Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua

Science

Volumn 334, Issue 6056, 2011, Pages 690-693

  Fryer, John D ^a,e   Yu, Peng ^a   Kang, Hyojin ^a   Mandel Brehm, Caleigh ^a   Carter, Angela N ^a   Crespo Barreto, Juan ^a,f   Gao, Yan ^a   Flora, Adriano ^a   Shaw, Chad ^a   Orr, Harry T ^b   Zoghbi, Huda Y ^a,c,d  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e MAYO CLINIC   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; EPIDERMAL GROWTH FACTOR;

DISEASE PREVALENCE; GENETIC ANALYSIS; NUMERICAL MODEL; PHENOTYPE; RODENT; SURVIVAL; TOXICITY;

ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CAPICUA GENE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; EXERCISE; GAIN OF FUNCTION MUTATION; GENE; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPRESSOR GENE; SURVIVAL; UPREGULATION;

MUS;

EID: 80555125089     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1212673     Document Type: Article

References (15)

1. H. T. Orr et al., Nat. Genet. 4, 221 (1993).
2. H. Y. Zoghbi, H. T. Orr, J. Biol. Chem. 284, 7425 (2009).
3. C. W. Cotman, N. C. Berchtold, L.-A. Christie, Trends Neurosci. 30, 464 (2007).
4. A. Chiò, G. Benzi, M. Dossena, R. Mutani, G. Mora, Brain 128, 472 (2005).
5. D. J. Mahoney, C. Rodriguez, M. Devries, N. Yasuda, M. A. Tarnopolsky, Muscle Nerve 29, 656 (2004).
6. K. Watase et al., Neuron 34, 905 (2002).
7. S. Astigarraga et al., EMBO J. 26, 668 (2007).
8. Y. C. Lam et al., Cell 127, 1335 (2006).
9. J. Crespo-Barreto, J. D. Fryer, C. A. Shaw, H. T. Orr, H. Y. Zoghbi, PLoS Genet. 6, e1001021 (2010).
10. M. Kawamura-Saito et al., Hum. Mol. Genet. 15, 2125 (2006).
11. J. Lim et al., Nature 452, 713 (2008).
12. P. S. Thomas Jr. et al., Hum. Mol. Genet. 15, 2225 (2006).
13. J. M. Van Raamsdonk et al., Hum. Mol. Genet. 14, 1379 (2005).
14. D. V. Vaz et al., Clin. Rehabil. 22, 234 (2008).
15. W. Ilg et al., Neurology 73, 1823 (2009).