메뉴 건너뛰기




Volumn 33, Issue 5, 2012, Pages 832-844

Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes

Author keywords

Endothelium; Erectile dysfunction; Extracellular matrix; Nitric oxide synthase

Indexed keywords

AGENTS ACTING ON THE GENITAL SYSTEM; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ICARISIDE II; NITRIC OXIDE SYNTHASE; PLACEBO; SMAD2 PROTEIN; SODIUM CHLORIDE; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN; CONNECTIVE TISSUE GROWTH FACTOR; CTGF PROTEIN, RAT; FLAVONOID; ICARISID II; MADH2 PROTEIN, RAT; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NOS1 PROTEIN, RAT; NOS3 PROTEIN, RAT; PHOSPHODIESTERASE V INHIBITOR; TGFB1 PROTEIN, RAT; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

EID: 84872831139     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.111.015172     Document Type: Article
Times cited : (59)

References (39)
  • 2
    • 24944472650 scopus 로고    scopus 로고
    • Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes
    • Ahn GJ, Yu JY, Choi SM, Kang KK, Ahn BO, Kwon JW, Kang SK, Lee BC, Hwang WS. Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes. Int J Androl. 2005b;28:260-266.
    • (2005) Int J Androl , vol.28 , pp. 260-266
    • Ahn, G.J.1    Yu, J.Y.2    Choi, S.M.3    Kang, K.K.4    Ahn, B.O.5    Kwon, J.W.6    Kang, S.K.7    Lee, B.C.8    Hwang, W.S.9
  • 3
    • 80051474423 scopus 로고    scopus 로고
    • Functional, metabolic, and morphologic characteristics of a novel rat model of type 2 diabetes-associated erectile dysfunction
    • Albersen M, Lin G, Fandel TM, Zhang H, Qiu X, Lin CS, Lue TF. Functional, metabolic, and morphologic characteristics of a novel rat model of type 2 diabetes-associated erectile dysfunction. Urology. 2011;78(2):476.e1-476.e8.
    • (2011) Urology , vol.78 , Issue.2
    • Albersen, M.1    Lin, G.2    Fandel, T.M.3    Zhang, H.4    Qiu, X.5    Lin, C.S.6    Lue, T.F.7
  • 4
    • 77954129006 scopus 로고    scopus 로고
    • Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases
    • Bahk JY, Jung JH, Han H, Min SK, Lee YS. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp Clin Transplant. 2010;8:150-160.
    • (2010) Exp Clin Transplant , vol.8 , pp. 150-160
    • Bahk, J.Y.1    Jung, J.H.2    Han, H.3    Min, S.K.4    Lee, Y.S.5
  • 5
    • 33947101455 scopus 로고    scopus 로고
    • FK1706 enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat
    • discussion 346-347
    • Bella AJ, Hayashi N, Carrion RE, Price R, Lue TF. FK1706 enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat. J SexMed. 2007;4:341-346; discussion 346-347.
    • (2007) J SexMed , vol.4 , pp. 341-346
    • Bella, A.J.1    Hayashi, N.2    Carrion, R.E.3    Price, R.4    Lue, T.F.5
  • 6
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 7
    • 72149099381 scopus 로고    scopus 로고
    • Hypothesis: the metabolic memory, the new challenge of diabetes
    • Ceriello A. Hypothesis: the "metabolic memory,"the new challenge of diabetes. Diabetes Res Clin Pract. 2009;86:S2-S6.
    • (2009) Diabetes Res Clin Pract , vol.86
    • Ceriello, A.1
  • 8
    • 33947230295 scopus 로고    scopus 로고
    • Differential expression of neurotrophins in penises of streptozotocin-induced diabetic rats
    • Chen Y, Yang R, Yao L, Sun Z, Wang R, Dai Y. Differential expression of neurotrophins in penises of streptozotocin-induced diabetic rats. J Androl. 2007;28:306-312.
    • (2007) J Androl , vol.28 , pp. 306-312
    • Chen, Y.1    Yang, R.2    Yao, L.3    Sun, Z.4    Wang, R.5    Dai, Y.6
  • 11
    • 21344433921 scopus 로고    scopus 로고
    • Therapy insight: sexual and bladder dysfunction associated with diabetes mellitus
    • quiz 309
    • Fedele D. Therapy insight: sexual and bladder dysfunction associated with diabetes mellitus. Nat Clin Pract Urol. 2005;2:282-290; quiz 309.
    • (2005) Nat Clin Pract Urol , vol.2 , pp. 282-290
    • Fedele, D.1
  • 12
    • 63849091443 scopus 로고    scopus 로고
    • Review type 2 diabetes mellitus and erectile dysfunction
    • Hidalgo-Tamola J, Chitaley K. Review type 2 diabetes mellitus and erectile dysfunction. J Sex Med. 2009;6:916-926.
    • (2009) J Sex Med , vol.6 , pp. 916-926
    • Hidalgo-Tamola, J.1    Chitaley, K.2
  • 14
    • 0036674283 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase
    • Hyman KM, Seghezzi G, Pintucci G, Stellari G, Kim JH, Grossi EA, Galloway AC, Mignatti P. Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase. Surgery. 2002;132:173-179.
    • (2002) Surgery , vol.132 , pp. 173-179
    • Hyman, K.M.1    Seghezzi, G.2    Pintucci, G.3    Stellari, G.4    Kim, J.H.5    Grossi, E.A.6    Galloway, A.C.7    Mignatti, P.8
  • 15
    • 79952404359 scopus 로고    scopus 로고
    • Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse
    • Jin HR, Kim WJ, Song JS, Piao S, Choi MJ, Tumurbaatar M, Shin SH, Yin GN, Koh GY, Ryu JK, Suh JK. Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. Diabetes. 2011;60:969-980.
    • (2011) Diabetes , vol.60 , pp. 969-980
    • Jin, H.R.1    Kim, W.J.2    Song, J.S.3    Piao, S.4    Choi, M.J.5    Tumurbaatar, M.6    Shin, S.H.7    Yin, G.N.8    Koh, G.Y.9    Ryu, J.K.10    Suh, J.K.11
  • 16
    • 0034979598 scopus 로고    scopus 로고
    • Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment
    • Kandeel FR, Koussa VK, Swerdloff RS. Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocr Rev. 2001;22:342-388.
    • (2001) Endocr Rev , vol.22 , pp. 342-388
    • Kandeel, F.R.1    Koussa, V.K.2    Swerdloff, R.S.3
  • 20
    • 29244473849 scopus 로고    scopus 로고
    • Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats
    • Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J Androl. 2005;7:381-388.
    • (2005) Asian J Androl , vol.7 , pp. 381-388
    • Liu, W.J.1    Xin, Z.C.2    Xin, H.3    Yuan, Y.M.4    Tian, L.5    Guo, Y.L.6
  • 21
    • 0027751670 scopus 로고
    • Rat model for the study of penile erection: pharmacologic and electrical-stimulation parameters
    • Martinez-Pineiro L, Brock G, Trigo-Rocha F, Hsu GL, Lue TF, Tanagho EA. Rat model for the study of penile erection: pharmacologic and electrical-stimulation parameters. Eur Urol. 1994; 25:62-70.
    • (1994) Eur Urol , vol.25 , pp. 62-70
    • Martinez-Pineiro, L.1    Brock, G.2    Trigo-Rocha, F.3    Hsu, G.L.4    Lue, T.F.5    Tanagho, E.A.6
  • 22
    • 33845332378 scopus 로고    scopus 로고
    • Pathophysiology and treatment of diabetic erectile dysfunction
    • Moore CR, Wang R. Pathophysiology and treatment of diabetic erectile dysfunction. Asian J Androl. 2006;8:675-684.
    • (2006) Asian J Androl , vol.8 , pp. 675-684
    • Moore, C.R.1    Wang, R.2
  • 23
    • 0031805037 scopus 로고    scopus 로고
    • Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence
    • Moreland RB. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res. 1998;10:113-120.
    • (1998) Int J Impot Res , vol.10 , pp. 113-120
    • Moreland, R.B.1
  • 24
    • 0028836204 scopus 로고
    • PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle
    • Moreland RB, Traish A, McMillin MA, Smith B, Goldstein I, Saenz de Tejada I. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol. 1995;153:826-834.
    • (1995) J Urol , vol.153 , pp. 826-834
    • Moreland, R.B.1    Traish, A.2    McMillin, M.A.3    Smith, B.4    Goldstein, I.5    Saenz de Tejada, I.6
  • 25
    • 68549118890 scopus 로고    scopus 로고
    • Posttranslational modification of constitutive nitric oxide synthase in the penis
    • Musicki B, Ross AE, Champion HC, Burnett AL, Bivalacqua TJ. Posttranslational modification of constitutive nitric oxide synthase in the penis. J Androl. 2009;30:352-362.
    • (2009) J Androl , vol.30 , pp. 352-362
    • Musicki, B.1    Ross, A.E.2    Champion, H.C.3    Burnett, A.L.4    Bivalacqua, T.J.5
  • 26
    • 33845296134 scopus 로고    scopus 로고
    • Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells
    • Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006; 68:1350-1354.
    • (2006) Urology , vol.68 , pp. 1350-1354
    • Ning, H.1    Xin, Z.C.2    Lin, G.3    Banie, L.4    Lue, T.F.5    Lin, C.S.6
  • 27
    • 43749089808 scopus 로고    scopus 로고
    • Statistically designed enzymatic hydrolysis for optimized production of icariside II as a novel melanogenesis inhibitor
    • Park JS, Park HY, Rho HS, Ahn S, Kim DH, Chang IS. Statistically designed enzymatic hydrolysis for optimized production of icariside II as a novel melanogenesis inhibitor. J Microbiol Biotechnol. 2008;18:110-117.
    • (2008) J Microbiol Biotechnol , vol.18 , pp. 110-117
    • Park, J.S.1    Park, H.Y.2    Rho, H.S.3    Ahn, S.4    Kim, D.H.5    Chang, I.S.6
  • 28
    • 33746519146 scopus 로고    scopus 로고
    • The role of endothelial dysfunction in the pathophysiology of erectile dysfunction in diabetes and in determining response to treatment
    • Pegge NC, Twomey AM, Vaughton K, Gravenor MB, Ramsey MW, Price DE. The role of endothelial dysfunction in the pathophysiology of erectile dysfunction in diabetes and in determining response to treatment. Diabetic Med. 2006;23:873-878.
    • (2006) Diabetic Med , vol.23 , pp. 873-878
    • Pegge, N.C.1    Twomey, A.M.2    Vaughton, K.3    Gravenor, M.B.4    Ramsey, M.W.5    Price, D.E.6
  • 31
    • 33645968445 scopus 로고    scopus 로고
    • The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocininduced diabetic rats: preventive versus curative treatment
    • Usta MF, Kendirci M, Gur S, Foxwell NA, Bivalacqua TJ, Cellek S, Hellstrom WJ. The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocininduced diabetic rats: preventive versus curative treatment. J Sex Med. 2006;3:242-250.
    • (2006) J Sex Med , vol.3 , pp. 242-250
    • Usta, M.F.1    Kendirci, M.2    Gur, S.3    Foxwell, N.A.4    Bivalacqua, T.J.5    Cellek, S.6    Hellstrom, W.J.7
  • 32
    • 0036934069 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus
    • Vickers MA, Satyanarayana R. Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res. 2002;14:466-471.
    • (2002) Int J Impot Res , vol.14 , pp. 466-471
    • Vickers, M.A.1    Satyanarayana, R.2
  • 35
    • 77954217199 scopus 로고    scopus 로고
    • Preparation of icariside II from icariin by enzymatic hydrolysis method
    • Xia Q, Xu D, Huang Z, Liu J, Wang X, Liu S. Preparation of icariside II from icariin by enzymatic hydrolysis method. Fitoterapia. 2010;81:437-442.
    • (2010) Fitoterapia , vol.81 , pp. 437-442
    • Xia, Q.1    Xu, D.2    Huang, Z.3    Liu, J.4    Wang, X.5    Liu, S.6
  • 37
    • 35548960004 scopus 로고    scopus 로고
    • LC-MS/ MS method for the simultaneous determination of icariin and its major metabolites in rat plasma
    • Xu W, Zhang Y, Yang M, Shen Z, Zhang X, Zhang W, Li H. LC-MS/ MS method for the simultaneous determination of icariin and its major metabolites in rat plasma. J Pharm Biomed Anal. 2007; 45:667-672.
    • (2007) J Pharm Biomed Anal , vol.45 , pp. 667-672
    • Xu, W.1    Zhang, Y.2    Yang, M.3    Shen, Z.4    Zhang, X.5    Zhang, W.6    Li, H.7
  • 38
    • 53549106900 scopus 로고    scopus 로고
    • Role of increased penile expression of transforming growth factor-beta 1 and activation of the smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats
    • Zhang LW, Piao S, Choi MJ, Shin HY, Jin HR, Kim WJ, Song SU, Han JY, Park SH, Mamura M, Kim SJ, Ryu JK, Suh JK. Role of increased penile expression of transforming growth factor-beta 1 and activation of the smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. J Sex Med. 2008;5:2318-2329.
    • (2008) J Sex Med , vol.5 , pp. 2318-2329
    • Zhang, L.W.1    Piao, S.2    Choi, M.J.3    Shin, H.Y.4    Jin, H.R.5    Kim, W.J.6    Song, S.U.7    Han, J.Y.8    Park, S.H.9    Mamura, M.10    Kim, S.J.11    Ryu, J.K.12    Suh, J.K.13
  • 39
    • 77949406671 scopus 로고    scopus 로고
    • Expression changes of transforming growth factor-beta1 and thrombospondin-1 in cavernous tissues of diabetic rats
    • Zhang XM, Shi PH, Cao SH, Yu HJ, Azad J, Ling SC. Expression changes of transforming growth factor-beta1 and thrombospondin-1 in cavernous tissues of diabetic rats. Urol Int. 2010;84:221-225.
    • (2010) Urol Int , vol.84 , pp. 221-225
    • Zhang, X.M.1    Shi, P.H.2    Cao, S.H.3    Yu, H.J.4    Azad, J.5    Ling, S.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.