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Volumn 4, Issue 1, 2014, Pages 4-18

The application of RNAi-based treatments for inflammatory bowel disease

Author keywords

Clinical translation; Crohn's disease; Inflammatory bowel disease; RNAi; siRNA; Ulcerative colitis

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; IMMUNOSUPPRESSIVE AGENT; SMALL INTERFERING RNA;

EID: 84893610897     PISSN: 2190393X     EISSN: 21903948     Source Type: Journal    
DOI: 10.1007/s13346-013-0156-9     Document Type: Review
Times cited : (13)

References (160)
  • 1
    • 79958049764 scopus 로고    scopus 로고
    • Necessity of phenotypic classification of inflammatory bowel disease
    • doi:10.1016/s1521-6918(11)70003-8
    • Louis E, van Kemseke C, Reenaers C. Necessity of phenotypic classification of inflammatory bowel disease. Best Pract Res Clin Gastroenterol. 2011;25 Suppl 1: S2-7. doi: 10. 1016/s1521-6918(11)70003-8.
    • (2011) Best Pract Res Clin Gastroenterol , vol.25 , Issue.SUPPL. 1
    • Louis, E.1    van Kemseke, C.2    Reenaers, C.3
  • 2
    • 84862294952 scopus 로고    scopus 로고
    • Classification of inflammatory bowel disease: the old and the new
    • doi:10.1097/MOG.0b013e328354be1e
    • Vermeire S, van Assche G, Rutgeerts P. Classification of inflammatory bowel disease: the old and the new. Curr Opin Gastroenterol. 2012;28(4): 321-6. doi: 10. 1097/MOG. 0b013e328354be1e.
    • (2012) Curr Opin Gastroenterol , vol.28 , Issue.4 , pp. 321-326
    • Vermeire, S.1    van Assche, G.2    Rutgeerts, P.3
  • 3
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • doi:10.1038/nri1132
    • Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3(7): 521-33. doi: 10. 1038/nri1132.
    • (2003) Nat Rev Immunol , vol.3 , Issue.7 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 4
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • doi:10.1056/NEJMra020831
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002;347(6): 417-29. doi: 10. 1056/NEJMra020831.
    • (2002) N Engl J Med , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 5
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • doi:10.1172/jci30587
    • Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Investig. 2007;117(3): 514-21. doi: 10. 1172/jci30587.
    • (2007) J Clin Investig , vol.117 , Issue.3 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 6
    • 84862644846 scopus 로고    scopus 로고
    • Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa
    • doi:10.1016/j.jconrel.2012.01.028
    • Collnot EM, Ali H, Lehr CM. Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa. J Control Release. 2012;161(2): 235-46. doi: 10. 1016/j. jconrel. 2012. 01. 028.
    • (2012) J Control Release , vol.161 , Issue.2 , pp. 235-246
    • Collnot, E.M.1    Ali, H.2    Lehr, C.M.3
  • 7
    • 84871255034 scopus 로고    scopus 로고
    • Diagnosis and therapeutic management of extra-intestinal manifestations of inflammatory bowel disease
    • doi:10.2165/11638120-000000000-00000
    • Trikudanathan G, Venkatesh PG, Navaneethan U. Diagnosis and therapeutic management of extra-intestinal manifestations of inflammatory bowel disease. Drugs. 2012;72(18): 2333-49. doi: 10. 2165/11638120-000000000-00000.
    • (2012) Drugs , vol.72 , Issue.18 , pp. 2333-2349
    • Trikudanathan, G.1    Venkatesh, P.G.2    Navaneethan, U.3
  • 8
    • 79955561083 scopus 로고    scopus 로고
    • Epidemiology and natural history of inflammatory bowel diseases
    • doi:10.1053/j.gastro.2011.01.055
    • Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140(6): 1785-94. doi: 10. 1053/j. gastro. 2011. 01. 055.
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1785-1794
    • Cosnes, J.1    Gower-Rousseau, C.2    Seksik, P.3    Cortot, A.4
  • 9
    • 80051507729 scopus 로고    scopus 로고
    • From intestinal stem cells to inflammatory bowel diseases
    • doi:10.3748/wjg.v17.i27.3198
    • Gersemann M, Stange EF, Wehkamp J. From intestinal stem cells to inflammatory bowel diseases. World J Gastroenterol. 2011;17(27): 3198-203. doi: 10. 3748/wjg. v17. i27. 3198.
    • (2011) World J Gastroenterol , vol.17 , Issue.27 , pp. 3198-3203
    • Gersemann, M.1    Stange, E.F.2    Wehkamp, J.3
  • 10
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • doi:10.1038/nature10209
    • Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474(7351): 307-17. doi: 10. 1038/nature10209.
    • (2011) Nature , vol.474 , Issue.7351 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 11
    • 0027441514 scopus 로고
    • Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology. 1993;78(1): 127-31.
    • (1993) Immunology , vol.78 , Issue.1 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3    Walker-Smith, J.A.4    MacDonald, T.T.5
  • 12
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol (Baltimore, Md: 1950). 1996;157(3): 1261-70.
    • (1996) J Immunol (Baltimore, Md: 1950) , vol.157 , Issue.3 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    de la Motte, C.5    Strong, S.A.6
  • 13
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
    • Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol. 1997;150(3): 823-32.
    • (1997) Am J Pathol , vol.150 , Issue.3 , pp. 823-832
    • Parronchi, P.1    Romagnani, P.2    Annunziato, F.3    Sampognaro, S.4    Becchio, A.5    Giannarini, L.6
  • 14
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52(1): 65-70.
    • (2003) Gut , vol.52 , Issue.1 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3    Ogawa, A.4    Hata, K.5    Araki, Y.6
  • 15
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss IJ, Becker C, Yang Z, Groden C, Hornung RL, Heller F, et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis. 2006;12(1): 9-15.
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.1 , pp. 9-15
    • Fuss, I.J.1    Becker, C.2    Yang, Z.3    Groden, C.4    Hornung, R.L.5    Heller, F.6
  • 16
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • doi:10.1053/j.gastro.2011.02.016
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6): 1756-67. doi: 10. 1053/j. gastro. 2011. 02. 016.
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 17
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • doi:10.1172/jci19836
    • Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Investig. 2004;113(10): 1490-7. doi: 10. 1172/jci19836.
    • (2004) J Clin Investig , vol.113 , Issue.10 , pp. 1490-1497
    • Fuss, I.J.1    Heller, F.2    Boirivant, M.3    Leon, F.4    Yoshida, M.5    Fichtner-Feigl, S.6
  • 18
    • 0025145696 scopus 로고
    • A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease
    • Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol. 1990;86(2): 202-10.
    • (1990) J Allergy Clin Immunol , vol.86 , Issue.2 , pp. 202-210
    • Saxon, A.1    Shanahan, F.2    Landers, C.3    Ganz, T.4    Targan, S.5
  • 19
    • 0027222889 scopus 로고
    • Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis
    • Das KM, Dasgupta A, Mandal A, Geng X. Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis. J Immunol (Baltimore, Md: 1950). 1993;150(6): 2487-93.
    • (1993) J Immunol (Baltimore, Md: 1950) , vol.150 , Issue.6 , pp. 2487-2493
    • Das, K.M.1    Dasgupta, A.2    Mandal, A.3    Geng, X.4
  • 20
    • 0036270399 scopus 로고    scopus 로고
    • Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins
    • Wehkamp J, Schwind B, Herrlinger KR, Baxmann S, Schmidt K, Duchrow M, et al. Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins. Dig Dis Sci. 2002;47(6): 1349-55.
    • (2002) Dig Dis Sci , vol.47 , Issue.6 , pp. 1349-1355
    • Wehkamp, J.1    Schwind, B.2    Herrlinger, K.R.3    Baxmann, S.4    Schmidt, K.5    Duchrow, M.6
  • 21
    • 77957236209 scopus 로고    scopus 로고
    • The immune system and the gut microbiota: friends or foes?
    • doi:10.1038/nri2850
    • Cerf-Bensussan N, Gaboriau-Routhiau V. The immune system and the gut microbiota: friends or foes? Nat Rev Immunol. 2010;10(10): 735-44. doi: 10. 1038/nri2850.
    • (2010) Nat Rev Immunol , vol.10 , Issue.10 , pp. 735-744
    • Cerf-Bensussan, N.1    Gaboriau-Routhiau, V.2
  • 22
    • 2942625916 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease with antibiotics
    • doi:10.1016/j.gtc.2004.02.006
    • Isaacs KL, Sartor RB. Treatment of inflammatory bowel disease with antibiotics. Gastroenterol Clin N Am. 2004;33(2): 335-45. doi: 10. 1016/j. gtc. 2004. 02. 006.
    • (2004) Gastroenterol Clin N Am , vol.33 , Issue.2 , pp. 335-345
    • Isaacs, K.L.1    Sartor, R.B.2
  • 23
    • 80054021388 scopus 로고    scopus 로고
    • Current and emerging drugs for the treatment of inflammatory bowel disease
    • doi:10.2147/DDDT.S11290
    • Triantafillidis JK, Merikas E, Georgopoulos F. Current and emerging drugs for the treatment of inflammatory bowel disease. Drug Des Devel Ther. 2011;5: 185-210. doi: 10. 2147/DDDT. S11290.
    • (2011) Drug Des Devel Ther , vol.5 , pp. 185-210
    • Triantafillidis, J.K.1    Merikas, E.2    Georgopoulos, F.3
  • 24
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • doi:10.1136/gut.2005.073817
    • Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut. 2006;55(2): 205-11. doi: 10. 1136/gut. 2005. 073817.
    • (2006) Gut , vol.55 , Issue.2 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3    Gloux, K.4    Pelletier, E.5    Frangeul, L.6
  • 25
    • 79959961092 scopus 로고    scopus 로고
    • Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis
    • doi:10.1053/j.gastro.2011.04.011
    • Lepage P, Hasler R, Spehlmann ME, Rehman A, Zvirbliene A, Begun A, et al. Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 2011;141(1): 227-36. doi: 10. 1053/j. gastro. 2011. 04. 011.
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 227-236
    • Lepage, P.1    Hasler, R.2    Spehlmann, M.E.3    Rehman, A.4    Zvirbliene, A.5    Begun, A.6
  • 26
    • 84867173210 scopus 로고    scopus 로고
    • Antibiotic exposure and IBD development among children: a population-based cohort study
    • doi:10.1542/peds.2011-3886
    • Kronman MP, Zaoutis TE, Haynes K, Feng R, Coffin SE. Antibiotic exposure and IBD development among children: a population-based cohort study. Pediatrics. 2012;130(4): e794-803. doi: 10. 1542/peds. 2011-3886.
    • (2012) Pediatrics , vol.130 , Issue.4
    • Kronman, M.P.1    Zaoutis, T.E.2    Haynes, K.3    Feng, R.4    Coffin, S.E.5
  • 27
    • 33645104228 scopus 로고    scopus 로고
    • Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression
    • doi:10.1016/j.bbrc.2006.02.080
    • Sougioultzis S, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S, et al. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006;343(1): 69-76. doi: 10. 1016/j. bbrc. 2006. 02. 080.
    • (2006) Biochem Biophys Res Commun , vol.343 , Issue.1 , pp. 69-76
    • Sougioultzis, S.1    Simeonidis, S.2    Bhaskar, K.R.3    Chen, X.4    Anton, P.M.5    Keates, S.6
  • 28
    • 59449084229 scopus 로고    scopus 로고
    • The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis
    • doi:10.1007/s10620-008-0357-0
    • Lee SK, Kim YW, Chi SG, Joo YS, Kim HJ. The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis. Dig Dis Sci. 2009;54(2): 255-63. doi: 10. 1007/s10620-008-0357-0.
    • (2009) Dig Dis Sci , vol.54 , Issue.2 , pp. 255-263
    • Lee, S.K.1    Kim, Y.W.2    Chi, S.G.3    Joo, Y.S.4    Kim, H.J.5
  • 29
    • 79955787820 scopus 로고    scopus 로고
    • Current immunosuppressive treatment after kidney transplantation
    • doi:10.1517/14656566.2011.552428
    • Kho M, Cransberg K, Weimar W, van Gelder T. Current immunosuppressive treatment after kidney transplantation. Expert Opin Pharmacother. 2011;12(8): 1217-31. doi: 10. 1517/14656566. 2011. 552428.
    • (2011) Expert Opin Pharmacother , vol.12 , Issue.8 , pp. 1217-1231
    • Kho, M.1    Cransberg, K.2    Weimar, W.3    van Gelder, T.4
  • 31
    • 77749343043 scopus 로고    scopus 로고
    • Gastrointestinal and liver adverse effects of drugs used for treating IBD
    • doi:10.1016/j.bpg.2009.10.011
    • Rogler G. Gastrointestinal and liver adverse effects of drugs used for treating IBD. Best Pract Res Clin Gastroenterol. 2010;24(2): 157-65. doi: 10. 1016/j. bpg. 2009. 10. 011.
    • (2010) Best Pract Res Clin Gastroenterol , vol.24 , Issue.2 , pp. 157-165
    • Rogler, G.1
  • 32
    • 0024457688 scopus 로고
    • 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity
    • Present DH, Meltzer SJ, Krumholz MP, Wolke A, Korelitz BI. 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann Intern Med. 1989;111(8): 641-9.
    • (1989) Ann Intern Med , vol.111 , Issue.8 , pp. 641-649
    • Present, D.H.1    Meltzer, S.J.2    Krumholz, M.P.3    Wolke, A.4    Korelitz, B.I.5
  • 33
    • 33847707327 scopus 로고    scopus 로고
    • Drug insight: aminosalicylates for the treatment of IBD
    • doi:10.1038/ncpgasthep0696
    • Nielsen OH, Munck LK. Drug insight: aminosalicylates for the treatment of IBD. Nat Clin Pract Gastroenterol Hepatol. 2007;4(3): 160-70. doi: 10. 1038/ncpgasthep0696.
    • (2007) Nat Clin Pract Gastroenterol Hepatol , vol.4 , Issue.3 , pp. 160-170
    • Nielsen, O.H.1    Munck, L.K.2
  • 34
    • 0019458713 scopus 로고
    • Inhibition of leucocyte motility by drugs used in ulcerative colitis
    • Rhodes JM, Bartholomew TC, Jewell DP. Inhibition of leucocyte motility by drugs used in ulcerative colitis. Gut. 1981;22(8): 642-7.
    • (1981) Gut , vol.22 , Issue.8 , pp. 642-647
    • Rhodes, J.M.1    Bartholomew, T.C.2    Jewell, D.P.3
  • 35
    • 0028985095 scopus 로고
    • 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells
    • Stevens C, Lipman M, Fabry S, Moscovitch-Lopatin M, Almawi W, Keresztes S, et al. 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells. J Pharmacol Exp Ther. 1995;272(1): 399-406.
    • (1995) J Pharmacol Exp Ther , vol.272 , Issue.1 , pp. 399-406
    • Stevens, C.1    Lipman, M.2    Fabry, S.3    Moscovitch-Lopatin, M.4    Almawi, W.5    Keresztes, S.6
  • 36
    • 0026081338 scopus 로고
    • 5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease
    • Mahida YR, Lamming CE, Gallagher A, Hawthorne AB, Hawkey CJ. 5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease. Gut. 1991;32(1): 50-4.
    • (1991) Gut , vol.32 , Issue.1 , pp. 50-54
    • Mahida, Y.R.1    Lamming, C.E.2    Gallagher, A.3    Hawthorne, A.B.4    Hawkey, C.J.5
  • 37
    • 0033047588 scopus 로고    scopus 로고
    • Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes
    • Kaiser GC, Yan F, Polk DB. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology. 1999;116(3): 602-9.
    • (1999) Gastroenterology , vol.116 , Issue.3 , pp. 602-609
    • Kaiser, G.C.1    Yan, F.2    Polk, D.B.3
  • 38
    • 20944445862 scopus 로고    scopus 로고
    • Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma
    • doi:10.1084/jem.20041948
    • Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med. 2005;201(8): 1205-15. doi: 10. 1084/jem. 20041948.
    • (2005) J Exp Med , vol.201 , Issue.8 , pp. 1205-1215
    • Rousseaux, C.1    Lefebvre, B.2    Dubuquoy, L.3    Lefebvre, P.4    Romano, O.5    Auwerx, J.6
  • 39
    • 33845352518 scopus 로고    scopus 로고
    • Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity
    • doi:10.1093/carcin/bgl071
    • Bos CL, Diks SH, Hardwick JC, Walburg KV, Peppelenbosch MP, Richel DJ. Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity. Carcinogenesis. 2006;27(12): 2371-82. doi: 10. 1093/carcin/bgl071.
    • (2006) Carcinogenesis , vol.27 , Issue.12 , pp. 2371-2382
    • Bos, C.L.1    Diks, S.H.2    Hardwick, J.C.3    Walburg, K.V.4    Peppelenbosch, M.P.5    Richel, D.J.6
  • 40
    • 76749145568 scopus 로고    scopus 로고
    • Beta-catenin pathway in ulcerative colitis-associated colorectal cancer and therapeutic implication
    • doi:10.1007/s12029-009-9070-2
    • Chen J, Huang XF. Beta-catenin pathway in ulcerative colitis-associated colorectal cancer and therapeutic implication. J Gastrointest Cancer. 2009;40(1-2): 64-5. doi: 10. 1007/s12029-009-9070-2.
    • (2009) J Gastrointest Cancer , vol.40 , Issue.1-2 , pp. 64-65
    • Chen, J.1    Huang, X.F.2
  • 41
    • 79955557278 scopus 로고    scopus 로고
    • Conventional medical management of inflammatory bowel disease
    • 10.1053/j.gastro.2011.02.045
    • Burger D, Travis S. Conventional medical management of inflammatory bowel disease. Gastroenterology. 2011;140(6): 1827-37. 10. 1053/j. gastro. 2011. 02. 045.
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1827-1837
    • Burger, D.1    Travis, S.2
  • 42
    • 8344233333 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid receptor signaling during inflammation
    • doi:10.1016/j.mad.2004.06.010
    • Smoak KA, Cidlowski JA. Mechanisms of glucocorticoid receptor signaling during inflammation. Mech Ageing Dev. 2004;125(10-11): 697-706. doi: 10. 1016/j. mad. 2004. 06. 010.
    • (2004) Mech Ageing Dev , vol.125 , Issue.10-11 , pp. 697-706
    • Smoak, K.A.1    Cidlowski, J.A.2
  • 43
    • 65349138972 scopus 로고    scopus 로고
    • Infliximab and the TNF-alpha system
    • doi:10.1152/ajpgi.90576.2008
    • Ebert EC. Infliximab and the TNF-alpha system. Am J Physiol Gastrointest Liver Physiol. 2009;296(3): G612-20. doi: 10. 1152/ajpgi. 90576. 2008.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , Issue.3
    • Ebert, E.C.1
  • 44
    • 0034798807 scopus 로고    scopus 로고
    • Review article: the limitations of corticosteroid therapy in Crohn's disease
    • Rutgeerts PJ. Review article: the limitations of corticosteroid therapy in Crohn's disease. Aliment Pharmacol Ther. 2001;15(10): 1515-25.
    • (2001) Aliment Pharmacol Ther , vol.15 , Issue.10 , pp. 1515-1525
    • Rutgeerts, P.J.1
  • 45
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • Matzke MA, Birchler JA. RNAi-mediated pathways in the nucleus. Nat Rev Genet. 2005;6(1): 24-35.
    • (2005) Nat Rev Genet , vol.6 , Issue.1 , pp. 24-35
    • Matzke, M.A.1    Birchler, J.A.2
  • 46
    • 22144436236 scopus 로고    scopus 로고
    • The role of the RNAi machinery in heterochromatin formation
    • doi:10.1016/j.cell.2005.06.034
    • Wassenegger M. The role of the RNAi machinery in heterochromatin formation. Cell. 2005;122(1): 13-6. doi: 10. 1016/j. cell. 2005. 06. 034.
    • (2005) Cell , vol.122 , Issue.1 , pp. 13-16
    • Wassenegger, M.1
  • 47
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister G, Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature. 2004;431(7006): 343-9.
    • (2004) Nature , vol.431 , Issue.7006 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 48
    • 0035859046 scopus 로고    scopus 로고
    • Gene silencing as an adaptive defence against viruses
    • doi:10.1038/35081168
    • Waterhouse PM, Wang MB, Lough T. Gene silencing as an adaptive defence against viruses. Nature. 2001;411(6839): 834-42. doi: 10. 1038/35081168.
    • (2001) Nature , vol.411 , Issue.6839 , pp. 834-842
    • Waterhouse, P.M.1    Wang, M.B.2    Lough, T.3
  • 49
    • 0037123630 scopus 로고    scopus 로고
    • Induction and suppression of RNA silencing by an animal virus
    • doi:10.1126/science.1070948
    • Li H, Li WX, Ding SW. Induction and suppression of RNA silencing by an animal virus. Science. 2002;296(5571): 1319-21. doi: 10. 1126/science. 1070948.
    • (2002) Science , vol.296 , Issue.5571 , pp. 1319-1321
    • Li, H.1    Li, W.X.2    Ding, S.W.3
  • 50
    • 0032717319 scopus 로고    scopus 로고
    • The rde-1 gene, RNA interference, and transposon silencing in C. elegans
    • Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999;99(2): 123-32.
    • (1999) Cell , vol.99 , Issue.2 , pp. 123-132
    • Tabara, H.1    Sarkissian, M.2    Kelly, W.G.3    Fleenor, J.4    Grishok, A.5    Timmons, L.6
  • 51
    • 2942714830 scopus 로고    scopus 로고
    • RNAi protects the Caenorhabditis elegans germline against transposition
    • doi:10.1016/j.tig.2004.04.011
    • Vastenhouw NL, Plasterk RH. RNAi protects the Caenorhabditis elegans germline against transposition. Trends Genet. 2004;20(7): 314-9. doi: 10. 1016/j. tig. 2004. 04. 011.
    • (2004) Trends Genet , vol.20 , Issue.7 , pp. 314-319
    • Vastenhouw, N.L.1    Plasterk, R.H.2
  • 52
    • 19344374219 scopus 로고    scopus 로고
    • Genetic and functional diversification of small RNA pathways in plants
    • doi:10.1371/journal.pbio.0020104
    • Xie Z, Johansen LK, Gustafson AM, Kasschau KD, Lellis AD, Zilberman D, et al. Genetic and functional diversification of small RNA pathways in plants. PLoS Biol. 2004;2(5): E104. doi: 10. 1371/journal. pbio. 0020104.
    • (2004) PLoS Biol , vol.2 , Issue.5
    • Xie, Z.1    Johansen, L.K.2    Gustafson, A.M.3    Kasschau, K.D.4    Lellis, A.D.5    Zilberman, D.6
  • 53
    • 84883805211 scopus 로고    scopus 로고
    • The role of miRNAs in regulating gene expression networks
    • doi:10.1016/j.jmb.2013.03.007
    • Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks. J Mol Biol. 2013. doi: 10. 1016/j. jmb. 2013. 03. 007.
    • (2013) J Mol Biol
    • Gurtan, A.M.1    Sharp, P.A.2
  • 54
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391(6669): 806-11.
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 55
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • doi:10.1101/gad.1158803
    • Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003;17(24): 3011-6. doi: 10. 1101/gad. 1158803.
    • (2003) Genes Dev , vol.17 , Issue.24 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 56
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000;101(1): 25-33.
    • (2000) Cell , vol.101 , Issue.1 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 57
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • doi:10.1016/j.cell.2004.06.017
    • Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W. Single processing center models for human Dicer and bacterial RNase III. Cell. 2004;118(1): 57-68. doi: 10. 1016/j. cell. 2004. 06. 017.
    • (2004) Cell , vol.118 , Issue.1 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhof, E.4    Filipowicz, W.5
  • 58
    • 58449134534 scopus 로고    scopus 로고
    • Small silencing RNAs: an expanding universe
    • doi:10.1038/nrg2504
    • Ghildiyal M, Zamore PD. Small silencing RNAs: an expanding universe. Nat Rev Genet. 2009;10(2): 94-108. doi: 10. 1038/nrg2504.
    • (2009) Nat Rev Genet , vol.10 , Issue.2 , pp. 94-108
    • Ghildiyal, M.1    Zamore, P.D.2
  • 59
    • 13844281898 scopus 로고    scopus 로고
    • Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
    • doi:10.1038/nbt1051
    • Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol. 2005;23(2): 222-6. doi: 10. 1038/nbt1051.
    • (2005) Nat Biotechnol , vol.23 , Issue.2 , pp. 222-226
    • Kim, D.H.1    Behlke, M.A.2    Rose, S.D.3    Chang, M.S.4    Choi, S.5    Rossi, J.J.6
  • 60
    • 22844448088 scopus 로고    scopus 로고
    • Functional polarity is introduced by Dicer processing of short substrate RNAs
    • doi:10.1093/nar/gki732
    • Rose SD, Kim DH, Amarzguioui M, Heidel JD, Collingwood MA, Davis ME, et al. Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res. 2005;33(13): 4140-56. doi: 10. 1093/nar/gki732.
    • (2005) Nucleic Acids Res , vol.33 , Issue.13 , pp. 4140-4156
    • Rose, S.D.1    Kim, D.H.2    Amarzguioui, M.3    Heidel, J.D.4    Collingwood, M.A.5    Davis, M.E.6
  • 61
    • 0032417618 scopus 로고    scopus 로고
    • RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    • Montgomery MK, Xu S, Fire A. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998;95(26): 15502-7.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.26 , pp. 15502-15507
    • Montgomery, M.K.1    Xu, S.2    Fire, A.3
  • 62
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411(6836): 494-8.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 63
    • 34447559636 scopus 로고    scopus 로고
    • Interfering with disease: a progress report on siRNA-based therapeutics
    • doi:10.1038/nrd2310
    • de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov. 2007;6(6): 443-53. doi: 10. 1038/nrd2310.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.6 , pp. 443-453
    • de Fougerolles, A.1    Vornlocher, H.P.2    Maraganore, J.3    Lieberman, J.4
  • 64
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • doi:10.1038/nrg2968
    • Davidson BL, McCray Jr PB. Current prospects for RNA interference-based therapies. Nat Rev Genet. 2011;12(5): 329-40. doi: 10. 1038/nrg2968.
    • (2011) Nat Rev Genet , vol.12 , Issue.5 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 65
    • 38349096679 scopus 로고    scopus 로고
    • Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides
    • Rahbek UL, Howard KA, Oupicky D, Manickam DS, Dong M, Nielsen AF, et al. Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides. J Gene Med. 2008;10(1): 81-93.
    • (2008) J Gene Med , vol.10 , Issue.1 , pp. 81-93
    • Rahbek, U.L.1    Howard, K.A.2    Oupicky, D.3    Manickam, D.S.4    Dong, M.5    Nielsen, A.F.6
  • 66
    • 0036294527 scopus 로고    scopus 로고
    • Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
    • Zeng Y, Wagner EJ, Cullen BR. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell. 2002;9(6): 1327-33.
    • (2002) Mol Cell , vol.9 , Issue.6 , pp. 1327-1333
    • Zeng, Y.1    Wagner, E.J.2    Cullen, B.R.3
  • 67
    • 34548012848 scopus 로고    scopus 로고
    • The let-7 microRNA represses cell proliferation pathways in human cells
    • doi:10.1158/0008-5472.can-07-1083
    • Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007;67(16): 7713-22. doi: 10. 1158/0008-5472. can-07-1083.
    • (2007) Cancer Res , vol.67 , Issue.16 , pp. 7713-7722
    • Johnson, C.D.1    Esquela-Kerscher, A.2    Stefani, G.3    Byrom, M.4    Kelnar, K.5    Ovcharenko, D.6
  • 69
    • 77949658280 scopus 로고    scopus 로고
    • Regression of murine lung tumors by the let-7 microRNA
    • doi:10.1038/onc.2009.445
    • Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, et al. Regression of murine lung tumors by the let-7 microRNA. Oncogene. 2010;29(11): 1580-7. doi: 10. 1038/onc. 2009. 445.
    • (2010) Oncogene , vol.29 , Issue.11 , pp. 1580-1587
    • Trang, P.1    Medina, P.P.2    Wiggins, J.F.3    Ruffino, L.4    Kelnar, K.5    Omotola, M.6
  • 71
    • 50649103008 scopus 로고    scopus 로고
    • Potent RNAi by short RNA triggers
    • C-y C, Rana TM. Potent RNAi by short RNA triggers. RNA. 2008;14(9): 1714-9.
    • (2008) Rna , vol.14 , Issue.9 , pp. 1714-1719
    • C-Y, C.1    Rana, T.M.2
  • 72
    • 57449107290 scopus 로고    scopus 로고
    • Asymmetric RNA duplexes mediate RNA interference in mammalian cells
    • Sun X, Rogoff HA, Li CJ. Asymmetric RNA duplexes mediate RNA interference in mammalian cells. Nat Biotechnol. 2008;26(12): 1379-82.
    • (2008) Nat Biotechnol , vol.26 , Issue.12 , pp. 1379-1382
    • Sun, X.1    Rogoff, H.A.2    Li, C.J.3
  • 73
    • 63949084982 scopus 로고    scopus 로고
    • Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects
    • Chang CI, Yoo JW, Hong SW, Lee SE, Kang HS, Sun X, et al. Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects. Mol Ther. 2009;17(4): 725-32.
    • (2009) Mol Ther , vol.17 , Issue.4 , pp. 725-732
    • Chang, C.I.1    Yoo, J.W.2    Hong, S.W.3    Lee, S.E.4    Kang, H.S.5    Sun, X.6
  • 74
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • doi:10.1126/science.1068999
    • Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296(5567): 550-3. doi: 10. 1126/science. 1068999.
    • (2002) Science , vol.296 , Issue.5567 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 75
    • 79960047585 scopus 로고    scopus 로고
    • RNAi-inducing lentiviral vectors for anti-HIV-1 gene therapy
    • doi:10.1007/978-1-61779-037-9_18
    • Liu YP, Westerink JT, ter Brake O, Berkhout B. RNAi-inducing lentiviral vectors for anti-HIV-1 gene therapy. Methods Mol Biol. 2011;721: 293-311. doi: 10. 1007/978-1-61779-037-9_18.
    • (2011) Methods Mol Biol , vol.721 , pp. 293-311
    • Liu, Y.P.1    Westerink, J.T.2    ter Brake, O.3    Berkhout, B.4
  • 76
    • 68949158451 scopus 로고    scopus 로고
    • In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles
    • doi:10.1016/j.ymeth.2009.06.004
    • Dissen GA, Lomniczi A, Neff TL, Hobbs TR, Kohama SG, Kroenke CD, et al. In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles. Methods. 2009;49(1): 70-7. doi: 10. 1016/j. ymeth. 2009. 06. 004.
    • (2009) Methods , vol.49 , Issue.1 , pp. 70-77
    • Dissen, G.A.1    Lomniczi, A.2    Neff, T.L.3    Hobbs, T.R.4    Kohama, S.G.5    Kroenke, C.D.6
  • 77
    • 28844441229 scopus 로고    scopus 로고
    • Stable plasmid-based siRNA silencing of gene expression in human embryonic stem cells
    • doi:10.1089/scd.2005.14.487
    • Liu YP, Dambaeva SV, Dovzhenko OV, Garthwaite MA, Golos TG. Stable plasmid-based siRNA silencing of gene expression in human embryonic stem cells. Stem Cells Dev. 2005;14(5): 487-92. doi: 10. 1089/scd. 2005. 14. 487.
    • (2005) Stem Cells Dev , vol.14 , Issue.5 , pp. 487-492
    • Liu, Y.P.1    Dambaeva, S.V.2    Dovzhenko, O.V.3    Garthwaite, M.A.4    Golos, T.G.5
  • 78
    • 24144441215 scopus 로고    scopus 로고
    • Gene therapy for severe combined immunodeficiencies
    • doi:10.1517/14712598.5.9.1175
    • Gaspar HB, Thrasher AJ. Gene therapy for severe combined immunodeficiencies. Expert Opin Biol Ther. 2005;5(9): 1175-82. doi: 10. 1517/14712598. 5. 9. 1175.
    • (2005) Expert Opin Biol Ther , vol.5 , Issue.9 , pp. 1175-1182
    • Gaspar, H.B.1    Thrasher, A.J.2
  • 79
    • 58149232358 scopus 로고    scopus 로고
    • Artificial MicroRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo
    • Boudreau RL, Martins I, Davidson BL. Artificial MicroRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol Ther. 2008;17(1): 169-75.
    • (2008) Mol Ther , vol.17 , Issue.1 , pp. 169-175
    • Boudreau, R.L.1    Martins, I.2    Davidson, B.L.3
  • 80
    • 77949446144 scopus 로고    scopus 로고
    • Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system
    • Ehlert EM, Eggers R, Niclou SP, Verhaagen J. Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system. BMC Neurosci. 2010;11: 20.
    • (2010) BMC Neurosci , vol.11 , pp. 20
    • Ehlert, E.M.1    Eggers, R.2    Niclou, S.P.3    Verhaagen, J.4
  • 81
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 2006;441(7092): 537-41.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 537-541
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3    Storm, T.A.4    Pandey, K.5    Davis, C.R.6
  • 82
    • 33750201146 scopus 로고    scopus 로고
    • Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification
    • doi:10.1093/nar/gkl464
    • Puthenveetil S, Whitby L, Ren J, Kelnar K, Krebs JF, Beal PA. Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification. Nucleic Acids Res. 2006;34(17): 4900-11. doi: 10. 1093/nar/gkl464.
    • (2006) Nucleic Acids Res , vol.34 , Issue.17 , pp. 4900-4911
    • Puthenveetil, S.1    Whitby, L.2    Ren, J.3    Kelnar, K.4    Krebs, J.F.5    Beal, P.A.6
  • 83
    • 33751511117 scopus 로고    scopus 로고
    • Gene expression analysis in blood cells in response to unmodified and 2′-modified siRNAs reveals TLR-dependent and independent effects
    • doi:10.1016/j.jmb.2006.09.034
    • Cekaite L, Furset G, Hovig E, Sioud M. Gene expression analysis in blood cells in response to unmodified and 2′-modified siRNAs reveals TLR-dependent and independent effects. J Mol Biol. 2007;365(1): 90-108. doi: 10. 1016/j. jmb. 2006. 09. 034.
    • (2007) J Mol Biol , vol.365 , Issue.1 , pp. 90-108
    • Cekaite, L.1    Furset, G.2    Hovig, E.3    Sioud, M.4
  • 84
    • 77953543643 scopus 로고    scopus 로고
    • Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist
    • doi:10.1016/j.imbio.2009.09.003
    • Hamm S, Latz E, Hangel D, Muller T, Yu P, Golenbock D, et al. Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology. 2010;215(7): 559-69. doi: 10. 1016/j. imbio. 2009. 09. 003.
    • (2010) Immunobiology , vol.215 , Issue.7 , pp. 559-569
    • Hamm, S.1    Latz, E.2    Hangel, D.3    Muller, T.4    Yu, P.5    Golenbock, D.6
  • 85
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    • Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA. 2006;12(7): 1197-205.
    • (2006) Rna , vol.12 , Issue.7 , pp. 1197-1205
    • Jackson, A.L.1    Burchard, J.2    Leake, D.3    Reynolds, A.4    Schelter, J.5    Guo, J.6
  • 86
    • 77957241115 scopus 로고    scopus 로고
    • A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects
    • Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, et al. A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects. Nucleic Acids Res. 2010;38(17): 5761-73.
    • (2010) Nucleic Acids Res , vol.38 , Issue.17 , pp. 5761-5773
    • Bramsen, J.B.1    Pakula, M.M.2    Hansen, T.B.3    Bus, C.4    Langkjær, N.5    Odadzic, D.6
  • 87
    • 13744250159 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
    • Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res. 2005;33(1): 439-47.
    • (2005) Nucleic Acids Res , vol.33 , Issue.1 , pp. 439-447
    • Elmén, J.1    Thonberg, H.2    Ljungberg, K.3    Frieden, M.4    Westergaard, M.5    Xu, Y.6
  • 88
    • 34447507937 scopus 로고    scopus 로고
    • Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
    • Sipa K, Sochacka E, Kazmierczak-Baranska J, Maszewska M, Janicka M, Nowak G, et al. Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. RNA. 2007;13(8): 1301-16.
    • (2007) Rna , vol.13 , Issue.8 , pp. 1301-1316
    • Sipa, K.1    Sochacka, E.2    Kazmierczak-Baranska, J.3    Maszewska, M.4    Janicka, M.5    Nowak, G.6
  • 89
    • 14844303872 scopus 로고    scopus 로고
    • The effects of thiophosphate substitutions on native siRNA gene silencing
    • Li Z-Y, Mao H, Kallick DA, Gorenstein DG. The effects of thiophosphate substitutions on native siRNA gene silencing. Biochem Biophys Res Commun. 2005;329(3): 1026-30.
    • (2005) Biochem Biophys Res Commun , vol.329 , Issue.3 , pp. 1026-1030
    • Li, Z.-Y.1    Mao, H.2    Kallick, D.A.3    Gorenstein, D.G.4
  • 90
    • 38649099969 scopus 로고    scopus 로고
    • Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
    • Chen PY, Weinmann L, Gaidatzis D, Pei Y, Zavolan M, Tuschl T, et al. Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA. 2008;14(2): 263-74.
    • (2008) Rna , vol.14 , Issue.2 , pp. 263-274
    • Chen, P.Y.1    Weinmann, L.2    Gaidatzis, D.3    Pei, Y.4    Zavolan, M.5    Tuschl, T.6
  • 91
    • 79953144826 scopus 로고    scopus 로고
    • Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
    • Vaish N, Chen F, Seth S, Fosnaugh K, Liu Y, Adami R, et al. Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs. Nucleic Acids Res. 2011;39(5): 1823-32.
    • (2011) Nucleic Acids Res , vol.39 , Issue.5 , pp. 1823-1832
    • Vaish, N.1    Chen, F.2    Seth, S.3    Fosnaugh, K.4    Liu, Y.5    Adami, R.6
  • 92
    • 33746070441 scopus 로고    scopus 로고
    • Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules
    • doi:10.1124/dmd.106.009555
    • van de Water FM, Boerman OC, Wouterse AC, Peters JG, Russel FG, Masereeuw R. Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules. Drug Metab Dispos. 2006;34(8): 1393-7. doi: 10. 1124/dmd. 106. 009555.
    • (2006) Drug Metab Dispos , vol.34 , Issue.8 , pp. 1393-1397
    • van de Water, F.M.1    Boerman, O.C.2    Wouterse, A.C.3    Peters, J.G.4    Russel, F.G.5    Masereeuw, R.6
  • 93
    • 76749108989 scopus 로고    scopus 로고
    • Human host factors required for influenza virus replication
    • doi:10.1038/nature08699
    • Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, et al. Human host factors required for influenza virus replication. Nature. 2010;463(7282): 813-7. doi: 10. 1038/nature08699.
    • (2010) Nature , vol.463 , Issue.7282 , pp. 813-817
    • Konig, R.1    Stertz, S.2    Zhou, Y.3    Inoue, A.4    Hoffmann, H.H.5    Bhattacharyya, S.6
  • 94
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis ME, Zuckerman JE, Choi CHJ, Seligson D, Tolcher A, Alabi CA, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature. 2010;464(7291): 1067-70.
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.J.3    Seligson, D.4    Tolcher, A.5    Alabi, C.A.6
  • 95
    • 33748054817 scopus 로고    scopus 로고
    • RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system
    • Howard KA, Rahbek UL, Liu X, Damgaard CK, Glud SZ, Andersen M, et al. RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system. Mol Ther. 2006;14(4): 476-84.
    • (2006) Mol Ther , vol.14 , Issue.4 , pp. 476-484
    • Howard, K.A.1    Rahbek, U.L.2    Liu, X.3    Damgaard, C.K.4    Glud, S.Z.5    Andersen, M.6
  • 96
    • 37049003720 scopus 로고    scopus 로고
    • Polycation-based nanoparticle delivery for improved RNA interference therapeutics
    • Howard KA, Kjems J. Polycation-based nanoparticle delivery for improved RNA interference therapeutics. Expert Opin Biol Ther. 2007;7(12): 1811-22.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.12 , pp. 1811-1822
    • Howard, K.A.1    Kjems, J.2
  • 97
    • 67349242729 scopus 로고    scopus 로고
    • Delivery of RNA interference therapeutics using polycation-based nanoparticles
    • Howard KA. Delivery of RNA interference therapeutics using polycation-based nanoparticles. Adv Drug Deliv Rev. 2009;61(9): 710-20.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.9 , pp. 710-720
    • Howard, K.A.1
  • 99
    • 33751419974 scopus 로고    scopus 로고
    • The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing
    • doi:10.1016/j.biomaterials.2006.11.004
    • Liu X, Howard KA, Dong M, Andersen MO, Rahbek UL, Johnsen MG, et al. The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials. 2007;28(6): 1280-8. doi: 10. 1016/j. biomaterials. 2006. 11. 004.
    • (2007) Biomaterials , vol.28 , Issue.6 , pp. 1280-1288
    • Liu, X.1    Howard, K.A.2    Dong, M.3    Andersen, M.O.4    Rahbek, U.L.5    Johnsen, M.G.6
  • 101
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • doi:10.1038/nature04688
    • Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, et al. RNAi-mediated gene silencing in non-human primates. Nature. 2006;441(7089): 111-4. doi: 10. 1038/nature04688.
    • (2006) Nature , vol.441 , Issue.7089 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.2    Akinc, A.3    Bramlage, B.4    Bumcrot, D.5    Fedoruk, M.N.6
  • 102
    • 76349111051 scopus 로고    scopus 로고
    • Rational design of cationic lipids for siRNA delivery
    • doi:10.1038/nbt.1602
    • Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010;28(2): 172-6. doi: 10. 1038/nbt. 1602.
    • (2010) Nat Biotechnol , vol.28 , Issue.2 , pp. 172-176
    • Semple, S.C.1    Akinc, A.2    Chen, J.3    Sandhu, A.P.4    Mui, B.L.5    Cho, C.K.6
  • 103
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • doi:10.1038/nbt1402
    • Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol. 2008;26(5): 561-9. doi: 10. 1038/nbt1402.
    • (2008) Nat Biotechnol , vol.26 , Issue.5 , pp. 561-569
    • Akinc, A.1    Zumbuehl, A.2    Goldberg, M.3    Leshchiner, E.S.4    Busini, V.5    Hossain, N.6
  • 104
    • 0035289710 scopus 로고    scopus 로고
    • Key issues in non-viral gene delivery
    • Pouton CW, Seymour LW. Key issues in non-viral gene delivery. Adv Drug Deliv Rev. 2001;46(1-3): 187-203.
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 187-203
    • Pouton, C.W.1    Seymour, L.W.2
  • 106
    • 84878887964 scopus 로고    scopus 로고
    • Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles
    • doi:10.1038/mtna.2013.2
    • Ballarin-Gonzalez B, Dagnaes-Hansen F, Fenton RA, Gao S, Hein S, Dong M, et al. Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles. Mol Ther Nucleic Acids. 2013;2: e76. doi: 10. 1038/mtna. 2013. 2.
    • (2013) Mol Ther Nucleic Acids , vol.2
    • Ballarin-Gonzalez, B.1    Dagnaes-Hansen, F.2    Fenton, R.A.3    Gao, S.4    Hein, S.5    Dong, M.6
  • 107
    • 41649115210 scopus 로고    scopus 로고
    • Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
    • doi:10.1038/nature06765
    • Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi JZ, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008;452(7187): 591-7. doi: 10. 1038/nature06765.
    • (2008) Nature , vol.452 , Issue.7187 , pp. 591-597
    • Kleinman, M.E.1    Yamada, K.2    Takeda, A.3    Chandrasekaran, V.4    Nozaki, M.5    Baffi, J.Z.6
  • 108
    • 66349125020 scopus 로고    scopus 로고
    • Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth
    • doi:10.1073/pnas.0812317106
    • Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, et al. Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth. Proc Natl Acad Sci U S A. 2009;106(17): 7137-42. doi: 10. 1073/pnas. 0812317106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.17 , pp. 7137-7142
    • Cho, W.G.1    Albuquerque, R.J.2    Kleinman, M.E.3    Tarallo, V.4    Greco, A.5    Nozaki, M.6
  • 109
    • 2942620143 scopus 로고    scopus 로고
    • Protection against lethal influenza virus challenge by RNA interference in vivo
    • doi:10.1073/pnas.0402630101
    • Tompkins SM, Lo CY, Tumpey TM, Epstein SL. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A. 2004;101(23): 8682-6. doi: 10. 1073/pnas. 0402630101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.23 , pp. 8682-8686
    • Tompkins, S.M.1    Lo, C.Y.2    Tumpey, T.M.3    Epstein, S.L.4
  • 110
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • doi:10.1073/pnas.0402486101
    • Ge Q, Filip L, Bai A, Nguyen T, Eisen HN, Chen J. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci U S A. 2004;101(23): 8676-81. doi: 10. 1073/pnas. 0402486101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.23 , pp. 8676-8681
    • Ge, Q.1    Filip, L.2    Bai, A.3    Nguyen, T.4    Eisen, H.N.5    Chen, J.6
  • 111
    • 54949095836 scopus 로고    scopus 로고
    • Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
    • doi:10.1089/hum.2008.131
    • Robbins M, Judge A, Ambegia E, Choi C, Yaworski E, Palmer L, et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum Gene Ther. 2008;19(10): 991-9. doi: 10. 1089/hum. 2008. 131.
    • (2008) Hum Gene Ther , vol.19 , Issue.10 , pp. 991-999
    • Robbins, M.1    Judge, A.2    Ambegia, E.3    Choi, C.4    Yaworski, E.5    Palmer, L.6
  • 112
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
    • doi:10.1038/nri2707
    • Abreu MT. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol. 2010;10(2): 131-44. doi: 10. 1038/nri2707.
    • (2010) Nat Rev Immunol , vol.10 , Issue.2 , pp. 131-144
    • Abreu, M.T.1
  • 113
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • doi:10.1038/35099560
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857): 732-8. doi: 10. 1038/35099560.
    • (2001) Nature , vol.413 , Issue.6857 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 114
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
    • Heil F. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science. 2004;303(5663): 1526-9.
    • (2004) Science , vol.303 , Issue.5663 , pp. 1526-1529
    • Heil, F.1
  • 116
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-{pipe}[alpha]{pipe} by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, et al. Sequence-specific potent induction of IFN-{pipe}[alpha]{pipe} by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005;11(3): 263-70.
    • (2005) Nat Med , vol.11 , Issue.3 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3    Ablasser, A.4    Schlee, M.5    Uematsu, S.6
  • 117
    • 33646544416 scopus 로고    scopus 로고
    • Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses
    • Sioud M. Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses. Eur J Immunol. 2006;36(5): 1222-30.
    • (2006) Eur J Immunol , vol.36 , Issue.5 , pp. 1222-1230
    • Sioud, M.1
  • 118
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
    • Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J Mol Biol. 2005;348(5): 1079-90.
    • (2005) J Mol Biol , vol.348 , Issue.5 , pp. 1079-1090
    • Sioud, M.1
  • 119
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • doi:10.1038/nbt1081
    • Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol. 2005;23(4): 457-62. doi: 10. 1038/nbt1081.
    • (2005) Nat Biotechnol , vol.23 , Issue.4 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 121
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis E, Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 2004;303(5663): 1529-31.
    • (2004) Science , vol.303 , Issue.5663 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis, E.5    Sousa, C.6
  • 122
    • 44649137559 scopus 로고    scopus 로고
    • Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    • Forsbach A, Nemorin JG, Montino C, Müller C, Samulowitz U, Vicari AP, et al. Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses. J Immunol. 2008;180(6): 3729-38.
    • (2008) J Immunol , vol.180 , Issue.6 , pp. 3729-3738
    • Forsbach, A.1    Nemorin, J.G.2    Montino, C.3    Müller, C.4    Samulowitz, U.5    Vicari, A.P.6
  • 123
    • 0042972933 scopus 로고    scopus 로고
    • Activation of the interferon system by short-interfering RNAs
    • doi:10.1038/ncb1038
    • Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol. 2003;5(9): 834-9. doi: 10. 1038/ncb1038.
    • (2003) Nat Cell Biol , vol.5 , Issue.9 , pp. 834-839
    • Sledz, C.A.1    Holko, M.2    de Veer, M.J.3    Silverman, R.H.4    Williams, B.R.5
  • 124
    • 33645698822 scopus 로고    scopus 로고
    • siRNA binding proteins of microglial cells: PKR is an unanticipated ligand
    • doi:10.1002/jcb.20716
    • Zhang Z, Weinschenk T, Guo K, Schluesener HJ. siRNA binding proteins of microglial cells: PKR is an unanticipated ligand. J Cell Biochem. 2006;97(6): 1217-29. doi: 10. 1002/jcb. 20716.
    • (2006) J Cell Biochem , vol.97 , Issue.6 , pp. 1217-1229
    • Zhang, Z.1    Weinschenk, T.2    Guo, K.3    Schluesener, H.J.4
  • 125
    • 0035800333 scopus 로고    scopus 로고
    • Signal integration via PKR
    • doi:10.1126/stke.2001.89.re2
    • Williams BR. Signal integration via PKR. Sci STKE. 2001;2001(89): re2. doi: 10. 1126/stke. 2001. 89. re2.
    • (2001) Sci STKE , vol.2001 , Issue.89
    • Williams, B.R.1
  • 126
    • 0033213918 scopus 로고    scopus 로고
    • Translation initiation: adept at adapting
    • Dever TE. Translation initiation: adept at adapting. Trends Biochem Sci. 1999;24(10): 398-403.
    • (1999) Trends Biochem Sci , vol.24 , Issue.10 , pp. 398-403
    • Dever, T.E.1
  • 127
    • 25144477805 scopus 로고    scopus 로고
    • Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition
    • Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, et al. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition. Cell. 2005;122(6): 901-13.
    • (2005) Cell , vol.122 , Issue.6 , pp. 901-913
    • Dey, M.1    Cao, C.2    Dar, A.C.3    Tamura, T.4    Ozato, K.5    Sicheri, F.6
  • 128
    • 84865511926 scopus 로고    scopus 로고
    • Novel role of PKR in inflammasome activation and HMGB1 release
    • doi:10.1038/nature11290
    • Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundback P, et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012;488(7413): 670-4. doi: 10. 1038/nature11290.
    • (2012) Nature , vol.488 , Issue.7413 , pp. 670-674
    • Lu, B.1    Nakamura, T.2    Inouye, K.3    Li, J.4    Tang, Y.5    Lundback, P.6
  • 129
    • 33750984771 scopus 로고    scopus 로고
    • RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates
    • doi:10.1126/science.1132998
    • Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, et al. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science. 2006;314(5801): 997-1001. doi: 10. 1126/science. 1132998.
    • (2006) Science , vol.314 , Issue.5801 , pp. 997-1001
    • Pichlmair, A.1    Schulz, O.2    Tan, C.P.3    Naslund, T.I.4    Liljestrom, P.5    Weber, F.6
  • 130
    • 33750976374 scopus 로고    scopus 로고
    • 5′-Triphosphate RNA is the ligand for RIG-I
    • doi:10.1126/science.1132505
    • Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science. 2006;314(5801): 994-7. doi: 10. 1126/science. 1132505.
    • (2006) Science , vol.314 , Issue.5801 , pp. 994-997
    • Hornung, V.1    Ellegast, J.2    Kim, S.3    Brzozka, K.4    Jung, A.5    Kato, H.6
  • 131
    • 46949097299 scopus 로고    scopus 로고
    • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    • Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med. 2008;205(7): 1601-10.
    • (2008) J Exp Med , vol.205 , Issue.7 , pp. 1601-1610
    • Kato, H.1    Takeuchi, O.2    Mikamo-Satoh, E.3    Hirai, R.4    Kawai, T.5    Matsushita, K.6
  • 132
    • 33646561864 scopus 로고    scopus 로고
    • A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
    • doi:10.1038/nbt1205
    • Marques JT, Devosse T, Wang D, Zamanian-Daryoush M, Serbinowski P, Hartmann R, et al. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol. 2006;24(5): 559-65. doi: 10. 1038/nbt1205.
    • (2006) Nat Biotechnol , vol.24 , Issue.5 , pp. 559-565
    • Marques, J.T.1    Devosse, T.2    Wang, D.3    Zamanian-Daryoush, M.4    Serbinowski, P.5    Hartmann, R.6
  • 133
    • 84855960242 scopus 로고    scopus 로고
    • From virus to inflammation: mechanisms of RIG-I-induced IL-1beta production
    • doi:10.1016/j.ejcb.2011.01.013
    • Poeck H, Ruland J. From virus to inflammation: mechanisms of RIG-I-induced IL-1beta production. Eur J Cell Biol. 2012;91(1): 59-64. doi: 10. 1016/j. ejcb. 2011. 01. 013.
    • (2012) Eur J Cell Biol , vol.91 , Issue.1 , pp. 59-64
    • Poeck, H.1    Ruland, J.2
  • 134
    • 68249159577 scopus 로고    scopus 로고
    • Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase
    • doi:10.1111/j.1365-2567.2009.03093.x
    • Flatekval GF, Sioud M. Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2, 3-dioxygenase. Immunology. 2009;128(1 Suppl): e837-48. doi: 10. 1111/j. 1365-2567. 2009. 03093. x.
    • (2009) Immunology , vol.128 , Issue.1 SUPPL.
    • Flatekval, G.F.1    Sioud, M.2
  • 135
    • 33746913567 scopus 로고    scopus 로고
    • Engineering mucosal RNA interference in vivo
    • doi:10.1016/j.ymthe.2006.04.001
    • Zhang Y, Cristofaro P, Silbermann R, Pusch O, Boden D, Konkin T, et al. Engineering mucosal RNA interference in vivo. Mol Ther. 2006;14(3): 336-42. doi: 10. 1016/j. ymthe. 2006. 04. 001.
    • (2006) Mol Ther , vol.14 , Issue.3 , pp. 336-342
    • Zhang, Y.1    Cristofaro, P.2    Silbermann, R.3    Pusch, O.4    Boden, D.5    Konkin, T.6
  • 136
    • 84856544764 scopus 로고    scopus 로고
    • Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice
    • Ocampo SM, Romero C, Aviñó A, Burgueño J, Gassull MA, Bermúdez J et al. (2011) Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice. Mol Ther. 2012;20: 382-90.
    • (2011) Mol Ther. , vol.20 , pp. 382-390
    • Ocampo, S.M.1    Romero, C.2    Aviñó, A.3    Burgueño, J.4    Gassull, M.A.5    Bermúdez, J.6
  • 137
    • 38849166053 scopus 로고    scopus 로고
    • Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
    • doi: 10. 1126/science. 1149859
    • Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008;319(5863): 627-30. doi: 10. 1126/science. 1149859.
    • (2008) Science , vol.319 , Issue.5863 , pp. 627-630
    • Peer, D.1    Park, E.J.2    Morishita, Y.3    Carman, C.V.4    Shimaoka, M.5
  • 138
    • 58149215702 scopus 로고    scopus 로고
    • Chitosan/siRNA nanoparticle-mediated TNF-[alpha] knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    • Howard KA, Paludan SR, Behlke MA, Besenbacher F, Deleuran B, Kjems J. Chitosan/siRNA nanoparticle-mediated TNF-[alpha] knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther. 2008;17(1): 162-8.
    • (2008) Mol Ther , vol.17 , Issue.1 , pp. 162-168
    • Howard, K.A.1    Paludan, S.R.2    Behlke, M.A.3    Besenbacher, F.4    Deleuran, B.5    Kjems, J.6
  • 139
    • 77957858210 scopus 로고    scopus 로고
    • Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFalpha prevents radiation-induced fibrosis
    • doi:10.1016/j.radonc.2010.09.010
    • Nawroth I, Alsner J, Behlke MA, Besenbacher F, Overgaard J, Howard KA, et al. Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFalpha prevents radiation-induced fibrosis. Radiother Oncol. 2010;97(1): 143-8. doi: 10. 1016/j. radonc. 2010. 09. 010.
    • (2010) Radiother Oncol , vol.97 , Issue.1 , pp. 143-148
    • Nawroth, I.1    Alsner, J.2    Behlke, M.A.3    Besenbacher, F.4    Overgaard, J.5    Howard, K.A.6
  • 140
    • 77958494386 scopus 로고    scopus 로고
    • Orally delivered thioketal nanoparticles loaded with TNF-alpha-siRNA target inflammation and inhibit gene expression in the intestines
    • doi:10.1038/nmat2859
    • Wilson DS, Dalmasso G, Wang L, Sitaraman SV, Merlin D, Murthy N. Orally delivered thioketal nanoparticles loaded with TNF-alpha-siRNA target inflammation and inhibit gene expression in the intestines. Nat Mater. 2010;9(11): 923-8. doi: 10. 1038/nmat2859.
    • (2010) Nat Mater , vol.9 , Issue.11 , pp. 923-928
    • Wilson, D.S.1    Dalmasso, G.2    Wang, L.3    Sitaraman, S.V.4    Merlin, D.5    Murthy, N.6
  • 141
    • 79951955176 scopus 로고    scopus 로고
    • Oral TNF-alpha gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease
    • doi:10.1016/j.jconrel.2010.10.002
    • Kriegel C, Amiji M. Oral TNF-alpha gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease. J Control Release. 2011;150(1): 77-86. doi: 10. 1016/j. jconrel. 2010. 10. 002.
    • (2011) J Control Release , vol.150 , Issue.1 , pp. 77-86
    • Kriegel, C.1    Amiji, M.2
  • 142
    • 84859430095 scopus 로고    scopus 로고
    • Dual TNF-alpha/cyclin D1 gene silencing with an oral polymeric microparticle system as a novel strategy for the treatment of inflammatory bowel disease
    • doi:10.1038/ctg.2011.1
    • Kriegel C, Amiji MM. Dual TNF-alpha/cyclin D1 gene silencing with an oral polymeric microparticle system as a novel strategy for the treatment of inflammatory bowel disease. Clin Transl Gastroenterol. 2011;2: e2. doi: 10. 1038/ctg. 2011. 1.
    • (2011) Clin Transl Gastroenterol , vol.2
    • Kriegel, C.1    Amiji, M.M.2
  • 143
    • 65949106130 scopus 로고    scopus 로고
    • Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
    • doi:10.1038/nature07774
    • Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, et al. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature. 2009;458(7242): 1180-4. doi: 10. 1038/nature07774.
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1180-1184
    • Aouadi, M.1    Tesz, G.J.2    Nicoloro, S.M.3    Wang, M.4    Chouinard, M.5    Soto, E.6
  • 144
    • 84875258221 scopus 로고    scopus 로고
    • Galactosylated trimethyl chitosan-cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages
    • doi:10.1016/j.biomaterials.2013.01.079
    • Zhang J, Tang C, Yin C. Galactosylated trimethyl chitosan-cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages. Biomaterials. 2013;34(14): 3667-77. doi: 10. 1016/j. biomaterials. 2013. 01. 079.
    • (2013) Biomaterials , vol.34 , Issue.14 , pp. 3667-3677
    • Zhang, J.1    Tang, C.2    Yin, C.3
  • 145
    • 33745698756 scopus 로고    scopus 로고
    • Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium
    • doi:10.1002/path.1978
    • Kobayashi K, Arimura Y, Goto A, Okahara S, Endo T, Shinomura Y, et al. Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium. J Pathol. 2006;209(3): 376-83. doi: 10. 1002/path. 1978.
    • (2006) J Pathol , vol.209 , Issue.3 , pp. 376-383
    • Kobayashi, K.1    Arimura, Y.2    Goto, A.3    Okahara, S.4    Endo, T.5    Shinomura, Y.6
  • 146
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • doi:10.1038/nbt.1543
    • Khan AA, Betel D, Miller ML, Sander C, Leslie CS, Marks DS. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol. 2009;27(6): 549-55. doi: 10. 1038/nbt. 1543.
    • (2009) Nat Biotechnol , vol.27 , Issue.6 , pp. 549-555
    • Khan, A.A.1    Betel, D.2    Miller, M.L.3    Sander, C.4    Leslie, C.S.5    Marks, D.S.6
  • 147
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • doi:10.1038/nature04791
    • Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 2006;441(7092): 537-41. doi: 10. 1038/nature04791.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 537-541
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3    Storm, T.A.4    Pandey, K.5    Davis, C.R.6
  • 148
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    • Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, et al. Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA. 2006;12(7): 1179-87.
    • (2006) Rna , vol.12 , Issue.7 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6
  • 149
    • 42449091989 scopus 로고    scopus 로고
    • Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
    • Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, et al. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 2008;36(7): 2136-51.
    • (2008) Nucleic Acids Res , vol.36 , Issue.7 , pp. 2136-2151
    • Ui-Tei, K.1    Naito, Y.2    Zenno, S.3    Nishi, K.4    Yamato, K.5    Takahashi, F.6
  • 151
    • 4644293047 scopus 로고    scopus 로고
    • Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies
    • doi:10.1080/10611860400003858
    • Khan A, Benboubetra M, Sayyed PZ, Ng KW, Fox S, Beck G, et al. Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies. J Drug Target. 2004;12(6): 393-404. doi: 10. 1080/10611860400003858.
    • (2004) J Drug Target , vol.12 , Issue.6 , pp. 393-404
    • Khan, A.1    Benboubetra, M.2    Sayyed, P.Z.3    Ng, K.W.4    Fox, S.5    Beck, G.6
  • 152
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: a chemical modification analysis
    • Chiu YL, Rana TM. siRNA function in RNAi: a chemical modification analysis. RNA (New York, NY). 2003;9(9): 1034-48.
    • (2003) RNA (New York, NY) , vol.9 , Issue.9 , pp. 1034-1048
    • Chiu, Y.L.1    Rana, T.M.2
  • 153
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a siRNA
    • Amarzguioui M, Holen T, Babaie E, Prydz H. Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res. 2003;31(2): 589-95.
    • (2003) Nucleic Acids Res , vol.31 , Issue.2 , pp. 589-595
    • Amarzguioui, M.1    Holen, T.2    Babaie, E.3    Prydz, H.4
  • 154
    • 0038606999 scopus 로고    scopus 로고
    • Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
    • Czauderna F, Fechtner M, Dames S, Aygun H, Klippel A, Pronk GJ, et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res. 2003;31(11): 2705-16.
    • (2003) Nucleic Acids Res , vol.31 , Issue.11 , pp. 2705-2716
    • Czauderna, F.1    Fechtner, M.2    Dames, S.3    Aygun, H.4    Klippel, A.5    Pronk, G.J.6
  • 155
    • 0038385504 scopus 로고    scopus 로고
    • RNA interference in mammalian cells by chemically-modified RNA
    • doi:10.1021/bi0343774
    • Braasch DA, Jensen S, Liu Y, Kaur K, Arar K, White MA, et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry. 2003;42(26): 7967-75. doi: 10. 1021/bi0343774.
    • (2003) Biochemistry , vol.42 , Issue.26 , pp. 7967-7975
    • Braasch, D.A.1    Jensen, S.2    Liu, Y.3    Kaur, K.4    Arar, K.5    White, M.A.6
  • 156
    • 34147180058 scopus 로고    scopus 로고
    • Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
    • doi:10.1158/1535-7163.mct-06-0195
    • Mook OR, Baas F, de Wissel MB, Fluiter K. Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol Cancer Ther. 2007;6(3): 833-43. doi: 10. 1158/1535-7163. mct-06-0195.
    • (2007) Mol Cancer Ther , vol.6 , Issue.3 , pp. 833-843
    • Mook, O.R.1    Baas, F.2    de Wissel, M.B.3    Fluiter, K.4
  • 157
    • 77952329345 scopus 로고    scopus 로고
    • Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo
    • doi:10.1039/b918869j
    • Laursen MB, Pakula MM, Gao S, Fluiter K, Mook OR, Baas F, et al. Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Mol Biosyst. 2010;6(5): 862-70. doi: 10. 1039/b918869j.
    • (2010) Mol Biosyst , vol.6 , Issue.5 , pp. 862-870
    • Laursen, M.B.1    Pakula, M.M.2    Gao, S.3    Fluiter, K.4    Mook, O.R.5    Baas, F.6
  • 158
    • 34547652313 scopus 로고    scopus 로고
    • Structural characterization and biological evaluation of small interfering RNAs containing cyclohexenyl nucleosides
    • doi:10.1021/ja067047q
    • Nauwelaerts K, Fisher M, Froeyen M, Lescrinier E, Aerschot AV, Xu D, et al. Structural characterization and biological evaluation of small interfering RNAs containing cyclohexenyl nucleosides. J Am Chem Soc. 2007;129(30): 9340-8. doi: 10. 1021/ja067047q.
    • (2007) J Am Chem Soc , vol.129 , Issue.30 , pp. 9340-9348
    • Nauwelaerts, K.1    Fisher, M.2    Froeyen, M.3    Lescrinier, E.4    Aerschot, A.V.5    Xu, D.6
  • 159
    • 60949112943 scopus 로고    scopus 로고
    • Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf
    • doi:10.1016/j.ejphar.2009.01.030
    • Fisher M, Abramov M, van Aerschot A, Rozenski J, Dixit V, Juliano RL, et al. Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf. Eur J Pharmacol. 2009;606(1-3): 38-44. doi: 10. 1016/j. ejphar. 2009. 01. 030.
    • (2009) Eur J Pharmacol , vol.606 , Issue.1-3 , pp. 38-44
    • Fisher, M.1    Abramov, M.2    van Aerschot, A.3    Rozenski, J.4    Dixit, V.5    Juliano, R.L.6
  • 160
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • doi:10.1146/annurev.immunol.20.100301.064816
    • Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002;20: 495-549. doi: 10. 1146/annurev. immunol. 20. 100301. 064816.
    • (2002) Annu Rev Immunol , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3


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