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Volumn 369, Issue 2, 2008, Pages 444-448

Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner

Author keywords

Bone regeneration; Icariin; Osteoblast; Osteogenic differentiation

Indexed keywords

BONE MORPHOGENETIC PROTEIN; EPIMEDIUM EXTRACT; EPIMEDIUM PUBESCENS EXTRACT; ICARIIN; SMAD6 PROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

EID: 40849100000     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.054     Document Type: Article
Times cited : (169)

References (27)
  • 1
    • 1342344014 scopus 로고    scopus 로고
    • Tomorrow′s skeleton staff: mesenchymal stem cells and the repair of bone and cartilage
    • Otto W.R., and Rao J. Tomorrow′s skeleton staff: mesenchymal stem cells and the repair of bone and cartilage. Cell Prolif. 37 (2004) 97-110
    • (2004) Cell Prolif. , vol.37 , pp. 97-110
    • Otto, W.R.1    Rao, J.2
  • 4
    • 11144238386 scopus 로고    scopus 로고
    • Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization
    • Byers B.A., Guldberg R.E., and Garcia A.J. Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Tissue Eng. 10 (2004) 1757-1766
    • (2004) Tissue Eng. , vol.10 , pp. 1757-1766
    • Byers, B.A.1    Guldberg, R.E.2    Garcia, A.J.3
  • 5
    • 0033985633 scopus 로고    scopus 로고
    • Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel
    • Yamamoto M., Tabata Y., Hong L., Miyamoto S., Hashimoto N., and Ikada Y. Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. J. Control. Release 64 (2000) 133-142
    • (2000) J. Control. Release , vol.64 , pp. 133-142
    • Yamamoto, M.1    Tabata, Y.2    Hong, L.3    Miyamoto, S.4    Hashimoto, N.5    Ikada, Y.6
  • 6
    • 0036599845 scopus 로고    scopus 로고
    • The role of growth factors in the repair of bone. Biology and clinical applications
    • Lieberman J.R., Daluiski A., and Einhorn T.A. The role of growth factors in the repair of bone. Biology and clinical applications. J. Bone Joint Surg. Am. 84-A (2002) 1032-1044
    • (2002) J. Bone Joint Surg. Am. , vol.84 -A , pp. 1032-1044
    • Lieberman, J.R.1    Daluiski, A.2    Einhorn, T.A.3
  • 8
    • 0032728667 scopus 로고    scopus 로고
    • Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect
    • Geesink R.G., Hoefnagels N.H., and Bulstra S.K. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J. Bone Joint Surg. Br. 81 (1999) 710-718
    • (1999) J. Bone Joint Surg. Br. , vol.81 , pp. 710-718
    • Geesink, R.G.1    Hoefnagels, N.H.2    Bulstra, S.K.3
  • 9
    • 33747378565 scopus 로고    scopus 로고
    • Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2
    • Zhao B., Katagiri T., Toyoda H., Takada T., Yanai T., and Fukuda T. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J. Biol. Chem. 281 (2006) 23246-23253
    • (2006) J. Biol. Chem. , vol.281 , pp. 23246-23253
    • Zhao, B.1    Katagiri, T.2    Toyoda, H.3    Takada, T.4    Yanai, T.5    Fukuda, T.6
  • 11
    • 0028294976 scopus 로고
    • Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture
    • Notoya K., Yoshida K., Tsukuda R., and Taketomi S. Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture. J. Bone Miner. Res. 9 (1994) 395-400
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 395-400
    • Notoya, K.1    Yoshida, K.2    Tsukuda, R.3    Taketomi, S.4
  • 12
    • 0030810999 scopus 로고    scopus 로고
    • In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics
    • Civitelli R. In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics. Calcif. Tissue Int. 61 Suppl. 1 (1997) S12-S14
    • (1997) Calcif. Tissue Int. , vol.61 , Issue.SUPPL. 1
    • Civitelli, R.1
  • 14
    • 0033068888 scopus 로고    scopus 로고
    • Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariectomized rats
    • Ma Z., Wang R., and Qiu M. Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariectomized rats. Chin. J. Obstet. Gynecol. 34 (1999) 82-85
    • (1999) Chin. J. Obstet. Gynecol. , vol.34 , pp. 82-85
    • Ma, Z.1    Wang, R.2    Qiu, M.3
  • 15
    • 0034569812 scopus 로고    scopus 로고
    • Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat
    • Wang B., Quan J., and Guo S. Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat. Chin. J. Obstet. Gynecol. 35 (2000) 724-726
    • (2000) Chin. J. Obstet. Gynecol. , vol.35 , pp. 724-726
    • Wang, B.1    Quan, J.2    Guo, S.3
  • 16
    • 0033077077 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the effect of a Chinese herb medicine on osteoclastic bone resorption
    • Yu S., Chen K., Li S., and Zhang K. In vitro and in vivo studies of the effect of a Chinese herb medicine on osteoclastic bone resorption. Chin. J. Dent. Res. 2 (1999) 7-11
    • (1999) Chin. J. Dent. Res. , vol.2 , pp. 7-11
    • Yu, S.1    Chen, K.2    Li, S.3    Zhang, K.4
  • 18
    • 33644993478 scopus 로고    scopus 로고
    • Regulation of Cbfa1 expression by total flavonoids of Herba epimedii
    • Qian G., Zhang X., Lu L., Wu X., Li S., and Meng J. Regulation of Cbfa1 expression by total flavonoids of Herba epimedii. Endocr. J. 53 (2006) 87-94
    • (2006) Endocr. J. , vol.53 , pp. 87-94
    • Qian, G.1    Zhang, X.2    Lu, L.3    Wu, X.4    Li, S.5    Meng, J.6
  • 19
    • 14844328102 scopus 로고    scopus 로고
    • Osteoblastic proliferative activity of Epimedium brevicornum Maxim
    • Meng F., Li Y., Xiong Z., Jiang Z., and Li F. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine 12 (2005) 189-193
    • (2005) Phytomedicine , vol.12 , pp. 189-193
    • Meng, F.1    Li, Y.2    Xiong, Z.3    Jiang, Z.4    Li, F.5
  • 20
    • 33847023701 scopus 로고    scopus 로고
    • The experimental study of the effects of icariin on increasing smad4 mRNA level in MC3T3-E1 cell in vitro
    • Xue Y., Wang P., Qi Q., Ni H., Ma X., and Guo S. The experimental study of the effects of icariin on increasing smad4 mRNA level in MC3T3-E1 cell in vitro. Chin. J. Orthop. 25 (2005) 119-123
    • (2005) Chin. J. Orthop. , vol.25 , pp. 119-123
    • Xue, Y.1    Wang, P.2    Qi, Q.3    Ni, H.4    Ma, X.5    Guo, S.6
  • 22
    • 0025857671 scopus 로고
    • Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
    • Yamaguchi A., Katagiri T., Ikeda T., Wozney J.M., Rosen V., Wang E.A., Kahn A.J., Suda T., and Yoshiki S. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J. Cell Biol. 113 (1991) 681-687
    • (1991) J. Cell Biol. , vol.113 , pp. 681-687
    • Yamaguchi, A.1    Katagiri, T.2    Ikeda, T.3    Wozney, J.M.4    Rosen, V.5    Wang, E.A.6    Kahn, A.J.7    Suda, T.8    Yoshiki, S.9
  • 23
    • 2142653473 scopus 로고    scopus 로고
    • Requisite roles of Runx2 and Cbfb in skeletal development
    • Komori T. Requisite roles of Runx2 and Cbfb in skeletal development. J. Bone Miner. Metab. 21 (2003) 193-197
    • (2003) J. Bone Miner. Metab. , vol.21 , pp. 193-197
    • Komori, T.1
  • 24
    • 22644440847 scopus 로고    scopus 로고
    • Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo
    • Zhao Z., Zhao M., Xiao G., and Franceschi R.T. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol. Ther. 12 (2005) 247-253
    • (2005) Mol. Ther. , vol.12 , pp. 247-253
    • Zhao, Z.1    Zhao, M.2    Xiao, G.3    Franceschi, R.T.4
  • 26
    • 33644805061 scopus 로고    scopus 로고
    • Biological approaches to bone regeneration by gene therapy
    • Franceschi R.T. Biological approaches to bone regeneration by gene therapy. J. Dent. Res. 84 (2005) 1093-1103
    • (2005) J. Dent. Res. , vol.84 , pp. 1093-1103
    • Franceschi, R.T.1
  • 27
    • 33847080418 scopus 로고    scopus 로고
    • Icariin stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2
    • Yin X., Chen Z., Liu Z., MA Q., and Dang G. Icariin stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chin. Med. J. 120 (2007) 204-210
    • (2007) Chin. Med. J. , vol.120 , pp. 204-210
    • Yin, X.1    Chen, Z.2    Liu, Z.3    MA, Q.4    Dang, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.