Quantitative trait loci for physical activity traits in mice

Physiological Genomics

Volumn 32, Issue 3, 2008, Pages 401-408

  Lightfoot, J Timothy ^a   Turner, Michael J ^a   Pomp, Daniel ^b   Kleeberger, Steven R ^c   Leamy, Larry J ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b IL   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Genetics; Linkage mapping; Locomotion

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME 7; CHROMOSOME 9; COHORT ANALYSIS; CONTROLLED STUDY; EXERCISE; FEMALE; GENETIC EPISTASIS; GENOTYPE; HAPLOTYPE MAP; INBRED STRAIN; MALE; MOUSE; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RUNNING; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VELOCITY;

ANIMALS; CROSSES, GENETIC; EPISTASIS, GENETIC; FEMALE; GENOTYPE; MALE; MICE; MICE, INBRED C3H; MICE, INBRED STRAINS; MOTOR ACTIVITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RUNNING; SEX FACTORS; SPECIES SPECIFICITY; TIME FACTORS;

ANIMALIA; MUS;

EID: 40149096547     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00241.2007     Document Type: Article

References (39)

1. Beavis WD. The power and deceit of QTL experiments: lessons from comparative QTL studies. Corn and Sorghum Research Conference. Washington, DC: American Seed Trace Association, 1994, p. 252-268.
2. Bogue MA. Mouse Phenome Project: understanding human biology through mouse genetics and genomics. J Appl Physiol 95: 1335-1337, 2003.
3. Chakravarthy M, Booth F. Eating, exercise, and "thrift" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. J Appl Physiol 96: 3-10, 2004.
4. Cheverud J. A simple correction for multiple comparisons in interval mapping genome scans. Heredity 87: 52-58, 2001.
5. Conti LH, Jirout M, Breen L, Vanella JJ, Schork NJ, Printz MP. Identification of quantitative trait loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. Behav Genet 34: 93-103, 2004.
6. Eppig J, Bult C, Kadin J, Richardson J, Blake J, members of the Mouse Genome Database Group. The Mouse Genome Database (MGD): from genes to mice - a community resource for mouse biology. Nucleic Acids Res 33: D471-D475, 2005.
7. Festing MFW. Notes on genetic analysis. In: Inbred Strains in Biomedical Research. New York: Oxford Univ. Press, 1979, p. 80-98.
8. Gershenfeld HK, Neumann PE, Mathis C, Crawley JN, Li Z, Paul SM. Mapping quantitative trait loci for open-field behavior in mice. Behav Genet 27: 201-210, 1997.
9. Goodman S. Multiple comparisons, explained. Am J Epidemiol 147: 807-812, 1998.
10. Haley CS, Knott SA. A simple regression technique for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315-324, 1992.
11. Kenney-Hunt J, Vaughn T, Pletscher L, Peripato A, Routman E, Cothran K, Durand D, Norgard E, Perel C, Cheverud J. Quantitative trait loci for body size components in mice. Mamm Genome 17: 526-537, 2006.
12. Koteja P, Swallow JG, Carter PA, Garland T Jr. Energy cost of wheel running in house mice: implications for coadaptation of locomotion and energy budgets. Physiol Biochem Zool 72: 238-249, 1999.
13. Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199, 1989.
14. Leamy LJ, Pomp D, Eisen EJ, Cheverud JM. Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice. Physiol Genomics 10: 21-29, 2002.
15. Leamy LJ, Routman EJ, Cheverud JM. Quantitative trait loci for early- and late-developing skull characters in mice. Am Naturalist 153: 201-214, 1999.
16. Lerman I, Harrison BC, Freeman K, Hewett TE, Allen DL, Robbins J, Leinwand LA. Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol 92: 2245-2255, 2002.
17. Li JS, Huang YC. Early androgen treatment influences the pattern and amount of locomotion activity differently and sexually differentially in an animal model of ADHD. Behav Brain Res 175: 176-182, 2006.
18. Li X, Quigg RJ, Zhou J, Xu S, Masinde G, Mohan S, Baylink DJ. A critical evaluation of the effect of population size and phenotypic measurement on QTL detection and localization using a large F2 murine mapping population. Genet Mol Biol 29: 166-173, 2006.
19. Lightfoot JT, Turner MJ, Daves M, Vordermark A, Kleeberger SR. Genetic influence on daily wheel running activity level. Physiol Genomics 19: 270-276, 2004.
20. Lightfoot JT, Turner MJ, DeBate KA, Kleeberger SR. Interstrain variation in murine aerobic capacity. Med Sci Sports Exerc 33: 2053-2057, 2001.
21. Lightfoot JT, Turner MJ, Knab AK, Jedlicka AE, Oshimura T, Marzec JM, Gladwell W, Leamy L, Kleeberger S. Quantitative trait loci associated with maximal exercise endurance in mice. J Appl Physiol 103: 105-110, 2007.
22. Lynch M, Walsh B. Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer, 1998.
23. Mill J, Galsworthy M, Paya-Cano J, Sluyter F, Schalkwyk L, Plomin R, Asherson P. Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes Brain Behav 1: 166-173, 2002.
24. Morgan M, Schulkin J, Pfaff D. Estrogens and non-reproductive behaviors related to activity and fear. Neurosci Biobehav Rev 28: 55-63, 2004.
25. Phillips TJ, Huson MG, McKinnon CS. Localization of genes mediating acute and sensitized locomotor responses to cocaine in BSD/Ty recombinant inbred mice. J Neurosci 18: 3023-3034, 1998.
26. Rhodes JS, Garland T Jr. Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology (Berl) 167: 242-250, 2003.
27. Rhodes JS, Hosack G, Girard I, Kelley A, Mitchell G, Garland T Jr. Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology (Berl) 158: 120-131, 2001.
28. Roberts C, Barnard R. Effects of exercise and diet on chronic disease. J Appl Physiol 98: 3-30, 2005.
29. Seburn K. Mouse Phenome Database: metabolic characterization. Jackson Laboratory, 2001.
30. Servin B, Stephens M. Efficient multipoint analysis of association studies: candidate regions and quantitative traits. PLOS Genet 3: e114, 2007.
31. Stubbe JH, Boomsma DI, De Geus EJC. Sports participation during adolescence: a shift from environmental to genetic factors. Med Sci Sports Exerc 37: 563-570, 2005.
32. Swallow JG, Carter PA, Garland T Jr. Artificial selection for increased wheel-running behavior in house mice. Behav Genet 28: 227-237, 1998.
33. Toth LA, Williams RW. A quantitative genetic analysis of locomotor activity in CXB recombinant inbred mice. Behav Genet 29: 319-328, 1999.
34. Tsao TS, Li J, Change KS, Stenbit AE, Galuska D, Anderson JE, Zierath JR, McCarter RJ, Charron MJ. Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity. FASEB J 15: 958-969, 2001.
35. Turner MJ, Kleeberger SR, Lightfoot JT. Influence of genetic background on daily running-wheel activity differs with aging. Physiol Genomics 19: 270-276, 2005.
36. Wellcome Trust Centre for Human Genetics. Wellcome-CTC Mouse Strain SNP Genotype Set, 2005.
37. Wolf J, Pomp D, Eisen E, Leamy L. The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice. Evol Dev 8: 468-476, 2006.
38. Yang H, Bell TA, Churchill GA, Pardo-Manual de Villena F. On the subspecific origin of the laboratory mouse. Nat Genet 39: 1100-1107, 2007.
39. Yi N, Yandell B, Churchill GA, Allison D, Eisen E, Pomp D. Bayesian model selection for genome-wide epistatic quantitative trait loci analysis. Genetics 170: 1333-1344, 2005.