FGF21 is an Akt-regulated myokine

FEBS Letters

Volumn 582, Issue 27, 2008, Pages 3805-3810

  Izumiya, Yasuhiro ^a   Bina, Holly A ^b   Ouchi, Noriyuki ^a   Akasaki, Yuichi ^a   Kharitonenkov, Alexei ^b   Walsh, Kenneth ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Akt; FGF21; Metabolism; Transcript; Transgenic mice

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FIBROBLAST GROWTH FACTOR 21; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; LIVER; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; SKELETAL MUSCLE; TRANSGENE; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; CHROMONES; FIBROBLAST GROWTH FACTORS; INSULIN; LIVER; MICE; MICE, TRANSGENIC; MORPHOLINES; MUSCLE, SKELETAL; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UP-REGULATION;

MUS; MUS MUSCULUS;

EID: 54849438574     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.10.021     Document Type: Article

References (32)

1. Nishimura T., Nakatake Y., Konishi M., and Itoh N. Identification of a novel FGF, FGF21, preferentially expressed in the liver. Biochim. Biophys. Acta 1492 (2000) 203-206
2. Kharitonenkov A., et al. FGF21 as a novel metabolic regulator. J. Clin. Invest. 115 (2005) 1627-1635
3. Arner P., Pettersson A., Mitchell P.J., Dunbar J.D., Kharitonenkov A., and Ryden M. FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. FEBS Lett. 582 (2008) 1725-1730
4. Kharitonenkov A., et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 148 (2007) 774-781
5. Coskun, T., Bina, H.A., Schneider, M.A., Dunbar, J.D., Hu, C.C., Chen, Y., Moller, D.E. and Kharitonenkov, A. (2008) FGF21 corrects obesity in mice. Endocrinology [Epub ahead of print].
6. Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J.S., and Maratos-Flier E. Hepatic fibroblast growth factor-21 is regulated by PPAR alpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5 (2007) 426-437
7. Inagaki T., et al. Endocrine regulation of the fasting response by PPAR alpha-mediated induction of fibroblast growth factor-21. Cell Metab. 5 (2007) 415-425
8. Lundasen T., Hunt M.C., Nilsson L.M., Sanyal S., Angelin B., Alexson S.E., and Rudling M. PPAR alpha is a key regulator of hepatic FGF21. Biochem. Biophys. Res. Commun. 360 (2007) 437-440
9. Wang H., Qiang L., and Farmer S.R. Identification of a domain within PPAR gamma regulating expression of a group of genes containing FGF21 that are selectively repressed by SIRT1 in adipocytes. Mol. Cell Biol. (2007)
10. Muise E.S., et al. Adipose fibroblast growth factor-21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Mol. Pharmacol. 74 (2008) 403-412
11. Moyers J.S., Shiyanova T.L., Mehrbod F., Dunbar J.D., Noblitt T.W., Otto K.A., Reifel-Miller A., and Kharitonenkov A. Molecular determinants of FGF21 activity-synergy and cross-talk with PPAR gamma signaling. J. Cell Physiol. 210 (2007) 1-6
12. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: a play in three Akts. Gene Dev. 13 (1999) 2905-2927
13. Shiojima I., and Walsh K. Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Gene Dev. 20 (2006) 3347-3365
14. Bodine S.C., et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3 (2001) 1014-1019
15. Lai K.M., et al. Conditional activation of Akt in adult skeletal muscle induces rapid hypertrophy. Mol. Cell Biol. 24 (2004) 9295-9304
16. Takahashi A., et al. Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth. Mol. Cell Biol. 22 (2002) 4803-4814
17. Izumiya Y., et al. Fast/glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 7 (2008) 159-172
18. Pedersen B.K., Akerstrom T.C., Nielsen A.R., and Fischer C.P. Role of myokines in exercise and metabolism. J. Appl. Physiol. 103 (2007) 1093-1098
19. Arany Z., et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1 alpha. Nature 451 (2008) 1008-1012
20. Pedersen B.K., and Febbraio M. Muscle-derived interleukin-6 - a possible link between skeletal muscle, adipose tissue, liver, and brain. Brain Behav. Immun. 19 (2005) 371-376
21. Krzysik-Walker S.M., Ocon-Grove O.M., Maddineni S.R., Hendricks III G.L., and Ramachandran R. Is visfatin an adipokine or myokine? Evidence for greater visfatin expression in skeletal muscle than visceral fat in chickens. Endocrinology 149 (2008) 1543-1550
22. Grill M.A., Bales M.A., Fought A.N., Rosburg K.C., Munger S.J., and Antin P.B. Tetracycline-inducible system for regulation of skeletal muscle-specific gene expression in transgenic mice. Transgenic Res. 12 (2003) 33-43
23. Shiojima I., Sato K., Izumiya Y., Schiekofer S., Ito M., Liao R., Colucci W.S., and Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115 (2005) 2108-2118
24. Ouchi N., Shibata R., and Walsh K. AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ. Res. 96 (2005) 838-846
25. Schiekofer S., Shiojima I., Sato K., Galasso G., Oshima Y., and Walsh K. Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol. Genomics 27 (2006) 156-170
26. Galman C., et al. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPAR alpha activation in man. Cell Metab. 8 (2008) 169-174
27. Shield M.A., Haugen H.S., Clegg C.H., and Hauschka S.D. E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice. Mol. Cell Biol. 16 (1996) 5058-5068
28. Kharitonenkov A., and Shanafelt A.B. Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases. BioDrugs 22 (2008) 37-44
29. Wente W., et al. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 55 (2006) 2470-2478
30. Atherton P.J., Babraj J., Smith K., Singh J., Rennie M.J., and Wackerhage H. Selective activation of AMPK-PGC-1 alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. Faseb J. 19 (2005) 786-788
31. Nader G.A., and Esser K.A. Intracellular signaling specificity in skeletal muscle in response to different modes of exercise. J. Appl. Physiol. 90 (2001) 1936-1942
32. Bolster D.R., Kubica N., Crozier S.J., Williamson D.L., Farrell P.A., Kimball S.R., and Jefferson L.S. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J. Physiol. 553 (2003) 213-220