J Appl Physiol. 2012;112:2139-2147.
-
(2012)
Eur J Appl Physiol.
, vol.112
, pp. 2139-2147
-
-
La Gerche, A.1
Burns, A.T.2
Taylor, A.J.3
Macisaac, A.I.4
Heidbüchel, H.5
Prior, D.L.6
-
114
-
-
78751618772
-
Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training
-
Benito B, Gay-Jordi G, Serrano-Mollar A, Guasch E, Shi Y, Tardif JC, Brugada J, Nattel S, Mont L. Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation. 2011;123:13-22.
-
(2011)
Circulation.
, vol.123
, pp. 13-22
-
-
Benito, B.1
Gay-Jordi, G.2
Serrano-Mollar, A.3
Guasch, E.4
Shi, Y.5
Tardif, J.C.6
Brugada, J.7
Nattel, S.8
Mont, L.9
-
115
-
-
84873259868
-
Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model
-
Gay-Jordi G, Guash E, Benito B, Brugada J, Nattel S, Mont L, Serrano-Mollar A. Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. PLoS One. 2013;8:e55427.
-
(2013)
PLoS One.
, vol.8
-
-
Gay-Jordi, G.1
Guash, E.2
Benito, B.3
Brugada, J.4
Nattel, S.5
Mont, L.6
Serrano-Mollar, A.7
-
116
-
-
70349254437
-
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
-
Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol. 2009;94:1062-1069.
-
(2009)
Exp Physiol.
, vol.94
, pp. 1062-1069
-
-
Rasmussen, P.1
Brassard, P.2
Adser, H.3
Pedersen, M.V.4
Leick, L.5
Hart, E.6
Secher, N.H.7
Pedersen, B.K.8
Pilegaard, H.9
-
117
-
-
75449112809
-
Endurance training enhances BDNF release from the human brain
-
Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol. 2010;298:R372-R377.
-
(2010)
Am J Physiol Regul Integr Comp Physiol.
, vol.298
, pp. 372-377
-
-
Seifert, T.1
Brassard, P.2
Wissenberg, M.3
Rasmussen, P.4
Nordby, P.5
Stallknecht, B.6
Adser, H.7
Jakobsen, A.H.8
Pilegaard, H.9
Nielsen, H.B.10
Secher, N.H.11
-
118
-
-
0033360314
-
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
-
van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999;2:266-270.
-
(1999)
Nat Neurosci.
, vol.2
, pp. 266-270
-
-
Van Praag, H.1
Kempermann, G.2
Gage, F.H.3
-
119
-
-
79952611543
-
Exercise training increases size of hippocampus and improves memory
-
Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA. 2011;108:3017-3022.
-
(2011)
Proc Natl Acad Sci U.S.A.
, vol.108
, pp. 3017-3022
-
-
Erickson, K.I.1
Voss, M.W.2
Prakash, R.S.3
Basak, C.4
Szabo, A.5
Chaddock, L.6
Kim, J.S.7
Heo, S.8
Alves, H.9
White, S.M.10
Wojcicki, T.R.11
Mailey, E.12
Vieira, V.J.13
Martin, S.A.14
Pence, B.D.15
Woods, J.A.16
McAuley, E.17
Kramer, A.F.18
-
120
-
-
56749180855
-
Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
-
Gomez-Pinilla F, Vaynman S, Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci. 2008;28:2278-2287.
-
(2008)
Eur J Neurosci.
, vol.28
, pp. 2278-2287
-
-
Gomez-Pinilla, F.1
Vaynman, S.2
Ying, Z.3
-
121
-
-
40049093899
-
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
-
Duman CH, Schlesinger L, Russell DS, Duman RS. Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Res. 2008;1199:148-158.
-
(2008)
Brain Res.
, vol.1199
, pp. 148-158
-
-
Duman, C.H.1
Schlesinger, L.2
Russell, D.S.3
Duman, R.S.4
-
122
-
-
80054691291
-
Exercise training increases mitochondrial biogenesis in the brain
-
Steiner JL, Murphy EA, McClellan JL, Carmichael MD, Davis JM. Exercise training increases mitochondrial biogenesis in the brain. J Appl Physiol (1985). 2011;111:1066-1071.
-
(2011)
J Appl Physiol (1985).
, vol.111
, pp. 1066-1071
-
-
Steiner, J.L.1
Murphy, E.A.2
McClellan, J.L.3
Carmichael, M.D.4
Davis, J.M.5
-
123
-
-
84871728323
-
Involvement of PGC-1 in the formation and maintenance of neuronal dendritic spines
-
Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X, Luo Y, Okun E, Mattson MP. Involvement of PGC-1 in the formation and maintenance of neuronal dendritic spines. Nat Commun. 2012;3:1250.
-
(2012)
Nat Commun.
, vol.3
, pp. 1250
-
-
Cheng, A.1
Wan, R.2
Yang, J.L.3
Kamimura, N.4
Son, T.G.5
Ouyang, X.6
Luo, Y.7
Okun, E.8
Mattson, M.P.9
-
124
-
-
63349097497
-
Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis
-
Llorens-Martín M, Torres-Alemán I, Trejo JL. Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis. Neuroscientist. 2009;15:134-148.
-
(2009)
Neuroscientist.
, vol.15
, pp. 134-148
-
-
Llorens-Martín, M.1
Torres-Alemán, I.2
Trejo, J.L.3
-
125
-
-
84866150837
-
Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice
-
Huang GJ, Ben-David E, Tort Piella A, Edwards A, Flint J, Shifman S. Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice. PLoS One. 2012;7:e35901.
-
(2012)
PLoS One.
, vol.7
-
-
Huang, G.J.1
Ben-David, E.2
Tort Piella, A.3
Edwards, A.4
Flint, J.5
Shifman, S.6
-
126
-
-
36849092030
-
Antidepressant actions of the exercise-regulated gene VGF
-
Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. Antidepressant actions of the exercise-regulated gene VGF. Nat Med. 2007;13:1476-1482.
-
(2007)
Nat Med.
, vol.13
, pp. 1476-1482
-
-
Hunsberger, J.G.1
Newton, S.S.2
Bennett, A.H.3
Duman, C.H.4
Russell, D.S.5
Salton, S.R.6
Duman, R.S.7
-
127
-
-
84864697365
-
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise
-
Moon HY, Kim SH, Yang YR, Song P, Yu HS, Park HG, Hwang O, Lee-Kwon W, Seo JK, Hwang D, Choi JH, Bucala R, Ryu SH, Kim YS, Suh PG. Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc Natl Acad Sci USA. 2012;109:13094-13099.
-
(2012)
Proc Natl Acad Sci U.S.A.
, vol.109
, pp. 13094-13099
-
-
Moon, H.Y.1
Kim, S.H.2
Yang, Y.R.3
Song, P.4
Yu, H.S.5
Park, H.G.6
Hwang, O.7
Lee-Kwon, W.8
Seo, J.K.9
Hwang, D.10
Choi, J.H.11
Bucala, R.12
Ryu, S.H.13
Kim, Y.S.14
Suh, P.G.15
-
128
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard- Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011;477:90-94.
-
(2011)
Nature.
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
Luo, J.2
Mosher, K.I.3
Zou, B.4
Britschgi, M.5
Bieri, G.6
Stan, T.M.7
Fainberg, N.8
Ding, Z.9
Eggel, A.10
Lucin, K.M.11
Czirr, E.12
Park, J.S.13
Couillard- Després, S.14
Aigner, L.15
Li, G.16
Peskind, E.R.17
Kaye, J.A.18
Quinn, J.F.19
Galasko, D.R.20
Xie, X.S.21
Rando, T.A.22
Wyss-Coray, T.23
more..
-
129
-
-
35548978046
-
Effect of exercise training on plasma visfatin and eotaxin levels
-
Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, Kim SM. Effect of exercise training on plasma visfatin and eotaxin levels. Eur J Endocrinol. 2007;157:437-442.
-
(2007)
Eur J Endocrinol.
, vol.157
, pp. 437-442
-
-
Choi, K.M.1
Kim, J.H.2
Cho, G.J.3
Baik, S.H.4
Park, H.S.5
Kim, S.M.6
-
130
-
-
20044377403
-
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
-
Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 2005;120:701-713.
-
(2005)
Cell.
, vol.120
, pp. 701-713
-
-
Lazarov, O.1
Robinson, J.2
Tang, Y.P.3
Hairston, I.S.4
Korade-Mirnics, Z.5
Lee, V.M.6
Hersh, L.B.7
Sapolsky, R.M.8
Mirnics, K.9
Sisodia, S.S.10
-
131
-
-
79953292347
-
Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinsons disease with moderate neurodegeneration
-
Lau YS, Patki G, Das-Panja K, Le WD, Ahmad SO. Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinsons disease with moderate neurodegeneration. Eur J Neurosci. 2011;33:1264-1274.
-
(2011)
Eur J Neurosci.
, vol.33
, pp. 1264-1274
-
-
Lau, Y.S.1
Patki, G.2
Das-Panja, K.3
Le, W.D.4
Ahmad, S.O.5
-
132
-
-
84865092868
-
Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice
-
Gerecke KM, Jiao Y, Pagala V, Smeyne RJ. Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice. PLoS One. 2012;7:e43250.
-
(2012)
PLoS One.
, vol.7
-
-
Gerecke, K.M.1
Jiao, Y.2
Pagala, V.3
Smeyne, R.J.4
-
133
-
-
80555125089
-
Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua
-
Fryer JD, Yu P, Kang H, Mandel-Brehm C, Carter AN, Crespo-Barreto J, Gao Y, Flora A, Shaw C, Orr HT, Zoghbi HY. Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science. 2011;334:690-693.
-
(2011)
Science.
, vol.334
, pp. 690-693
-
-
Fryer, J.D.1
Yu, P.2
Kang, H.3
Mandel-Brehm, C.4
Carter, A.N.5
Crespo-Barreto, J.6
Gao, Y.7
Flora, A.8
Shaw, C.9
Orr, H.T.10
Zoghbi, H.Y.11
-
134
-
-
80255123489
-
Intrinsic aerobic capacity sets a divide for aging and longevity
-
Koch LG, Kemi OJ, Qi N, Leng SX, Bijma P, Gilligan LJ, Wilkinson JE, Wisløff H, Høydal MA, Rolim N, Abadir PM, van Grevenhof EM, Smith GL, Burant CF, Ellingsen O, Britton SL, Wisløff U. Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res. 2011;109:1162-1172.
-
(2011)
Circ Res.
, vol.109
, pp. 1162-1172
-
-
Koch, L.G.1
Kemi, O.J.2
Qi, N.3
Leng, S.X.4
Bijma, P.5
Gilligan, L.J.6
Wilkinson, J.E.7
Wisløff, H.8
Høydal, M.A.9
Rolim, N.10
Abadir, P.M.11
Van Grevenhof, E.M.12
Smith, G.L.13
Burant, C.F.14
Ellingsen, O.15
Britton, S.L.16
Wisløff, U.17
-
135
-
-
0031838608
-
Artificial selection for increased wheel-running behavior in house mice
-
Swallow JG, Carter PA, Garland T Jr. Artificial selection for increased wheel-running behavior in house mice. Behav Genet. 1998;28:227-237.
-
(1998)
Behav Genet.
, vol.28
, pp. 227-237
-
-
Swallow, J.G.1
Carter, P.A.2
Garland Jr., T.3
-
136
-
-
40149096547
-
Quantitative trait loci for physical activity traits in mice
-
Lightfoot JT, Turner MJ, Pomp D, Kleeberger SR, Leamy LJ. Quantitative trait loci for physical activity traits in mice. Physiol Genomics. 2008;32:401-408.
-
(2008)
Physiol Genomics.
, vol.32
, pp. 401-408
-
-
Lightfoot, J.T.1
Turner, M.J.2
Pomp, D.3
Kleeberger, S.R.4
Leamy, L.J.5
-
137
-
-
0033778944
-
Effects of voluntary activity and genetic selection on muscle metabolic capacities in house mice Mus domesticus
-
Houle-Leroy P, Garland T Jr, Swallow JG, Guderley H. Effects of voluntary activity and genetic selection on muscle metabolic capacities in house mice Mus domesticus. J Appl Physiol (1985). 2000;89:1608-1616.
-
(2000)
J Appl Physiol (1985).
, vol.89
, pp. 1608-1616
-
-
Houle-Leroy, P.1
Garland Jr., T.2
Swallow, J.G.3
Guderley, H.4
-
138
-
-
39449127712
-
Protein synthesis and antioxidant capacity in aging mice: Effects of longterm voluntary exercise
-
Vaanholt LM, Speakman JR, Garland T Jr, Lobley GE, Visser GH. Protein synthesis and antioxidant capacity in aging mice: Effects of longterm voluntary exercise. Physiol Biochem Zool. 2008;81:148-157.
-
(2008)
Physiol Biochem Zool.
, vol.81
, pp. 148-157
-
-
Vaanholt, L.M.1
Speakman, J.R.2
Garland Jr., T.3
Lobley, G.E.4
Visser, G.H.5
-
139
-
-
77952189872
-
Does the difference between physically active and couch potato lie in the dopamine system
-
Knab AM, Lightfoot JT. Does the difference between physically active and couch potato lie in the dopamine system Int J Biol Sci. 2010;6:133-150.
-
(2010)
Int J Biol Sci.
, vol.6
, pp. 133-150
-
-
Knab, A.M.1
Lightfoot, J.T.2
-
140
-
-
33745224150
-
Integration of feeding and spontaneous physical activity: Role for orexin
-
Kotz CM. Integration of feeding and spontaneous physical activity: Role for orexin. Physiol Behav. 2006;88:294-301.
-
(2006)
Physiol Behav.
, vol.88
, pp. 294-301
-
-
Kotz, C.M.1
-
141
-
-
0034992322
-
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
-
Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron. 2001;30:345-354.
-
(2001)
Neuron.
, vol.30
, pp. 345-354
-
-
Hara, J.1
Beuckmann, C.T.2
Nambu, T.3
Willie, J.T.4
Chemelli, R.M.5
Sinton, C.M.6
Sugiyama, F.7
Yagami, K.8
Goto, K.9
Yanagisawa, M.10
Sakurai, T.11
-
142
-
-
0037076018
-
Exercise capacity and mortality among men referred for exercise testing
-
Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
-
(2002)
N Engl J Med.
, vol.346
, pp. 793-801
-
-
Myers, J.1
Prakash, M.2
Froelicher, V.3
Do, D.4
Partington, S.5
Atwood, J.E.6
-
143
-
-
0034612262
-
Prognostic value of treadmill exercise testing in elderly persons
-
Goraya TY, Jacobsen SJ, Pellikka PA, Miller TD, Khan A, Weston SA, Gersh BJ, Roger VL. Prognostic value of treadmill exercise testing in elderly persons. Ann Intern Med. 2000;132:862-870.
-
(2000)
Ann Intern Med.
, vol.132
, pp. 862-870
-
-
Goraya, T.Y.1
Jacobsen, S.J.2
Pellikka, P.A.3
Miller, T.D.4
Khan, A.5
Weston, S.A.6
Gersh, B.J.7
Roger, V.L.8
-
144
-
-
49449085232
-
Reduced disability and mortality among aging runners: A 21-year longitudinal study
-
Chakravarty EF, Hubert HB, Lingala VB, Fries JF. Reduced disability and mortality among aging runners: A 21-year longitudinal study. Arch Intern Med. 2008;168:1638-1646.
-
(2008)
Arch Intern Med.
, vol.168
, pp. 1638-1646
-
-
Chakravarty, E.F.1
Hubert, H.B.2
Lingala, V.B.3
Fries, J.F.4
-
145
-
-
37849052672
-
Systemic and mitochondrial adaptive responses to moderate exercise in rodents
-
Boveris A, Navarro A. Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic Biol Med. 2008;44:224-229.
-
(2008)
Free Radic Biol Med.
, vol.44
, pp. 224-229
-
-
Boveris, A.1
Navarro, A.2
-
146
-
-
0027252538
-
Exercise increases average longevity of female rats despite increased food intake and no growth retardation
-
Holloszy JO. Exercise increases average longevity of female rats despite increased food intake and no growth retardation. J Gerontol. 1993;48:B97-100.
-
(1993)
J Gerontol.
, vol.48
, pp. 97-100
-
-
Holloszy, J.O.1
-
147
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
-
(1956)
J Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
148
-
-
0015870249
-
Free radical theory of aging
-
Harman D. Free radical theory of aging. Triangle. 1973;12:153-158.
-
(1973)
Triangle.
, vol.12
, pp. 153-158
-
-
Harman, D.1
-
150
-
-
0032013592
-
Aging and oxidative stress
-
Harman D. Aging and oxidative stress. J Int Fed Clin Chem. 1998;10:24-27.
-
(1998)
J Int Fed Clin Chem.
, vol.10
, pp. 24-27
-
-
Harman, D.1
-
151
-
-
0142213542
-
The free radical theory of aging
-
Harman D. The free radical theory of aging. Antioxid Redox Signal. 2003;5:557-561.
-
(2003)
Antioxid Redox Signal.
, vol.5
, pp. 557-561
-
-
Harman, D.1
-
152
-
-
71349087186
-
Origin and evolution of the free radical theory of aging: A brief personal history 1954-2
-
Harman D. Origin and evolution of the free radical theory of aging: A brief personal history, 1954-2 Biogerontology. 2009;10:773-781.
-
(2009)
Biogerontology.
, vol.10
, pp. 773-781
-
-
Harman, D.1
-
153
-
-
79959450877
-
Mitochondrial DNA mutations in disease and aging
-
Park CB, Larsson NG. Mitochondrial DNA mutations in disease and aging. J Cell Biol. 2011;193:809-818.
-
(2011)
J Cell Biol.
, vol.193
, pp. 809-818
-
-
Park, C.B.1
Larsson, N.G.2
-
154
-
-
0035028427
-
Exercise at old age: Does it increase or alleviate oxidative stress
-
Ji LL. Exercise at old age: Does it increase or alleviate oxidative stress Ann N Y Acad Sci. 2001;928:236-247.
-
(2001)
Ann N y Acad Sci.
, vol.928
, pp. 236-247
-
-
Ji, L.L.1
-
155
-
-
67649204729
-
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
-
Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation. 2009;119:2789-2797.
-
(2009)
Circulation.
, vol.119
, pp. 2789-2797
-
-
Dai, D.F.1
Santana, L.F.2
Vermulst, M.3
Tomazela, D.M.4
Emond, M.J.5
Maccoss, M.J.6
Gollahon, K.7
Martin, G.M.8
Loeb, L.A.9
Ladiges, W.C.10
Rabinovitch, P.S.11
-
156
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005;308:1909-1911.
-
(2005)
Science.
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
Van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
157
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309:481-484.
-
(2005)
Science.
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
158
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-YM, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429:417-423.
-
(2004)
Nature.
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly-Ym Gidlöf, S.7
Oldfors, A.8
Wibom, R.9
Törnell, J.10
Jacobs, H.T.11
Larsson, N.G.12
-
159
-
-
79952753140
-
Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
-
Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci USA. 2011;108:4135-4140.
-
(2011)
Proc Natl Acad Sci U.S.A.
, vol.108
, pp. 4135-4140
-
-
Safdar, A.1
Bourgeois, J.M.2
Ogborn, D.I.3
Little, J.P.4
Hettinga, B.P.5
Akhtar, M.6
Thompson, J.E.7
Melov, S.8
Mocellin, N.J.9
Kujoth, G.C.10
Prolla, T.A.11
Tarnopolsky, M.A.12
-
160
-
-
0035887745
-
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice
-
Sörensen L, Ekstrand M, Silva JP, Lindqvist E, Xu B, Rustin P, Olson L, Larsson NG. Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice. J Neurosci. 2001;21:8082-8090.
-
(2001)
J Neurosci.
, vol.21
, pp. 8082-8090
-
-
Sörensen, L.1
Ekstrand, M.2
Silva, J.P.3
Lindqvist, E.4
Xu, B.5
Rustin, P.6
Olson, L.7
Larsson, N.G.8
-
161
-
-
63849186508
-
Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue
-
Sutherland LN, Bomhof MR, Capozzi LC, Basaraba SA, Wright DC. Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue. J Physiol. 2009;587(pt 7):1607-1617.
-
(2009)
J Physiol.
, vol.587
, Issue.PART 7
, pp. 1607-1617
-
-
Sutherland, L.N.1
Bomhof, M.R.2
Capozzi, L.C.3
Basaraba, S.A.4
Wright, D.C.5
-
162
-
-
77954329816
-
The future: Genes, physical activity and health
-
Booth FW, Laye MJ. The future: Genes, physical activity and health. Acta Physiol (Oxf). 2010;199:549-556.
-
(2010)
Acta Physiol (Oxf).
, vol.199
, pp. 549-556
-
-
Booth, F.W.1
Laye, M.J.2
-
163
-
-
54849438798
-
Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation
-
Dietrich MO, Andrews ZB, Horvath TL. Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci. 2008;28:10766-10771.
-
(2008)
J Neurosci.
, vol.28
, pp. 10766-10771
-
-
Dietrich, M.O.1
Andrews, Z.B.2
Horvath, T.L.3
-
164
-
-
33749999530
-
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
-
St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006;127:397-408.
-
(2006)
Cell.
, vol.127
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jäger, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
Simon, D.K.11
Bachoo, R.12
Spiegelman, B.M.13
-
165
-
-
73949099327
-
Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
-
Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA. 2009;106:20405-20410.
-
(2009)
Proc Natl Acad Sci U.S.A.
, vol.106
, pp. 20405-20410
-
-
Wenz, T.1
Rossi, S.G.2
Rotundo, R.L.3
Spiegelman, B.M.4
Moraes, C.T.5
-
166
-
-
84860445228
-
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse
-
Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, Lincoln J, Moraes CT. Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet. 2012;21:2288-2297.
-
(2012)
Hum Mol Genet.
, vol.21
, pp. 2288-2297
-
-
Dillon, L.M.1
Williams, S.L.2
Hida, A.3
Peacock, J.D.4
Prolla, T.A.5
Lincoln, J.6
Moraes, C.T.7
-
167
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433:760-764.
-
(2005)
Nature.
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
Rando, T.A.6
-
168
-
-
84862908705
-
Rejuvenation of regeneration in the aging central nervous system
-
Ruckh JM, Zhao JW, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, Franklin RJ. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell. 2012;10:96-103.
-
(2012)
Cell Stem Cell.
, vol.10
, pp. 96-103
-
-
Ruckh, J.M.1
Zhao, J.W.2
Shadrach, J.L.3
Van Wijngaarden, P.4
Rao, T.N.5
Wagers, A.J.6
Franklin, R.J.7
-
169
-
-
34547941973
-
The common biology of cancer and ageing
-
Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing. Nature. 2007;448:767-774.
-
(2007)
Nature.
, vol.448
, pp. 767-774
-
-
Finkel, T.1
Serrano, M.2
Blasco, M.A.3
-
170
-
-
78650990326
-
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
-
Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011;469:102-106.
-
(2011)
Nature.
, vol.469
, pp. 102-106
-
-
Jaskelioff, M.1
Muller, F.L.2
Paik, J.H.3
Thomas, E.4
Jiang, S.5
Adams, A.C.6
Sahin, E.7
Kost-Alimova, M.8
Protopopov, A.9
Cadiñanos, J.10
Horner, J.W.11
Maratos-Flier, E.12
Depinho, R.A.13
-
172
-
-
0037308404
-
Association between telomere length in blood and mortality in people aged 60 years or older
-
Cawthon RM, Smith KR, OBrien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-395.
-
(2003)
Lancet.
, vol.361
, pp. 393-395
-
-
Cawthon, R.M.1
Smith, K.R.2
Obrien, E.3
Sivatchenko, A.4
Kerber, R.A.5
-
173
-
-
76549104441
-
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
-
Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci USA. 2010;107(suppl 1):1710-1717.
-
(2010)
Proc Natl Acad Sci U.S.A.
, vol.107
, Issue.SUPPL. 1
, pp. 1710-1717
-
-
Atzmon, G.1
Cho, M.2
Cawthon, R.M.3
Budagov, T.4
Katz, M.5
Yang, X.6
Siegel, G.7
Bergman, A.8
Huffman, D.M.9
Schechter, C.B.10
Wright, W.E.11
Shay, J.W.12
Barzilai, N.13
Govindaraju, D.R.14
Suh, Y.15
-
174
-
-
0037011958
-
P53 Mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Park SH, Thompson T, Karsenty G, Bradley A, Donehower LA. p53 Mutant mice that display early ageing-associated phenotypes. Nature. 2002;415:45-53.
-
(2002)
Nature.
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Park, S.H.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
175
-
-
73349128101
-
Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall
-
Werner C, Fürster T, Widmann T, Pöss J, Roggia C, Hanhoun M, Scharhag J, Büchner N, Meyer T, Kindermann W, Haendeler J, Böhm M, Laufs U. Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation. 2009;120:2438-2447.
-
(2009)
Circulation.
, vol.120
, pp. 2438-2447
-
-
Werner, C.1
Fürster, T.2
Widmann, T.3
Pöss, J.4
Roggia, C.5
Hanhoun, M.6
Scharhag, J.7
Büchner, N.8
Meyer, T.9
Kindermann, W.10
Haendeler, J.11
Böhm, M.12
Laufs, U.13
-
176
-
-
79951812916
-
Telomere dysfunction induces metabolic and mitochondrial compromise
-
Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011;470:359-365.
-
(2011)
Nature.
, vol.470
, pp. 359-365
-
-
Sahin, E.1
Colla, S.2
Liesa, M.3
Moslehi, J.4
Müller, F.L.5
Guo, M.6
Cooper, M.7
Kotton, D.8
Fabian, A.J.9
Walkey, C.10
Maser, R.S.11
Tonon, G.12
Foerster, F.13
Xiong, R.14
Wang, Y.A.15
Shukla, S.A.16
Jaskelioff, M.17
Martin, E.S.18
Heffernan, T.P.19
Protopopov, A.20
Ivanova, E.21
Mahoney, J.E.22
Kost-Alimova, M.23
Perry, S.R.24
Bronson, R.25
Liao, R.26
Mulligan, R.27
Shirihai, O.S.28
Chin, L.29
Depinho, R.A.30
more..
-
177
-
-
48449094498
-
AMPK and PPARdelta agonists are exercise mimetics
-
Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008;134:405-415.
-
(2008)
Cell.
, vol.134
, pp. 405-415
-
-
Narkar, V.A.1
Downes, M.2
Yu, R.T.3
Embler, E.4
Wang, Y.X.5
Banayo, E.6
Mihaylova, M.M.7
Nelson, M.C.8
Zou, Y.9
Juguilon, H.10
Kang, H.11
Shaw, R.J.12
Evans, R.M.13
-
178
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109-1122.
-
(2006)
Cell.
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
179
-
-
34147109662
-
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
-
Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev. 2007;21:770-783.
-
(2007)
Genes Dev.
, vol.21
, pp. 770-783
-
-
Handschin, C.1
Kobayashi, Y.M.2
Chin, S.3
Seale, P.4
Campbell, K.P.5
Spiegelman, B.M.6
|