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Volumn 49, Issue 4, 2007, Pages 207-213

Vasorelaxant effects of icariin on isolated canine coronary artery

Author keywords

Canine coronary artery; Icariin; NO dependent; Vasorelaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLIBENCLAMIDE; ICARIIN; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CHLORIDE; PROSTAGLANDIN F2 ALPHA; TETRYLAMMONIUM; VASODILATOR AGENT;

EID: 34247190773     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3180325abe     Document Type: Article
Times cited : (34)

References (34)
  • 1
    • 0025965439 scopus 로고
    • Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis
    • Zeiher AM, Drexler H, Wollschlager H, et al. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation. 1991;83:391-401.
    • (1991) Circulation , vol.83 , pp. 391-401
    • Zeiher, A.M.1    Drexler, H.2    Wollschlager, H.3
  • 2
    • 0001442633 scopus 로고    scopus 로고
    • Endothelial dysfunction: Implications for therapy of cardiovascular diseases
    • Bell DM, Johna TE, Loupz FM. Endothelial dysfunction: implications for therapy of cardiovascular diseases. Ann Pharmcother. 1998;32:459-470.
    • (1998) Ann Pharmcother , vol.32 , pp. 459-470
    • Bell, D.M.1    Johna, T.E.2    Loupz, F.M.3
  • 3
    • 0029111787 scopus 로고
    • Immunoregulatory effects of the herba Epimediia glycoside icariin
    • He W, Sun H, Yang B, et al. Immunoregulatory effects of the herba Epimediia glycoside icariin. Arzneimittelforschung. 1995;45:910-913.
    • (1995) Arzneimittelforschung , vol.45 , pp. 910-913
    • He, W.1    Sun, H.2    Yang, B.3
  • 4
    • 0034023515 scopus 로고    scopus 로고
    • Screening of Anti-hypoxia/ reoxygenation agents by an in vitro model: Part 1. Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells
    • Zhang YW, Morita I, Zhao G, et al. Screening of Anti-hypoxia/ reoxygenation agents by an in vitro model: Part 1. Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells. Planta Med. 2000;66:114-118.
    • (2000) Planta Med , vol.66 , pp. 114-118
    • Zhang, Y.W.1    Morita, I.2    Zhao, G.3
  • 5
    • 0013006346 scopus 로고    scopus 로고
    • Expression of phosphodiesterase 5 in clitoris cavernosum and effect of icariin on cGMP levels in vitro
    • Qiao L, Xin ZC, Fu J, et al. Expression of phosphodiesterase 5 in clitoris cavernosum and effect of icariin on cGMP levels in vitro. Chin J Urol. 2002;23:670-672.
    • (2002) Chin J Urol , vol.23 , pp. 670-672
    • Qiao, L.1    Xin, Z.C.2    Fu, J.3
  • 6
    • 20844440722 scopus 로고    scopus 로고
    • Effects of Epimedium pubescens icariin on proliferation and differentiation of human osteoblasts
    • Yin XX, Chen ZQ, Dang GT, et al. Effects of Epimedium pubescens icariin on proliferation and differentiation of human osteoblasts. Zhongguo Zhong Yao Za Zhi. 2005;30:289-291.
    • (2005) Zhongguo Zhong Yao Za Zhi , vol.30 , pp. 289-291
    • Yin, X.X.1    Chen, Z.Q.2    Dang, G.T.3
  • 7
    • 32944467958 scopus 로고    scopus 로고
    • Effect of icariin on hypoxia induced vascular endothelial cells injury
    • Ji RR, Li FY, Zhang XJ. Effect of icariin on hypoxia induced vascular endothelial cells injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005;25:525-530.
    • (2005) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.25 , pp. 525-530
    • Ji, R.R.1    Li, F.Y.2    Zhang, X.J.3
  • 8
    • 19344369685 scopus 로고    scopus 로고
    • Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells
    • Zhu DY, Qu LH, Zhang XN, et al. Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. Eur J Pharmacol. 2005;514:99-110.
    • (2005) Eur J Pharmacol , vol.514 , pp. 99-110
    • Zhu, D.Y.1    Qu, L.H.2    Zhang, X.N.3
  • 10
    • 3242726006 scopus 로고    scopus 로고
    • Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in canines
    • Ling HY, Lou YJ, Lou HG, et al. Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in canines. J Ethnopharmacol. 2004;94,101-107.
    • (2004) J Ethnopharmacol , vol.94 , pp. 101-107
    • Ling, H.Y.1    Lou, Y.J.2    Lou, H.G.3
  • 11
    • 0033969547 scopus 로고    scopus 로고
    • Relaxation of flavones and flavonols in rat isolated thoracic aorta: Mechanism of action and structure-activity relationships
    • Chan EC, Pannangpetch P, Woodman OL. Relaxation of flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. J Cardiovasc Pharmacol. 2000;35:326-333.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 326-333
    • Chan, E.C.1    Pannangpetch, P.2    Woodman, O.L.3
  • 12
    • 0025011716 scopus 로고
    • Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
    • Rees DD, Palmer RM, Schulz R, et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol. 1990;101:746-752.
    • (1990) Br J Pharmacol , vol.101 , pp. 746-752
    • Rees, D.D.1    Palmer, R.M.2    Schulz, R.3
  • 14
    • 0033969547 scopus 로고    scopus 로고
    • Relaxation of flavones and flavonols in rat isolated thoracic aorta: Mechanism of action and structure-activity relationships
    • Chan ECH, Pannangpetch P, Woodman OL. Relaxation of flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. J Cardiovasc Pharmacol. 2000;35:326-333.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 326-333
    • Chan, E.C.H.1    Pannangpetch, P.2    Woodman, O.L.3
  • 15
    • 0242667857 scopus 로고    scopus 로고
    • Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta
    • Ajay M, Gilani AU, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74:603-612.
    • (2003) Life Sci , vol.74 , pp. 603-612
    • Ajay, M.1    Gilani, A.U.2    Mustafa, M.R.3
  • 16
    • 24344466900 scopus 로고    scopus 로고
    • Vasorelaxant and antioxidant activity of flavonols and flavones: Structure-activity relationships
    • Woodman OL, Meeker WF, Boujaoude M. Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. J Cardiovasc Pharmacol. 2005;46:302-309.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 302-309
    • Woodman, O.L.1    Meeker, W.F.2    Boujaoude, M.3
  • 17
    • 0034921313 scopus 로고    scopus 로고
    • Icariin on the relaxation effect of copurs cavenosm smooth muscle
    • Xin ZC, Kim EK, Tian ZJ, et al. Icariin on the relaxation effect of copurs cavenosm smooth muscle. Chin Sci Bull. 2001;46:1186-1190.
    • (2001) Chin Sci Bull , vol.46 , pp. 1186-1190
    • Xin, Z.C.1    Kim, E.K.2    Tian, Z.J.3
  • 18
    • 34247241323 scopus 로고    scopus 로고
    • Relaxant effects of icariin on the rabbit copurs cavenosm and its mechanism
    • Jiang ZJ, Hu BR, Fu Q, et al. Relaxant effects of icariin on the rabbit copurs cavenosm and its mechanism. J Huazhong Univ Sci Tech (Health Sci). 2004;33:679-682.
    • (2004) J Huazhong Univ Sci Tech (Health Sci) , vol.33 , pp. 679-682
    • Jiang, Z.J.1    Hu, B.R.2    Fu, Q.3
  • 19
    • 0032842945 scopus 로고    scopus 로고
    • i during inhibition of coronary smooth muscle contraction by 17-estradiol, progesterone, and testosterone
    • i during inhibition of coronary smooth muscle contraction by 17-estradiol, progesterone, and testosterone. J Pharmacol Exp Ther. 1999;291:44-52.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 44-52
    • Jason, G.1    Raouf, A.2
  • 20
    • 0032548099 scopus 로고    scopus 로고
    • + is an endothelium-derived hyperpolarizing factor in rat arteries
    • + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature. 1998;396:269-272.
    • (1998) Nature , vol.396 , pp. 269-272
    • Edwards, G.1    Dora, K.A.2    Gardener, M.J.3
  • 21
    • 0025925187 scopus 로고
    • 2+ channel in cardiac excitation-contraction coupling in the rat: Evidence from Ca2+ transients and contraction
    • 2+ channel in cardiac excitation-contraction coupling in the rat: evidence from Ca2+ transients and contraction. J Physiol. 1991;432:283-312.
    • (1991) J Physiol , vol.432 , pp. 283-312
    • Cleemann, L.1    Morad, M.2
  • 22
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999;399:597-601.
    • (1999) Nature , vol.399 , pp. 597-601
    • Fulton, D.1    Gratton, J.P.2    McCabe, T.J.3
  • 23
    • 8744271481 scopus 로고    scopus 로고
    • Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols
    • Anter E, Thomas SR, Schulz E, et al. Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J Biol Chem. 2004;279:46637-46643.
    • (2004) J Biol Chem , vol.279 , pp. 46637-46643
    • Anter, E.1    Thomas, S.R.2    Schulz, E.3
  • 24
    • 1242294387 scopus 로고    scopus 로고
    • A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vaso-relaxation
    • Lorenz M, Wessler S, Follmann E, et al. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vaso-relaxation. J Biol Chem. 2004;279:6190-6195.
    • (2004) J Biol Chem , vol.279 , pp. 6190-6195
    • Lorenz, M.1    Wessler, S.2    Follmann, E.3
  • 25
    • 3543034002 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment
    • Xu JW, Ikeda K, Yamori Y. Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Hypertension. 2004;44:217-222.
    • (2004) Hypertension , vol.44 , pp. 217-222
    • Xu, J.W.1    Ikeda, K.2    Yamori, Y.3
  • 26
    • 0033615069 scopus 로고    scopus 로고
    • The Akt kinase signals directly to endothelial nitric oxide synthase
    • Michell BJ, Griffiths JE, Mitchelhill KI, et al. The Akt kinase signals directly to endothelial nitric oxide synthase. Curr Biol. 1999;9:845-848.
    • (1999) Curr Biol , vol.9 , pp. 845-848
    • Michell, B.J.1    Griffiths, J.E.2    Mitchelhill, K.I.3
  • 27
    • 0034884468 scopus 로고    scopus 로고
    • Signaling by eNOS through a superoxide-dependent p42/44 mitogen-activated protein kinase pathway
    • Wang W, Wang S, Nishanian EV, et al. Signaling by eNOS through a superoxide-dependent p42/44 mitogen-activated protein kinase pathway. Am J Physiol Cell Physiol. 2001;281:544-554.
    • (2001) Am J Physiol Cell Physiol , vol.281 , pp. 544-554
    • Wang, W.1    Wang, S.2    Nishanian, E.V.3
  • 28
    • 5644283668 scopus 로고    scopus 로고
    • Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: Rat pharmacokinetic studies after administration of icariin
    • Liu J, Lou YJ. Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin. J Pharm Biomed Anal. 2004;36:365-370.
    • (2004) J Pharm Biomed Anal , vol.36 , pp. 365-370
    • Liu, J.1    Lou, Y.J.2
  • 29
    • 8444230563 scopus 로고    scopus 로고
    • Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells
    • Wang ZQ, Lou YJ. Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur J Pharmacol. 2004;504:147-153.
    • (2004) Eur J Pharmacol , vol.504 , pp. 147-153
    • Wang, Z.Q.1    Lou, Y.J.2
  • 30
    • 14944347050 scopus 로고    scopus 로고
    • Acute administration of 17beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women
    • Lima SM, Aldrighi JM, Consolim-Colombo FM, et al. Acute administration of 17beta-estradiol improves endothelium-dependent vasodilation in postmenopausal women. Maturitas. 2005;50:266-274.
    • (2005) Maturitas , vol.50 , pp. 266-274
    • Lima, S.M.1    Aldrighi, J.M.2    Consolim-Colombo, F.M.3
  • 31
    • 14844295766 scopus 로고    scopus 로고
    • Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells
    • Klinge CM, Blankenship KA, Risinger KE, et al. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem. 2005;280:7460-7468.
    • (2005) J Biol Chem , vol.280 , pp. 7460-7468
    • Klinge, C.M.1    Blankenship, K.A.2    Risinger, K.E.3
  • 32
    • 18944378257 scopus 로고    scopus 로고
    • Relaxations to oestrogen receptor subtype selective agonists in rat and mouse arteries
    • Al Zubair K, Razak A, Bexis S, et al. Relaxations to oestrogen receptor subtype selective agonists in rat and mouse arteries. Eur J Pharmacol. 2005;513:101-108.
    • (2005) Eur J Pharmacol , vol.513 , pp. 101-108
    • Al Zubair, K.1    Razak, A.2    Bexis, S.3
  • 33
    • 0034597646 scopus 로고    scopus 로고
    • Prasad S, Wilkinson J, Gatzoulis MA. Sildenafil in primary pulmonary hypertension. N Engl J Med. 2000;343:1342.
    • Prasad S, Wilkinson J, Gatzoulis MA. Sildenafil in primary pulmonary hypertension. N Engl J Med. 2000;343:1342.
  • 34
    • 0037360716 scopus 로고    scopus 로고
    • Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities
    • Xin ZC, Kim EK, Lin CS, et al. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003;5:15-18.
    • (2003) Asian J Androl , vol.5 , pp. 15-18
    • Xin, Z.C.1    Kim, E.K.2    Lin, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.