Icariin inhibits neurotoxicity of β-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts

NeuroReport

Volumn 20, Issue 17, 2009, Pages 1564-1567

  Sha, Dujuan ^a   Li, Lingling ^a,b   Ye, Lan ^a,b   Liu, Rong ^a,b   Xu, Yun ^a,b,c  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

; amyloid peptide; Cart; Icariin; Mitogen activated protein kinase extracellular signal regulated kinase; Neuroprotection

Indexed keywords

AMYLOID BETA PROTEIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; ICARIIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG RESPONSE; EMBRYO; IN VITRO STUDY; MOUSE; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TRANSCRIPTION REGULATION; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; MICE; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; RNA, MESSENGER; UP-REGULATION;

EID: 75149115354     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328332d345     Document Type: Article

References (20)

1. Fahrenholz F. Alpha-secretase as a therapeutic target. Curr Alzheimer Res 2007; 4:412-417.
2. Pratico D. Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann NY Acad Sci 2008; 1147:70-78.
3. Shah RS, Lee H-G, Xiongwei Z, Perry G, Smith MA, Castellani RJ. Current approaches in the treatment of Alzheimer's disease. Biomed Pharmacother 2008; 62:199-207.
4. Ding L, Liang X-G, Zhu D-Y, Lou Y-J. Icariin promotes expression of PGC-1-a, PPARa, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacol Sin 2007; 28:1541-1549. (Pubitemid 47493296)
5. Pan Y, Zhang W-Y, Xia X, Kong LD. Effects of icariin on hypothalamicpituitary-adrenal axis action and cytokine levles in stressed Sprague-Dawley rats. Biol Pharm Bul 2006; 29:2399-2403.
6. Liu Z-Q. Icariin: a special antioxidant to protect linoleic acid against free-radical-induced peroxidation in micelles. J Phys Chem A 2006; 110:6372-6378.
7. Chung B-H, Kim J-D, Kim C-K, Kim J-W, Won M-H, Lww H-S, et al. Icariin stimulates angiogenesis by activating the MEK/ERK-and P13K/Ake/ eNOS-dependent signal pathways in human endothelian cells. Biochem Biophys Res Commun 2008; 376:404-408.
8. Hengerson VW. Estrogen-containing hormone therapy and Alzheimer's disease risk: understanding discrepant inferences from observational and experimental research. Neuroscience 2006; 138:1031-1039.
9. Xu Y, Zhang W, Klaus J, Young J, Koerner L, Sheldahl LC, et al. Role of cocaine-and amphetamine-regulated transcript in estradiol-mediated neuroprotection. PANS 2006; 103:14489-14494.
10. Rogge GA, Jones DC, Green T, Nestler E, Kuhar MJ. Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain Res 2009; 1251:42-52.
11. Jia J, Chen X, Zhu W, Luo Y, Hua Z, Xu Y. CART protects brain from damage through ERK activation in ischemic stroke. Neuropeptides 2008; 42:653-661.
12. Eggert S, Midthune B, Cottrell B, Koo EH. Induced dimerization of the amyloid precursor protein (APP) leads to decreased amyloid-b (Ab) production. J Biol Chem 2009 [Epub ahead of print]
13. Crouch PJ, Harding SM, White AR, Camakais J, Bush AI, Masters CL. Mechanism of Abeta mediated neurodegeneration in Alzheimer's disease. Int J Biochem Cell Biol 2008; 40:181-198.
14. Kirkitadze MD, Kowalska A. Molecular mechanisms initiating amyloid b-fibiril formation in Alzheimer's disease. Acta Biochimica Polonica 2005; 52:417-423.
15. Da-wei W, Xiu-lan D, Jian-zhao N, Ji-feng W, Li-ping S. Estrogenic effect of Herba Epimedii and monosomic icariin in mice. J Beijing Univ Trad Chin Med 2009; 32:164-166.
16. Ban JY. Protection of amyloid beta protein (25-35)-induced neurotoxicity by methanol extract of Smilacis chinae rhizome in cultured rat cortical neurons. J Ethnopharmacol 2006; 106:230-237.
17. Du B, Ohmichi M, Takahashi K, Kawagoe J, Ohshima C, Igarashi H, et al. Both estrogen and raloxifene protect against b-amyloid-induced neurotoxicity in estrogen receptor a-transfected PC12 cell by activation of telomerase activity via Akt cascade. J Endocrinol 2004; 183:605-615.
18. Gutierrez-Zepeda A, Santell R, Wu Z, Brown M, Wu Y, Khan I, et al. Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BWC Neurosci 2005; 6:54.
19. Lv L, Jimenez-Krassel F, Sen A, Bettegowda A, Mondal M, Joseph K, et al. Evidence supporting a role for cocaine-and amphetamine-regulated transcript (CARTPT) in control of granulose cell estradiol production associated with dominant follicle selection in cattle. Biol Reprod 2009; 81:580-586.
20. Lliff JJ, Alkayed NJ, Golshani KJ,Weinestein J, Traystman RJ, AlexanderWest G. In vivo cerebrovascular effects of cocaine-and amphetamine-regulated transcript (CART) peptide. Cardiovasc Pharmaco 2008; 52:82-89.