Marathon rat: Myocardial remodeling in an animal model of vigorous endurance exercise and implications for humans

Circulation

Volumn 123, Issue 1, 2011, Pages 5-7

  Volders, Paul G A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

arrhythmia; Editorials; exercise; myocardial fibrosis; remodeling

Indexed keywords

ENDURANCE SPORT; EXERCISE; HEART LEFT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE; HEART VENTRICLE REMODELING; HUMAN; MARATHON RUNNER; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; EXERCISE; HUMANS; MODELS, ANIMAL; MYOCARDIUM; PHYSICAL ENDURANCE; RATS; VENTRICULAR REMODELING;

EID: 78751625426     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.000174     Document Type: Review

References (20)

1. Pluim BM, Zwinderman AH, van der Laarse A, van der Wall EE. The athlete's heart: a meta-analysis of cardiac structure and function. Circulation. 2000;101:336-344.
2. Pelliccia A, Kinoshita N, Pisicchio C, Quattrini F, DiPaolo FM, Ciardo R, Di Giacinto B, Guerra E, De Blasiis E, Casasco M, Culasso F, Maron BJ. Long-term clinical consequences of intense, uninterrupted endurance training in Olympic athletes. J Am Coll Cardiol. 2010;55:1619-1625.
3. La Gerche A, Prior DL, Heidbüchel H. Clinical consequences of intense endurance exercise must include assessment of the right ventricle [comment]. J Am Coll Cardiol. 2010;56:1263.
4. La Gerche A, Connelly KA, Mooney DJ, MacIsaac AI, Prior DL. Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise. Heart. 2008;94:860-866.
5. Teske AJ, Prakken NH, De Boeck BW, Velthuis BK, Martens EP, Doevendans PA, Cramer MJ. Echocardiographic tissue deformation imaging of right ventricular systolic function in endurance athletes. Eur Heart J. 2009;30:969-977.
6. Hauser AM, Dressendorfer RH, Vos M, Hashimoto T, Gordon S, Timmis GC. Symmetric cardiac enlargement in highly trained endurance athletes: a two-dimensional echocardiographic study. Am Heart J. 1985;109: 1038-1044.
7. Teske AJ, Prakken NH, De Boeck BWL, Velthuis BK, Doevendans PA, Cramer MJM. Effect of long term and intensive endurance training in athletes on the age related decline in left and right ventricular diastolic function as assessed by Doppler echocardiography. Am J Cardiol. 2009; 104:1145-1151.
8. Ector J, Ganame J, van der Merwe N, Adriaenssens B, Pison L, Willems R, Gewillig M, Heidbüchel H. Reduced right ventricular ejection fraction in endurance athletes presenting with ventricular arrhythmias: a quantitative angiographic assessment. Eur Heart J. 2007;28:345-353.
9. La Gerche A, Robberecht C, Kuiperi C, Nuyens D, Willems R, de Ravel T, Matthijs G, Heidbüchel H. Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. Heart. 2010;96:1268-1274.
10. Mont L, Sambola A, Brugada J, Vacca M, Marrugat J, Elosua R, Pare C, Azqueta M, Sanz G. Long-lasting sport practice and lone atrial fibrillation. Eur Heart J. 2002;23:477-482. (Pubitemid 35204187)
11. Aizer A, Gaziano JM, Cook NR, Manson JE, Buring JE, Albert CM. Relation of vigorous exercise to risk of atrial fibrillation. Am J Cardiol. 2009;103:1572-1577.
12. Maron BJ. Sudden death in young athletes. N Engl J Med. 2003;349: 1064-1075.
13. Whyte G, Sheppard M, George K, Shave R, Wilson M, Prasad S, O'Hanlon R, Sharma S. Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause? Br J Sports Med. 2008;42:304-305.
14. Cocker MS, Strohm O, Smith DJ, Butler C, Belenkie I, Meeuwisse W, Friedrich MG. Increased incidence of myocardial fibrosis with reduced cardiac function in elite high-endurance athletes: a cardiovascular magnetic resonance (CMR) study [abstract]. Circulation. 2008;118: S-840.
15. Benito B, Gay-Jordi G, Serrano-Molar A, Guasch E, Shi Y, Tardif J-C, Brugada J, Nattel S, Mont L. Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation. 2011;123: 13-22.
16. O'Neill BT, Abel ED. Akt1 in the cardiovascular system: friend or foe? J Clin Invest. 2005;115:2059-2064.
17. Xu X, Wan W, Ji L, Lao S, Powers AS, Zhao W, Erikson JM, Zhang JQ. Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Cardiovasc Res. 2008;78: 523-532.
18. Wiegerinck RF, Verkerk AO, Belterman CN, van Veen TAB, Baartscheer A, Opthof T, Wilders R, de Bakker JMT, Coronel R. Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration. Circulation. 2006;113:806-813.
19. + current in electrical remodelling induced by voluntary exercise in female rat hearts. Basic Res Cardiol. 2009;104:643-652.
20. Biffi A, Maron BJ, Verdile L, Fernando F, Spataro A, Marcello G, Ciardo R, Ammirati F, Colivicchi F, Pelliccia A. Impact of physical decondi-tioning on ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol. 2004;44:1053-1058.