메뉴 건너뛰기




Volumn 142, Issue 3, 2012, Pages 746-753

Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats

Author keywords

Aging; Icariin; Morris water maze; Quiescent neural stem cells

Indexed keywords

BROXURIDINE; GLIAL FIBRILLARY ACIDIC PROTEIN; ICARIIN;

EID: 84863985277     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.05.056     Document Type: Article
Times cited : (50)

References (34)
  • 1
    • 10044251181 scopus 로고    scopus 로고
    • Quiescent neural cells regain multipotent stem cell characteristics influenced by adult neural stem cells in co-culture
    • DOI 10.1016/j.expneurol.2004.10.006, PII S0014488604004005
    • A.R. Alexanian, and S.N. Kurpad Quiescent neural cells regain multipotent stem cell characteristics influenced by adult neural stem cells in co-culture Experimental Neurology 191 2005 193 197 (Pubitemid 39612405)
    • (2005) Experimental Neurology , vol.191 , Issue.1 , pp. 193-197
    • Alexanian, A.R.1    Kurpad, S.N.2
  • 3
    • 0037240518 scopus 로고    scopus 로고
    • The neurobiology of memory changes in normal aging
    • DOI 10.1016/S0531-5565(02)00160-2, PII S0531556502001602
    • C.A. Barnes, and C.A. Erickson The neurobiology of memory changes in normal aging Experimental Gerontology 38 2003 61 69 (Pubitemid 36110499)
    • (2003) Experimental Gerontology , vol.38 , Issue.1-2 , pp. 61-69
    • Erickson, C.A.1    Barnes, C.A.2
  • 4
    • 33846787025 scopus 로고    scopus 로고
    • Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease
    • DOI 10.1073/pnas.0610180104
    • M. Becker, V. Lavie, and B. Solomon Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 104 2007 1691 1696 (Pubitemid 46214652)
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.5 , pp. 1691-1696
    • Becker, M.1    Lavie, V.2    Solomon, B.3
  • 6
    • 83755186160 scopus 로고    scopus 로고
    • Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans
    • W.J. Cai, J.H. Huang, S.Q. Zhang, B. Wu, P. Kapahi, X.M. Zhang, and Z.Y. Shen Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans Plos One 2011 6
    • (2011) Plos One , pp. 6
    • Cai, W.J.1    Huang, J.H.2    Zhang, S.Q.3    Wu, B.4    Kapahi, P.5    Zhang, X.M.6    Shen, Z.Y.7
  • 8
    • 69749084619 scopus 로고    scopus 로고
    • Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus
    • J.H. Chen, X. Gao, and G. Enikolopov Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus Experimental Neurology 219 2009 516 523
    • (2009) Experimental Neurology , vol.219 , pp. 516-523
    • Chen, J.H.1    Gao, X.2    Enikolopov, G.3
  • 9
    • 77956616914 scopus 로고    scopus 로고
    • Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats
    • J. Guo, F. Li, Q. Wu, Q. Gong, Y. Lu, and J. Shi Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats Phytomedicine 17 2010 950 955
    • (2010) Phytomedicine , vol.17 , pp. 950-955
    • Guo, J.1    Li, F.2    Wu, Q.3    Gong, Q.4    Lu, Y.5    Shi, J.6
  • 10
    • 22344444522 scopus 로고    scopus 로고
    • Experimental study on effect of epimedium flavonoids in protecting telomere length of senescence cells HU
    • Z.W. Hu, Z.Y. Shen, and J.H. Huang Experimental study on effect of epimedium flavonoids in protecting telomere length of senescence cells HU Zhongguo Zhong Xi Yi Jie He Za Zhi 24 2004 1094 1097
    • (2004) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.24 , pp. 1094-1097
    • Hu, Z.W.1    Shen, Z.Y.2    Huang, J.H.3
  • 11
    • 27144487469 scopus 로고    scopus 로고
    • In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
    • DOI 10.1038/nature03994, PII N03994
    • A.L. Joyner, and S. Ahn In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog Nature 437 2005 894 897 (Pubitemid 41486765)
    • (2005) Nature , vol.437 , Issue.7060 , pp. 894-897
    • Ahn, S.1    Joyner, A.L.2
  • 14
    • 77954758416 scopus 로고    scopus 로고
    • Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by D-galactose in rats
    • F. Li, Q.H. Gong, Q. Wu, Y.F. Lu, and J.S. Shi Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by D-galactose in rats Pharmacology Biochemistry and Behavior 96 2010 301 305
    • (2010) Pharmacology Biochemistry and Behavior , vol.96 , pp. 301-305
    • Li, F.1    Gong, Q.H.2    Wu, Q.3    Lu, Y.F.4    Shi, J.S.5
  • 15
    • 36249032488 scopus 로고    scopus 로고
    • Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats
    • DOI 10.1016/j.neuroscience.2007.07.065, PII S0306452207009955
    • L. Li, R. Wang, Y. Tang, B. Feng, C. Ye, L. Fang, and L. Zhang Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats Neuroscience 149 2007 739 746 (Pubitemid 350130289)
    • (2007) Neuroscience , vol.149 , Issue.4 , pp. 739-746
    • Wang, R.1    Tang, Y.2    Feng, B.3    Ye, C.4    Fang, L.5    Zhang, L.6    Li, L.7
  • 16
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • L.H. Li, and H. Clevers Coexistence of quiescent and active adult stem cells in mammals Science 327 2010 542 545
    • (2010) Science , vol.327 , pp. 542-545
    • Li, L.H.1    Clevers, H.2
  • 17
    • 0031281862 scopus 로고    scopus 로고
    • Reliability, distribution, and validity of age-related cognitive deficits in the Morris water maze
    • DOI 10.1006/nlme.1997.3782
    • M.D. Lindner Reliability, distribution, and validity of age-related cognitive deficits in the Morris water maze Neurobiology of Learning and Memory 68 1997 203 220 (Pubitemid 27506318)
    • (1997) Neurobiology of Learning and Memory , vol.68 , Issue.3 , pp. 203-220
    • Lindner, M.D.1
  • 18
    • 34347339423 scopus 로고    scopus 로고
    • Protective effects of icariin against learning and memory deficits induced by aluminium in rats
    • DOI 10.1111/j.1440-1681.2007.04647.x
    • Y. Luo, J. Nie, Q.H. Gong, Y.F. Lu, Q. Wu, and J.S. Shi Protective effects of icariin against learning and memory deficits induced by aluminium in rats Clinical and Experimental Pharmacology and Physiology 34 2007 792 795 (Pubitemid 47013494)
    • (2007) Clinical and Experimental Pharmacology and Physiology , vol.34 , Issue.8 , pp. 792-795
    • Luo, Y.1    Nie, J.2    Gong, Q.-H.3    Lu, Y.-F.4    Wu, Q.5    Shi, J.-S.6
  • 19
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • DOI 10.1016/0165-0270(84)90007-4
    • R. Morris Developments of a water-maze procedure for studying spatial-learning in the rat Journal of Neuroscience Methods 11 1984 47 60 (Pubitemid 14088970)
    • (1984) Journal of Neuroscience Methods , vol.11 , Issue.1 , pp. 47-60
    • Morris, R.1
  • 21
    • 27644597444 scopus 로고    scopus 로고
    • Melatonin, aging, and age-related diseases - Perspectives for prevention, intervention, and therapy
    • B. Poeggeler Melatonin, aging, and age-related diseases - perspectives for prevention, intervention, and therapy Endocrine 27 2005 201 212
    • (2005) Endocrine , vol.27 , pp. 201-212
    • Poeggeler, B.1
  • 22
    • 1242341960 scopus 로고    scopus 로고
    • Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice
    • DOI 10.1523/JNEUROSCI.4608-03.2004
    • S.C. Pruitt, A.Y. Maslov, T.A. Barone, and R.J. Plunkett Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice Journal of Neuroscience 24 2004 1726 1733 (Pubitemid 38240970)
    • (2004) Journal of Neuroscience , vol.24 , Issue.7 , pp. 1726-1733
    • Maslov, A.Y.1    Barone, T.A.2    Plunkett, R.J.3    Pruitt, S.C.4
  • 23
    • 47549117219 scopus 로고    scopus 로고
    • Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium
    • DOI 10.1039/b800923f
    • Z.Y. Shen, B. Wu, S.K. Yan, Z.Y. Lin, Q. Wang, Y. Yang, G.J. Yang, and W.D. Zhang Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium Molecular Biosystems 4 2008 855 861 (Pubitemid 352009215)
    • (2008) Molecular BioSystems , vol.4 , Issue.8 , pp. 855-861
    • Wu, B.1    Yan, S.2    Lin, Z.3    Wang, Q.4    Yang, Y.5    Yang, G.6    Shen, Z.7    Zhang, W.8
  • 24
  • 25
    • 70349325134 scopus 로고    scopus 로고
    • The efficacy of epimedium flavonoids on senescence-delaying in Drosophila and its underlying molecular mechanisms
    • Z.Y. Shen, C.Y. Yuan, J.H. Huang, A.K. Ge, and Z.W. Hu The efficacy of epimedium flavonoids on senescence-delaying in Drosophila and its underlying molecular mechanisms Chinese Journal of Gerontology 25 2005 1061 1063
    • (2005) Chinese Journal of Gerontology , vol.25 , pp. 1061-1063
    • Shen, Z.Y.1    Yuan, C.Y.2    Huang, J.H.3    Ge, A.K.4    Hu, Z.W.5
  • 26
    • 36048947606 scopus 로고    scopus 로고
    • Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    • DOI 10.1016/j.neurobiolaging.2006.09.015, PII S019745800600340X
    • A.K. Shetty, and B. Hattiangady Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus Neurobiology of Aging 29 2008 129 147 (Pubitemid 350102711)
    • (2008) Neurobiology of Aging , vol.29 , Issue.1 , pp. 129-147
    • Hattiangady, B.1    Shetty, A.K.2
  • 27
    • 33846611555 scopus 로고    scopus 로고
    • Adult Neurogenesis and Hippocampal Memory Function: New Cells, More Plasticity, New Memories?
    • DOI 10.1016/j.nec.2006.10.008, PII S1042368006001240, Neural Stem Cells
    • H.J. Song, Y. Kitabatake, K.A. Sailor, and G.L. Ming Adult neurogenesis and hippocampal memory function: new cells, more plasticity, new memories? Neurosurgery Clinics of North America 18 2007 105 113 (Pubitemid 46172429)
    • (2007) Neurosurgery Clinics of North America , vol.18 , Issue.1 , pp. 105-113
    • Kitabatake, Y.1    Sailor, K.A.2    Ming, G.-l.3    Song, H.4
  • 28
    • 78649472934 scopus 로고    scopus 로고
    • Herba Epimedii: Anti-oxidative properties and its medical implications
    • S.C.W. Sze, Y. Tong, T.B. Ng, C.L.Y. Cheng, and H.P. Cheung Herba Epimedii: anti-oxidative properties and its medical implications Molecules 15 2010 7861 7870
    • (2010) Molecules , vol.15 , pp. 7861-7870
    • Sze, S.C.W.1    Tong, Y.2    Ng, T.B.3    Cheng, C.L.Y.4    Cheung, H.P.5
  • 29
    • 0033965420 scopus 로고    scopus 로고
    • Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance
    • X.C. Tang, J.W. Ye, Y.Z. Shang, and Z.M. Wang Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance Acta Pharmacologica Sinica 21 2000 65 69
    • (2000) Acta Pharmacologica Sinica , vol.21 , pp. 65-69
    • Tang, X.C.1    Ye, J.W.2    Shang, Y.Z.3    Wang, Z.M.4
  • 30
    • 77955368742 scopus 로고    scopus 로고
    • Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
    • V. Taylor, S. Lugert, O. Basak, P. Knuckles, U. Haussler, K. Fabel, M. Gotz, C.A. Haas, G. Kempermann, and C. Giachino Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging Cell Stem Cell 6 2010 445 456
    • (2010) Cell Stem Cell , vol.6 , pp. 445-456
    • Taylor, V.1    Lugert, S.2    Basak, O.3    Knuckles, P.4    Haussler, U.5    Fabel, K.6    Gotz, M.7    Haas, C.A.8    Kempermann, G.9    Giachino, C.10
  • 31
    • 78049443933 scopus 로고    scopus 로고
    • Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid beta-induced neurite atrophy
    • T. Urano, and C. Tohda Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid beta-induced neurite atrophy Phytotherapy Research 24 2010 1658 1663
    • (2010) Phytotherapy Research , vol.24 , pp. 1658-1663
    • Urano, T.1    Tohda, C.2
  • 32
    • 77950191531 scopus 로고    scopus 로고
    • Biodemography of human ageing
    • J.W. Vaupel Biodemography of human ageing Nature 464 2010 536 542
    • (2010) Nature , vol.464 , pp. 536-542
    • Vaupel, J.W.1
  • 33
    • 79957601409 scopus 로고    scopus 로고
    • Concise review: Quiescent and active states of endogenous adult neural stem cells: Identification and characterization
    • Y.Z. Wang, J.M. Plane, P. Jiang, C.J.J. Zhou, and W.B. Deng Concise review: quiescent and active states of endogenous adult neural stem cells: identification and characterization Stem Cells 29 2011 907 912
    • (2011) Stem Cells , vol.29 , pp. 907-912
    • Wang, Y.Z.1    Plane, J.M.2    Jiang, P.3    Zhou, C.J.J.4    Deng, W.B.5
  • 34
    • 77950229880 scopus 로고    scopus 로고
    • Neural mechanisms of ageing and cognitive decline
    • B.A. Yankner, N.A. Bishop, and T. Lu Neural mechanisms of ageing and cognitive decline Nature 464 2010 529 535
    • (2010) Nature , vol.464 , pp. 529-535
    • Yankner, B.A.1    Bishop, N.A.2    Lu, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.