Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression

Phytomedicine

Volumn 17, Issue 6, 2010, Pages 414-423

  Hsieh, Tsai Pei ^a   Sheu, Shiow Yunn ^a   Sun, Jui Sheng ^a,b,c,d   Chen, Ming Hong ^b   Liu, Man Hai ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

BMP 2; Cbfa1; Gene expression; Icariin; OPG; Osteoblast; RANKL; SMAD4

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CASPASE 3; ICARIIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NOGGIN; OSTEOCLAST DIFFERENTIATION FACTOR; SMAD4 PROTEIN; TRANSCRIPTION FACTOR RUNX2; BONE DENSITY CONSERVATION AGENT; CASPASE; FLAVONOID; MESSENGER RNA; PLANT EXTRACT; SIGNAL PEPTIDE; SMAD PROTEIN; TRANSCRIPTION FACTOR RUNX;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL MATURATION; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; EPIMEDIUM; FRACTURE HEALING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BONE DEVELOPMENT; CELL SURVIVAL; CHEMISTRY; CULTURE TECHNIQUE; DRUG EFFECTS; FEMALE; GENE; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; OSTEOPOROSIS; PHYTOTHERAPY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE MORPHOGENETIC PROTEIN 2; CASPASES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR ALPHA SUBUNITS; EPIMEDIUM; FEMALE; FLAVONOIDS; GENE EXPRESSION; GENES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NITRIC OXIDE; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; PHYTOTHERAPY; PLANT EXTRACTS; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMAD PROTEINS;

EPIMEDIUM PUBESCENS; MUS;

EID: 77950021664     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.08.007     Document Type: Article

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