The neurobiology of sirtuins and their role in neurodegeneration

Trends in Pharmacological Sciences

Volumn 33, Issue 9, 2012, Pages 494-501

  Donmez, Gizem ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; ENZYME ACTIVATOR; NICOTINAMIDE; RESVERATROL; SIRTINOL; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; SRT 1460; SRT 1720; SRT 2183; TAU PROTEIN; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN ISCHEMIA; DEACETYLATION; DISEASE ASSOCIATION; DOPAMINERGIC NERVE CELL; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVITY; ENZYME LOCALIZATION; HEARING LOSS; HUMAN; HUNTINGTON CHOREA; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NEUROBIOLOGY; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN TARGETING; RETINA INJURY; REVIEW;

AGING; ANIMALS; DRUG DISCOVERY; HUMANS; INFLAMMATION; NEURODEGENERATIVE DISEASES; SIRTUINS; STILBENES; STRESS, PHYSIOLOGICAL; YEASTS;

EID: 84865274411     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.05.007     Document Type: Review

References (64)

1. J. Rine, and I. Herskowitz Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae Genetics 116 1987 9 22
2. S.I. Imai, and L. Guarente Ten years of NAD-dependent SIR2 family deacetylases - implications for metabolic diseases Trends Pharm. Sci. 31 2010 212 220
3. J. Du Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase Science 334 2011 806 819
4. J. Sakamoto Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain FEBS Lett. 556 2004 281 286 (Pubitemid 38058593)
5. G. Ramadori Brain SIRT1: anatomical distribution and regulation by energy availability J. Neurosci. 28 2008 9989 9996
6. E. Michishita Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins Mol. Biol. Cell 16 2005 4623 4635 (Pubitemid 41416446)
7. +-dependent histone deacetylase SIRT1 J. Biol. Chem. 282 2007 6823 6832 (Pubitemid 47100909)
8. W. Li Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin J. Neurosci. 27 2007 2606 2616 (Pubitemid 46393594)
9. K. Suzuki, and T. Koike Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation Neuroscience 147 2007 599 612 (Pubitemid 46990654)
10. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356 (Pubitemid 34790756)
11. N.V. Patel Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models Neurobiol. Aging 26 2005 995 1000 (Pubitemid 40312661)
12. W. Qin Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in squirrel monkeys (Saimiri sciureus) J. Alzheimers Dis. 10 2006 417 422
13. W. Qin Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction J. Biol. Chem. 281 2006 21745 21754 (Pubitemid 44181878)
14. D. Kim SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO J. 26 2007 3169 3179 (Pubitemid 47057498)
15. J. Chen SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling J. Biol. Chem. 280 2005 40364 40374 (Pubitemid 41779174)
16. G. Donmez SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10 Cell 142 2010 320 332
17. C. Julien Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease J. Neuropathol. Exp. Neurol. 68 2009 48 58
18. S.W. Min Acetylation of tau inhibits its degradation and contributes to tauopathy Neuron 67 2010 953 966
19. L. Gan, and L. Mucke Paths of convergence: sirtuins in aging and neurodegeneration Neuron 58 2008 10 14 (Pubitemid 351467036)
20. W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 2003 889 909 (Pubitemid 37130207)
21. W. Duan, and M.P. Mattson Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease J. Neurosci. Res. 57 2009 195 206
22. G. Donmez SIRT1 protects against α-synuclein aggregation by activating molecular chaperones J. Neurosci. 32 2012 124 132
23. P. Wareski PGC-1α and PGC-1β regulate mitochondrial density in neurons J. Biol. Chem. 284 2009 21379 21385
24. K. Kakefuda Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection Biochem. Biophys. Res. Commun. 387 2009 784 788
25. +-induced apoptosis in dopaminergic cells FEBS Lett. 585 2011 219 224
26. M. Okawara Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults Biochem. Pharmacol. 73 2007 550 560 (Pubitemid 46038859)
27. D. Albani The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide J. Neurochem. 110 2009 1445 1456
28. J. Chao Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity Free Radic. Biol. Med. 45 2008 1019 1026
29. T.F. Outeiro Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease Science 317 2007 516 519 (Pubitemid 47196116)
30. M.M. Maxwell The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS Hum. Mol. Genet. 20 2011 3986 3996
31. J.R. Gatchel, and H.Y. Zoghbi Diseases of unstable repeat expansion: mechanisms and common principles Nat. Rev. Genet. 6 2005 743 755 (Pubitemid 41400832)
32. J.A. Parker Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons Nat. Genet. 37 2005 349 350
33. D.J. Ho Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease Exp. Neurol. 225 2010 74 84
34. H. Jeong Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway Nat. Med. 18 2011 159 165
35. R. Luthi-Carter SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis Proc. Natl. Acad. Sci. U.S.A. 107 2010 7927 7932
36. D.M. Taylor A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase ACS Chem. Biol. 6 2011 540 546
37. J. Pallos Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease Hum. Mol. Genet. 17 2008 3767 3775
38. N. Bizat Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans J. Neurosci. 30 2010 5394 5403
39. D. Chen The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration Exp. Gerontol. 43 2008 1086 1093
40. D.R. Rosen Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 364 1993 362 (Pubitemid 23265284)
41. C.D. Markert A single dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis J. Med. Food 13 2010 1081 1085
42. K.S. Shindler Oral resveratrol reduces neuronal damage in a model of multiple sclerosis J. Neuroophthalmol. 30 2010 328 339
43. A.P. Raval Resveratrol mimics ischemic preconditioning in the brain J. Cereb. Blood Flow Metab. 26 2006 1141 1147 (Pubitemid 44268176)
44. D. Della-Morte Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway Neuroscience 159 2009 993 1002
45. P. Wang Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway Ann. Neurol. 69 2011 360 374
46. V.H. Perry Evidence that the rate of Wallerian degeneration is controlled by a single autosomal dominant gene Eur. J. Neurosci. 2 1990 408 413 (Pubitemid 20170138)
47. T. Araki Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 2004 1010 1013 (Pubitemid 39071777)
48. S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration J. Cell Biol. 184 2009 501 513
49. E. Babetto Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo J. Neurosci. 30 2010 13291 13304
50. H.L. Cheng Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice Proc. Natl. Acad. Sci. U.S.A. 100 2003 10794 10799
51. K.S. Shindler SIRT1 activation confers neuroprotection in experimental optic neuritis Invest. Ophthalmol. Vis. Sci. 48 2007 3602 3609 (Pubitemid 351261095)
52. S. Someya Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction Cell 143 2010 802 812
53. J.A. Baur Biochemical effects of SIRT1 activators Biochim. Biophys. Acta 1804 2010 1626 1634
54. R.A. Miller Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice J. Gerontol. A: Biol. Sci. Med. Sci. 66 2011 191 201
55. J.C. Milne Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 2007 712 716 (Pubitemid 350207685)
56. G. Donmez, and L. Guarente Aging and disease: connections to sirtuins Aging Cell 9 2010 285 290
57. M. Pacholec SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 J. Biol. Chem. 285 2010 8340 8351
58. + cosubstrate specificity of a Sir2 enzyme Mol. Cell 17 2005 855 868 (Pubitemid 40386946)
59. C.M. Grozinger Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening J. Biol. Chem. 276 2001 38837 38843
60. H. Ota Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells Oncogene 25 2006 176 185 (Pubitemid 43083679)
61. B. Jung-Hynes Role of sirtuin histone deacetylase Sirt1 in prostate cancer: a target for prostate cancer management via its inhibition? J. Biol. Chem. 284 2008 3823 3832
62. K. Kojima A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells Biochem. Biophys. Res. Commun. 373 2008 423 428
63. M. Kaeberlein The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Genes Dev. 13 1999 2570 2580 (Pubitemid 29489648)
64. C. Burnett Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila Nature 477 2011 482 485