Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β 1 and type IV collagen expression in rats

Journal of Ethnopharmacology

Volumn 138, Issue 3, 2011, Pages 731-736

  Qi, Min You ^a   Kai Chen, ^a   Liu, Hao Ran ^b   Su, Yan Hui ^a   Yu, Su Qing ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b HUNAN UNIVERSITY   (China)

Author keywords

Collagen IV; Diabetic nephropathy; Icariin; Transforming growth factor 1

Indexed keywords

CREATININE; GELATINASE A; GLUCOSE; HYDROXYPROLINE; ICARIIN; MALONALDEHYDE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; GLOMERULUS; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; COLLAGEN TYPE IV; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUGS, CHINESE HERBAL; FLAVONOIDS; HYDROXYPROLINE; KIDNEY; MALE; MALONDIALDEHYDE; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS;

EID: 82455164280     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.10.015     Document Type: Article

References (29)

1. T. Atsuo, T. Junko, T. Yuichi, Y. Takeyuki, and S. Masayuki Vasopressin increases type IV collagen production through the induction of transforming growth factor-beta secretion in rat mesangial cells Pharmacological Research 57 2008 142 150
2. M. Busch, S. Franke, C. Ruster, and G. Wolf Advanced glycation end-products and the kidney European Journal of Clinical Investigation 40 2010 742 755
3. J. Chaudhry, N.N. Ghosh, K. Roy, and R. Chandra Antihyperglycemic effect of a new thiazolidinedione analogue and its role in ameliorating oxidative stress in alloxan-induced diabetic rats Life Sciences 80 2007 1135 1142
4. Y. Cai, J. Chen, J. Jiang, W. Cao, and L. He Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats Journal of Ethnopharmacology 131 2010 88 94
5. F.Q. Dong, H. Li, W.M. Cai, J. Tao, Q. Li, Y. Ruan, F.P. Zheng, and Z. Zhang Effects of pioglitazone on expressions of matrix metalloproteinases 2 and 9 in kidneys of diabetic rats Chinese Medical Journal 117 2004 1040 1044
6. J.M. Forbes, K. Fukami, and M.E. Cooper Diabetic nephropathy: where hemodynamics meets metabolism Experimental and Clinical Endocrinology and Diabetes 115 2007 69 84
7. E. Guneli, K. Tugyan, H. Ozturk, M. Gumustekin, S. Cilaker, and N. Uysal Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats European Surgical Research 40 2008 354 360
8. F. Giacco, and M. Brownlee Oxidative stress and diabetic complications Circulation Research 107 2010 1058 1070
9. W.Y. Huang, Z.G. Li, H. Rus, X. Wang, P.A. Jose, and S.Y. Chen RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells Journal of Biological Chemistry 284 2009 9426 9432
10. P. Huang, Y. Zhang, T. Jiang, W. Zeng, and N. Zhang Aldose reductase is a potent regulator of TGF-β1 induced expression of fibronectin in human mesangial cells Molecular Biology Reports 37 2010 3097 3103
11. Y.Y. Hu, S.D. Ye, L.L. Zhao, M. Zheng, and Y. Chen Hydrochloride pioglitazone decreases urinary TGF-beta1 excretion in type 2 diabetics European Journal of Clinical Investigation 40 2010 571 574
12. D.B. Ji, J. Ye, C.L. Li, Y.H. Wang, J. Zhao, and S.Q. Cai Antiaging effect of Cordyceps sinensis extract Phytotherapy Research 23 2009 116 122
13. W. Jiang, Y. Zhang, H. Wu, X. Zhang, H. Gan, J. Sun, Q. Chen, M. Guo, and Z. Zhang Role of cross-talk between the Smad2 and MAPK pathways in TGF-beta1-induced collagen IV expression in mesangial cells International Journal of Molecular Medicine 26 2010 571 576
14. M. Kuroda, Y. Mimaki, Y. Sashida, E. Umegaki, M. Yamazaki, K. Chiba, T. Mohri, M. Kitahara, A. Yasuda, N. Naoi, Z.W. Xu, and M.R. Li Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells Planta Medica 66 2000 575 577
15. K. Kedziora-Kornatowska, S. Szram, T. Kornatowski, L. Szadujkis-Szadurski, J. Kedziora, and G. Bartosz The effect of verapamil on the antioxidant defence system in diabetic kidney Clinica Chimica Acta 322 2002 105 112
16. D. Koya, K. Hayashi, M. Kitada, A. Kashiwagi, R. Kikkawa, and M. Haneda Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats Journal of the American Society of Nephrology 14 2003 S250 S253
17. N. Karaaa, F. Salman, S. Doru-Abbasolu, and M. Uysal Changes in prooxidant-antioxidant balance in tissues of rats following long-term hyperglycemic status Endocrine Research 36 2011 124 133
18. W.L. Li, H.C. Zheng, J. Bukuru, and N. De Kimpe Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus Journal of Ethnopharmacology 92 2004 1 21
19. R.M. Liu Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis Antioxidants and Redox Signalling 10 2008 303 319
20. X. Li, X. Cui, X. Sun, X. Li, Q. Zhu, and W. Li Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats Phytotherapy Research 24 2010 893 899
21. S. Nishibayashi, K. Hattori, T. Hirano, K. Uehara, Y. Nakano, M. Aihara, Y. Yamada, M. Muraguchi, F. Iwata, and Y. Takiguchi Functional and structural changes in end-stage kidney disease due to glomerulonephritis induced by the recombinant alpha3(IV) NC1 domain Experimental Animals 59 2010 157 170
22. L.M. Russo, R.E. Del, D. Brown, and H.Y. Lin Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor Diabetes 56 2007 380 388
23. P. Shen, B.L. Guo, Y. Gong, D.Y. Hong, Y. Hong, and E.L. Yong Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species Phytochemistry 68 2007 1448 1458
24. V. Vallon The proximal tubule in the pathophysiology of the diabetic kidney American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 300 2011 1009 1022
25. Z.Q. Wang, and Y.J. Lou Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells European Journal of Pharmacology 504 2004 147 153
26. Y. Wang, K. Heilig, T. Saunders, A. Minto, D.K. Deb, A. Chang, F. Brosius, C. Monteiro, and C.W. Heilig Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis American Journal of Physiology. Renal Physiology 299 2010 99 111
27. S.P. Wong, P. Shen, L. Lee, J. Li, and E.L. Yong Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract Journal of Pharmaceutical and Biomedical Analysis 50 2009 216 223
28. N. Yamabe, K.S. Kang, E. Goto, T. Tanaka, and T. Yokozawa Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats Biological and Pharmaceutical Bulletin 30 2007 520 526
29. Z.B. Zhang, and Q.T. Yang The testosterone mimetic properties of Icariin Asian Journal of Andrology 8 2006 601 605