Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

Science

Volumn 319, Issue 5863, 2008, Pages 627-630

  Peer, Dan ^a   Eun, Jeong Park ^a   Morishita, Yoshiyuki ^a   Carman, Christopher V ^a   Shimaoka, Motomu ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA7 INTEGRIN; CYCLIN D1; CYTOKINE; NANOPARTICLE; SMALL INTERFERING RNA; TARGETED STABILIZED NANOPARTICLE; UNCLASSIFIED DRUG;

ANTIBODY; CANCER; DISEASE TREATMENT; EXPERIMENTAL STUDY; GENE EXPRESSION; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COLITIS; ENTERITIS; GENE EXPRESSION; GENE REPRESSION; HELPER CELL; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

ANIMALS; ANTIBODIES; CELL PROLIFERATION; COLITIS; COLON; CYCLINS; CYTOKINES; DRUG CARRIERS; GENES, BCL-1; HYALURONIC ACID; INFLAMMATORY BOWEL DISEASES; INTEGRIN BETA CHAINS; LEUKOCYTES; LIPOSOMES; MICE; NANOPARTICLES; PROTAMINES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; T-LYMPHOCYTES, HELPER-INDUCER;

MUS;

EID: 38849166053     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1149859     Document Type: Article

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23. We thank J. Lieberman for critically reading manuscript and discussion; R. Margalit, R. S. Langer, and P. Sicinski for discussions; and Y. Imai, A. Zur, P. Sage, and R. Yoo for technical assistance. D.P. is supported by the Dorot Foundation and Pfizer Inc. Y.M. is supported by the Uehara Memorial Foundation. This work was supported by the Arthritis Foundation (C.V.C.) and NIH grants HL048675 and AI63421 (M.S.).