Innate immunity and colonic inflammation: Enhanced expression of epithelial α-defensins

Digestive Diseases and Sciences

Volumn 47, Issue 6, 2002, Pages 1349-1355

  Wehkamp, J ^a   Schwind, B ^a   Herrlinger, K R ^a   Baxmann, S ^a   Schmidt, K ^a   Duchrow, M ^a   Wohlschlager C ^a   Feller, A C ^a   Stange, E F ^a   Fellermann, K ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Antimicrobial peptide; Defensin; Inflammatory bowel disease; Innate immunity; Paneth cell

Indexed keywords

ALPHA DEFENSIN; MESSENGER RNA; PEPTIDE;

ARTICLE; CELL STRAIN CACO 2; CLINICAL ARTICLE; COLITIS; COLON CROHN DISEASE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INTESTINE EPITHELIUM CELL; PANETH CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS;

ALPHA-DEFENSINS; CACO-2 CELLS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; DIVERTICULITIS, COLONIC; EPITHELIUM; HUMANS; IMMUNITY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; PANETH CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036270399     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015334917273     Document Type: Article

References (39)

1. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
2. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum
3. Split ileostomy and ileocolostomy for Crohn's disease of the colon and ulcerative colitis: A 20-year survey
4. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
5. T cell specifity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans
6. Interleukin-10-deficient mice develop chronic enterocolitis
7. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
8. Ulcerative colitis-like disease in mice with a disrupted interleukin- 2 gene
9. T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment
10. Experimental models of inflammatory bowel disease
11. Defensins
12. Mouse Paneth cell defensins: Primary structures and antibacterial activities of numerous cryptdin isoforms
13. Enteric defensins: Antibiotic peptide components of intestinal host defense
14. Defensins - Innate immunity at the epithelial fontier
15. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry
16. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation
17. Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23.1
18. Human enteric defensin genes: Chromosomal map position and a model for possible evolutionary relationships
19. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA
20. Epithelial antibiotics induced at sites of inflammation
21. Enteric beta-defensin: Molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection
22. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity
23. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes
24. Paneth cells of the human small intestine express an antimicrobial peptide gene
25. Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel
26. Isolation of human intestinal defensins from ileal neobladder urine
27. Human enteric defensins. Gene structure and developmental expression
28. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
29. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells
30. Enteric defensin expression in necrotizing enterocolitis
31. A peptide antibiotic from human skin
32. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic
33. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium
34. Intestinal expression of human heat shock protein 90 in patients with Crohn's disease and ulcerative colitis
35. Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel disease
36. Detection of human defensin 5 in reproductive tissues
37. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract