메뉴 건너뛰기




Volumn 292, Issue 1, 2007, Pages

Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice

Author keywords

Apoptosis; Diabetes; Fibrosis; Heart; Hypertrophy

Indexed keywords

ATRIAL NATRIURETIC FACTOR; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA II; PROTEIN KINASE C ZETA; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 33846196307     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00569.2006     Document Type: Article
Times cited : (38)

References (61)
  • 1
    • 0035958935 scopus 로고    scopus 로고
    • Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)
    • Agnihotri R, Crawford HC, Haro H, Matrisian LM, Havrda MC, Liaw L. Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J Biol Chem 276: 28261-28267, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 28261-28267
    • Agnihotri, R.1    Crawford, H.C.2    Haro, H.3    Matrisian, L.M.4    Havrda, M.C.5    Liaw, L.6
  • 3
    • 0029844965 scopus 로고    scopus 로고
    • Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction
    • Ashizawa N, Graf K, Do YS, Nunohiro T, Giachelli CM, Meehan WP, Tuan TL, Hsueh WA. Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction. J Clin Invest 98: 2218-2227, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 2218-2227
    • Ashizawa, N.1    Graf, K.2    Do, Y.S.3    Nunohiro, T.4    Giachelli, C.M.5    Meehan, W.P.6    Tuan, T.L.7    Hsueh, W.A.8
  • 4
    • 0029060453 scopus 로고
    • Diabetic cardiomyopathy: A unique entity or a complication of coronary artery disease?
    • Bell DS. Diabetic cardiomyopathy: a unique entity or a complication of coronary artery disease? Diabetes Care 18: 708-714, 1995.
    • (1995) Diabetes Care , vol.18 , pp. 708-714
    • Bell, D.S.1
  • 6
    • 0030696157 scopus 로고    scopus 로고
    • Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates
    • Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM. Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100: 2189-2195, 1997.
    • (1997) J Clin Invest , vol.100 , pp. 2189-2195
    • Bowman, J.C.1    Steinberg, S.F.2    Jiang, T.3    Geenen, D.L.4    Fishman, G.I.5    Buttrick, P.M.6
  • 7
    • 0036267006 scopus 로고    scopus 로고
    • Hyperglycemia- induced apoptosis in mouse myocardium: Mitochondrial cytochrome C-mediated caspase-3 activation pathway
    • Cai L, Li W, Wang G, Guo L, Jiang Y, Kang YJ. Hyperglycemia- induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 51: 1938-1948, 2002.
    • (2002) Diabetes , vol.51 , pp. 1938-1948
    • Cai, L.1    Li, W.2    Wang, G.3    Guo, L.4    Jiang, Y.5    Kang, Y.J.6
  • 8
    • 0037215683 scopus 로고    scopus 로고
    • Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells
    • Cataldi A, Centurione L, Di Pietro R, Rapino M, Bosco D, Grifone G, Garaci F, Rana R. Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells. J Cell Biochem 88: 144-151, 2003.
    • (2003) J Cell Biochem , vol.88 , pp. 144-151
    • Cataldi, A.1    Centurione, L.2    Di Pietro, R.3    Rapino, M.4    Bosco, D.5    Grifone, G.6    Garaci, F.7    Rana, R.8
  • 10
    • 7244229584 scopus 로고    scopus 로고
    • Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: Modulation by PPAR-gamma ligand pioglitazone
    • Chen K, Chen J, Li D, Zhang X, Mehta JL. Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: modulation by PPAR-gamma ligand pioglitazone. Hypertension 44: 655-661, 2004.
    • (2004) Hypertension , vol.44 , pp. 655-661
    • Chen, K.1    Chen, J.2    Li, D.3    Zhang, X.4    Mehta, J.L.5
  • 11
    • 0008996894 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice
    • Chen Z, Chua CC, Ho YS, Hamdy RC, Chua BH. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol 280: H2313-H2320, 2001.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Chen, Z.1    Chua, C.C.2    Ho, Y.S.3    Hamdy, R.C.4    Chua, B.H.5
  • 13
    • 0027131418 scopus 로고
    • Osteopontin: A protein with diverse functions
    • Denhardt DT, Guo X. Osteopontin: a protein with diverse functions. FASEB J 7: 1475-1482, 1993.
    • (1993) FASEB J , vol.7 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 14
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107: 1055-1061, 2001.
    • (2001) J Clin Invest , vol.107 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O'Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 15
    • 0032804839 scopus 로고    scopus 로고
    • Substantial background reduction in ligase-based apoptosis detection using newly designed hairpin oligonucleotide probes
    • Didenko VV, Boudreaux DJ, Baskin DS. Substantial background reduction in ligase-based apoptosis detection using newly designed hairpin oligonucleotide probes. Biotechniques 27: 1130-1132, 1999.
    • (1999) Biotechniques , vol.27 , pp. 1130-1132
    • Didenko, V.V.1    Boudreaux, D.J.2    Baskin, D.S.3
  • 16
    • 0032128194 scopus 로고    scopus 로고
    • Left-ventricular structural and functional remodeling in the mouse after myocardial infarction: Assessment with the isovolumetrically-contracting Langendorff heart
    • Eberli FR, Sam F, Ngoy S, Apstein CS, Colucci WS. Left-ventricular structural and functional remodeling in the mouse after myocardial infarction: assessment with the isovolumetrically-contracting Langendorff heart. J Mol Cell Cardiol 30: 1443-1447, 1998.
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 1443-1447
    • Eberli, F.R.1    Sam, F.2    Ngoy, S.3    Apstein, C.S.4    Colucci, W.S.5
  • 17
    • 12344303574 scopus 로고    scopus 로고
    • Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse
    • Finsen AV, Christensen G, Sjaastad I. Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse. J Appl Physiol 98: 680-689, 2005.
    • (2005) J Appl Physiol , vol.98 , pp. 680-689
    • Finsen, A.V.1    Christensen, G.2    Sjaastad, I.3
  • 21
    • 0037440204 scopus 로고    scopus 로고
    • Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes
    • Guo M, Wu MH, Korompai F, Yuan SY. Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes. Physiol Genomics 12: 139-146, 2003.
    • (2003) Physiol Genomics , vol.12 , pp. 139-146
    • Guo, M.1    Wu, M.H.2    Korompai, F.3    Yuan, S.Y.4
  • 22
    • 0034674064 scopus 로고    scopus 로고
    • The activation state of αvβ 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin
    • Helluin O, Chan C, Vilaire G, Mousa S, DeGrado WF, Bennett JS. The activation state of αvβ 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin. J Biol Chem 275: 18337-18343, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 18337-18343
    • Helluin, O.1    Chan, C.2    Vilaire, G.3    Mousa, S.4    DeGrado, W.F.5    Bennett, J.S.6
  • 23
    • 0000643333 scopus 로고
    • Specific determination of blood glucose with o-toluidine
    • Hyvarinen A, Nikkila EA. Specific determination of blood glucose with o-toluidine. Clin Chim Acta 7: 140-143, 1962.
    • (1962) Clin Chim Acta , vol.7 , pp. 140-143
    • Hyvarinen, A.1    Nikkila, E.A.2
  • 24
    • 0141928168 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension
    • Iglarz M, Touyz RM, Viel EC, Paradis P, Amiri F, Diep QN, Schiffrin EL. Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension 42: 737-743, 2003.
    • (2003) Hypertension , vol.42 , pp. 737-743
    • Iglarz, M.1    Touyz, R.M.2    Viel, E.C.3    Paradis, P.4    Amiri, F.5    Diep, Q.N.6    Schiffrin, E.L.7
  • 25
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform β II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform β II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89: 11059-11063, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3    Sportsman, J.R.4    Heath, W.5    King, G.L.6
  • 27
    • 0033432818 scopus 로고    scopus 로고
    • Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: Noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway
    • Joffe II, Travers KE, Perreault-Micale CL, Hampton T, Katz SE, Morgan JP, Douglas PS. Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. J Am Coll Cardiol 34: 2111-2119, 1999.
    • (1999) J Am Coll Cardiol , vol.34 , pp. 2111-2119
    • Joffe, I.I.1    Travers, K.E.2    Perreault-Micale, C.L.3    Hampton, T.4    Katz, S.E.5    Morgan, J.P.6    Douglas, P.S.7
  • 28
    • 0033556025 scopus 로고    scopus 로고
    • Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding properties
    • Kaartinen MT, Pirhonen A, Linnala-Kankkunen A, Maenpaa PH. Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding properties. J Biol Chem 274: 1729-1735, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 1729-1735
    • Kaartinen, M.T.1    Pirhonen, A.2    Linnala-Kankkunen, A.3    Maenpaa, P.H.4
  • 30
    • 0025728655 scopus 로고
    • Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter
    • Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone Miner 13: 235-250, 1991.
    • (1991) Bone Miner , vol.13 , pp. 235-250
    • Kasugai, S.1    Zhang, Q.2    Overall, C.M.3    Wrana, J.L.4    Butler, W.T.5    Sodek, J.6
  • 31
    • 0000922621 scopus 로고    scopus 로고
    • Diabetic vascular dysfunctions: A model of excessive activation of protein kinase C
    • King GL, Ishii H, Koya D. Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C. Kidney Int Suppl 60: S77-S85, 1997.
    • (1997) Kidney Int Suppl , vol.60
    • King, G.L.1    Ishii, H.2    Koya, D.3
  • 32
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 47: 859-866, 1998.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 33
    • 21644447437 scopus 로고    scopus 로고
    • Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis
    • Leroy I, de Thonel A, Laurent G, and Quillet-Mary A. Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis. Cell Signal 17: 1149-1157, 2005.
    • (2005) Cell Signal , vol.17 , pp. 1149-1157
    • Leroy, I.1    de Thonel, A.2    Laurent, G.3    Quillet-Mary, A.4
  • 37
    • 0030784596 scopus 로고    scopus 로고
    • Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade
    • Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, Buttrick PM. Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade. Circ Res 81: 1027-1033, 1997.
    • (1997) Circ Res , vol.81 , pp. 1027-1033
    • Malhotra, A.1    Reich, D.2    Reich, D.3    Nakouzi, A.4    Sanghi, V.5    Geenen, D.L.6    Buttrick, P.M.7
  • 40
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614, 1992.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 42
    • 0037246185 scopus 로고    scopus 로고
    • Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice
    • Persy VP, Verhulst A, Ysebaert DK, De Greef KE, De Broe ME. Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice. Kidney Int 63: 543-553, 2003.
    • (2003) Kidney Int , vol.63 , pp. 543-553
    • Persy, V.P.1    Verhulst, A.2    Ysebaert, D.K.3    De Greef, K.E.4    De Broe, M.E.5
  • 44
    • 1642534461 scopus 로고    scopus 로고
    • Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion
    • Sam F, Xie Z, Ooi H, Kerstetter DL, Colucci WS, Singh M, Singh K. Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion. Am J Hypertens 17: 188-193, 2004.
    • (2004) Am J Hypertens , vol.17 , pp. 188-193
    • Sam, F.1    Xie, Z.2    Ooi, H.3    Kerstetter, D.L.4    Colucci, W.S.5    Singh, M.6    Singh, K.7
  • 45
    • 13944283346 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and cardiovascular remodeling
    • Schiffrin EL. Peroxisome proliferator-activated receptors and cardiovascular remodeling. Am J Physiol Heart Circ Physiol 288: H1037-H1043, 2005.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Schiffrin, E.L.1
  • 46
    • 0030575895 scopus 로고    scopus 로고
    • Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin
    • Senger DR, Perruzzi CA. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin. Biochim Biophys Acta 1314: 13-24, 1996.
    • (1996) Biochim Biophys Acta , vol.1314 , pp. 13-24
    • Senger, D.R.1    Perruzzi, C.A.2
  • 47
    • 0037058874 scopus 로고    scopus 로고
    • Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction
    • Shiomi T, Tsutsui H, Hayashidani S, Suematsu N, Ikeuchi M, Wen J, Ishibashi M, Kubota T, Egashira K, Takeshita A. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 106: 3126-3132, 2002.
    • (2002) Circulation , vol.106 , pp. 3126-3132
    • Shiomi, T.1    Tsutsui, H.2    Hayashidani, S.3    Suematsu, N.4    Ikeuchi, M.5    Wen, J.6    Ishibashi, M.7    Kubota, T.8    Egashira, K.9    Takeshita, A.10
  • 48
    • 0028862326 scopus 로고
    • Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells. Role in regulation of inducible nitric oxide synthase
    • Singh K, Balligand JL, Fischer TA, Smith TW, Kelly RA. Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells. Role in regulation of inducible nitric oxide synthase. J Biol Chem 270: 28471-28478, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 28471-28478
    • Singh, K.1    Balligand, J.L.2    Fischer, T.A.3    Smith, T.W.4    Kelly, R.A.5
  • 51
    • 0030930807 scopus 로고    scopus 로고
    • Osteopontin, a coordinator of host defense system: A cytokine or an extracellular adhesive protein?
    • Uede T, Katagiri Y, Iizuka J, Murakami M. Osteopontin, a coordinator of host defense system: a cytokine or an extracellular adhesive protein? Microbiol Immunol 41: 641-648, 1997.
    • (1997) Microbiol Immunol , vol.41 , pp. 641-648
    • Uede, T.1    Katagiri, Y.2    Iizuka, J.3    Murakami, M.4
  • 52
    • 2942670612 scopus 로고    scopus 로고
    • PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: Role of diacylglycerol kinase
    • Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble JR, Chatterjee VK, Vadas MA, Xia P. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. Circ Res 94: 1515-1522, 2004.
    • (2004) Circ Res , vol.94 , pp. 1515-1522
    • Verrier, E.1    Wang, L.2    Wadham, C.3    Albanese, N.4    Hahn, C.5    Gamble, J.R.6    Chatterjee, V.K.7    Vadas, M.A.8    Xia, P.9
  • 55
    • 20244386058 scopus 로고    scopus 로고
    • Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
    • Weber GF, Zawaideh S, Hikita S, Kumar VA, Cantor H, Ashkar S. Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J Leukoc Biol 72: 752-761, 2002.
    • (2002) J Leukoc Biol , vol.72 , pp. 752-761
    • Weber, G.F.1    Zawaideh, S.2    Hikita, S.3    Kumar, V.A.4    Cantor, H.5    Ashkar, S.6
  • 56
    • 0027981889 scopus 로고
    • Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
    • Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 43: 1122-1129, 1994.
    • (1994) Diabetes , vol.43 , pp. 1122-1129
    • Xia, P.1    Inoguchi, T.2    Kern, T.S.3    Engerman, R.L.4    Oates, P.J.5    King, G.L.6
  • 57
    • 0035018532 scopus 로고    scopus 로고
    • Regulation of angiotensin II-stimulated osteopontin expression in cardiac microvascular endothelial cells: Role of p42/44 mitogen-activated protein kinase and reactive oxygen species
    • Xie Z, Pimental DR, Lohan S, Vasertriger A, Pligavko C, Colucci WS, Singh K. Regulation of angiotensin II-stimulated osteopontin expression in cardiac microvascular endothelial cells: role of p42/44 mitogen-activated protein kinase and reactive oxygen species. J Cell Physiol 188: 132-138, 2001.
    • (2001) J Cell Physiol , vol.188 , pp. 132-138
    • Xie, Z.1    Pimental, D.R.2    Lohan, S.3    Vasertriger, A.4    Pligavko, C.5    Colucci, W.S.6    Singh, K.7
  • 58
    • 9644266547 scopus 로고    scopus 로고
    • Osteopontin modulates myocardial hypertrophy in response to chronic pressure overload in mice
    • Xie Z, Singh M, Singh K. Osteopontin modulates myocardial hypertrophy in response to chronic pressure overload in mice. Hypertension 44: 826-831, 2004.
    • (2004) Hypertension , vol.44 , pp. 826-831
    • Xie, Z.1    Singh, M.2    Singh, K.3
  • 59
    • 1542467581 scopus 로고    scopus 로고
    • Osteopontin inhibits interleukin-1beta-stimulated increases in matrix metalloproteinase activity in adult rat cardiac fibroblasts: Role of protein kinase C-zeta
    • Xie Z, Singh M, Siwik DA, Joyner WL, Singh K. Osteopontin inhibits interleukin-1beta-stimulated increases in matrix metalloproteinase activity in adult rat cardiac fibroblasts: role of protein kinase C-zeta. J Biol Chem 278: 48546-48552, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 48546-48552
    • Xie, Z.1    Singh, M.2    Siwik, D.A.3    Joyner, W.L.4    Singh, K.5
  • 60
    • 0034283423 scopus 로고    scopus 로고
    • Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
    • Yuan SY, Ustinova EE, Wu MH, Tinsley JH, Xu W, Korompai FL, Taulman AC. Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes. Circ Res 87: 412-417, 2000.
    • (2000) Circ Res , vol.87 , pp. 412-417
    • Yuan, S.Y.1    Ustinova, E.E.2    Wu, M.H.3    Tinsley, J.H.4    Xu, W.5    Korompai, F.L.6    Taulman, A.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.