Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats

Psychopharmacology

Volumn 212, Issue 2, 2010, Pages 181-191

  Cheng, Yu Fang ^a,b   Wang, Chuang ^a,b   Lin, Huan Bing ^a   Li, Yun Feng ^b,c   Huang, Ying ^b   Xu, Jiang Ping ^a   Zhang, Han Ting ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Amyloid peptide (A ); Alzheimer's disease; CREB; Memory; Phosphodiesterase 4 (PDE4); Rolipram

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[25-35]; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; ESCAPE BEHAVIOR; HIPPOCAMPUS; LONG TERM CARE; MALE; MAZE TEST; MEMORY; MEMORY DISORDER; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REINFORCEMENT; SIGNAL TRANSDUCTION; SWIMMING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AVOIDANCE LEARNING; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; PEPTIDE FRAGMENTS; PHOSPHODIESTERASE 4 INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; SWIMMING;

EID: 77957354074     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1943-3     Document Type: Article

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