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Volumn 2, Issue , 2013, Pages e76-

Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles

Author keywords

Chitosan; Mucosal; Nanoparticles; Oral; SiRNA; Stability; Systemic translocation

Indexed keywords

CHITOSAN; NANOPARTICLE; SMALL INTERFERING RNA;

EID: 84878887964     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2013.2     Document Type: Article
Times cited : (63)

References (31)
  • 1
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • DOI 10.1038/nature02873
    • Meister, G and Tuschl, T (2004). Mechanisms of gene silencing by double-stranded RNA. Nature 431: 343-349. (Pubitemid 39265674)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 2
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore, PD, Tuschl, T, Sharp, PA and Bartel, DP (2000). RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101: 25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 3
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson, BL and McCray, PB Jr (2011). Current prospects for RNA interference-based therapies. Nat Rev Genet 12: 329-340.
    • (2011) Nat Rev Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 8
    • 77958494386 scopus 로고    scopus 로고
    • Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines
    • Wilson, DS, Dalmasso, G, Wang, L, Sitaraman, SV, Merlin, D, Murthy, N. (2010). Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines. Nat Mater 9: 923-928.
    • (2010) Nat Mater , vol.9 , pp. 923-928
    • Wilson, D.S.1    Dalmasso, G.2    Wang, L.3    Sitaraman, S.V.4    Merlin, D.5    Murthy, N.6
  • 9
    • 79951955176 scopus 로고    scopus 로고
    • Oral TNF - A gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease
    • Kriegel, C and Amiji, M (2011). Oral TNF-a gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease. J Control Release 150: 77-86.
    • (2011) J Control Release , vol.150 , pp. 77-86
    • Kriegel, C.1    Amiji, M.2
  • 10
    • 65949106130 scopus 로고    scopus 로고
    • Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
    • Aouadi, M, Tesz, GJ, Nicoloro, SM, Wang, M, Chouinard, M, Soto, E et al. (2009). Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 458: 1180-1184.
    • (2009) Nature , vol.458 , pp. 1180-1184
    • Aouadi, M.1    Tesz, G.J.2    Nicoloro, S.M.3    Wang, M.4    Chouinard, M.5    Soto, E.6
  • 11
    • 75149133614 scopus 로고    scopus 로고
    • Chitosan-based formulations for delivery of DNA and siRNA
    • Mao, S, Sun, W and Kissel, T (2010). Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 62: 12-27.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 12-27
    • Mao, S.1    Sun, W.2    Kissel, T.3
  • 12
    • 0031783879 scopus 로고    scopus 로고
    • Chitosan and its use as a pharmaceutical excipient
    • DOI 10.1023/A:1011929016601
    • Illum, L (1998). Chitosan and its use as a pharmaceutical excipient. Pharm Res 15: 1326-1331. (Pubitemid 28427917)
    • (1998) Pharmaceutical Research , vol.15 , Issue.9 , pp. 1326-1331
    • Illum, L.1
  • 14
    • 0031004232 scopus 로고    scopus 로고
    • Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers
    • DOI 10.1021/js960182o
    • Aspden, TJ, Mason, JD, Jones, NS, Lowe, J, Skaugrud, O and Illum, L (1997). Chitosan as a nasal delivery system: the effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers. J Pharm Sci 86: 509-513. (Pubitemid 27154770)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.4 , pp. 509-513
    • Aspden, T.J.1    Mason, J.D.T.2    Jones, N.S.3    Lowe, J.4    Skaugrud, O.5    Illum, L.6
  • 15
    • 78651341419 scopus 로고    scopus 로고
    • Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles
    • Nielsen, EJ, Nielsen, JM, Becker, D, Karlas, A, Prakash, H, Glud, SZ et al. (2010). Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles. Pharm Res 27: 2520-2527.
    • (2010) Pharm Res , vol.27 , pp. 2520-2527
    • Nielsen, E.J.1    Nielsen, J.M.2    Becker, D.3    Karlas, A.4    Prakash, H.5    Glud, S.Z.6
  • 16
    • 58149215702 scopus 로고    scopus 로고
    • Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    • Howard, KA, Paludan, SR, Behlke, MA, Besenbacher, F, Deleuran, B and Kjems, J (2009). Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther 17: 162-168.
    • (2009) Mol Ther , vol.17 , pp. 162-168
    • Howard, K.A.1    Paludan, S.R.2    Behlke, M.A.3    Besenbacher, F.4    Deleuran, B.5    Kjems, J.6
  • 17
    • 77957858210 scopus 로고    scopus 로고
    • Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFa prevents radiation-induced fibrosis
    • Nawroth, I, Alsner, J, Behlke, MA, Besenbacher, F, Overgaard, J, Howard, KA et al. (2010). Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFa prevents radiation-induced fibrosis. Radiother Oncol 97: 143-148.
    • (2010) Radiother Oncol , vol.97 , pp. 143-148
    • Nawroth, I.1    Alsner, J.2    Behlke, M.A.3    Besenbacher, F.4    Overgaard, J.5    Howard, K.A.6
  • 18
    • 33751419974 scopus 로고    scopus 로고
    • The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing
    • DOI 10.1016/j.biomaterials.2006.11.004, PII S0142961206009501
    • Liu, X, Howard, KA, Dong, M, Andersen, MØ, Rahbek, UL, Johnsen, MG et al. (2007). The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials 28: 1280-1288. (Pubitemid 44816373)
    • (2007) Biomaterials , vol.28 , Issue.6 , pp. 1280-1288
    • Liu, X.1    Howard, K.A.2    Dong, M.3    Andersen, M.O.4    Rahbek, U.L.5    Johnsen, M.G.6    Hansen, O.C.7    Besenbacher, F.8    Kjems, J.9
  • 20
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • DOI 10.1089/oli.2008.0164
    • Behlke, MA (2008). Chemical modification of siRNAs for in vivo use. Oligonucleotides 18: 305-319. (Pubitemid 352791344)
    • (2008) Oligonucleotides , vol.18 , Issue.4 , pp. 305-319
    • Behlke, M.A.1
  • 21
    • 33751511117 scopus 로고    scopus 로고
    • Gene Expression Analysis in Blood Cells in Response to Unmodified and 2'-Modified siRNAs Reveals TLR-dependent and Independent Effects
    • DOI 10.1016/j.jmb.2006.09.034, PII S0022283606012253
    • Cekaite, L, Furset, G, Hovig, E and Sioud, M (2007). Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects. J Mol Biol 365: 90-108. (Pubitemid 44830036)
    • (2007) Journal of Molecular Biology , vol.365 , Issue.1 , pp. 90-108
    • Cekaite, L.1    Furset, G.2    Hovig, E.3    Sioud, M.4
  • 23
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • DOI 10.1016/j.immuni.2005.06.008, PII S1074761305002116
    • Karikó, K, Buckstein, M, Ni, H and Weissman, D (2005). Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23: 165-175. (Pubitemid 41169286)
    • (2005) Immunity , vol.23 , Issue.2 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 24
    • 67649865399 scopus 로고    scopus 로고
    • The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
    • Gao, S, Dagnaes-Hansen, F, Nielsen, EJ, Wengel, J, Besenbacher, F, Howard, KA et al. (2009). The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. Mol Ther 17: 1225-1233.
    • (2009) Mol Ther , vol.17 , pp. 1225-1233
    • Gao, S.1    Dagnaes-Hansen, F.2    Nielsen, E.J.3    Wengel, J.4    Besenbacher, F.5    Howard, K.A.6
  • 25
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • DOI 10.1016/j.bbrc.2006.02.049, PII S0006291X06003366
    • Choung, S, Kim, YJ, Kim, S, Park, HO and Choi, YC (2006). Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem Biophys Res Commun 342: 919-927. (Pubitemid 43320485)
    • (2006) Biochemical and Biophysical Research Communications , vol.342 , Issue.3 , pp. 919-927
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H.-O.4    Choi, Y.-C.5
  • 26
    • 0038578021 scopus 로고    scopus 로고
    • Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA
    • DOI 10.1093/nar/gkg409
    • Grünweller, A, Wyszko, E, Bieber, B, Jahnel, R, Erdmann, VA and Kurreck, J (2003). Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res 31: 3185-3193. (Pubitemid 37441778)
    • (2003) Nucleic Acids Research , vol.31 , Issue.12 , pp. 3185-3193
    • Grunweller, A.1    Wyszko, E.2    Bieber, B.3    Jahnel, R.4    Erdmann, V.A.5    Kurreck, J.6
  • 27
    • 66349108231 scopus 로고    scopus 로고
    • A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
    • Bramsen, JB, Laursen, MB, Nielsen, AF, Hansen, TB, Bus, C, Langkjaer, N et al. (2009). A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res 37: 2867-2881.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2867-2881
    • Bramsen, J.B.1    Laursen, M.B.2    Nielsen, A.F.3    Hansen, T.B.4    Bus, C.5    Langkjaer, N.6
  • 30
    • 70349335809 scopus 로고    scopus 로고
    • RNAi using a chitosan/siRNA nanoparticle system: In vitro and in vivo applications
    • Andersen, MØ, Howard, KA and Kjems, J (2009). RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications. Methods Mol Biol 555: 77-86.
    • (2009) Methods Mol Biol , vol.555 , pp. 77-86
    • Andersen, M.O.1    Howard, K.A.2    Kjems, J.3
  • 31
    • 58349117208 scopus 로고    scopus 로고
    • Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells
    • Moeller, HB, Knepper, MA and Fenton, RA (2009). Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int 75: 295-303.
    • (2009) Kidney Int , vol.75 , pp. 295-303
    • Moeller, H.B.1    Knepper, M.A.2    Fenton, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.