Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid β1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease

Journal of Neuroscience

Volumn 28, Issue 22, 2008, Pages 5784-5793

  Richard, Karine L ^c   Filali, Mohammed ^c   Préfontaine, Paul ^c   Rivest, Serge ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c NONE

Author keywords

Bone marrow stem cells; Inflammation; Innate immunity microglia; Neuroprotection; Postsynaptic receptors; Transforming growth factor 1

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PRESENILIN 1; PRESENILIN 2; PRESENILIN 2A; TOLL LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; GENE THERAPY; HIPPOCAMPUS; LENTIVIRINAE; MEMORY DISORDER; MICROGLIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AGE; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; AVOIDANCE BEHAVIOR; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REACTION TIME; SENILE PLAQUE; STEREOTACTIC PROCEDURE; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PRESENILIN-1; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; SENILE PLAQUES; STEREOTAXIC TECHNIQUES; TOLL-LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

EID: 45949106077     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1146-08.2008     Document Type: Article

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