Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats

Pharmacology Biochemistry and Behavior

Volumn 96, Issue 3, 2010, Pages 301-305

  Li, Fei ^a   Gong, Qi Hai ^a   Wu, Qin ^b   Lu, Yuan Fu ^a   Shi, Jing Shan ^a,b  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b The Key Laboratory of Basic Pharmacology of Guizhou Province   (China)

Author keywords

BDNF; D galactose; Hippocampus; Icariin; Learning and memory; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; EPIMEDIUM BREVICORNUM EXTRACT; GALACTOSE; ICARIIN; MESSENGER RNA; PLANT EXTRACT; UNCLASSIFIED DRUG; FLAVONOID; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR DISORDER; BRAIN REGION; CONTROLLED STUDY; EPIMEDIUM; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; NERVE CELL; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN LEVEL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; LEARNING DISORDERS; MEMORY DISORDERS; METABOLISM; PATHOLOGY; PSYCHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALS; BLOTTING, WESTERN; BRAIN CHEMISTRY; BRAIN-DERIVED NEUROTROPHIC FACTOR; EPIMEDIUM; FLAVONOIDS; GALACTOSE; HIPPOCAMPUS; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMORY DISORDERS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EPIMEDIUM BREVICORNUM; RATTUS;

EID: 77954758416     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.05.021     Document Type: Article

References (29)

1. Chen K.M., Ge B.F., Ma H.P., Liu X.Y., Bai M.H., Wang Y. Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells. Pharmazie 2005, 60:939-942.
2. Chen C.F., Lang S.Y., Zuo P.P., Yang N., Wang X.Q., Xia C. Effects of d-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats. Psychoneuroendocrinology 2006, 31:805-811.
3. Cui X., Zuo P., Zhang Q., Hu Y., Long J., Packer L., et al. Chronic systemic d-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-a-Lipoic acid. J Neurosci Res 2006, 84:647-654.
4. Dwivedi Y. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat 2009, 5:433-449.
5. Fumagalli F., Racagni G., Riva M.A. The expanding role of BDNF: a therapeutic target for Alzheimer's disease?. Pharmacogenomics J 2006, 6:8-15.
6. Gong Q.H., Wu Q., Huang X.N., Sun A.S., Shi J.S. Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats. Life Sci 2005, 77:140-148.
7. Hock C., Heese K., Hulette C., Rosenberg C., Otten U. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 2000, 57:846-851.
8. Ho S.C., Liu J.H., Wu R.Y. Establishment of the mimetic aging effect in mice caused by d-galactose. Biogerontology 2003, 4:15-18.
9. Hua X., Lei M., Zhang Y., Ding J., Han Q., Hu G., et al. Long-term d-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer's disease. Life Sci 2007, 80:1897-1905.
10. Li L., Zhou Q.X., Shi J.S. Protective effects of icariin on neurons injured by cerebral ischemia/reperfusion. Chin Med J (Engl) 2005, 118:1637-1643.
11. Lu J., Zheng Y.L., Luo L., Wu D.M., Sun D.X., Feng Y.J. Quercetin reverses d-galactose induced neurotoxicity in mouse brain. Behav Brain Res 2006, 171:251-260.
12. Lindner M.D., Hogan J.B., Hodges D.B., Orie A.F., Chen P., Corsa J.A., et al. Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping. Psychopharmacology (Berl) 2006, 188:629-640.
13. Luo Y., Nie J., Gong Q.H., Lu Y.F., Wu Q., Shi J.S. Protective effects of icariin against learning and memory deficits induced by aluminium in rats. Clin Exp Pharmacol Physiol 2007, 34:792-795.
14. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984, 11:47-60.
15. Mizisin A.P., Bache M., DiStefano P.S., Acheson A., Lindsay R.M., Calcutt N.A. BDNF attenuates functional and structural disorders in nerves of galactose-fed rats. J Neuropathol Exp Neurol 1997, 56:1290-1301.
16. Nagahara A.H., Merrill D.A., Coppola G., Tsukada S., Schroeder B.E., Shaked G.M., et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009, 15:331-337.
17. Phillips H.S., Hains J.M., Armanini M., Laramee G.R., Johnson S.A., Winslow J.W. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 1991, 7:695-702.
18. Peng S., Garzon D.J., Marchese M., Klein W., Ginsberg S.D., Francis B.M., et al. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci 2009, 29:9321-9329.
19. Schinder A.F., Poo M. The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 2000, 23:639-645.
20. Sossin W.S., Barker P.A. Something old, something new: BDNF-induced neuron survival requires TRPC channel function. Nat Neurosci 2007, 10:537-538.
21. Schindowski K., Belarbi K., Buée L. Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav 2008, 1:43-56.
22. Takizawa S., Fukuyama N., Hirabayashi H., Kohara S., Kazahari S., Shinohara Y., et al. Quercetin, a natural flavonoid, attenuates vascular formation in the optic tract in rat chronic cerebral hypoperfution model. Brain Res 2003, 980:156-160.
23. Tapia-Arancibia L., Aliaga E., Silhol M., Arancibia S. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 2008, 59:201-220.
24. Vorhees C.V., Williams M.T. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006, 1:848-858.
25. Wu H., Lien E.J., Lien L.L. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res 2003, 60:1-57.
26. Wei H., Li L., Song Q., Ai H., Chu J., Li W. Behavioural study of the d-galactose induced aging model in C57BL/6J mice. Behav Brain Res 2005, 157:245-251.
27. Wang L., Zhang L., Chen Z.B., Wu J.Y., Zhang X., Xu Y. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol 2009, 609:40-44.
28. Xu R.X., Wu Q., Luo Y., Gong Q.H., Yu L.M., Huang X.N., et al. Protective effects of icarrin on cognitive deficits induced by chronic cerebral hypoperfusion in rats. Clin Exp Pharmacol Physiol 2009, 36:810-815.
29. Zhang Q., Li X., Cui X., Zuo P. d-galactose injured neurogenesis in the hippocampus of adult mice. Neurol Res 2005, 27:552-556.