Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase

Immunology

Volumn 128, Issue 1 PART 2, 2009, Pages

  Flatekval, Gro F ^a   Sioud, Mouldy ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Bifunctional small interfering RNA; Dendritic cells; Immunosuppression; Indoleamine 2,3 dioxygenase; Small interfering RNA

Indexed keywords

HELICASE; INDOLEAMINE 2,3 DIOXYGENASE; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTOPOIESIS; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANTISENSE ELEMENTS (GENETICS); CELL DIFFERENTIATION; DENDRITIC CELLS; GENE SILENCING; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LYMPHOCYTE ACTIVATION; MONOCYTES; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TRANSFECTION;

EID: 68249159577     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03093.x     Document Type: Article

References (37)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
2. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998 281 : 1191 3.
3. Munn DH, Mellor AL. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004 4 : 762 74.
4. Furset G, Floisand Y, Sioud M. Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands. Immunology 2008 123 : 263 71.
5. Munn DH, Sharma MD, Hou D et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest 2004 114 : 280 90.
6. Furset G, Sioud M. Design of bifunctional siRNAs: combining immunostimulation and gene-silencing in one single siRNA molecule. Biochem Biophys Res Commun 2007 352 : 642 9.
7. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998 391 : 806 11.
8. Sioud M. Therapeutic siRNAs. Trends Pharmacol Sci 2004 25 : 22 8.
9. Gilmore IR, Fox SP, Hollins AJ, Sohail M, Akhtar S. The design and exogenous delivery of siRNA for post-transcriptional gene silencing. J Drug Target 2004 12 : 315 40.
10. Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J Mol Biol 2005 348 : 1079 90.
11. Hornung V, Guenthner-Biller M, Bourquin C et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 2005 11 : 263 70.
12. Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 2005 23 : 457 62.
13. Takeuchi O, Akira S. Recognition of viruses by innate immunity. Immunol Rev 2007 220 : 214 24.
14. Sioud M, Kjeldsen-Kragh J, Quayle AJ, Wiker HG, Sorskaar D, Natvig JB, Forre O. Immune responses to 18.6 and 30-kDa mycobacterial antigens in rheumatoid patients, and V beta usage by specific synovial T-cell lines and fresh T cells. Scand J Immunol 1991 34 : 803 12.
15. Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol 2004 22 : 326 30.
16. Saetrom P, Snove O Jr. A comparison of siRNA efficacy predictors. Biochem Biophys Res Commun 2004 321 : 247 53.
17. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003 31 : 3406 15.
18. Mantei A, Rutz S, Janke M et al. siRNA stabilization prolongs gene knockdown in primary T lymphocytes. Eur J Immunol 2008 38 : 2616 25.
19. Hagemann C, Meyer C, Stojic J, Eicker S, Gerngras S, Kuhnel S, Roosen K, Vince GH. High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments. J Neurosci Methods 2006 156 : 194 202.
20. Geletu M, Balkhi MY, Peer Zada AA, Christopeit M, Pulikkan JA, Trivedi AK, Tenen DG, Behre G. Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9. Blood 2007 110 : 3301 9.
21. Merkerova M, Klamova H, Brdicka R, Bruchova H. Targeting of gene expression by siRNA in CML primary cells. Mol Biol Rep 2007 34 : 27 33.
22. Van Tendeloo VF, Ponsaerts P, Lardon F, Nijs G, Lenjou M, Van Broeckhoven C, Van Bockstaele DR, Berneman ZN. Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 2001 98 : 49 56.
23. Michiels A, Tuyaerts S, Bonehill A et al. Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines. Gene Ther 2005 12 : 772 82.
24. Prechtel AT, Turza NM, Theodoridis AA, Kummer M, Steinkasserer A. Small interfering RNA (siRNA) delivery into monocyte-derived dendritic cells by electroporation. J Immunol Methods 2006 311 : 139 52.
25. Sioud M. Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses. Eur J Immunol 2006 36 : 1222 30.
26. Forsbach A, Nemorin JG, Montino C et al. Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses. J Immunol 2008 180 : 3729 38.
27. Cekaite L, Furset G, Hovig E, Sioud M. Gene expression analysis in blood cells in response to unmodified and 2′-modified siRNAs reveals TLR-dependent and independent effects. J Mol Biol 2007 365 : 90 108.
28. Hornung V, Ellegast J, Kim S et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science 2006 314 : 994 7.
29. Terness P, Bauer TM, Rose L, Dufter C, Watzlik A, Simon H, Opelz G. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 2002 196 : 447 57.
30. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999 189 : 1363 72.
31. Schuler-Thurner B, Schultz ES, Berger TG et al. Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells. J Exp Med 2002 195 : 1279 88.
32. Luft T, Jefford M, Luetjens P et al. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood 2002 100 : 1362 72.
33. Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007 117 : 1184 94.
34. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005 17 : 1 14.
35. Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, Reis e Sousa C. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 2006 314 : 997 1001.
36. Corey DR. Chemical modification: the key to clinical application of RNA interference? J Clin Invest 2007 117 : 3615 22.
37. Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res 2008 36 : 2136 51.