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Volumn 17, Issue 12, 2010, Pages 950-955

Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats

Author keywords

Epimedium acuminatum; Icariin; Inflammation; Learning and memory; Lipopolysaccharide

Indexed keywords

CYCLOOXYGENASE 2; IBUPROFEN; ICARIIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77956616914     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.03.007     Document Type: Article
Times cited : (72)

References (25)
  • 2
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies
    • Etminan M., Gill S., Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 2003, 327:128.
    • (2003) BMJ , vol.327 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 3
    • 77954442281 scopus 로고    scopus 로고
    • Activated astroglia during chronic inflammation in Alzheimer's disease-do they neglect their neurosupportive roles?
    • Fuller S., Steele M., Münch G. Activated astroglia during chronic inflammation in Alzheimer's disease-do they neglect their neurosupportive roles?. Mutat Res 2009, 11.
    • (2009) Mutat Res , pp. 11
    • Fuller, S.1    Steele, M.2    Münch, G.3
  • 4
    • 18044392043 scopus 로고    scopus 로고
    • Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats
    • Gong Q.H., Wu Q., Huang X.N., Sun A.S., Shi J.S. Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats. Life Sci. 2005, 77:140-148.
    • (2005) Life Sci. , vol.77 , pp. 140-148
    • Gong, Q.H.1    Wu, Q.2    Huang, X.N.3    Sun, A.S.4    Shi, J.S.5
  • 5
    • 34547927630 scopus 로고    scopus 로고
    • Effects of LPS on the behavioural stress response of genetically selected aggressive and nonaggressive wild house mice
    • Gasparotto O.C., Carobrez S.G., Bohus B.G. Effects of LPS on the behavioural stress response of genetically selected aggressive and nonaggressive wild house mice. Behav. Brain Res. 2007, 183:52-59.
    • (2007) Behav. Brain Res. , vol.183 , pp. 52-59
    • Gasparotto, O.C.1    Carobrez, S.G.2    Bohus, B.G.3
  • 6
    • 0034677723 scopus 로고    scopus 로고
    • Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats
    • Hauss-Wegrzyniak B., Vannucchi M.G., Wenk G.L. Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats. Brain Res. 2000, 859:157-166.
    • (2000) Brain Res. , vol.859 , pp. 157-166
    • Hauss-Wegrzyniak, B.1    Vannucchi, M.G.2    Wenk, G.L.3
  • 7
    • 33644508018 scopus 로고    scopus 로고
    • Diverse microglial responses after intrahippocampal administration of lipopolysaccharide
    • Herber D.L., Maloney J.L., Roth L.M., Freeman M.J., Morgan D., Gordon M.N. Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia 2006, 53:382-391.
    • (2006) Glia , vol.53 , pp. 382-391
    • Herber, D.L.1    Maloney, J.L.2    Roth, L.M.3    Freeman, M.J.4    Morgan, D.5    Gordon, M.N.6
  • 8
    • 0036230270 scopus 로고    scopus 로고
    • Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs
    • Hüll M., Lieb K., Fiebich B.L. Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs. Curr. Med. Chem. 2002, 9:83-88.
    • (2002) Curr. Med. Chem. , vol.9 , pp. 83-88
    • Hüll, M.1    Lieb, K.2    Fiebich, B.L.3
  • 9
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates Tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • Kitazawa M., Oddo S., Yamasaki Tritia R., Green Kim N., LaFerla Frank M. Lipopolysaccharide-induced inflammation exacerbates Tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 2005, 25:8843-8853.
    • (2005) J. Neurosci. , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 10
    • 39749188810 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
    • Kotilinek L.A., Westerman M.A., Wang Q., Panizzon K., Lim G.P., Simonyi A., et al. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 2008, 131:651-664.
    • (2008) Brain. , vol.131 , pp. 651-664
    • Kotilinek, L.A.1    Westerman, M.A.2    Wang, Q.3    Panizzon, K.4    Lim, G.P.5    Simonyi, A.6
  • 11
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 2003, 304:1-7.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 12
    • 34347339423 scopus 로고    scopus 로고
    • Protective effects of icariin against learning and memory deficits induced by aluminium in rats
    • Luo Y., Nie J., Gong Q.H., Lu Y.F., Wu Q., Shi J.S. Protective effects of icariin against learning and memory deficits induced by aluminium in rats. Clin. Exp. Pharmacol. Physiol. 2007, 34:792-795.
    • (2007) Clin. Exp. Pharmacol. Physiol. , vol.34 , pp. 792-795
    • Luo, Y.1    Nie, J.2    Gong, Q.H.3    Lu, Y.F.4    Wu, Q.5    Shi, J.S.6
  • 13
    • 62249199743 scopus 로고    scopus 로고
    • Progress of pharmacological research on icariin
    • Li L., Wang X.M. Progress of pharmacological research on icariin. Zhongguo Zhong Yao Za Zhi 2008, 33:2727-2732.
    • (2008) Zhongguo Zhong Yao Za Zhi , vol.33 , pp. 2727-2732
    • Li, L.1    Wang, X.M.2
  • 14
    • 70849136305 scopus 로고    scopus 로고
    • Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus
    • Nie J., Luo Y., Huang X.N., Gong Q.H., Wu Q., Shi J.S. Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus. Eur. J. Pharmacol. 2010, 626:213-218.
    • (2010) Eur. J. Pharmacol. , vol.626 , pp. 213-218
    • Nie, J.1    Luo, Y.2    Huang, X.N.3    Gong, Q.H.4    Wu, Q.5    Shi, J.S.6
  • 15
    • 34249781984 scopus 로고    scopus 로고
    • Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats
    • Pan Y., Kong L.D., Li Y.C., Xia X., Kung H.F., Jiang F.X. Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats. Pharmacol. Biochem. Behav. 2007, 87:130-140.
    • (2007) Pharmacol. Biochem. Behav. , vol.87 , pp. 130-140
    • Pan, Y.1    Kong, L.D.2    Li, Y.C.3    Xia, X.4    Kung, H.F.5    Jiang, F.X.6
  • 16
    • 14744289768 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation
    • Shaw K.N., Commins S., O'Mara S.M. Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation. Brain Res. 2005, 1038:231-237.
    • (2005) Brain Res. , vol.1038 , pp. 231-237
    • Shaw, K.N.1    Commins, S.2    O'Mara, S.M.3
  • 17
    • 15744382068 scopus 로고    scopus 로고
    • Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice
    • Sparkman N.L., Martin L.A., Calvert W.S., Boehm G.W. Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice. Behav. Brain Res. 2005, 159:145-151.
    • (2005) Behav. Brain Res. , vol.159 , pp. 145-151
    • Sparkman, N.L.1    Martin, L.A.2    Calvert, W.S.3    Boehm, G.W.4
  • 18
    • 37849044699 scopus 로고    scopus 로고
    • NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type
    • Szekely C.A., Breitner J.C., Fitzpatrick A.L., Rea T.D., Psaty B.M., Kuller L.H., et al. NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type. Neurology 2008, 70:17-24.
    • (2008) Neurology , vol.70 , pp. 17-24
    • Szekely, C.A.1    Breitner, J.C.2    Fitzpatrick, A.L.3    Rea, T.D.4    Psaty, B.M.5    Kuller, L.H.6
  • 19
    • 0035038917 scopus 로고    scopus 로고
    • Inflammation and Alzheimer disease: the good, the bad, and the ugly
    • Weninger S.C., Yankner B.A. Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat. Med. 2001, 7:527-528.
    • (2001) Nat. Med. , vol.7 , pp. 527-528
    • Weninger, S.C.1    Yankner, B.A.2
  • 20
    • 34547136457 scopus 로고    scopus 로고
    • Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities
    • Xie J., Sun W., Duan K., Zhang Y. Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities. Nat. Prod. Res. 2007, 21:600-605.
    • (2007) Nat. Prod. Res. , vol.21 , pp. 600-605
    • Xie, J.1    Sun, W.2    Duan, K.3    Zhang, Y.4
  • 21
    • 34249280557 scopus 로고    scopus 로고
    • Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro
    • Xu H.B., Huang Z.Q. Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascul. Pharmacol. 2007, 47:18-24.
    • (2007) Vascul. Pharmacol. , vol.47 , pp. 18-24
    • Xu, H.B.1    Huang, Z.Q.2
  • 22
    • 68549115432 scopus 로고    scopus 로고
    • Protective effects of icarrin on cognitive deficits induced by chronic cerebral hypoperfusion in rats
    • Xu R.X., Wu Q., Luo Y., Gong Q.H., Yu L.M., Huang X.N., et al. Protective effects of icarrin on cognitive deficits induced by chronic cerebral hypoperfusion in rats. Clin. Exp. Pharmacol. Physiol. 2009, 36:810-815.
    • (2009) Clin. Exp. Pharmacol. Physiol. , vol.36 , pp. 810-815
    • Xu, R.X.1    Wu, Q.2    Luo, Y.3    Gong, Q.H.4    Yu, L.M.5    Huang, X.N.6
  • 23
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan Q., Zhang J., Liu H., Babu-Khan S., Vassar R., Biere A.L., et al. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J. Neurosci. 2003, 23:7504-7509.
    • (2003) J. Neurosci. , vol.23 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3    Babu-Khan, S.4    Vassar, R.5    Biere, A.L.6
  • 24
    • 36849000237 scopus 로고    scopus 로고
    • Protective effect of icariin on DNA against radical-induced oxidative damage
    • Zhao F., Tang Y.Z., Liu Z.Q. Protective effect of icariin on DNA against radical-induced oxidative damage. J. Pharm. Pharmacol. 2007, 59:1729-1732.
    • (2007) J. Pharm. Pharmacol. , vol.59 , pp. 1729-1732
    • Zhao, F.1    Tang, Y.Z.2    Liu, Z.Q.3
  • 25
    • 44149119320 scopus 로고    scopus 로고
    • Effects of icariin combined with Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat
    • 597-560
    • Zheng M., Qu L., Lou Y. Effects of icariin combined with Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat. Phytother. Res. 2008, 22. 597-560.
    • (2008) Phytother. Res. , vol.22
    • Zheng, M.1    Qu, L.2    Lou, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.