Icariin induces the expression of toll-like receptor 9 in Ana-1 murine macrophages

Phytotherapy Research

Volumn 25, Issue 11, 2011, Pages 1732-1735

  Li, Li ^a   Peng, Lina ^b   Miao, Jianhua ^a   Qiu, Yafeng ^b   Zhou, Ying ^c   Gao, Xiaoqi ^b   Xu, Yongli ^a   Shi, Zixue ^b   Shao, Donghua ^b   Ma, Zhiyong ^b  

^a Guangxi Botanical Garden of Medicinal Plants   (China)

^b INSTITUTE OF EDIBLE FUNGI   (China)

^c Fisheries and Husbandry School of Guangxi   (China)

Author keywords

Herba epimedii; Icariin; Innate immunity; Toll like receptor 9

Indexed keywords

ICARIIN; INTERLEUKIN 6; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION REGULATION; IMMUNOREACTIVITY; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FLAVONOIDS; GENE EXPRESSION REGULATION; INTERLEUKIN-6; MACROPHAGES; MICE; MYELOID DIFFERENTIATION FACTOR 88; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 80054954467     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3514     Document Type: Article

References (19)

1. Bergner P. 2005. Antiviral botanicals in herbal medicine. Med Herbalism 14: 1-12.
2. Chen SR, Xu XZ, Wang YH et al. 2010. Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways. Biol Pharm Bull 33: 1307-1313.
3. Colić M, Doslov-Kokorus Z, Backović A, Stojanović D, Antić-Stanković J, Kovacević N. 2007. Evaluation of the stimulatory effect of Epimedium alpinum L. methanolic extract on the immune response in vivo. Pharmazie 62: 705-708. (Pubitemid 47507846)
4. Dell'Agli M, Galli GV, Dal Cero E et al. 2008. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod 71: 1513-1517.
5. He W, Sun H, Yang B, Zhang D, Kabelitz D. 1995. Immunoregulatory effects of the herba Epimediia glycoside icariin. Arzneimittelforschung 45: 910-913.
6. Kong X, Hu Y, Rui R, Wang D, Li X. 2004. Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. Int Immunopharmacol 4: 975-982. (Pubitemid 38739102)
7. Koretzky G. 2002. Stimulation and inhibition of immune responses: an intricate balancing act. J Clin Invest 109: 7-8. (Pubitemid 34052534)
8. Li ST, Li TJ, Zheng QY. 1995. Effect of icariin on function of murine peritoneal macrophages (article in Chinese). Acad J Second Milit Med Univ 16: 541-543.
9. Liu FX, Sun S, Cui ZZ. 2010. Analysis of immunological enhancement of immunosuppressed chickens by Chinese herbal extracts. J Ethnopharmacol 127: 251-256.
10. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408. (Pubitemid 34164012)
11. Qiu Y, Shen Y, Li X, Liu Q, Ma Z. 2008. Polyclonal antibody to porcine p53 protein: a new tool for studying the p53 pathway in a porcine model. Biochem Biophys Res Commun 377: 151-155.
12. Ravindran C, Cheng YC, Liang SM. 2010. CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. Cell Immunol 260: 113-118.
13. Teng F, Zeng YY, Huang XY et al. 2008a. Effect of icariin on intermediate and advanced activation of murine T lymphocytes in vitro (article in Chinese). Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 1059-1061.
14. Teng F, Zeng YY, Huang XY et al. 2008b. Effect of icariin on proliferation, phagocytosis and NO production of murine peritoneal macrophages in vitro (article in Chinese). Curr Immunol 28: 372-376.
15. Trinchieri G, Sher A. 2007. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7: 179-190.
16. Vollmer J, Krieg AM. 2009. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev 61: 195-204.
17. Wu H, Lien EJ, Lien LL. 2003. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res 60: 1-57. (Pubitemid 36538112)
18. Xu CQ, Liu BJ, Wu JF et al. 2010. Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway. Eur J Pharmacol 642: 146-153.
19. Zhang G, Gong S, Yu D, Yuan H. 2009. Propolis and Herba Epimedii extracts enhance the non-specific immune response and disease resistance of Chinese sucker, Myxocyprinus asiaticus. Fish Shellfish Immunol 26: 467-472.