메뉴 건너뛰기




Volumn 58, Issue 1, 2014, Pages 49-60

Plant polyphenols in the treatment of age-associated diseases: Revealing the pleiotropic effects of icariin by network analysis

Author keywords

Alzheimer; Network; Osteoporosis; Toxicogenomics; Traditional Chinese Medicine (TCM)

Indexed keywords

FLAVONOID; ICARIIN; NITRIC OXIDE SYNTHASE; PDE5A PROTEIN, HUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHODIESTERASE V; POLYPHENOL; SIRT1 PROTEIN, HUMAN; SIRTUIN 1;

EID: 84891433544     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300409     Document Type: Review
Times cited : (33)

References (160)
  • 1
    • 84857435066 scopus 로고    scopus 로고
    • Natural polyphenols against neurodegenerative disorders: potentials and pitfalls
    • Ebrahimi, A., Schluesener, H. J., Natural polyphenols against neurodegenerative disorders: potentials and pitfalls. Age. Res. Rev. 2012, 11, 329-345.
    • (2012) Age. Res. Rev. , vol.11 , pp. 329-345
    • Ebrahimi, A.1    Schluesener, H.J.2
  • 2
    • 79960722781 scopus 로고    scopus 로고
    • Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases
    • Mandel, S. A., Amit, T., Weinreb, O., Youdim, M. B. H., Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases. J. Alzheimers Dis. 2011, 25, 187-208.
    • (2011) J. Alzheimers Dis. , vol.25 , pp. 187-208
    • Mandel, S.A.1    Amit, T.2    Weinreb, O.3    Youdim, M.B.H.4
  • 3
    • 79551538975 scopus 로고    scopus 로고
    • Revisiting dietary antioxidants, neurodegeneration and dementia
    • Craggs, L., Kalaria, R. N., Revisiting dietary antioxidants, neurodegeneration and dementia. Neuroreport 2011, 22, 1-3.
    • (2011) Neuroreport , vol.22 , pp. 1-3
    • Craggs, L.1    Kalaria, R.N.2
  • 4
    • 77957753126 scopus 로고    scopus 로고
    • A review of natural and synthetic antioxidants important for health and longevity
    • Wojcik, M., Burzynska-Pedziwiatr, I., Wozniak, L. A., A review of natural and synthetic antioxidants important for health and longevity. Curr. Med. Chem. 2010, 17, 3262-3288.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 3262-3288
    • Wojcik, M.1    Burzynska-Pedziwiatr, I.2    Wozniak, L.A.3
  • 5
    • 33747586544 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: role in liver and brain
    • Knauf, C., Rieusset, J., Foretz, M., Cani, P. D. et al., Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: role in liver and brain. Endocrinology 2006, 147, 4067-4078.
    • (2006) Endocrinology , vol.147 , pp. 4067-4078
    • Knauf, C.1    Rieusset, J.2    Foretz, M.3    Cani, P.D.4
  • 6
    • 84868686732 scopus 로고    scopus 로고
    • Ranking transitive chemical-disease inferences using local network topology in the comparative toxicogenomics database
    • King, B. L., Davis, A. P., Rosenstein, M. C., Wiegers, T. C. et al., Ranking transitive chemical-disease inferences using local network topology in the comparative toxicogenomics database. PLoS One 2012, 7, e46524.
    • (2012) PLoS One , vol.7
    • King, B.L.1    Davis, A.P.2    Rosenstein, M.C.3    Wiegers, T.C.4
  • 7
    • 84870171600 scopus 로고    scopus 로고
    • Phosphodiesterases in neurodegenerative disorders
    • Bollen, E., Prickaerts, J., Phosphodiesterases in neurodegenerative disorders. IUBMB Life 2012, 64, 965-970.
    • (2012) IUBMB Life , vol.64 , pp. 965-970
    • Bollen, E.1    Prickaerts, J.2
  • 9
    • 77957354074 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats
    • Cheng, Y.-F., Wang, C., Lin, H.-B., Li, Y.-F. et al., Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats. Psychopharmacology (Berl.) 2010, 212, 181-191.
    • (2010) Psychopharmacology (Berl.) , vol.212 , pp. 181-191
    • Cheng, Y.-F.1    Wang, C.2    Lin, H.-B.3    Li, Y.-F.4
  • 10
    • 0037360716 scopus 로고    scopus 로고
    • Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities
    • Xin, Z. C., Kim, E., Lin, C., Liu, W. et al., Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J. Androl. 2003, 5, 15-18.
    • (2003) Asian J. Androl. , vol.5 , pp. 15-18
    • Xin, Z.C.1    Kim, E.2    Lin, C.3    Liu, W.4
  • 11
    • 29244473849 scopus 로고    scopus 로고
    • Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats
    • Liu, W.-J., Xin, Z.-C., Xin, H., Yuan, Y.-M. et al., Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J. Androl. 2005, 7, 381-388.
    • (2005) Asian J. Androl. , vol.7 , pp. 381-388
    • Liu, W.-J.1    Xin, Z.-C.2    Xin, H.3    Yuan, Y.-M.4
  • 12
    • 33845296134 scopus 로고    scopus 로고
    • Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells
    • Ning, H., Xin, Z.-C., Lin, G., Banie, L. et al., Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 2006, 68, 1350-1354.
    • (2006) Urology , vol.68 , pp. 1350-1354
    • Ning, H.1    Xin, Z.-C.2    Lin, G.3    Banie, L.4
  • 13
    • 84872831139 scopus 로고    scopus 로고
    • Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes
    • Zhou, F., Xin, H., Liu, T., Li, G. Y. et al., Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes. J. Androl. 2012, 33, 832-844.
    • (2012) J. Androl. , vol.33 , pp. 832-844
    • Zhou, F.1    Xin, H.2    Liu, T.3    Li, G.Y.4
  • 14
    • 78650172130 scopus 로고    scopus 로고
    • Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia
    • Tanaka, Y., Tanaka, R., Liu, M., Hattori, N. et al., Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia. Neuroscience 2010, 171, 1367-1376.
    • (2010) Neuroscience , vol.171 , pp. 1367-1376
    • Tanaka, Y.1    Tanaka, R.2    Liu, M.3    Hattori, N.4
  • 15
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • Zhang, R., Wang, Y., Zhang, L., Zhang, Z. et al., Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 2002, 33, 2675-2680.
    • (2002) Stroke , vol.33 , pp. 2675-2680
    • Zhang, R.1    Wang, Y.2    Zhang, L.3    Zhang, Z.4
  • 16
    • 16844372455 scopus 로고    scopus 로고
    • Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor
    • Zhang, L., Zhang, R. L., Wang, Y., Zhang, C. et al., Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 2005, 36, 847-852.
    • (2005) Stroke , vol.36 , pp. 847-852
    • Zhang, L.1    Zhang, R.L.2    Wang, Y.3    Zhang, C.4
  • 17
    • 5044251651 scopus 로고    scopus 로고
    • Prevention action of Chinese herbs for tonifying kidney on bone loss in senile males: 1 year follow-up
    • Available: .]
    • Xie, J., Shen, L., Yang, Y.-P., Zhou, P.-Q. et al., Prevention action of Chinese herbs for tonifying kidney on bone loss in senile males: 1 year follow-up. Chin. J. Clin. Rehabil. 2004, 4, 5180-5181. [Available: http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/700/CN-00516700/frame.html.]
    • (2004) Chin. J. Clin. Rehabil. , vol.4 , pp. 5180-5181
    • Xie, J.1    Shen, L.2    Yang, Y.-P.3    Zhou, P.-Q.4
  • 18
    • 34548577294 scopus 로고    scopus 로고
    • Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial
    • Zhang, G., Qin, L., Shi, Y., Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J. Bone Miner. Res. 2007, 22, 1072-1079.
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 1072-1079
    • Zhang, G.1    Qin, L.2    Shi, Y.3
  • 19
    • 54149089653 scopus 로고    scopus 로고
    • Potent inhibition of human phosphodiesterase-5 by icariin derivatives
    • Dell'Agli, M., Galli, G. V., Dal Cero, E., Belluti, F. et al., Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J. Nat. Prod. 2008, 71, 1513-1517.
    • (2008) J. Nat. Prod. , vol.71 , pp. 1513-1517
    • Dell'Agli, M.1    Galli, G.V.2    Dal Cero, E.3    Belluti, F.4
  • 20
    • 70849136305 scopus 로고    scopus 로고
    • Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus
    • Nie, J., Luo, Y., Huang, X.-N., Gong, Q.-H. et al., Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus. Eur. J. Pharmacol. 2010, 626, 213-218.
    • (2010) Eur. J. Pharmacol. , vol.626 , pp. 213-218
    • Nie, J.1    Luo, Y.2    Huang, X.-N.3    Gong, Q.-H.4
  • 21
    • 77956920667 scopus 로고    scopus 로고
    • Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells
    • Zeng, K.-W., Ko, H., Yang, H. O., Wang, X.-M., Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology 2010, 59, 542-550.
    • (2010) Neuropharmacology , vol.59 , pp. 542-550
    • Zeng, K.-W.1    Ko, H.2    Yang, H.O.3    Wang, X.-M.4
  • 22
    • 78049443933 scopus 로고    scopus 로고
    • Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy
    • Urano, T., Tohda, C., Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy. Phytother. Res. 2010, 24, 1658-1663.
    • (2010) Phytother. Res. , vol.24 , pp. 1658-1663
    • Urano, T.1    Tohda, C.2
  • 23
    • 84863985277 scopus 로고    scopus 로고
    • Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats
    • Wu, B., Chen, Y., Huang, J., Ning, Y. et al., Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats. J. Ethnopharmacol. 2012, 142, 746-753.
    • (2012) J. Ethnopharmacol. , vol.142 , pp. 746-753
    • Wu, B.1    Chen, Y.2    Huang, J.3    Ning, Y.4
  • 24
    • 77954758416 scopus 로고    scopus 로고
    • Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats
    • Available: ]
    • Li, F., Gong, Q.-H., Wu, Q., Lu, Y.-F., Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats. Pharmacol. Biochem. Behav. 2010, 96, 301-305. [Available: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20566405&retmode=ref&cmd=prlinks]
    • (2010) Pharmacol. Biochem. Behav. , vol.96 , pp. 301-305
    • Li, F.1    Gong, Q.-H.2    Wu, Q.3    Lu, Y.-F.4
  • 25
    • 34347339423 scopus 로고    scopus 로고
    • Protective effects of icariin against learning and memory deficits induced by aluminium in rats
    • Luo, Y., Nie, J., Gong, Q.-H., Lu, Y.-F. et al., Protective effects of icariin against learning and memory deficits induced by aluminium in rats. Clin. Exp. Pharmacol. Physiol. 2007, 34, 792-795.
    • (2007) Clin. Exp. Pharmacol. Physiol. , vol.34 , pp. 792-795
    • Luo, Y.1    Nie, J.2    Gong, Q.-H.3    Lu, Y.-F.4
  • 26
    • 77952104760 scopus 로고    scopus 로고
    • Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice
    • He, X.-L., Zhou, W.-Q., Bi, M.-G., Du, G.-H., Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice. Brain Res. 2010, 1334, 73-83.
    • (2010) Brain Res. , vol.1334 , pp. 73-83
    • He, X.-L.1    Zhou, W.-Q.2    Bi, M.-G.3    Du, G.-H.4
  • 27
    • 31844440851 scopus 로고    scopus 로고
    • Antidepressant-like effect of icariin and its possible mechanism in mice
    • Pan, Y., Kong, L., Xia, X., Zhang, W. et al., Antidepressant-like effect of icariin and its possible mechanism in mice. Pharmacol. Biochem. Behav. 2005, 82, 686-694.
    • (2005) Pharmacol. Biochem. Behav. , vol.82 , pp. 686-694
    • Pan, Y.1    Kong, L.2    Xia, X.3    Zhang, W.4
  • 28
    • 77953285783 scopus 로고    scopus 로고
    • Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke
    • Zhu, H.-R., Wang, Z.-Y., Zhu, X.-L., Wu, X.-X. et al., Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 2010, 59, 70-76.
    • (2010) Neuropharmacology , vol.59 , pp. 70-76
    • Zhu, H.-R.1    Wang, Z.-Y.2    Zhu, X.-L.3    Wu, X.-X.4
  • 29
    • 68549115432 scopus 로고    scopus 로고
    • Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats
    • Xu, R.-X., Wu, Q., Luo, Y., Gong, Q.-H. et al., Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats. Clin. Exp. Pharmacol. Physiol. 2009, 36, 810-815.
    • (2009) Clin. Exp. Pharmacol. Physiol. , vol.36 , pp. 810-815
    • Xu, R.-X.1    Wu, Q.2    Luo, Y.3    Gong, Q.-H.4
  • 30
    • 75149115354 scopus 로고    scopus 로고
    • Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts
    • Sha, D., Li, L., Ye, L., Liu, R. et al., Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts. Neuroreport 2009, 20, 1564-1567.
    • (2009) Neuroreport , vol.20 , pp. 1564-1567
    • Sha, D.1    Li, L.2    Ye, L.3    Liu, R.4
  • 31
    • 0037424442 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents
    • Chaki, S., Kawashima, N., Suzuki, Y., Shimazaki, T. et al., Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents. Eur. J. Pharmacol. 2003, 464, 49-54.
    • (2003) Eur. J. Pharmacol. , vol.464 , pp. 49-54
    • Chaki, S.1    Kawashima, N.2    Suzuki, Y.3    Shimazaki, T.4
  • 32
    • 77958608333 scopus 로고    scopus 로고
    • Cocaine-and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour
    • doi:10.1371/journal.pone.0012980.
    • James, M. H., Charnley, J. L., Jones, E., Levi, E. M. et al., Cocaine-and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour. PLoS One 2010, 5, e12980. doi:10.1371/journal.pone.0012980.
    • (2010) PLoS One , vol.5
    • James, M.H.1    Charnley, J.L.2    Jones, E.3    Levi, E.M.4
  • 33
    • 84861078831 scopus 로고    scopus 로고
    • A review: inflammatory process in Alzheimer's disease, role of cytokines
    • doi: 10.1100/2012/756357.
    • Rubio-Perez, J. M., Morillas-Ruiz, J. M., A review: inflammatory process in Alzheimer's disease, role of cytokines. Scientif. World J. 2012, 2012, 756357. doi: 10.1100/2012/756357.
    • (2012) Scientif. World J. , vol.2012 , pp. 756357
    • Rubio-Perez, J.M.1    Morillas-Ruiz, J.M.2
  • 35
    • 37349054326 scopus 로고    scopus 로고
    • Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease
    • Hamel, E., Nicolakakis, N., Aboulkassim, T., Ongali, B. et al., Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease. Exp. Physiol. 2008, 93, 116-120.
    • (2008) Exp. Physiol. , vol.93 , pp. 116-120
    • Hamel, E.1    Nicolakakis, N.2    Aboulkassim, T.3    Ongali, B.4
  • 36
    • 79551595931 scopus 로고    scopus 로고
    • In vivo and in vitro anti-inflammatory effects of a novel derivative of icariin
    • Wu, J., Du, J., Xu, C., Le, J. et al., In vivo and in vitro anti-inflammatory effects of a novel derivative of icariin. Immunopharmacol. Immunotoxicol. 2011, 33, 49-54.
    • (2011) Immunopharmacol. Immunotoxicol. , vol.33 , pp. 49-54
    • Wu, J.1    Du, J.2    Xu, C.3    Le, J.4
  • 37
    • 67649617842 scopus 로고    scopus 로고
    • Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD
    • Schipper, H., Gupta, A., Szarek, W., Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD. Curr. Alzheimer Res. 2009, 6, 424-430.
    • (2009) Curr. Alzheimer Res. , vol.6 , pp. 424-430
    • Schipper, H.1    Gupta, A.2    Szarek, W.3
  • 38
    • 42049090394 scopus 로고    scopus 로고
    • Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections
    • Cuadrado, A., Rojo, A. I., Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr. Pharm. Des. 2008, 14, 429-442.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 429-442
    • Cuadrado, A.1    Rojo, A.I.2
  • 39
    • 84856086398 scopus 로고    scopus 로고
    • Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes
    • Wu, J., Zhou, J., Chen, X., Fortenbery, N. et al., Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes. Int. Immunopharmacol. 2012, 12, 74-79.
    • (2012) Int. Immunopharmacol. , vol.12 , pp. 74-79
    • Wu, J.1    Zhou, J.2    Chen, X.3    Fortenbery, N.4
  • 40
    • 79958061935 scopus 로고    scopus 로고
    • Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions
    • Zhou, J., Wu, J., Chen, X., Fortenbery, N. et al., Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions. Int. Immunopharmacol. 2011, 11, 890-898.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 890-898
    • Zhou, J.1    Wu, J.2    Chen, X.3    Fortenbery, N.4
  • 41
    • 45949106077 scopus 로고    scopus 로고
    • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
    • Richard, K. L., Filali, M., Préfontaine, P., Rivest, S., Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J. Neurosci. 2008, 28, 5784-5793.
    • (2008) J. Neurosci. , vol.28 , pp. 5784-5793
    • Richard, K.L.1    Filali, M.2    Préfontaine, P.3    Rivest, S.4
  • 42
    • 77956616914 scopus 로고    scopus 로고
    • Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats
    • Guo, J., Li, F., Wu, Q., Gong, Q. et al., Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. Phytomedicine 2010, 17, 950-955.
    • (2010) Phytomedicine , vol.17 , pp. 950-955
    • Guo, J.1    Li, F.2    Wu, Q.3    Gong, Q.4
  • 43
    • 73949131135 scopus 로고    scopus 로고
    • Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats
    • Pan, Y., Wang, F.-M, Qiang, L.-Q., Zhang, D.-M. et al., Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology 2010, 35, 272-283.
    • (2010) Psychoneuroendocrinology , vol.35 , pp. 272-283
    • Pan, Y.1    Wang, F.-M.2    Qiang, L.-Q.3    Zhang, D.-M.4
  • 44
    • 80054954467 scopus 로고    scopus 로고
    • Icariin induces the expression of toll-like receptor 9 in ana-1 murine macrophages
    • Li, L., Peng, L., Miao, J., Qiu, Y. et al., Icariin induces the expression of toll-like receptor 9 in ana-1 murine macrophages. Phytother. Res. 2011, 25, 1732-1735.
    • (2011) Phytother. Res. , vol.25 , pp. 1732-1735
    • Li, L.1    Peng, L.2    Miao, J.3    Qiu, Y.4
  • 45
    • 77950021664 scopus 로고    scopus 로고
    • Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression
    • Hsieh, T.-P., Sheu, S.-Y., Sun, J.-S., Chen, M.-H. et al., Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomedicine 2010, 17, 414-423.
    • (2010) Phytomedicine , vol.17 , pp. 414-423
    • Hsieh, T.-P.1    Sheu, S.-Y.2    Sun, J.-S.3    Chen, M.-H.4
  • 46
    • 35348986425 scopus 로고    scopus 로고
    • Icariin enhances the osteogenic differentiation of bone marrow stromal cells but has no effects on the differentiation of newborn calvarial osteoblasts of rats
    • Chen, K. M., Ma, H. P., Ge, B. F., Liu, X. Y. et al., Icariin enhances the osteogenic differentiation of bone marrow stromal cells but has no effects on the differentiation of newborn calvarial osteoblasts of rats. Pharmazie 2007, 62, 785-789.
    • (2007) Pharmazie , vol.62 , pp. 785-789
    • Chen, K.M.1    Ma, H.P.2    Ge, B.F.3    Liu, X.Y.4
  • 47
    • 47949109779 scopus 로고    scopus 로고
    • Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats
    • Schakman, O., Kalista, S., Bertrand, L., Lause, P. et al., Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats. Endocrinology 2008, 149, 3900-3908.
    • (2008) Endocrinology , vol.149 , pp. 3900-3908
    • Schakman, O.1    Kalista, S.2    Bertrand, L.3    Lause, P.4
  • 48
    • 60649102477 scopus 로고    scopus 로고
    • Up-regulation of receptor activator nuclear factor-kappaB ligand expression by root canal sealers in human osteoblastic cells
    • Huang, F.-M., Lee, S.-S., Yang, S.-F., Chang, Y.-C., Up-regulation of receptor activator nuclear factor-kappaB ligand expression by root canal sealers in human osteoblastic cells. J. Endod. 2009, 35, 363-366.
    • (2009) J. Endod. , vol.35 , pp. 363-366
    • Huang, F.-M.1    Lee, S.-S.2    Yang, S.-F.3    Chang, Y.-C.4
  • 49
    • 84862639620 scopus 로고    scopus 로고
    • Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies
    • Kang, H. K., Choi, Y.-H., Kwon, H., Lee, S.-B. et al., Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies. Food Chem. Toxicol. 2012, 50, 2751-2759.
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 2751-2759
    • Kang, H.K.1    Choi, Y.-H.2    Kwon, H.3    Lee, S.-B.4
  • 50
    • 57049161959 scopus 로고    scopus 로고
    • Zoledronate reverses mandibular bone loss in osteoprotegerin-deficient mice
    • Sheng, Z.-F., Xu, K., Ma, Y.-L., Liu, J.-H. et al., Zoledronate reverses mandibular bone loss in osteoprotegerin-deficient mice. Osteoporos. Int. 2009, 20, 151-159.
    • (2009) Osteoporos. Int. , vol.20 , pp. 151-159
    • Sheng, Z.-F.1    Xu, K.2    Ma, Y.-L.3    Liu, J.-H.4
  • 51
    • 27144535338 scopus 로고    scopus 로고
    • Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells
    • Ye, H. Y., Lou, Y. J., Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells. Phytomedicine 2005, 12, 735-741.
    • (2005) Phytomedicine , vol.12 , pp. 735-741
    • Ye, H.Y.1    Lou, Y.J.2
  • 52
    • 23044509872 scopus 로고    scopus 로고
    • The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy
    • Morony, S., Warmington, K., Adamu, S., Asuncion, F. et al., The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy. Endocrinology 2005, 146, 3235-3243.
    • (2005) Endocrinology , vol.146 , pp. 3235-3243
    • Morony, S.1    Warmington, K.2    Adamu, S.3    Asuncion, F.4
  • 53
    • 34948883973 scopus 로고    scopus 로고
    • Association between osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) gene polymorphisms and circulating OPG, soluble RANKL levels, and bone mineral density in Korean postmenopausal women
    • Kim, J. G., Kim, J. H., Kim, J. Y., Ku, S. Y. et al., Association between osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) gene polymorphisms and circulating OPG, soluble RANKL levels, and bone mineral density in Korean postmenopausal women. Menopause 2007, 14, 913-918.
    • (2007) Menopause , vol.14 , pp. 913-918
    • Kim, J.G.1    Kim, J.H.2    Kim, J.Y.3    Ku, S.Y.4
  • 54
    • 34548841961 scopus 로고    scopus 로고
    • Osteoporosis: non-hormonal treatment
    • Rizzoli, R., Osteoporosis: non-hormonal treatment. Climacteric 2007, 10, 74-78.
    • (2007) Climacteric , vol.10 , pp. 74-78
    • Rizzoli, R.1
  • 55
    • 0037303261 scopus 로고    scopus 로고
    • Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease
    • Croucher, P. I., Shipman, C. M., Van Camp, B., Vanderkerken, K., Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease. Cancer 2003, 97, 818-824.
    • (2003) Cancer , vol.97 , pp. 818-824
    • Croucher, P.I.1    Shipman, C.M.2    Van Camp, B.3    Vanderkerken, K.4
  • 56
    • 43549103987 scopus 로고    scopus 로고
    • Involvement of NF-kappaB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells
    • Wo, Y., Zhu, D.-Y., Yu, Y., Lou, Y., Involvement of NF-kappaB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. Eur. J. Pharmacol. 2008, 586, 59-66.
    • (2008) Eur. J. Pharmacol. , vol.586 , pp. 59-66
    • Wo, Y.1    Zhu, D.-Y.2    Yu, Y.3    Lou, Y.4
  • 57
    • 34848828497 scopus 로고    scopus 로고
    • Icariin promotes expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro
    • Ding, L., Liang, X.-G., Zhu, D.-Y., Lou, Y., Icariin promotes expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta. Pharmacologica. Sinica. 2007, 28, 1541-1549.
    • (2007) Acta. Pharmacologica. Sinica. , vol.28 , pp. 1541-1549
    • Ding, L.1    Liang, X.-G.2    Zhu, D.-Y.3    Lou, Y.4
  • 58
    • 34047126320 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    • Andrulionyte, L., Kuulasmaa, T., Chiasson, J.-L., Laakso, M. et al., Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2007, 56, 1181-1186.
    • (2007) Diabetes , vol.56 , pp. 1181-1186
    • Andrulionyte, L.1    Kuulasmaa, T.2    Chiasson, J.-L.3    Laakso, M.4
  • 59
    • 0842347859 scopus 로고    scopus 로고
    • Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone
    • Jové, M., Salla, J., Planavila, A., Cabrero, A. et al., Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. J. Lipid. Res. 2004, 45, 113-123.
    • (2004) J. Lipid. Res. , vol.45 , pp. 113-123
    • Jové, M.1    Salla, J.2    Planavila, A.3    Cabrero, A.4
  • 60
    • 0141507040 scopus 로고    scopus 로고
    • Relationship between peroxisome proliferator-activated receptors (PPAR alpha and PPAR gamma) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats
    • Kanie, N., Matsumoto, T., Kobayashi, T., Kamata, K., Relationship between peroxisome proliferator-activated receptors (PPAR alpha and PPAR gamma) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 2003, 140, 23-32.
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 23-32
    • Kanie, N.1    Matsumoto, T.2    Kobayashi, T.3    Kamata, K.4
  • 61
    • 0033695790 scopus 로고    scopus 로고
    • Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
    • Memon, R. A., Tecott, L. H., Nonogaki, K., Beigneux, A. et al., Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 2000, 141, 4021-4031.
    • (2000) Endocrinology , vol.141 , pp. 4021-4031
    • Memon, R.A.1    Tecott, L.H.2    Nonogaki, K.3    Beigneux, A.4
  • 62
    • 32844466263 scopus 로고    scopus 로고
    • Fibrate prevents cisplatin-induced proximal tubule cell death
    • Nagothu, K. K., Bhatt, R., Kaushal, G. P., Portilla, D., Fibrate prevents cisplatin-induced proximal tubule cell death. Kidney Int. 2005, 68, 2680-2693.
    • (2005) Kidney Int. , vol.68 , pp. 2680-2693
    • Nagothu, K.K.1    Bhatt, R.2    Kaushal, G.P.3    Portilla, D.4
  • 63
    • 71749115788 scopus 로고    scopus 로고
    • Niacin improves renal lipid metabolism and slows progression in chronic kidney disease
    • Cho, K.-H., Kim, H.-J., Kamanna, V. S., Vaziri, N. D., Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim. Biophys. Acta. 2010, 1800, 6-15.
    • (2010) Biochim. Biophys. Acta. , vol.1800 , pp. 6-15
    • Cho, K.-H.1    Kim, H.-J.2    Kamanna, V.S.3    Vaziri, N.D.4
  • 64
    • 12944308811 scopus 로고    scopus 로고
    • Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
    • Andrulionyte, L., Zacharova, J., Chiasson, J.-L., Laakso, M. et al., Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. Diabetologia 2004, 47, 2176-2184.
    • (2004) Diabetologia , vol.47 , pp. 2176-2184
    • Andrulionyte, L.1    Zacharova, J.2    Chiasson, J.-L.3    Laakso, M.4
  • 65
    • 16644403795 scopus 로고    scopus 로고
    • Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arterigenic erectile dysfunction rat model
    • Tian, L., Xin, Z.-C., Liu, W.-J., Yang, Y.-M. et al., Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arterigenic erectile dysfunction rat model. Zhonghua Yi Xue Za Zhi 2004, 84, 954-957.
    • (2004) Zhonghua Yi Xue Za Zhi , vol.84 , pp. 954-957
    • Tian, L.1    Xin, Z.-C.2    Liu, W.-J.3    Yang, Y.-M.4
  • 66
    • 34247190773 scopus 로고    scopus 로고
    • Vasorelaxant effects of icariin on isolated canine coronary artery
    • Xu, H.-B., Huang, Z.-Q., Vasorelaxant effects of icariin on isolated canine coronary artery. J. Cardiovasc. Pharmacol. 2007, 49, 207-213.
    • (2007) J. Cardiovasc. Pharmacol. , vol.49 , pp. 207-213
    • Xu, H.-B.1    Huang, Z.-Q.2
  • 67
    • 34249280557 scopus 로고    scopus 로고
    • Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro
    • Xu, H.-B., Huang, Z.-Q., Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascul. Pharmacol. 2007, 47, 18-24.
    • (2007) Vascul. Pharmacol. , vol.47 , pp. 18-24
    • Xu, H.-B.1    Huang, Z.-Q.2
  • 68
    • 84869217927 scopus 로고    scopus 로고
    • Sarcopenia: pharmacology of today and tomorrow
    • Brotto, M., Abreu, E. L., Sarcopenia: pharmacology of today and tomorrow. J. Pharmacol. Exp. Ther. 2012, 343, 540-546.
    • (2012) J. Pharmacol. Exp. Ther. , vol.343 , pp. 540-546
    • Brotto, M.1    Abreu, E.L.2
  • 69
    • 33644821653 scopus 로고    scopus 로고
    • Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro1
    • Zhu, D.-Y., Lou, Y., Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro1. Acta. Pharmacologica. Sinica. 2006, 27, 311-320.
    • (2006) Acta. Pharmacologica. Sinica. , vol.27 , pp. 311-320
    • Zhu, D.-Y.1    Lou, Y.2
  • 70
    • 0031596581 scopus 로고    scopus 로고
    • Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy
    • Brodde, O. E., Vogelsang, M., Broede, A., Michel-Reher, M. et al., Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy. J. Cardiovasc. Pharmacol. 1998, 31, 585-594.
    • (1998) J. Cardiovasc. Pharmacol. , vol.31 , pp. 585-594
    • Brodde, O.E.1    Vogelsang, M.2    Broede, A.3    Michel-Reher, M.4
  • 71
    • 0033930491 scopus 로고    scopus 로고
    • Protection against myocardial dysfunction induced by global ischemia-reperfusion by antisense-oligodeoxynucleotides directed at beta(1)-adrenoceptor mRNA
    • Chen, H., Zhang, Y. C., Li, D., Phillips, M. I. et al., Protection against myocardial dysfunction induced by global ischemia-reperfusion by antisense-oligodeoxynucleotides directed at beta(1)-adrenoceptor mRNA. J. Pharmacol. Exp. Ther. 2000, 294, 722-727.
    • (2000) J. Pharmacol. Exp. Ther. , vol.294 , pp. 722-727
    • Chen, H.1    Zhang, Y.C.2    Li, D.3    Phillips, M.I.4
  • 72
    • 79952220470 scopus 로고    scopus 로고
    • Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts
    • He, W., Li, Z.-L., Cui, Y.-L., Yi, B. et al., Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts. Beijing Da Xue Xue Bao 2009, 41, 669-673.
    • (2009) Beijing Da Xue Xue Bao , vol.41 , pp. 669-673
    • He, W.1    Li, Z.-L.2    Cui, Y.-L.3    Yi, B.4
  • 73
    • 33644993478 scopus 로고    scopus 로고
    • Regulation of Cbfa1 expression by total flavonoids of Herba epimedii
    • Qian, G., Zhang, X., Lu, L., Wu, X. et al., Regulation of Cbfa1 expression by total flavonoids of Herba epimedii. Endocr. J. 2006, 53, 87-94.
    • (2006) Endocr. J. , vol.53 , pp. 87-94
    • Qian, G.1    Zhang, X.2    Lu, L.3    Wu, X.4
  • 74
    • 33847080418 scopus 로고    scopus 로고
    • Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2
    • Yin, X.-X., Chen, Z.-Q., Liu, Z.-J., Ma, Q.-J. et al., Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chin. Med. J. 2007, 120, 204-210.
    • (2007) Chin. Med. J. , vol.120 , pp. 204-210
    • Yin, X.-X.1    Chen, Z.-Q.2    Liu, Z.-J.3    Ma, Q.-J.4
  • 75
    • 20844440722 scopus 로고    scopus 로고
    • Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts
    • Yin, X.-X., Chen, Z.-Q., Dang, G.-T., Ma, Q.-J., Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts. Zhongguo Zhong Yao Za Zhi 2005, 30, 289-291.
    • (2005) Zhongguo Zhong Yao Za Zhi , vol.30 , pp. 289-291
    • Yin, X.-X.1    Chen, Z.-Q.2    Dang, G.-T.3    Ma, Q.-J.4
  • 76
    • 84855422820 scopus 로고    scopus 로고
    • Material-related effects of BMP-2 delivery systems on bone regeneration
    • Hernández, A., Sánchez, E., Soriano, I., Reyes, R. et al., Material-related effects of BMP-2 delivery systems on bone regeneration. Acta. Biomater. 2012, 8, 781-791.
    • (2012) Acta. Biomater. , vol.8 , pp. 781-791
    • Hernández, A.1    Sánchez, E.2    Soriano, I.3    Reyes, R.4
  • 77
    • 58049199370 scopus 로고    scopus 로고
    • A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia
    • Koleganova, N., Piecha, G., Ritz, E., Schmitt, C. P. et al., A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia. Kidney Int. 2008, 75, 60-71.
    • (2008) Kidney Int. , vol.75 , pp. 60-71
    • Koleganova, N.1    Piecha, G.2    Ritz, E.3    Schmitt, C.P.4
  • 78
    • 37549003252 scopus 로고    scopus 로고
    • RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression
    • Yadava, R. S., Frenzel-McCardell, C. D., Yu, Q., Srinivasan, V. et al., RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. Nat. Genet. 2008, 40, 61-68.
    • (2008) Nat. Genet. , vol.40 , pp. 61-68
    • Yadava, R.S.1    Frenzel-McCardell, C.D.2    Yu, Q.3    Srinivasan, V.4
  • 80
    • 36448936053 scopus 로고    scopus 로고
    • Common pathological processes in Alzheimer disease and type 2 diabetes: a review
    • Li, L., Hölscher, C., Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res. Rev. 2007, 56, 384-402.
    • (2007) Brain Res. Rev. , vol.56 , pp. 384-402
    • Li, L.1    Hölscher, C.2
  • 81
    • 84863074195 scopus 로고    scopus 로고
    • Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo
    • Xin, H., Zhou, F., Liu, T., Li, G.-Y. et al., Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo. Int. J. Mol. Sci. 2012, 13, 866-878.
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 866-878
    • Xin, H.1    Zhou, F.2    Liu, T.3    Li, G.-Y.4
  • 82
    • 82455164280 scopus 로고    scopus 로고
    • Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats
    • Qi, M.-Y., Kai-Chen, Liu, H.-R., Su, Y.-H. et al., Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats. J. Ethnopharmacol. 2011, 138, 731-736.
    • (2011) J. Ethnopharmacol. , vol.138 , pp. 731-736
    • Qi, M.-Y.1    Kai-Chen2    Liu, H.-R.3    Su, Y.-H.4
  • 83
    • 83755186160 scopus 로고    scopus 로고
    • Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans
    • Cai, W.-J., Huang, J.-H., Zhang, S.-Q., Wu, B. et al., Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 2011, 6, e28835.
    • (2011) PLoS One , vol.6
    • Cai, W.-J.1    Huang, J.-H.2    Zhang, S.-Q.3    Wu, B.4
  • 84
    • 0031762512 scopus 로고    scopus 로고
    • Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide
    • Tamatani, M., Ogawa, S., Nuñez, G., Tohyama, M., Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide. Cell Death Differ. 1998, 5, 911-919.
    • (1998) Cell Death Differ. , vol.5 , pp. 911-919
    • Tamatani, M.1    Ogawa, S.2    Nuñez, G.3    Tohyama, M.4
  • 85
    • 0031558628 scopus 로고    scopus 로고
    • Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice
    • Contreras, P. C., Vaught, J. L., Gruner, J. A., Brosnan, C. et al., Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice. Brain Res. 1997, 774, 20-26.
    • (1997) Brain Res. , vol.774 , pp. 20-26
    • Contreras, P.C.1    Vaught, J.L.2    Gruner, J.A.3    Brosnan, C.4
  • 86
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?
    • Steen, E., Terry, B. M., Rivera, E. J., Cannon, J. L. et al., Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J. Alzheimers Dis. 2005, 7, 63-80.
    • (2005) J. Alzheimers Dis. , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3    Cannon, J.L.4
  • 87
    • 0030345313 scopus 로고    scopus 로고
    • Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease
    • Vaught, J. L., Contreras, P. C., Glicksman, M. A., Neff, N. T., Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. Ciba Found Symp. 1996, 196, 18-38.
    • (1996) Ciba Found Symp. , vol.196 , pp. 18-38
    • Vaught, J.L.1    Contreras, P.C.2    Glicksman, M.A.3    Neff, N.T.4
  • 88
    • 67949089783 scopus 로고    scopus 로고
    • Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia
    • Harada, N., Okajima, K., Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia. Biosci. Biotechnol. Biochem. 2009, 73, 1456-1459.
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , pp. 1456-1459
    • Harada, N.1    Okajima, K.2
  • 89
    • 0034743753 scopus 로고    scopus 로고
    • IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress
    • Kajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B. et al., IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 2001, 50, 1414-1424.
    • (2001) Diabetes , vol.50 , pp. 1414-1424
    • Kajstura, J.1    Fiordaliso, F.2    Andreoli, A.M.3    Li, B.4
  • 90
    • 0030049112 scopus 로고    scopus 로고
    • The effect of recombinant human insulin-like growth factor-I on chronic puromycin aminonucleoside nephropathy in rats
    • Trachtman, H., Maesaka, J., Futterweit, S., Ma, C. et al., The effect of recombinant human insulin-like growth factor-I on chronic puromycin aminonucleoside nephropathy in rats. Pediatr. Res. 1996, 39, 13-19.
    • (1996) Pediatr. Res. , vol.39 , pp. 13-19
    • Trachtman, H.1    Maesaka, J.2    Futterweit, S.3    Ma, C.4
  • 91
    • 0032938267 scopus 로고    scopus 로고
    • Insulin-like growth factor I improves renal function in patients with end-stage chronic renal failure
    • Vijayan, A., Franklin, S. C., Behrend, T., Hammerman, M. R. et al., Insulin-like growth factor I improves renal function in patients with end-stage chronic renal failure. Am. J. Physiol. 1999, 276, R929-R934.
    • (1999) Am. J. Physiol. , vol.276
    • Vijayan, A.1    Franklin, S.C.2    Behrend, T.3    Hammerman, M.R.4
  • 92
    • 0038095648 scopus 로고    scopus 로고
    • Insulin-like growth factor-I enhances choleretic action of FK506 in rats
    • Mabuchi, M., Kawamura, I., Takeshita, S., Fushimi, M. et al., Insulin-like growth factor-I enhances choleretic action of FK506 in rats. Transplant. Proc. 2003, 35, 1596-1598.
    • (2003) Transplant. Proc. , vol.35 , pp. 1596-1598
    • Mabuchi, M.1    Kawamura, I.2    Takeshita, S.3    Fushimi, M.4
  • 93
    • 19944363162 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury
    • Sanz, S., Pucilowska, J. B., Liu, S., Rodríguez-Ortigosa, C. M. et al., Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Gut 2005, 54, 134-141.
    • (2005) Gut , vol.54 , pp. 134-141
    • Sanz, S.1    Pucilowska, J.B.2    Liu, S.3    Rodríguez-Ortigosa, C.M.4
  • 94
    • 25444524336 scopus 로고    scopus 로고
    • Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis
    • doi: 10.1186/1471-230X-5-7.
    • García-Fernández, M., Castilla-Cortázar, I., Díaz-Sanchez, M., Navarro, I. et al., Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis. BMC Gastroenterol. 2005, 5, 7. doi: 10.1186/1471-230X-5-7.
    • (2005) BMC Gastroenterol. , vol.5 , pp. 7
    • García-Fernández, M.1    Castilla-Cortázar, I.2    Díaz-Sanchez, M.3    Navarro, I.4
  • 95
    • 5044250426 scopus 로고    scopus 로고
    • Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2
    • Shen, Y.-C., Chiu, C.-F., Chow, K.-C., Chen, C.-L. et al., Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. Bone Marrow Transplant. 2004, 34, 609-614.
    • (2004) Bone Marrow Transplant. , vol.34 , pp. 609-614
    • Shen, Y.-C.1    Chiu, C.-F.2    Chow, K.-C.3    Chen, C.-L.4
  • 96
    • 62549091847 scopus 로고    scopus 로고
    • Antiosteoporotic activity of icariin in ovariectomized rats
    • Nian, H., Ma, M., Nian, S., Xu, L. L., Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 2009, 16, 320-326.
    • (2009) Phytomedicine , vol.16 , pp. 320-326
    • Nian, H.1    Ma, M.2    Nian, S.3    Xu, L.L.4
  • 97
    • 84870447931 scopus 로고    scopus 로고
    • Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling
    • Ming, L.-G., Chen, K.-M., Xian, C. J., Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J. Cell. Physiol. 2013, 228, 513-521.
    • (2013) J. Cell. Physiol. , vol.228 , pp. 513-521
    • Ming, L.-G.1    Chen, K.-M.2    Xian, C.J.3
  • 98
    • 40849100000 scopus 로고    scopus 로고
    • Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner
    • Zhao, J., Ohba, S., Shinkai, M., Chung, U.-I. et al, Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem. Biophys. Res. Commun. 2008, 369, 444-448.
    • (2008) Biochem. Biophys. Res. Commun. , vol.369 , pp. 444-448
    • Zhao, J.1    Ohba, S.2    Shinkai, M.3    Chung, U.-I.4
  • 99
    • 34548336512 scopus 로고    scopus 로고
    • Effects of Icariin on expression of OPN mRNA and type I collagen in rat osteoblasts in vitro
    • Xiao, Q., Chen, A., Guo, F., Effects of Icariin on expression of OPN mRNA and type I collagen in rat osteoblasts in vitro. J. Huazhong Univ. Sci. Technol. Med. Sci. 2005, 25, 690-692.
    • (2005) J. Huazhong Univ. Sci. Technol. Med. Sci. , vol.25 , pp. 690-692
    • Xiao, Q.1    Chen, A.2    Guo, F.3
  • 101
    • 30344445956 scopus 로고    scopus 로고
    • Osteopontin expression in normal and fibrotic liver. Altered liver healing in osteopontin-deficient mice
    • Lorena, D., Darby, I. A., Gadeau, A.-P., Leen, L. L. S. et al., Osteopontin expression in normal and fibrotic liver. Altered liver healing in osteopontin-deficient mice. J. Hepatol. 2006, 44, 383-390.
    • (2006) J. Hepatol. , vol.44 , pp. 383-390
    • Lorena, D.1    Darby, I.A.2    Gadeau, A.-P.3    Leen, L.L.S.4
  • 102
    • 54349092075 scopus 로고    scopus 로고
    • Potential relationship between hepatobiliary osteopontin and peroxisome proliferator-activated receptor alpha expression following ethanol-associated hepatic injury in vivo and in vitro
    • Lee, J.-H., Banerjee, A., Ueno, Y., Ramaiah, S. K., Potential relationship between hepatobiliary osteopontin and peroxisome proliferator-activated receptor alpha expression following ethanol-associated hepatic injury in vivo and in vitro. Toxicol. Sci. 2008, 106, 290-299.
    • (2008) Toxicol. Sci. , vol.106 , pp. 290-299
    • Lee, J.-H.1    Banerjee, A.2    Ueno, Y.3    Ramaiah, S.K.4
  • 103
    • 79951995185 scopus 로고    scopus 로고
    • Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood
    • Dadarkar, S. S., Fonseca, L. C., Mishra, P. B., Lobo, A. S. et al., Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. J. Appl. Toxicol. 2011, 31, 117-130.
    • (2011) J. Appl. Toxicol. , vol.31 , pp. 117-130
    • Dadarkar, S.S.1    Fonseca, L.C.2    Mishra, P.B.3    Lobo, A.S.4
  • 104
    • 84874108083 scopus 로고    scopus 로고
    • Seven sirtuins for seven deadly diseases of aging
    • Morris, B. J., Seven sirtuins for seven deadly diseases of aging. Free Radic. Biol. Med. 2012, 56, 133-171.
    • (2012) Free Radic. Biol. Med. , vol.56 , pp. 133-171
    • Morris, B.J.1
  • 105
    • 62149114892 scopus 로고    scopus 로고
    • NAD+, sirtuins, and cardiovascular disease
    • Borradaile, N., Pickering, J., NAD+, sirtuins, and cardiovascular disease. Curr. Pharm. Des. 2009, 15, 110-117.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 110-117
    • Borradaile, N.1    Pickering, J.2
  • 106
    • 84865465173 scopus 로고    scopus 로고
    • Sirtuins and pyridine nucleotides
    • Abdellatif, M., Sirtuins and pyridine nucleotides. Circ. Res. 2012, 111, 642-656.
    • (2012) Circ. Res. , vol.111 , pp. 642-656
    • Abdellatif, M.1
  • 107
    • 84867880208 scopus 로고    scopus 로고
    • SIRT1 in metabolic syndrome: where to target matters
    • Wang, Y., Xu, C., Liang, Y., Vanhoutte, P. M., SIRT1 in metabolic syndrome: where to target matters. Pharmacol. Ther. 2012, 136, 305-318.
    • (2012) Pharmacol. Ther. , vol.136 , pp. 305-318
    • Wang, Y.1    Xu, C.2    Liang, Y.3    Vanhoutte, P.M.4
  • 108
    • 84865274411 scopus 로고    scopus 로고
    • The neurobiology of sirtuins and their role in neurodegeneration
    • Donmez, G., The neurobiology of sirtuins and their role in neurodegeneration. Trends Pharmacol. Sci. 2012, 33, 494-501.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 494-501
    • Donmez, G.1
  • 109
    • 34447308268 scopus 로고    scopus 로고
    • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    • Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A. et al., SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007, 26, 3169-3179.
    • (2007) EMBO J. , vol.26 , pp. 3169-3179
    • Kim, D.1    Nguyen, M.D.2    Dobbin, M.M.3    Fischer, A.4
  • 110
    • 34648837170 scopus 로고    scopus 로고
    • SIRT1 activation confers neuroprotection in experimental optic neuritis
    • Shindler, K. S., Ventura, E., Rex, T. S., Elliott, P. et al., SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 2007, 48, 3602-3609.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 3602-3609
    • Shindler, K.S.1    Ventura, E.2    Rex, T.S.3    Elliott, P.4
  • 111
    • 64749083797 scopus 로고    scopus 로고
    • Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
    • Wang, L., Zhang, L., Chen, Z.-B., Wu, J.-Y. et al., Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur. J. Pharmacol. 2009, 609, 40-44.
    • (2009) Eur. J. Pharmacol. , vol.609 , pp. 40-44
    • Wang, L.1    Zhang, L.2    Chen, Z.-B.3    Wu, J.-Y.4
  • 112
    • 78650172708 scopus 로고    scopus 로고
    • Silent information regulator 1 protects the heart from ischemia/reperfusion
    • Hsu, C.-P., Zhai, P., Yamamoto, T., Maejima, Y. et al., Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 2010, 122, 2170-2182.
    • (2010) Circulation , vol.122 , pp. 2170-2182
    • Hsu, C.-P.1    Zhai, P.2    Yamamoto, T.3    Maejima, Y.4
  • 113
    • 84872008953 scopus 로고    scopus 로고
    • Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
    • Kitada, M., Kume, S., Takeda-Watanabe, A., Kanasaki, K. et al., Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clin. Sci. 2013, 124, 153-164.
    • (2013) Clin. Sci. , vol.124 , pp. 153-164
    • Kitada, M.1    Kume, S.2    Takeda-Watanabe, A.3    Kanasaki, K.4
  • 114
    • 79959272067 scopus 로고    scopus 로고
    • Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
    • Sakao, Y., Kato, A., Tsuji, T., Yasuda, H. et al., Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Clin. Exp. Nephrol. 2011, 15, 363-372.
    • (2011) Clin. Exp. Nephrol. , vol.15 , pp. 363-372
    • Sakao, Y.1    Kato, A.2    Tsuji, T.3    Yasuda, H.4
  • 115
    • 79951632056 scopus 로고    scopus 로고
    • Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
    • Jung-Hynes, B., Schmit, T. L., Reagan-Shaw, S. R., Siddiqui, I. A. et al., Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. J. Pineal. Res. 2011, 50, 140-149.
    • (2011) J. Pineal. Res. , vol.50 , pp. 140-149
    • Jung-Hynes, B.1    Schmit, T.L.2    Reagan-Shaw, S.R.3    Siddiqui, I.A.4
  • 116
    • 84876717815 scopus 로고    scopus 로고
    • Rejuvenating sirtuins: the rise of a new family of cancer drug targets
    • Bruzzone, S., Parenti, M. D., Grozio, A., Ballestrero, A. et al., Rejuvenating sirtuins: the rise of a new family of cancer drug targets. Curr. Pharm. Des. 2013, 19, 614-623.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 614-623
    • Bruzzone, S.1    Parenti, M.D.2    Grozio, A.3    Ballestrero, A.4
  • 117
    • 33846976509 scopus 로고    scopus 로고
    • SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
    • Kume, S., Haneda, M., Kanasaki, K., Sugimoto, T. et al., SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 2007, 282, 151-158.
    • (2007) J. Biol. Chem. , vol.282 , pp. 151-158
    • Kume, S.1    Haneda, M.2    Kanasaki, K.3    Sugimoto, T.4
  • 119
    • 84871599677 scopus 로고    scopus 로고
    • Natural-product-derived fragments for fragment-based ligand discovery
    • Over, B., Wetzel, S., Grütter, C., Nakai, Y. et al., Natural-product-derived fragments for fragment-based ligand discovery. Nat. Chem. 2012, 5, 21-28.
    • (2012) Nat. Chem. , vol.5 , pp. 21-28
    • Over, B.1    Wetzel, S.2    Grütter, C.3    Nakai, Y.4
  • 120
    • 84861898009 scopus 로고    scopus 로고
    • Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention
    • Azorín-Ortuño, M., Yáñez-Gascón, M. J., González-Sarrías, A., Larrosa, M. et al., Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention. J. Nutr. Biochem. 2012, 23, 829-837.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 829-837
    • Azorín-Ortuño, M.1    Yáñez-Gascón, M.J.2    González-Sarrías, A.3    Larrosa, M.4
  • 121
  • 122
    • 84863714863 scopus 로고    scopus 로고
    • Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects
    • doi:10.1155/2012/914273.
    • Vauzour, D., Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid. Med. Cell Longev. 2012, 2012, 914273. doi:10.1155/2012/914273.
    • (2012) Oxid. Med. Cell Longev. , vol.2012 , pp. 914273
    • Vauzour, D.1
  • 123
    • 37549050190 scopus 로고    scopus 로고
    • Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase
    • Wakade, C., Khan, M. M., De Sevilla, L. M., Zhang, Q.-G. et al., Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology 2008, 149, 367-379.
    • (2008) Endocrinology , vol.149 , pp. 367-379
    • Wakade, C.1    Khan, M.M.2    De Sevilla, L.M.3    Zhang, Q.-G.4
  • 124
    • 56649112931 scopus 로고    scopus 로고
    • The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia
    • Song, Y. S., Narasimhan, P., Kim, G. S., Jung, J. E. et al., The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2008, 28, 1917-1926.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 1917-1926
    • Song, Y.S.1    Narasimhan, P.2    Kim, G.S.3    Jung, J.E.4
  • 125
    • 33947204503 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents
    • Tureyen, K., Kapadia, R., Bowen, K. K., Satriotomo, I. et al., Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J. Neurochem. 2007, 101, 41-56.
    • (2007) J. Neurochem. , vol.101 , pp. 41-56
    • Tureyen, K.1    Kapadia, R.2    Bowen, K.K.3    Satriotomo, I.4
  • 126
    • 0031714239 scopus 로고    scopus 로고
    • Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats
    • Nagayama, M., Zhang, F., Iadecola, C., Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats. J. Cereb. Blood Flow Metab. 1998, 18, 1107-1113.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 1107-1113
    • Nagayama, M.1    Zhang, F.2    Iadecola, C.3
  • 127
    • 64749112957 scopus 로고    scopus 로고
    • Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha
    • Bullock, J. J., Mehta, S. L., Lin, Y., Lolla, P. et al., Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha. Neurosci. Lett. 2009, 456, 89-92.
    • (2009) Neurosci. Lett. , vol.456 , pp. 89-92
    • Bullock, J.J.1    Mehta, S.L.2    Lin, Y.3    Lolla, P.4
  • 128
    • 2142772632 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia
    • Maier, C. M., Hsieh, L., Yu, F., Bracci, P. et al., Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia. Stroke 2004, 35, 1169-1174.
    • (2004) Stroke , vol.35 , pp. 1169-1174
    • Maier, C.M.1    Hsieh, L.2    Yu, F.3    Bracci, P.e.a.4
  • 129
    • 80155142409 scopus 로고    scopus 로고
    • pH-dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations
    • Alies, B., Eury, H., Bijani, C., Rechignat, L. et al., pH-dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations. Inorg. Chem. 2011, 50, 11192-11201.
    • (2011) Inorg. Chem. , vol.50 , pp. 11192-11201
    • Alies, B.1    Eury, H.2    Bijani, C.3    Rechignat, L.4
  • 130
    • 79955650319 scopus 로고    scopus 로고
    • Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease
    • Watt, A. D., Perez, K. A., Faux, N. G., Pike, K. E. et al., Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease. J. Alzheimers Dis. 2011, 24, 47-59.
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 47-59
    • Watt, A.D.1    Perez, K.A.2    Faux, N.G.3    Pike, K.E.4
  • 131
    • 78651269012 scopus 로고    scopus 로고
    • Aβ40 oligomers identified as a potential biomarker for the diagnosis of alzheimer's disease
    • Gao, C. M., Yam, A. Y., Wang, X., Magdangal, E., Salisbury, C. et al., Aβ40 oligomers identified as a potential biomarker for the diagnosis of alzheimer's disease. PLoS One 2010, 5, e15725.
    • (2010) PLoS One , vol.5
    • Gao, C.M.1    Yam, A.Y.2    Wang, X.3    Magdangal, E.4    Salisbury, C.5
  • 132
    • 77956626762 scopus 로고    scopus 로고
    • On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study
    • Marino, T., Russo, N., Toscano, M., Pavelka, M., On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study. Interdiscip. Sci. 2010, 2, 57-69.
    • (2010) Interdiscip. Sci. , vol.2 , pp. 57-69
    • Marino, T.1    Russo, N.2    Toscano, M.3    Pavelka, M.4
  • 133
    • 77149145513 scopus 로고    scopus 로고
    • Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices
    • Marwarha, G., Dasari, B., Prasanthi, J. R. P., Schommer, J. et al., Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. J. Alzheimers Dis. 2010, 19, 1007-1019.
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 1007-1019
    • Marwarha, G.1    Dasari, B.2    Prasanthi, J.R.P.3    Schommer, J.4
  • 134
    • 62449330486 scopus 로고    scopus 로고
    • A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis
    • Di Fede, G., Catania, M., Morbin, M., Rossi, G. et al., A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 2009, 323, 1473-1477.
    • (2009) Science , vol.323 , pp. 1473-1477
    • Di Fede, G.1    Catania, M.2    Morbin, M.3    Rossi, G.4
  • 135
    • 45849148467 scopus 로고    scopus 로고
    • Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin
    • Lin, R., Chen, X., Li, W., Han, Y. et al., Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci. Lett. 2008, 440, 344-347.
    • (2008) Neurosci. Lett. , vol.440 , pp. 344-347
    • Lin, R.1    Chen, X.2    Li, W.3    Han, Y.4
  • 136
    • 33845898715 scopus 로고    scopus 로고
    • Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease
    • Agnati, L. F., Genedani, S., Leo, G., Forni, A. et al., Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease. J. Neural Transm. 2007, 114, 21-31.
    • (2007) J. Neural Transm. , vol.114 , pp. 21-31
    • Agnati, L.F.1    Genedani, S.2    Leo, G.3    Forni, A.4
  • 137
    • 33847044093 scopus 로고    scopus 로고
    • Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions
    • Kong, G. K.-W., Adams, J. J., Harris, H. H., Boas, J. F. et al., Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J. Mol. Biol. 2007, 367, 148-161.
    • (2007) J. Mol. Biol. , vol.367 , pp. 148-161
    • Kong, G.K.-W.1    Adams, J.J.2    Harris, H.H.3    Boas, J.F.4
  • 138
    • 33846983823 scopus 로고    scopus 로고
    • How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the 'LEARn' model (latent early-life associated regulation) may explain the triggering of AD
    • Lahiri, D. K., Maloney, B., Basha, M. R., Ge, Y. W. et al., How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the 'LEARn' model (latent early-life associated regulation) may explain the triggering of AD. Curr. Alzheimer Res. 2007, 4, 219-228.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 219-228
    • Lahiri, D.K.1    Maloney, B.2    Basha, M.R.3    Ge, Y.W.4
  • 139
    • 33644778691 scopus 로고    scopus 로고
    • Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease
    • Atamna, H., Boyle, K., Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2006, 103, 3381-3386.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 3381-3386
    • Atamna, H.1    Boyle, K.2
  • 140
    • 33745004381 scopus 로고    scopus 로고
    • Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease
    • Miller, L. M., Wang, Q., Telivala, T. P., Smith, R. J. et al., Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. J. Struct. Biol. 2006, 155, 30-37.
    • (2006) J. Struct. Biol. , vol.155 , pp. 30-37
    • Miller, L.M.1    Wang, Q.2    Telivala, T.P.3    Smith, R.J.4
  • 141
    • 33644530354 scopus 로고    scopus 로고
    • Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease
    • Syme, C. D., Viles, J. H., Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease. Biochim. Biophys. Acta. 2006, 1764, 246-256.
    • (2006) Biochim. Biophys. Acta. , vol.1764 , pp. 246-256
    • Syme, C.D.1    Viles, J.H.2
  • 142
    • 23444433225 scopus 로고    scopus 로고
    • Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro
    • Costello, D. A., O'Leary, D. M., Herron, C. E., Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. Neuropharmacology 2005, 49, 359-366.
    • (2005) Neuropharmacology , vol.49 , pp. 359-366
    • Costello, D.A.1    O'Leary, D.M.2    Herron, C.E.3
  • 143
    • 14844304305 scopus 로고    scopus 로고
    • Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide
    • Nelson, T. J., Alkon, D. L., Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. J. Biol. Chem. 2005, 280, 7377-7387.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7377-7387
    • Nelson, T.J.1    Alkon, D.L.2
  • 144
    • 28844467909 scopus 로고    scopus 로고
    • Peroxisomal proliferation protects from beta-amyloid neurodegeneration
    • Santos, M. J., Quintanilla, R. A., Toro, A., Grandy, R. et al., Peroxisomal proliferation protects from beta-amyloid neurodegeneration. J. Biol. Chem. 2005, 280, 41057-41068.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41057-41068
    • Santos, M.J.1    Quintanilla, R.A.2    Toro, A.3    Grandy, R.4
  • 145
    • 20044370990 scopus 로고    scopus 로고
    • Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    • Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J. et al., Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J. Biol. Chem. 2005, 280, 5892-5901.
    • (2005) J. Biol. Chem. , vol.280 , pp. 5892-5901
    • Yang, F.1    Lim, G.P.2    Begum, A.N.3    Ubeda, O.J.4
  • 146
    • 0037355742 scopus 로고    scopus 로고
    • Copper reduction by copper binding proteins and its relation to neurodegenerative diseases
    • Opazo, C., Barría, M. I., Ruiz, F. H., Inestrosa, N. C., Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. Biometals 2003, 16, 91-98.
    • (2003) Biometals , vol.16 , pp. 91-98
    • Opazo, C.1    Barría, M.I.2    Ruiz, F.H.3    Inestrosa, N.C.4
  • 147
    • 1242289391 scopus 로고    scopus 로고
    • Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation
    • Tatton, W., Chen, D., Chalmers-Redman, R., Wheeler, L. et al., Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. Surv. Ophthalmol. 2003, 48(Suppl 1), S25-S37.
    • (2003) Surv. Ophthalmol. , vol.48 , Issue.SUPPL. 1
    • Tatton, W.1    Chen, D.2    Chalmers-Redman, R.3    Wheeler, L.4
  • 148
    • 0038711760 scopus 로고    scopus 로고
    • Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease
    • Zhong, P., Gu, Z., Wang, X., Jiang, H. et al., Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J. Biol. Chem. 2003, 278, 26888-26896.
    • (2003) J. Biol. Chem. , vol.278 , pp. 26888-26896
    • Zhong, P.1    Gu, Z.2    Wang, X.3    Jiang, H.4
  • 149
    • 0037174856 scopus 로고    scopus 로고
    • Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)
    • Opazo, C., Huang, X., Cherny, R. A., Moir, R. D. et al., Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J. Biol. Chem. 2002, 277, 40302-40308.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40302-40308
    • Opazo, C.1    Huang, X.2    Cherny, R.A.3    Moir, R.D.4
  • 150
  • 151
    • 31044445398 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
    • Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N. et al., Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc. Natl. Acad. Sci. USA 2006, 103, 443-448.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 443-448
    • Sastre, M.1    Dewachter, I.2    Rossner, S.3    Bogdanovic, N.4
  • 152
    • 33746863741 scopus 로고    scopus 로고
    • Genetic association between endothelial nitric oxide synthase and Alzheimer disease
    • Akomolafe, A., Lunetta, K. L., Erlich, P. M., Cupples, L. A. et al., Genetic association between endothelial nitric oxide synthase and Alzheimer disease. Clin. Genet. 2006, 70, 49-56.
    • (2006) Clin. Genet. , vol.70 , pp. 49-56
    • Akomolafe, A.1    Lunetta, K.L.2    Erlich, P.M.3    Cupples, L.A.4
  • 153
    • 0032880253 scopus 로고    scopus 로고
    • Association between Alzheimer's disease and the NOS3 gene
    • Dahiyat, M., Cumming, A., Harrington, C., Wischik, C. et al., Association between Alzheimer's disease and the NOS3 gene. Ann. Neurol. 1999, 46, 664-667.
    • (1999) Ann. Neurol. , vol.46 , pp. 664-667
    • Dahiyat, M.1    Cumming, A.2    Harrington, C.3    Wischik, C.4
  • 154
    • 67349279818 scopus 로고    scopus 로고
    • Proteomic identification of HNE-bound proteins in early Alzheimer disease: insights into the role of lipid peroxidation in the progression of AD
    • Reed, T. T., Pierce, W. M., Markesbery, W. R., Butterfield, D. A., Proteomic identification of HNE-bound proteins in early Alzheimer disease: insights into the role of lipid peroxidation in the progression of AD. Brain Res. 2009, 1274, 66-76.
    • (2009) Brain Res. , vol.1274 , pp. 66-76
    • Reed, T.T.1    Pierce, W.M.2    Markesbery, W.R.3    Butterfield, D.A.4
  • 155
    • 33847711835 scopus 로고    scopus 로고
    • Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction
    • Bivalacqua, T. J., Deng, W., Kendirci, M., Usta, M. F. et al., Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2007, 292, H1278-H1290.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Bivalacqua, T.J.1    Deng, W.2    Kendirci, M.3    Usta, M.F.4
  • 156
    • 0036221668 scopus 로고    scopus 로고
    • Altered growth factor expression in the aging penis: the Brown-Norway rat model
    • Rajasekaran, M., Kasyan, A., Jain, A., Kim, S.-W. et al., Altered growth factor expression in the aging penis: the Brown-Norway rat model. J. Androl. 2002, 23, 393-399.
    • (2002) J. Androl. , vol.23 , pp. 393-399
    • Rajasekaran, M.1    Kasyan, A.2    Jain, A.3    Kim, S.-W.4
  • 157
    • 55749088930 scopus 로고    scopus 로고
    • Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density
    • Deng, F.-Y., Liu, Y.-Z., Li, L.-M., Jiang, C. et al., Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. Proteomics 2008, 8, 4259-4272.
    • (2008) Proteomics , vol.8 , pp. 4259-4272
    • Deng, F.-Y.1    Liu, Y.-Z.2    Li, L.-M.3    Jiang, C.4
  • 158
    • 0037403911 scopus 로고    scopus 로고
    • SNP detection in transforming growth factor-beta1 gene using bacterial magnetic particles
    • Ota, H., Takeyama, H., Nakayama, H., Katoh, T. et al., SNP detection in transforming growth factor-beta1 gene using bacterial magnetic particles. Biosens. Bioelectron. 2003, 18, 683-687.
    • (2003) Biosens. Bioelectron. , vol.18 , pp. 683-687
    • Ota, H.1    Takeyama, H.2    Nakayama, H.3    Katoh, T.4
  • 159
    • 31944439065 scopus 로고    scopus 로고
    • Atrophic remodeling of the transplanted rat heart
    • Sharma, S., Ying, J., Razeghi, P., Stepkowski, S., Atrophic remodeling of the transplanted rat heart. Cardiology 2006, 105, 128-136.
    • (2006) Cardiology , vol.105 , pp. 128-136
    • Sharma, S.1    Ying, J.2    Razeghi, P.3    Stepkowski, S.4
  • 160
    • 84867453251 scopus 로고    scopus 로고
    • Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice
    • Zhou, M., Wang, S., Zhao, A., Wang, K. et al., Transcriptomic and metabonomic profiling reveal synergistic effects of quercetin and resveratrol supplementation in high fat diet fed mice. J. Proteome. Res. 2012, 11, 4961-4971.
    • (2012) J. Proteome. Res. , vol.11 , pp. 4961-4971
    • Zhou, M.1    Wang, S.2    Zhao, A.3    Wang, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.