Revisiting dengue virus-host cell interaction: New insights into molecular and cellular virology

Advances in Virus Research

Volumn 88, Issue , 2014, Pages 1-109

  Acosta, Eliana G ^a   Kumar, Anil ^a   Bartenschlager, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dengue virus; DENV replication cycle; High throughput screen; Host dependency factors; Host restriction factors; Host directed antivirals; Lipidomics; Proteomics; SiRNA screen; Transcriptomics

Indexed keywords

ADAPTIVE IMMUNITY; ARTICLE; DENGUE; DENGUE VIRUS; DENV REPLICATION CYCLE; GENETICS; HIGH-THROUGHPUT SCREEN; HOST DEPENDENCY FACTORS; HOST PATHOGEN INTERACTION; HOST RESTRICTION FACTORS; HOST-DIRECTED ANTIVIRALS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; LIPIDOMICS; PHYSIOLOGY; PROTEOMICS; SIRNA SCREEN; TRANSCRIPTOMICS; VIROLOGY;

DENGUE VIRUS; DENV REPLICATION CYCLE; HIGH-THROUGHPUT SCREEN; HOST DEPENDENCY FACTORS; HOST RESTRICTION FACTORS; HOST-DIRECTED ANTIVIRALS; LIPIDOMICS; PROTEOMICS; SIRNA SCREEN; TRANSCRIPTOMICS;

ADAPTIVE IMMUNITY; DENGUE; DENGUE VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE;

EID: 84891084459     PISSN: 00653527     EISSN: 15578399     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800098-4.00001-5     Document Type: Chapter

References (490)

1. Ackermann M., Padmanabhan R. De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase. Journal of Biological Chemistry 2001, 276(43):39926-39937.
2. Acosta E.G., Castilla V., Damonte E.B. Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis. Journal of General Virology 2008, 89(Pt 2):474-484.
3. Acosta E.G., Castilla V., Damonte E.B. Alternative infectious entry pathways for dengue virus serotypes into mammalian cells. Cellular Microbiology 2009, 11(10):1533-1549.
4. Acosta E.G., Castilla V., Damonte E.B. Infectious dengue-1 virus entry into mosquito C6/36 cells. Virus Research 2011, 160(1-2):173-179.
5. Acosta E.G., Castilla V., Damonte E.B. Differential requirements in endocytic trafficking for penetration of dengue virus. PLoS One 2012, 7(9):e44835.
6. Aggarwal A., Chandra J., Aneja S., Patwari A.K., Dutta A.K. An epidemic of dengue hemorrhagic fever and dengue shock syndrome in children in Delhi. Indian Pediatrics 1998, 35(8):727-732.
7. Agis-Juarez R.A., Galvan I., Medina F., Daikoku T., Padmanabhan R., Ludert J.E., et al. Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells. Journal of General Virology 2009, 90(Pt 12):2893-2901.
8. Aguirre S., Maestre A.M., Pagni S., Patel J.R., Savage T., Gutman D., et al. DENV inhibits type I IFN production in infected cells by cleaving human STING. PLoS Pathogens 2012, 8(10):e1002934.
9. Alagarasu K., Honap T., Damle I.M., Mulay A.P., Shah P.S., Cecilia D. Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection. Infection, Genetics and Evolution 2013, 14C:390-395.
10. Albuquerque L.M., Trugilho M.R., Chapeaurouge A., Jurgilas P.B., Bozza P.T., Bozza F.A., et al. Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients. Journal of Proteome Research 2009, 8(12):5431-5441.
11. Alen M.M., Dallmeier K., Balzarini J., Neyts J., Schols D. Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection. Antiviral Research 2012, 96(3):280-287.
12. Alhoot M.A., Wang S.M., Sekaran S.D. RNA interference mediated inhibition of dengue virus multiplication and entry in HepG2 cells. PLoS One 2012, 7(3):e34060.
13. Alvarez D.E., De Lella Ezcurra A.L., Fucito S., Gamarnik A.V. Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replication. Virology 2005, 339(2):200-212.
14. Alvarez D.E., Filomatori C.V., Gamarnik A.V. Functional analysis of dengue virus cyclization sequences located at the 5' and 3'UTRs. Virology 2008, 375(1):223-235.
15. Alvarez D.E., Lodeiro M.F., Luduena S.J., Pietrasanta L.I., Gamarnik A.V. Long-range RNA-RNA interactions circularize the dengue virus genome. Journal of Virology 2005, 79(11):6631-6643.
16. Anderson S.L., Carton J.M., Lou J., Xing L., Rubin B.Y. Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus. Virology 1999, 256(1):8-14.
17. Anez G., Men R., Eckels K.H., Lai C.J. Passage of dengue virus type 4 vaccine candidates in fetal rhesus lung cells selects heparin-sensitive variants that result in loss of infectivity and immunogenicity in rhesus macaques. Journal of Virology 2009, 83(20):10384-10394.
18. Ang F., Wong A.P., Ng M.M., Chu J.J. Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus. Virology Journal 2010, 7:24.
19. Anwar A., Hosoya T., Leong K.M., Onogi H., Okuno Y., Hiramatsu T., et al. The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. PLoS One 2011, 6(8):e23246.
20. Anwar A., Leong K.M., Ng M.L., Chu J.J., Garcia-Blanco M.A. The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machinery. Journal of Biological Chemistry 2009, 284(25):17021-17029.
21. Aoki C., Hidari K.I., Itonori S., Yamada A., Takahashi N., Kasama T., et al. Identification and characterization of carbohydrate molecules in mammalian cells recognized by dengue virus type 2. Journal of Biochemistry 2006, 139(3):607-614.
22. Arias C.F., Preugschat F., Strauss J.H. Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain. Virology 1993, 193(2):888-899.
23. Ashburn P.M., Craig C.F. Experimental investigations regarding the etiology of dengue fever. 1907. Journal of Infectious Diseases 2004, 189(9):1747-1783. US Army Board for the Study of Tropical Diseases, discussion 1744-1746.
24. Ashour J., Laurent-Rolle M., Shi P.Y., Garcia-Sastre A. NS5 of dengue virus mediates STAT2 binding and degradation. Journal of Virology 2009, 83(11):5408-5418.
25. Ashour J., Morrison J., Laurent-Rolle M., Belicha-Villanueva A., Plumlee C.R., Bernal-Rubio D., et al. Mouse STAT2 restricts early dengue virus replication. Cell Host & Microbe 2010, 8(5):410-421.
26. Balsitis S.J., Coloma J., Castro G., Alava A., Flores D., McKerrow J.H., et al. Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. American Journal of Tropical Medicine and Hygiene 2009, 80(3):416-424.
27. Bartelma G., Padmanabhan R. Expression, purification, and characterization of the RNA 5'-triphosphatase activity of dengue virus type 2 nonstructural protein 3. Virology 2002, 299(1):122-132.
28. Bartholomeusz A.I., Wright P.J. Synthesis of dengue virus RNA in vitro: Initiation and the involvement of proteins NS3 and NS5. Archives of Virology 1993, 128(1-2):111-121.
29. Becerra A., Warke R.V., Martin K., Xhaja K., de Bosch N., Rothman A.L., et al. Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo. Journal of Medical Virology 2009, 81(8):1403-1411.
30. Beckham C.J., Parker R. P bodies, stress granules, and viral life cycles. Cell Host & Microbe 2008, 3(4):206-212.
31. Behura S.K., Gomez-Machorro C., Harker B.W., deBruyn B., Lovin D.D., Hemme R.R., et al. Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection. PLoS Neglected Tropical Diseases 2011, 5(11):e1385.
32. 2+-dependent and require a functional Walker B motif in the helicase catalytic core. Virology 2004, 328(2):208-218.
33. Best S.M., Morris K.L., Shannon J.G., Robertson S.J., Mitzel D.N., Park G.S., et al. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. Journal of Virology 2005, 79(20):12828-12839.
34. Bhatt S., Gething P.W., Brady O.J., Messina J.P., Farlow A.W., Moyes C.L., et al. The global distribution and burden of dengue. Nature 2013, 496(7446):504-507.
35. Bhattacharya D., Mayuri, Best S.M., Perera R., Kuhn R.J., Striker R. Protein kinase G phosphorylates mosquito-borne flavivirus NS5. Journal of Virology 2009, 83(18):9195-9205.
36. Bhuvanakantham R., Li J., Tan T.T., Ng M.L. Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus. Cellular Microbiology 2010, 12(4):453-472.
37. Bielefeldt-Ohmann H., Meyer M., Fitzpatrick D.R., Mackenzie J.S. Dengue virus binding to human leukocyte cell lines: Receptor usage differs between cell types and virus strains. Virus Research 2001, 73(1):81-89.
38. Billich A., Hammerschmid F., Peichl P., Wenger R., Zenke G., Quesniaux V., et al. Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: Interference with HIV protein-cyclophilin A interactions. Journal of Virology 1995, 69(4):2451-2461.
39. Blanchard E., Belouzard S., Goueslain L., Wakita T., Dubuisson J., Wychowski C., et al. Hepatitis C virus entry depends on clathrin-mediated endocytosis. Journal of Virology 2006, 80(14):6964-6972.
40. Bonizzoni M., Dunn W.A., Campbell C.L., Olson K.E., Marinotti O., James A.A. Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection. PLoS One 2012, 7(11):e50512.
41. Brass A.L., Dykxhoorn D.M., Benita Y., Yan N., Engelman A., Xavier R.J., et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008, 319(5865):921-926.
42. Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009, 139(7):1243-1254.
43. Brooks A.J., Johansson M., John A.V., Xu Y., Jans D.A., Vasudevan S.G. The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals. Journal of Biological Chemistry 2002, 277(39):36399-36407.
44. Brown M.G., McAlpine S.M., Huang Y.Y., Haidl I.D., Al-Afif A., Marshall J.S., et al. RNA sensors enable human mast cell anti-viral chemokine production and IFN-mediated protection in response to antibody-enhanced dengue virus infection. PLoS One 2012, 7(3):e34055.
45. Bryant J.E., Calvert A.E., Mesesan K., Crabtree M.B., Volpe K.E., Silengo S., et al. Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes. Virology 2007, 366(2):415-423.
46. Buchan J.R., Parker R. Eukaryotic stress granules: The ins and outs of translation. Molecular Cell 2009, 36(6):932-941.
47. Bulich R., Aaskov J.G. Nuclear localization of dengue 2 virus core protein detected with monoclonal antibodies. Journal of General Virology 1992, 73(Pt 11):2999-3003.
48. Bussetta C., Choi K.H. Dengue virus nonstructural protein 5 adopts multiple conformations in solution. Biochemistry 2012, 51(30):5921-5931.
49. Cabrera-Hernandez A., Thepparit C., Suksanpaisan L., Smith D.R. Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70. Journal of Medical Virology 2007, 79(4):386-392.
50. Cahour A., Falgout B., Lai C.J. Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease. Journal of Virology 1992, 66(3):1535-1542.
51. Cahour A., Pletnev A., Vazielle-Falcoz M., Rosen L., Lai C.J. Growth-restricted dengue virus mutants containing deletions in the 5' noncoding region of the RNA genome. Virology 1995, 207(1):68-76.
52. Cao W., Henry M.D., Borrow P., Yamada H., Elder J.H., Ravkov E.V., et al. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science 1998, 282(5396):2079-2081.
53. Carro A.C., Damonte E.B. Requirement of cholesterol in the viral envelope for dengue virus infection. Virus Research 2013, 174(1-2):78-87.
54. Carvalho F.A., Carneiro F.A., Martins I.C., Assuncao-Miranda I., Faustino A.F., Pereira R.M., et al. Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins. Journal of Virology 2012, 86(4):2096-2108.
55. Chakravarti A., Kumaria R. Circulating levels of tumour necrosis factor-alpha & interferon-gamma in patients with dengue & dengue haemorrhagic fever during an outbreak. Indian Journal of Medical Research 2006, 123(1):25-30.
56. Chan Y.K., Huang I.C., Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS One 2012, 7(3):e34508.
57. Chang T.H., Liao C.L., Lin Y.L. Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation. Microbes and Infection 2006, 8(1):157-171.
58. Chang J., Schul W., Butters T.D., Yip A., Liu B., Goh A., et al. Combination of alpha-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Research 2011, 89(1):26-34.
59. Chang J., Schul W., Yip A., Xu X., Guo J.T., Block T.M. Competitive inhibitor of cellular alpha-glucosidases protects mice from lethal dengue virus infection. Antiviral Research 2011, 92(2):369-371.
60. Chang J., Wang L., Ma D., Qu X., Guo H., Xu X., et al. Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. Antimicrobial Agents and Chemotherapy 2009, 53(4):1501-1508.
61. Chatterji U., Lim P., Bobardt M.D., Wieland S., Cordek D.G., Vuagniaux G., et al. HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. Journal of Hepatology 2010, 53(1):50-56.
62. Chauhan C., Behura S.K., Debruyn B., Lovin D.D., Harker B.W., Gomez-Machorro C., et al. Comparative expression profiles of midgut genes in dengue virus refractory and susceptible Aedes aegypti across critical period for virus infection. PLoS One 2012, 7(10):e47350.
63. Chen S.T., Lin Y.L., Huang M.T., Wu M.F., Cheng S.C., Lei H.Y., et al. CLEC5A is critical for dengue-virus-induced lethal disease. Nature 2008, 453(7195):672-676.
64. Chen Z., Lin X., Zhang Z., Huang J., Fu S., Huang R. EXO70 protein influences dengue virus secretion. Microbes and Infection 2011, 13(2):143-150.
65. Chen Y., Maguire T., Hileman R.E., Fromm J.R., Esko J.D., Linhardt R.J., et al. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nature Medicine 1997, 3(8):866-871.
66. Chen Y.C., Wang S.Y., King C.C. Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. Journal of Virology 1999, 73(4):2650-2657.
67. Chu J.J., Leong P.W., Ng M.L. Analysis of the endocytic pathway mediating the infectious entry of mosquito-borne flavivirus West Nile into Aedes albopictus mosquito (C6/36) cells. Virology 2006, 349(2):463-475.
68. Chu J.J., Ng M.L. Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway. Journal of Virology 2004, 78(19):10543-10555.
69. Chu J.J., Ng M.L. Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells. Journal of Biological Chemistry 2004, 279(52):54533-54541.
70. Chu J.J., Yang P.L. c-Src protein kinase inhibitors block assembly and maturation of dengue virus. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(9):3520-3525.
71. Clum S., Ebner K.E., Padmanabhan R. Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B. Journal of Biological Chemistry 1997, 272(49):30715-30723.
72. Clyde K., Barrera J., Harris E. The capsid-coding region hairpin element (cHP) is a critical determinant of dengue virus and West Nile virus RNA synthesis. Virology 2008, 379(2):314-323.
73. Clyde K., Harris E. RNA secondary structure in the coding region of dengue virus type 2 directs translation start codon selection and is required for viral replication. Journal of Virology 2006, 80(5):2170-2182.
74. Colpitts T.M., Cox J., Nguyen A., Feitosa F., Krishnan M.N., Fikrig E. Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector. Virology 2011, 417(1):179-187.
75. Colpitts T.M., Cox J., Vanlandingham D.L., Feitosa F.M., Cheng G., Kurscheid S., et al. Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. PLoS Pathogens 2011, 7(9):e1002189.
76. Costa V.V., Fagundes C.T., Souza D.G., Teixeira M.M. Inflammatory and innate immune responses in dengue infection: Protection versus disease induction. American Journal of Pathology 2013, 182(6):1950-1961.
77. Courageot M.P., Frenkiel M.P., Dos Santos C.D., Deubel V., Despres P. Alpha-glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum. Journal of Virology 2000, 74(1):564-572.
78. Crabbe R., Vuagniaux G., Dumont J.M., Nicolas-Metral V., Marfurt J., Novaroli L. An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C. Expert Opinion on Investigational Drugs 2009, 18(2):211-220.
79. Crabtree M.B., Kinney R.M., Miller B.R. Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: Construction and characterization of mutant viruses. Archives of Virology 2005, 150(4):771-786.
80. Crublet E., Andrieu J.P., Vives R.R., Lortat-Jacob H. The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site. Journal of Biological Chemistry 2008, 283(22):15193-15200.
81. Cruz D.J., Koishi A.C., Taniguchi J.B., Li X., Milan Bonotto R., No J.H., et al. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Neglected Tropical Diseases 2013, 7(2):e2073.
82. Cui T., Sugrue R.J., Xu Q., Lee A.K., Chan Y.C., Fu J. Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein. Virology 1998, 246(2):409-417.
83. da Conceicao T.M., Rust N.M., Berbel A.C., Martins N.B., do Nascimento Santos C.A., Da Poian A.T., et al. Essential role of RIG-I in the activation of endothelial cells by dengue virus. Virology 2013, 435(2):281-292.
84. Daffis S., Szretter K.J., Schriewer J., Li J., Youn S., Errett J., et al. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 2010, 468(7322):452-456.
85. Dalrymple N., Mackow E.R. Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors. Journal of Virology 2011, 85(18):9478-9485.
86. Davidson A.D. Chapter 2. New insights into flavivirus nonstructural protein 5. Advances in Virus Research 2009, 74:41-101.
87. De Nova-Ocampo M., Villegas-Sepulveda N., del Angel R.M. Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA. Virology 2002, 295(2):337-347.
88. Devignot S., Sapet C., Duong V., Bergon A., Rihet P., Ong S., et al. Genome-wide expression profiling deciphers host responses altered during dengue shock syndrome and reveals the role of innate immunity in severe dengue. PLoS One 2010, 5(7):e11671.
89. de Wispelaere M., Lacroix A.J., Yang P.L. Small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. Journal of Virology 2013, 87(13):7367-7381.
90. Diamond M.S., Farzan M. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nature Reviews Immunology 2013, 13(1):46-57.
91. Diamond M.S., Harris E. Interferon inhibits dengue virus infection by preventing translation of viral RNA through a PKR-independent mechanism. Virology 2001, 289(2):297-311.
92. Diamond M.S., Roberts T.G., Edgil D., Lu B., Ernst J., Harris E. Modulation of dengue virus infection in human cells by alpha, beta, and gamma interferons. Journal of Virology 2000, 74(11):4957-4966.
93. Dong H., Chang D.C., Hua M.H., Lim S.P., Chionh Y.H., Hia F., et al. 2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. PLoS Pathogens 2012, 8(4):e1002642.
94. Dong H., Chang D.C., Xie X., Toh Y.X., Chung K.Y., Zou G., et al. Biochemical and genetic characterization of dengue virus methyltransferase. Virology 2010, 405(2):568-578.
95. Doolittle J.M., Gomez S.M. Mapping protein interactions between Dengue virus and its human and insect hosts. PLoS Neglected Tropical Diseases 2011, 5(2):e954.
96. D'Souza-Schorey C., Chavrier P. ARF proteins: Roles in membrane traffic and beyond. Nature Reviews Molecular Cell Biology 2006, 7(5):347-358.
97. Duijsings D., Lanke K.H., van Dooren S.H., van Dommelen M.M., Wetzels R., de Mattia F., et al. Differential membrane association properties and regulation of class I and class II Arfs. Traffic 2009, 10(3):316-323.
98. Echeverri C.J., Perrimon N. High-throughput RNAi screening in cultured cells: A user's guide. Nature Reviews Genetics 2006, 7(5):373-384.
99. Egloff M.P., Benarroch D., Selisko B., Romette J.L., Canard B. An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: Crystal structure and functional characterization. EMBO Journal 2002, 21(11):2757-2768.
100. Egloff M.P., Decroly E., Malet H., Selisko B., Benarroch D., Ferron F., et al. Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5. Journal of Molecular Biology 2007, 372(3):723-736.
101. Emara M.M., Brinton M.A. Interaction of TIA-1/TIAR with West Nile and dengue virus products in infected cells interferes with stress granule formation and processing body assembly. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(21):9041-9046.
102. Evans J.D., Crown R.A., Sohn J.A., Seeger C. West Nile virus infection induces depletion of IFNAR1 protein levels. Viral Immunology 2011, 24(4):253-263.
103. Falgout B., Chanock R., Lai C.J. Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2a. Journal of Virology 1989, 63(5):1852-1860.
104. Falgout B., Markoff L. Evidence that flavivirus NS1-NS2A cleavage is mediated by a membrane-bound host protease in the endoplasmic reticulum. Journal of Virology 1995, 69(11):7232-7243.
105. Falgout B., Miller R.H., Lai C.J. Deletion analysis of dengue virus type 4 nonstructural protein NS2B: Identification of a domain required for NS2B-NS3 protease activity. Journal of Virology 1993, 67(4):2034-2042.
106. Falgout B., Pethel M., Zhang Y.M., Lai C.J. Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. Journal of Virology 1991, 65(5):2467-2475.
107. Fernandez-Garcia M.D., Meertens L., Bonazzi M., Cossart P., Arenzana-Seisdedos F., Amara A. Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication. Journal of Virology 2011, 85(6):2980-2989.
108. Fibriansah G., Ng T.S., Kostyuchenko V.A., Lee J., Lee S., Wang J., et al. Structural changes of dengue virus when exposed to 37°C. Journal of Virology 2013, 87(13):7585-7592. 10.1128/JVI.00757-13.
109. Filomatori C.V., Iglesias N.G., Villordo S.M., Alvarez D.E., Gamarnik A.V. RNA sequences and structures required for the recruitment and activity of the dengue virus polymerase. Journal of Biological Chemistry 2011, 286(9):6929-6939.
110. Filomatori C.V., Lodeiro M.F., Alvarez D.E., Samsa M.M., Pietrasanta L., Gamarnik A.V. A 5' RNA element promotes dengue virus RNA synthesis on a circular genome. Genes & Development 2006, 20(16):2238-2249.
111. Fink J., Gu F., Ling L., Tolfvenstam T., Olfat F., Chin K.C., et al. Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Neglected Tropical Diseases 2007, 1(2):e86.
112. Flamand M., Megret F., Mathieu M., Lepault J., Rey F.A., Deubel V. Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion. Journal of Virology 1999, 73(7):6104-6110.
113. Flisiak R., Feinman S.V., Jablkowski M., Horban A., Kryczka W., Pawlowska M., et al. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology 2009, 49(5):1460-1468.
114. Flisiak R., Horban A., Gallay P., Bobardt M., Selvarajah S., Wiercinska-Drapalo A., et al. The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology 2008, 47(3):817-826.
115. Folly B.B., Weffort-Santos A.M., Fathman C.G., Soares L.R. Dengue-2 structural proteins associate with human proteins to produce a coagulation and innate immune response biased interactome. BMC Infectious Diseases 2011, 11:34.
116. Forwood J.K., Brooks A., Briggs L.J., Xiao C.Y., Jans D.A., Vasudevan S.G. The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site. Biochemical and Biophysical Research Communications 1999, 257(3):731-737.
117. Friebe P., Harris E. Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replication. Journal of Virology 2010, 84(12):6103-6118.
118. Friebe P., Pena J., Pohl M.O., Harris E. Composition of the sequence downstream of the dengue virus 5' cyclization sequence (dCS) affects viral RNA replication. Virology 2012, 422(2):346-356.
119. Gebhard L.G., Kaufman S.B., Gamarnik A.V. Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase. PLoS One 2012, 7(4):e36244.
120. Germi R., Crance J.M., Garin D., Guimet J., Lortat-Jacob H., Ruigrok R.W., et al. Heparan sulfate-mediated binding of infectious dengue virus type 2 and yellow fever virus. Virology 2002, 292(1):162-168.
121. Gilfoy F.D., Mason P.W. West Nile virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR. Journal of Virology 2007, 81(20):11148-11158.
122. Gillespie L.K., Hoenen A., Morgan G., Mackenzie J.M. The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complex. Journal of Virology 2010, 84(20):10438-10447.
123. Gjenero-Margan I., Aleraj B., Krajcar D., Lesnikar V., Klobucar A., Pem-Novosel I., et al. Autochthonous dengue fever in Croatia, August-September 2010. Euro Surveillance 2011, 16(9).
124. Gomila R.C., Martin G.W., Gehrke L. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication. PLoS One 2011, 6(2):e16687.
125. Gould E.A., Gallian P., De Lamballerie X., Charrel R.N. First cases of autochthonous dengue fever and chikungunya fever in France: From bad dream to reality!. Clinical Microbiology and Infection 2010, 16(12):1702-1704.
126. Grant D., Tan G.K., Qing M., Ng J.K., Yip A., Zou G., et al. A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis. Journal of Virology 2011, 85(15):7775-7787.
127. Groat-Carmona A.M., Orozco S., Friebe P., Payne A., Kramer L., Harris E. A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells and regulates viral replication in Aedes aegypti mosquitoes. Virology 2012, 432(2):511-526.
128. Gubler D.J. Dengue and dengue hemorrhagic fever. Clinical Microbiology Reviews 1998, 11(3):480-496.
129. Gubler D.J. Dengue/dengue haemorrhagic fever: History and current status. Novartis Foundation Symposium 2006, 277:3-16. discussion 16-22, 71-13, 251-253.
130. Guo J.T., Hayashi J., Seeger C. West Nile virus inhibits the signal transduction pathway of alpha interferon. Journal of Virology 2005, 79(3):1343-1350.
131. Guo X., Xu Y., Bian G., Pike A.D., Xie Y., Xi Z. Response of the mosquito protein interaction network to dengue infection. BMC Genomics 2010, 11:380.
132. Gutsche I., Coulibaly F., Voss J.E., Salmon J., d'Alayer J., Ermonval M., et al. Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(19):8003-8008.
133. Guzman A., Isturiz R.E. Update on the global spread of dengue. International Journal of Antimicrobial Agents 2010, 36(Suppl. 1):S40-S42.
134. Hahn C.S., Hahn Y.S., Rice C.M., Lee E., Dalgarno L., Strauss E.G., et al. Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences. Journal of Molecular Biology 1987, 198(1):33-41.
135. Halstead S.B. Dengue. Lancet 2007, 370(9599):1644-1652.
136. Hammon W.M., Rudnick A., Sather G.E. Viruses associated with epidemic hemorrhagic fevers of the Philippines and Thailand. Science 1960, 131(3407):1102-1103.
137. Hanley K.A., Lee J.J., Blaney J.E., Murphy B.R., Whitehead S.S. Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes. Journal of Virology 2002, 76(2):525-531.
138. Hannemann H., Sung P.Y., Chiu H.C., Yousuf A., Bird J., Lim S.P., et al. Serotype specific differences in dengue virus non-structural protein 5 nuclear localization. Journal of Biological Chemistry 2013, 288(31):22621-22635. 10.1074/jbc.M113.481382.
139. Hanoulle X., Badillo A., Wieruszeski J.M., Verdegem D., Landrieu I., Bartenschlager R., et al. Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. Journal of Biological Chemistry 2009, 284(20):13589-13601.
140. Hao L., Sakurai A., Watanabe T., Sorensen E., Nidom C.A., Newton M.A., et al. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 2008, 454(7206):890-893.
141. Hase T., Summers P.L., Eckels K.H. Flavivirus entry into cultured mosquito cells and human peripheral blood monocytes. Archives of Virology 1989, 104(1-2):129-143.
142. Heaton N.S., Perera R., Berger K.L., Khadka S., Lacount D.J., Kuhn R.J., et al. Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(40):17345-17350.
143. Heaton N.S., Randall G. Dengue virus-induced autophagy regulates lipid metabolism. Cell Host & Microbe 2010, 8(5):422-432.
144. Heider M.R., Munson M. Exorcising the exocyst complex. Traffic 2012, 13(7):898-907.
145. Helbig K.J., Carr J.M., Calvert J.K., Wati S., Clarke J.N., Eyre N.S., et al. Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. PLoS Neglected Tropical Diseases 2013, 7(4):e2178.
146. Helbig K.J., Eyre N.S., Yip E., Narayana S., Li K., Fiches G., et al. The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A. Hepatology 2011, 54(5):1506-1517.
147. Higa L.M., Caruso M.B., Canellas F., Soares M.R., Oliveira-Carvalho A.L., Chapeaurouge D.A., et al. Secretome of HepG2 cells infected with dengue virus: Implications for pathogenesis. Biochimica et Biophysica Acta 2008, 1784(11):1607-1616.
148. Hinson E.R., Cresswell P. The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. Proceedings of the National Academy of Sciences 2009, 106(48):20452-20457.
149. Hilgard P., Stockert R. Heparan sulfate proteoglycans initiate dengue virus infection of hepatocytes. Hepatology 2000, 32(5):1069-1077.
150. Ho L.J., Hung L.F., Weng C.Y., Wu W.L., Chou P., Lin Y.L., et al. Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell. Journal of Immunology 2005, 174(12):8163-8172.
151. Hoang L.T., Lynn D.J., Henn M., Birren B.W., Lennon N.J., Le P.T., et al. The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults. Journal of Virology 2010, 84(24):12982-12994.
152. Holden K.L., Harris E. Enhancement of dengue virus translation: Role of the 3' untranslated region and the terminal 3' stem-loop domain. Virology 2004, 329(1):119-133.
153. Hori H., Lai C.J. Cleavage of dengue virus NS1-NS2A requires an octapeptide sequence at the C terminus of NS1. Journal of Virology 1990, 64(9):4573-4577.
154. Hotta S. Experimental studies on dengue. I. Isolation, identification and modification of the virus. Journal of Infectious Diseases 1952, 90(1):1-9.
155. Hsieh S.C., Zou G., Tsai W.Y., Qing M., Chang G.J., Shi P.Y., et al. The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry. Virology 2011, 410(1):170-180.
156. Hu H.P., Hsieh S.C., King C.C., Wang W.K. Characterization of retrovirus-based reporter viruses pseudotyped with the precursor membrane and envelope glycoproteins of four serotypes of dengue viruses. Virology 2007, 368(2):376-387.
157. Huang Q., Chen A.S., Li Q., Kang C. Expression, purification, and initial structural characterization of nonstructural protein 2B, an integral membrane protein of dengue-2 virus, in detergent micelles. Protein Expression and Purification 2011, 80(2):169-175.
158. Hung J.J., Hsieh M.T., Young M.J., Kao C.L., King C.C., Chang W. An external loop region of domain III of dengue virus type 2 envelope protein is involved in serotype-specific binding to mosquito but not mammalian cells. Journal of Virology 2004, 78(1):378-388.
159. Hung S.L., Lee P.L., Chen H.W., Chen L.K., Kao C.L., King C.C. Analysis of the steps involved in dengue virus entry into host cells. Virology 1999, 257(1):156-167.
160. Ichiyama K., Gopala Reddy S.B., Zhang L.F., Chin W.X., Muschin T., Heinig L., et al. Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: A possible candidate for clinical application. PLoS Neglected Tropical Diseases 2013, 7(4):e2188.
161. Iglesias N.G., Filomatori C.V., Gamarnik A.V. The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis. Journal of Virology 2011, 85(12):5745-5756.
162. Ikeda M., Abe K., Yamada M., Dansako H., Naka K., Kato N. Different anti-HCV profiles of statins and their potential for combination therapy with interferon. Hepatology 2006, 44(1):117-125.
163. Issur M., Geiss B.J., Bougie I., Picard-Jean F., Despins S., Mayette J., et al. The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure. RNA 2009, 15(12):2340-2350.
164. Itsui Y., Sakamoto N., Kakinuma S., Nakagawa M., Sekine-Osajima Y., Tasaka-Fujita M., et al. Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein. Hepatology 2009, 50(6):1727-1737.
165. Jacobs M.G., Robinson P.J., Bletchly C., Mackenzie J.M., Young P.R. Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction. FASEB Journal 2000, 14(11):1603-1610.
166. Jelinek T., Muhlberger N., Harms G., Corachan M., Grobusch M.P., Knobloch J., et al. Epidemiology and clinical features of imported dengue fever in Europe: Sentinel surveillance data from TropNetEurop. Clinical Infectious Diseases 2002, 35(9):1047-1052.
167. Jessie K., Fong M.Y., Devi S., Lam S.K., Wong K.T. Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. Journal of Infectious Diseases 2004, 189(8):1411-1418.
168. Jiang D., Guo H., Xu C., Chang J., Gu B., Wang L., et al. Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. Journal of Virology 2008, 82(4):1665-1678.
169. Jiang D., Weidner J.M., Qing M., Pan X.B., Guo H., Xu C., et al. Identification of five interferon-induced cellular proteins that inhibit west Nile virus and dengue virus infections. Journal of Virology 2010, 84(16):8332-8341.
170. Jiang L., Yao H., Duan X., Lu X., Liu Y. Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus. Biochemical and Biophysical Research Communications 2009, 385(2):187-192.
171. Jin Z., Deval J., Johnson K.A., Swinney D.C. Characterization of the elongation complex of dengue virus RNA polymerase: Assembly, kinetics of nucleotide incorporation, and fidelity. Journal of Biological Chemistry 2011, 286(3):2067-2077.
172. Jindadamrongwech S., Thepparit C., Smith D.R. Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2. Archives of Virology 2004, 149(5):915-927.
173. Johansson M., Brooks A.J., Jans D.A., Vasudevan S.G. A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3. Journal of General Virology 2001, 82(Pt. 4):735-745.
174. Johnson A.J., Guirakhoo F., Roehrig J.T. The envelope glycoproteins of dengue 1 and dengue 2 viruses grown in mosquito cells differ in their utilization of potential glycosylation sites. Virology 1994, 203(2):241-249.
175. Johnson A.J., Roehrig J.T. New mouse model for dengue virus vaccine testing. Journal of Virology 1999, 73(1):783-786.
176. Jones M., Davidson A., Hibbert L., Gruenwald P., Schlaak J., Ball S., et al. Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression. Journal of Virology 2005, 79(9):5414-5420.
177. Jones C.T., Ma L., Burgner J.W., Groesch T.D., Post C.B., Kuhn R.J. Flavivirus capsid is a dimeric alpha-helical protein. Journal of Virology 2003, 77(12):7143-7149.
178. Juffrie M., Meer G.M., Hack C.E., Haasnoot K., Sutaryo, Veerman A.J., et al. Inflammatory mediators in dengue virus infection in children: Interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2. American Journal of Tropical Medicine and Hygiene 2001, 65(1):70-75.
179. Junjhon J., Lausumpao M., Supasa S., Noisakran S., Songjaeng A., Saraithong P., et al. Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction. Journal of Virology 2008, 82(21):10776-10791.
180. Kalia M., Khasa R., Sharma M., Nain M., Vrati S. Japanese encephalitis virus infects neuronal cells through a clathrin-independent endocytic mechanism. Journal of Virology 2013, 87(1):148-162.
181. Kanlaya R., Pattanakitsakul S.N., Sinchaikul S., Chen S.T., Thongboonkerd V. Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration. Journal of Proteome Research 2009, 8(5):2551-2562.
182. Kanlaya R., Pattanakitsakul S.N., Sinchaikul S., Chen S.T., Thongboonkerd V. The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells. Journal of Proteome Research 2010, 9(10):4960-4971.
183. Kapadia S.B., Chisari F.V. Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(7):2561-2566.
184. Kapoor M., Zhang L., Ramachandra M., Kusukawa J., Ebner K.E., Padmanabhan R. Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. Journal of Biological Chemistry 1995, 270(32):19100-19106.
185. Karlas A., Machuy N., Shin Y., Pleissner K.P., Artarini A., Heuer D., et al. Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature 2010, 463(7282):818-822.
186. Kaul A., Stauffer S., Berger C., Pertel T., Schmitt J., Kallis S., et al. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathogens 2009, 5(8):e1000546.
187. Ke P.Y., Chen S.S. Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. Journal of Clinical Investigation 2011, 121(1):37-56.
188. Keelapang P., Sriburi R., Supasa S., Panyadee N., Songjaeng A., Jairungsri A., et al. Alterations of pr-M cleavage and virus export in pr-M junction chimeric dengue viruses. Journal of Virology 2004, 78(5):2367-2381.
189. Kelley J.F., Kaufusi P.H., Volper E.M., Nerurkar V.R. Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines. Virology 2011, 418(1):27-39.
190. Kelly E.P., Puri B., Sun W., Falgout B. Identification of mutations in a candidate dengue 4 vaccine strain 341750 PDK20 and construction of a full-length cDNA clone of the PDK20 vaccine candidate. Vaccine 2010, 28(17):3030-3037.
191. Khadka S., Vangeloff A.D., Zhang C., Siddavatam P., Heaton N.S., Wang L., et al. A physical interaction network of dengue virus and human proteins. Molecular and Cellular Proteomics 2011, 10(12). M111.012187.
192. Khakpoor A., Panyasrivanit M., Wikan N., Smith D.R. A role for autophagolysosomes in dengue virus 3 production in HepG2 cells. Journal of General Virology 2009, 90(Pt. 5):1093-1103.
193. Klein D.E., Choi J.L., Harrison S.C. Structure of a dengue virus envelope protein late-stage fusion intermediate. Journal of Virology 2013, 87(4):2287-2293.
194. Konig R., Stertz S., Zhou Y., Inoue A., Hoffmann H.H., Bhattacharyya S., et al. Human host factors required for influenza virus replication. Nature 2010, 463(7282):813-817.
195. Konig R., Zhou Y., Elleder D., Diamond T.L., Bonamy G.M., Irelan J.T., et al. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 2008, 135(1):49-60.
196. Korennykh A., Walter P. Structural basis of the unfolded protein response. Annual Review of Cell and Developmental Biology 2012, 28:251-277.
197. Kravtsova-Ivantsiv Y., Ciechanover A. Non-canonical ubiquitin-based signals for proteasomal degradation. Journal of Cell Science 2012, 125(Pt. 3):539-548.
198. Krishnan M.N., Ng A., Sukumaran B., Gilfoy F.D., Uchil P.D., Sultana H., et al. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008, 455(7210):242-245.
199. Krishnan M.N., Sukumaran B., Pal U., Agaisse H., Murray J.L., Hodge T.W., et al. Rab 5 is required for the cellular entry of dengue and West Nile viruses. Journal of Virology 2007, 81(9):4881-4885.
200. Kroschewski H., Lim S.P., Butcher R.E., Yap T.L., Lescar J., Wright P.J., et al. Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain. Journal of Biological Chemistry 2008, 283(28):19410-19421.
201. Kuadkitkan A., Wikan N., Fongsaran C., Smith D.R. Identification and characterization of prohibitin as a receptor protein mediating DENV-2 entry into insect cells. Virology 2010, 406(1):149-161.
202. Kudelko M., Brault J.B., Kwok K., Li M.Y., Pardigon N., Peiris J.S., et al. Class II ADP-ribosylation factors are required for efficient secretion of dengue viruses. Journal of Biological Chemistry 2012, 287(1):767-777.
203. Kuhn R.J., Zhang W., Rossmann M.G., Pletnev S.V., Corver J., Lenches E., et al. Structure of dengue virus: Implications for flavivirus organization, maturation, and fusion. Cell 2002, 108(5):717-725.
204. Kumar A., Buhler S., Selisko B., Davidson A., Mulder K., Canard B., et al. Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling. Journal of Virology 2013, 87(8):4545-4557.
205. Kumar Y., Liang C., Bo Z., Rajapakse J.C., Ooi E.E., Tannenbaum S.R. Serum proteome and cytokine analysis in a longitudinal cohort of adults with primary dengue infection reveals predictive markers of DHF. PLoS Neglected Tropical Diseases 2012, 6(11):e1887.
206. Kummerer B.M., Rice C.M. Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles. Journal of Virology 2002, 76(10):4773-4784.
207. Kuno G. Research on dengue and dengue-like illness in East Asia and the Western Pacific during the first half of the 20th century. Reviews in Medical Virology 2007, 17(5):327-341.
208. Kwan W.H., Navarro-Sanchez E., Dumortier H., Decossas M., Vachon H., dos Santos F.B., et al. Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth. PLoS Neglected Tropical Diseases 2008, 2(10):e311.
209. Kyle J.L., Harris E. Global spread and persistence of dengue. Annual Review of Microbiology 2008, 62:71-92.
210. La Ruche G., Souares Y., Armengaud A., Peloux-Petiot F., Delaunay P., Despres P., et al. First two autochthonous dengue virus infections in metropolitan France, September 2010. Euro Surveillance 2010, 15(39):19676.
211. Laurent-Rolle M., Boer E.F., Lubick K.J., Wolfinbarger J.B., Carmody A.B., Rockx B., et al. The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling. Journal of Virology 2010, 84(7):3503-3515.
212. Leblois H., Young P.R. Maturation of the dengue-2 virus NS1 protein in insect cells: Effects of downstream NS2A sequences on baculovirus-expressed gene constructs. Journal of General Virology 1995, 76(Pt. 4):979-984.
213. Le Breton M., Meyniel-Schicklin L., Deloire A., Coutard B., Canard B., de Lamballerie X., et al. Flavivirus NS3 and NS5 proteins interaction network: A high-throughput yeast two-hybrid screen. BMC Microbiology 2011, 11:234.
214. Lee E., Leang S.K., Davidson A., Lobigs M. Both E protein glycans adversely affect dengue virus infectivity but are beneficial for virion release. Journal of Virology 2010, 84(10):5171-5180.
215. Lee Y.R., Lei H.Y., Liu M.T., Wang J.R., Chen S.H., Jiang-Shieh Y.F., et al. Autophagic machinery activated by dengue virus enhances virus replication. Virology 2008, 374(2):240-248.
216. Lee C.J., Lin H.R., Liao C.L., Lin Y.L. Cholesterol effectively blocks entry of flavivirus. Journal of Virology 2008, 82(13):6470-6480.
217. Lee E., Pavy M., Young N., Freeman C., Lobigs M. Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. Antiviral Research 2006, 69(1):31-38.
218. Lee E., Wright P.J., Davidson A., Lobigs M. Virulence attenuation of Dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural dissemination. Journal of General Virology 2006, 87(Pt. 10):2791-2801.
219. Lei Y., Huang Y., Zhang H., Yu L., Zhang M., Dayton A. Functional interaction between cellular p100 and the dengue virus 3' UTR. Journal of General Virology 2011, 92(Pt. 4):796-806.
220. Leitmeyer K.C., Vaughn D.W., Watts D.M., Salas R., Villalobos I., de Chacon Dengue virus structural differences that correlate with pathogenesis. Journal of Virology 1999, 73(6):4738-4747.
221. Le Sommer C., Barrows N.J., Bradrick S.S., Pearson J.L., Garcia-Blanco M.A. G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. PLoS Neglected Tropical Diseases 2012, 6(9):e1820.
222. Leung J.Y., Pijlman G.P., Kondratieva N., Hyde J., Mackenzie J.M., Khromykh A.A. Role of nonstructural protein NS2A in flavivirus assembly. Journal of Virology 2008, 82(10):4731-4741.
223. Leung D., Schroder K., White H., Fang N.X., Stoermer M.J., Abbenante G., et al. Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. Journal of Biological Chemistry 2001, 276(49):45762-45771.
224. Li Q., Brass A.L., Ng A., Hu Z., Xavier R.J., Liang T.J., et al. A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(38):16410-16415.
225. Li H., Clum S., You S., Ebner K.E., Padmanabhan R. The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. Journal of Virology 1999, 73(4):3108-3116.
226. Li W., Li Y., Kedersha N., Anderson P., Emara M., Swiderek K.M., et al. Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. Journal of Virology 2002, 76(23):11989-12000.
227. Li K., Markosyan R.M., Zheng Y.M., Golfetto O., Bungart B., Li M., et al. IFITM proteins restrict viral membrane hemifusion. PLoS Pathogens 2013, 9(1):e1003124.
228. Li Y., Xie J., Wu S., Xia J., Zhang P., Liu C., et al. Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. PLoS One 2013, 8(1):e55108.
229. Liang P.H., Cheng W.C., Lee Y.L., Yu H.P., Wu Y.T., Lin Y.L., et al. Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis. Chembiochem 2006, 7(1):165-173.
230. Liang Z., Wu S., Li Y., He L., Wu M., Jiang L., et al. Activation of Toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-beta in cultured hepatoma cells. PLoS One 2011, 6(8):e23346.
231. Liew K.J., Chow V.T. Microarray and real-time RT-PCR analyses of a novel set of differentially expressed human genes in ECV304 endothelial-like cells infected with dengue virus type 2. Journal of Virological Methods 2006, 131(1):47-57.
232. Lim H.Y., Ng M.L. A different mode of entry by dengue-2 neutralisation escape mutant virus. Archives of Virology 1999, 144(5):989-995.
233. Limjindaporn T., Wongwiwat W., Noisakran S., Srisawat C., Netsawang J., Puttikhunt C., et al. Interaction of dengue virus envelope protein with endoplasmic reticulum-resident chaperones facilitates dengue virus production. Biochemical and Biophysical Research Communications 2009, 379(2):196-200.
234. Limon-Flores A.Y., Perez-Tapia M., Estrada-Garcia I., Vaughan G., Escobar-Gutierrez A., Calderon-Amador J., et al. Dengue virus inoculation to human skin explants: An effective approach to assess in situ the early infection and the effects on cutaneous dendritic cells. International Journal of Experimental Pathology 2005, 86(5):323-334.
235. Lin R.J., Chang B.L., Yu H.P., Liao C.L., Lin Y.L. Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. Journal of Virology 2006, 80(12):5908-5918.
236. Lin Y.L., Lei H.Y., Lin Y.S., Yeh T.M., Chen S.H., Liu H.S. Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Research 2002, 56(1):93-96.
237. Lin R.J., Yu H.P., Chang B.L., Tang W.C., Liao C.L., Lin Y.L. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. Journal of Immunology 2009, 183(12):8035-8043.
238. Lin S.R., Zou G., Hsieh S.C., Qing M., Tsai W.Y., Shi P.Y., et al. The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry. Journal of Virology 2011, 85(10):5159-5171.
239. Liu W.J., Wang X.J., Mokhonov V.V., Shi P.Y., Randall R., Khromykh A.A. Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. Journal of Virology 2005, 79(3):1934-1942.
240. Liu R., Yue L., Li X., Yu X., Zhao H., Jiang Z., et al. Identification and characterization of small sub-genomic RNAs in dengue 1-4 virus-infected cell cultures and tissues. Biochemical and Biophysical Research Communications 2010, 391(1):1099-1103.
241. Lloyd R.E. How do viruses interact with stress-associated RNA granulesα. PLoS Pathogens 2012, 8(6):e1002741.
242. Lohmann V. Hepatitis C virus RNA replication. Current Topics in Microbiology and Immunology 2013, 369:167-198.
243. Loke P., Hammond S.N., Leung J.M., Kim C.C., Batra S., Rocha C., et al. Gene expression patterns of dengue virus-infected children from Nicaragua reveal a distinct signature of increased metabolism. PLoS Neglected Tropical Diseases 2010, 4(6):e710.
244. Long H.T., Hibberd M.L., Hien T.T., Dung N.M., Van Ngoc T., Farrar J., et al. Patterns of gene transcript abundance in the blood of children with severe or uncomplicated dengue highlight differences in disease evolution and host response to dengue virus infection. Journal of Infectious Diseases 2009, 199(4):537-546.
245. Loo Y.M., Fornek J., Crochet N., Bajwa G., Perwitasari O., Martinez-Sobrido L., et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. Journal of Virology 2008, 82(1):335-345.
246. Lozach P.Y., Burleigh L., Staropoli I., Navarro-Sanchez E., Harriague J., Virelizier J.L., et al. Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals. Journal of Biological Chemistry 2005, 280(25):23698-23708.
247. Lozach P.Y., Huotari J., Helenius A. Late-penetrating viruses. Current Opinion in Virology 2011, 1(1):35-43.
248. Luo D., Wei N., Doan D.N., Paradkar P.N., Chong Y., Davidson A.D., et al. Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications. Journal of Biological Chemistry 2010, 285(24):18817-18827.
249. Luo D., Xu T., Hunke C., Gruber G., Vasudevan S.G., Lescar J. Crystal structure of the NS3 protease-helicase from dengue virus. Journal of Virology 2008, 82(1):173-183.
250. Ma L., Jones C.T., Groesch T.D., Kuhn R.J., Post C.B. Solution structure of dengue virus capsid protein reveals another fold. Proceedings of the National Academy of Sciences of the United States of America 2004, 101(10):3414-3419.
251. Mackenzie J.M., Jones M.K., Young P.R. Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication. Virology 1996, 220(1):232-240.
252. Mackenzie J.M., Khromykh A.A., Parton R.G. Cholesterol manipulation by West Nile virus perturbs the cellular immune response. Cell Host & Microbe 2007, 2(4):229-239.
253. Mairiang D., Zhang H., Sodja A., Murali T., Suriyaphol P., Malasit P., et al. Identification of new protein interactions between dengue fever virus and its hosts, human and mosquito. PLoS One 2013, 8(1):e53535.
254. Makino Y., Tadano M., Anzai T., Ma S.P., Yasuda S., Fukunaga T. Detection of dengue 4 virus core protein in the nucleus. II. Antibody against dengue 4 core protein produced by a recombinant baculovirus reacts with the antigen in the nucleus. Journal of General Virology 1989, 70(Pt. 6):1417-1425.
255. Malet H., Egloff M.P., Selisko B., Butcher R.E., Wright P.J., Roberts M., et al. Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5. Journal of Biological Chemistry 2007, 282(14):10678-10689.
256. Manzano M., Reichert E.D., Polo S., Falgout B., Kasprzak W., Shapiro B.A., et al. Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication. Journal of Biological Chemistry 2011, 286(25):22521-22534.
257. Manzo F., Nebbioso A., Miceli M., Conte M., De Bellis F., Carafa V., et al. TNF-related apoptosis-inducing ligand: Signalling of a 'smart' molecule. International Journal of Biochemistry & Cell Biology 2009, 41(3):460-466.
258. Marchette N.J., Halstead S.B., Falkler W.A., Stenhouse A., Nash D. Studies on the pathogenesis of dengue infection in monkeys. 3. Sequential distribution of virus in primary and heterologous infections. Journal of Infectious Diseases 1973, 128(1):23-30.
259. Martina B.E., Koraka P., Osterhaus A.D. Dengue virus pathogenesis: An integrated view. Clinical Microbiology Reviews 2009, 22(4):564-581.
260. Martinez-Barragan J.J., del Angel R.M. Identification of a putative coreceptor on Vero cells that participates in dengue 4 virus infection. Journal of Virology 2001, 75(17):7818-7827.
261. Martinez-Gutierrez M., Castellanos J.E., Gallego-Gomez J.C. Statins reduce dengue virus production via decreased virion assembly. Intervirology 2011, 54(4):202-216.
262. Martinez-Pomares L., Wienke D., Stillion R., McKenzie E.J., Arnold J.N., Harris J., et al. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. European Journal of Immunology 2006, 36(5):1074-1082.
263. Martins I.C., Gomes-Neto F., Faustino A.F., Carvalho F.A., Carneiro F.A., Bozza P.T., et al. The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif. Biochemical Journal 2012, 444(3):405-415.
264. Mateo R., Nagamine C.M., Spagnolo J., Mendez E., Rahe M., Gale M., et al. Inhibition of cellular autophagy deranges dengue virion maturation. Journal of Virology 2013, 87(3):1312-1321.
265. Matsuda T., Almasan A., Tomita M., Tamaki K., Saito M., Tadano M., et al. Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand. Journal of General Virology 2005, 86(Pt. 4):1055-1065.
266. Mattijssen S., Pruijn G.J. Viperin, a key player in the antiviral response. Microbes and Infection 2012, 14(5):419-426.
267. Matusan A.E., Kelley P.G., Pryor M.J., Whisstock J.C., Davidson A.D., Wright P.J. Mutagenesis of the dengue virus type 2 NS3 proteinase and the production of growth-restricted virus. Journal of General Virology 2001, 82(Pt. 7):1647-1656.
268. Matusan A.E., Pryor M.J., Davidson A.D., Wright P.J. Mutagenesis of the dengue virus type 2 NS3 protein within and outside helicase motifs: Effects on enzyme activity and virus replication. Journal of Virology 2001, 75(20):9633-9643.
269. Mazzon M., Jones M., Davidson A., Chain B., Jacobs M. Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation. Journal of Infectious Diseases 2009, 200(8):1261-1270.
270. McLean J.E., Wudzinska A., Datan E., Quaglino D., Zakeri Z. Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. Journal of Biological Chemistry 2011, 286(25):22147-22159.
271. Medin C.L., Fitzgerald K.A., Rothman A.L. Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion. Journal of Virology 2005, 79(17):11053-11061.
272. Meertens L., Carnec X., Lecoin M.P., Ramdasi R., Guivel-Benhassine F., Lew E., et al. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host & Microbe 2012, 12(4):544-557.
273. Men R., Bray M., Clark D., Chanock R.M., Lai C.J. Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: Analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys. Journal of Virology 1996, 70(6):3930-3937.
274. Menzel N., Fischl W., Hueging K., Bankwitz D., Frentzen A., Haid S., et al. MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. PLoS Pathogens 2012, 8(7):e1002829.
275. Mercer J., Helenius A. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 2008, 320(5875):531-535.
276. Mercer J., Schelhaas M., Helenius A. Virus entry by endocytosis. Annual Review of Biochemistry 2010, 79:803-833.
277. Miller J.L., de Wet B.J., Martinez-Pomares L., Radcliffe C.M., Dwek R.A., Rudd P.M., et al. The mannose receptor mediates dengue virus infection of macrophages. PLoS Pathogens 2008, 4(2):e17.
278. Miller S., Kastner S., Krijnse-Locker J., Buhler S., Bartenschlager R. The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. Journal of Biological Chemistry 2007, 282(12):8873-8882.
279. Miller S., Krijnse-Locker J. Modification of intracellular membrane structures for virus replication. Nature Reviews Microbiology 2008, 6(5):363-374.
280. Miller S., Sparacio S., Bartenschlager R. Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B. Journal of Biological Chemistry 2006, 281(13):8854-8863.
281. Mitchell D.A., Fadden A.J., Drickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. Journal of Biological Chemistry 2001, 276(31):28939-28945.
282. Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas M., et al. The lipid droplet is an important organelle for hepatitis C virus production. Nature Cell Biology 2007, 9(9):1089-1097.
283. Modis Y., Ogata S., Clements D., Harrison S.C. Structure of the dengue virus envelope protein after membrane fusion. Nature 2004, 427(6972):313-319.
284. Mohan P.M., Padmanabhan R. Detection of stable secondary structure at the 3' terminus of dengue virus type 2 RNA. Gene 1991, 108(2):185-191.
285. Mondotte J.A., Lozach P.Y., Amara A., Gamarnik A.V. Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation. Journal of Virology 2007, 81(13):7136-7148.
286. Mongkolsapaya J., Dejnirattisai W., Xu X.N., Vasanawathana S., Tangthawornchaikul N., Chairunsri A., et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nature Medicine 2003, 9(7):921-927.
287. Montero H., Trujillo-Alonso V. Stress granules in the viral replication cycle. Viruses 2011, 3(11):2328-2338.
288. Morrison J., Laurent-Rolle M., Maestre A.M., Rajsbaum R., Pisanelli G., Simon V., et al. Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. PLoS Pathogens 2013, 9(3):e1003265.
289. Mosso C., Galvan-Mendoza I.J., Ludert J.E., del Angel R.M. Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT. Virology 2008, 378(1):193-199.
290. Munoz-Jordan J.L., Laurent-Rolle M., Ashour J., Martinez-Sobrido L., Ashok M., Lipkin W.I., et al. Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. Journal of Virology 2005, 79(13):8004-8013.
291. Munoz-Jordan J.L., Sanchez-Burgos G.G., Laurent-Rolle M., Garcia-Sastre A. Inhibition of interferon signaling by dengue virus. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(24):14333-14338.
292. Nag D.K., Finley D. A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits dengue virus replication. Virus Research 2012, 165(1):103-106.
293. Nascimento E.J., Braga-Neto U., Calzavara-Silva C.E., Gomes A.L., Abath F.G., Brito C.A., et al. Gene expression profiling during early acute febrile stage of dengue infection can predict the disease outcome. PLoS One 2009, 4(11):e7892.
294. Nasirudeen A.M., Liu D.X. Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis. Journal of Medical Virology 2009, 81(6):1069-1081.
295. Nasirudeen A.M., Wong H.H., Thien P., Xu S., Lam K.P., Liu D.X. RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection. PLoS Neglected Tropical Diseases 2011, 5(1):e926.
296. Navarro-Sanchez E., Altmeyer R., Amara A., Schwartz O., Fieschi F., Virelizier J.L., et al. Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses. EMBO Reports 2003, 4(7):723-728.
297. Nawa M., Takasaki T., Yamada K., Kurane I., Akatsuka T. Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine. Journal of General Virology 2003, 84(Pt. 7):1737-1741.
298. Neil S.J., Zang T., Bieniasz P.D. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 2008, 451(7177):425-430.
299. Nene V., Wortman J.R., Lawson D., Haas B., Kodira C., Tu Z.J., et al. Genome sequence of Aedes aegypti, a major arbovirus vector. Science 2007, 316(5832):1718-1723.
300. Nguyen T.H., Nguyen T.L., Lei H.Y., Lin Y.S., Le B.L., Huang K.J., et al. Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene 2005, 72(4):370-374.
301. Niyomrattanakit P., Winoyanuwattikun P., Chanprapaph S., Angsuthanasombat C., Panyim S., Katzenmeier G. Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation. Journal of Virology 2004, 78(24):13708-13716.
302. Noble C.G., Chen Y.L., Dong H., Gu F., Lim S.P., Schul W., et al. Strategies for development of dengue virus inhibitors. Antiviral Research 2010, 85(3):450-462.
303. Noisakran S., Dechtawewat T., Avirutnan P., Kinoshita T., Siripanyaphinyo U., Puttikhunt C., et al. Association of dengue virus NS1 protein with lipid rafts. Journal of General Virology 2008, 89(Pt. 10):2492-2500.
304. Noisakran S., Dechtawewat T., Rinkaewkan P., Puttikhunt C., Kanjanahaluethai A., Kasinrerk W., et al. Characterization of dengue virus NS1 stably expressed in 293T cell lines. Journal of Virological Methods 2007, 142(1-2):67-80.
305. Olszewska M., Bujarski J.J., Kurpisz M. P-bodies and their functions during mRNA cell cycle: Mini-review. Cell Biochemistry and Function 2012, 30(3):177-182.
306. Orozco S., Schmid M.A., Parameswaran P., Lachica R., Henn M.R., Beatty R., et al. Characterization of a model of lethal dengue virus 2 infection in C57BL/6 mice deficient in the alpha/beta interferon receptor. Journal of General Virology 2012, 93(Pt. 10):2152-2157.
307. Paingankar M.S., Gokhale M.D., Deobagkar D.N. Dengue-2-virus-interacting polypeptides involved in mosquito cell infection. Archives of Virology 2010, 155(9):1453-1461.
308. Pan X.B., Han J.C., Cong X., Wei L. BST2/tetherin inhibits dengue virus release from human hepatoma cells. PLoS One 2012, 7(12):e51033.
309. Pan X.B., Qu X.W., Jiang D., Zhao X.L., Han J.C., Wei L. BST2/tetherin inhibits hepatitis C virus production in human hepatoma cells. Antiviral Research 2013, 98(1):54-60.
310. Pan W., Zuo X., Feng T., Shi X., Dai J. Guanylate-binding protein 1 participates in cellular antiviral response to dengue virus. Virology Journal 2012, 9:292.
311. Pang T., Cardosa M.J., Guzman M.G. Of cascades and perfect storms: The immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS). Immunology & Cell Biology 2007, 85(1):43-45.
312. Pang X., Zhang M., Dayton A.I. Development of dengue virus type 2 replicons capable of prolonged expression in host cells. BMC Microbiology 2001, 1:18.
313. Panyasrivanit M., Greenwood M.P., Murphy D., Isidoro C., Auewarakul P., Smith D.R. Induced autophagy reduces virus output in dengue infected monocytic cells. Virology 2011, 418(1):74-84.
314. Panyasrivanit M., Khakpoor A., Wikan N., Smith D.R. Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes. Journal of General Virology 2009, 90(Pt. 2):448-456.
315. Paranjape S.M., Harris E. Y box-binding protein-1 binds to the dengue virus 3'-untranslated region and mediates antiviral effects. Journal of Biological Chemistry 2007, 282(42):30497-30508.
316. Park G.S., Morris K.L., Hallett R.G., Bloom M.E., Best S.M. Identification of residues critical for the interferon antagonist function of Langat virus NS5 reveals a role for the RNA-dependent RNA polymerase domain. Journal of Virology 2007, 81(13):6936-6946.
317. Patel H., Heathcote E.J. Sustained virological response with 29 days of Debio 025 monotherapy in hepatitis C virus genotype 3. Gut 2011, 60(6):879.
318. Patramool S., Surasombatpattana P., Luplertlop N., Seveno M., Choumet V., Thomas F., et al. Proteomic analysis of an Aedes albopictus cell line infected with dengue serotypes 1 and 3 viruses. Parasites & Vectors 2011, 4:138.
319. Pattanakitsakul S.N., Rungrojcharoenkit K., Kanlaya R., Sinchaikul S., Noisakran S., Chen S.T., et al. Proteomic analysis of host responses in HepG2 cells during dengue virus infection. Journal of Proteome Research 2007, 6(12):4592-4600.
320. Paul D., Bartenschlager R. Architecture and biogenesis of plus-strand RNA virus replication factories. World Journal of Virology 2013, 2(2):32-48.
321. Peisley A., Hur S. Multi-level regulation of cellular recognition of viral dsRNA. Cellular and Molecular Life Sciences 2013, 70(11):1949-1963.
322. Pena J., Harris E. Dengue virus modulates the unfolded protein response in a time-dependent manner. Journal of Biological Chemistry 2011, 286(16):14226-14236.
323. Peng T., Wang J.L., Chen W., Zhang J.L., Gao N., Chen Z.T., et al. Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis. Canadian Journal of Microbiology 2009, 55(2):139-145.
324. Perera R., Kuhn R.J. Structural proteomics of dengue virus. Current Opinion in Microbiology 2008, 11(4):369-377.
325. Perera R., Riley C., Isaac G., Hopf-Jannasch A.S., Moore R.J., Weitz K.W., et al. Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathogens 2012, 8(3):e1002584.
326. Perez A.B., Garcia G., Sierra B., Alvarez M., Vazquez S., Cabrera M.V., et al. IL-10 levels in dengue patients: Some findings from the exceptional epidemiological conditions in Cuba. Journal of Medical Virology 2004, 73(2):230-234.
327. Perry S.T., Buck M.D., Lada S.M., Schindler C., Shresta S. STAT2 mediates innate immunity to dengue virus in the absence of STAT1 via the type I interferon receptor. PLoS Pathogens 2011, 7(2):e1001297.
328. Perry S.T., Buck M.D., Plummer E.M., Penmasta R.A., Batra H., Stavale E.J., et al. An iminosugar with potent inhibition of dengue virus infection in vivo 2013, Antiviral Research.
329. Pethel M., Falgout B., Lai C.J. Mutational analysis of the octapeptide sequence motif at the NS1-NS2A cleavage junction of dengue type 4 virus. Journal of Virology 1992, 66(12):7225-7231.
330. Pfaller C.K., Li Z., George C.X., Samuel C.E. Protein kinase PKR and RNA adenosine deaminase ADAR1: New roles for old players as modulators of the interferon response. Current Opinion in Immunology 2011, 23(5):573-582.
331. Pijlman G.P., Funk A., Kondratieva N., Leung J., Torres S., van der Aa L., et al. A highly structured, nuclease-resistant, noncoding RNA produced by flaviviruses is required for pathogenicity. Cell Host & Microbe 2008, 4(6):579-591.
332. Poh M.K., Shui G., Xie X., Shi P.Y., Wenk M.R., Gu F. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Research 2012, 93(1):191-198.
333. Pokidysheva E., Zhang Y., Battisti A.J., Bator-Kelly C.M., Chipman P.R., Xiao C., et al. Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Cell 2006, 124(3):485-493.
334. Polacek C., Foley J.E., Harris E. Conformational changes in the solution structure of the dengue virus 5' end in the presence and absence of the 3' untranslated region. Journal of Virology 2009, 83(2):1161-1166.
335. Polacek C., Friebe P., Harris E. Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiency. Journal of General Virology 2009, 90(Pt. 3):687-692.
336. Pong W.L., Huang Z.S., Teoh P.G., Wang C.C., Wu H.N. RNA binding property and RNA chaperone activity of dengue virus core protein and other viral RNA-interacting proteins. FEBS Letters 2011, 585(16):2575-2581.
337. Prestwood T.R., Prigozhin D.M., Sharar K.L., Zellweger R.M., Shresta S. A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads. Journal of Virology 2008, 82(17):8411-8421.
338. Preugschat F., Lenches E.M., Strauss J.H. Flavivirus enzyme-substrate interactions studied with chimeric proteinases: Identification of an intragenic locus important for substrate recognition. Journal of Virology 1991, 65(9):4749-4758.
339. Preugschat F., Strauss J.H. Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo. Virology 1991, 185(2):689-697.
340. Preugschat F., Yao C.W., Strauss J.H. In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3. Journal of Virology 1990, 64(9):4364-4374.
341. Pryor M.J., Gualano R.C., Lin B., Davidson A.D., Wright P.J. Growth restriction of dengue virus type 2 by site-specific mutagenesis of virus-encoded glycoproteins. Journal of General Virology 1998, 79(Pt. 11):2631-2639.
342. Pryor M.J., Rawlinson S.M., Butcher R.E., Barton C.L., Waterhouse T.A., Vasudevan S.G., et al. Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection. Traffic 2007, 8(7):795-807.
343. Pryor M.J., Wright P.J. The effects of site-directed mutagenesis on the dimerization and secretion of the NS1 protein specified by dengue virus. Virology 1993, 194(2):769-780.
344. Pryor M.J., Wright P.J. Glycosylation mutants of dengue virus NS1 protein. Journal of General Virology 1994, 75(Pt. 5):1183-1187.
345. Ptak R.G., Gallay P.A., Jochmans D., Halestrap A.P., Ruegg U.T., Pallansch L.A., et al. Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. Antimicrobial Agents and Chemotherapy 2008, 52(4):1302-1317.
346. Pu S.Y., Wu R.H., Yang C.C., Jao T.M., Tsai M.H., Wang J.C., et al. Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes. Journal of Virology 2011, 85(6):2927-2941.
347. Pujol C.A., Estevez J.M., Carlucci M.J., Ciancia M., Cerezo A.S., Damonte E.B. Novel dl-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus. Antiviral Chemistry & Chemotherapy 2002, 13(2):83-89.
348. Qing M., Yang F., Zhang B., Zou G., Robida J.M., Yuan Z., et al. Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein. Antimicrobial Agents and Chemotherapy 2009, 53(8):3226-3235.
349. Qiu H., Tang W., Tong X., Ding K., Zuo J. Structure elucidation and sulfated derivatives preparation of two alpha-d-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydrate Research 2007, 342(15):2230-2236.
350. Randolph V.B., Stollar V. Low pH-induced cell fusion in flavivirus-infected Aedes albopictus cell cultures. Journal of General Virology 1990, 71(Pt. 8):1845-1850.
351. Raviprakash K., Sinha M., Hayes C.G., Porter K.R. Conversion of dengue virus replicative form RNA (RF) to replicative intermediate (RI) by nonstructural proteins NS-5 and NS-3. American Journal of Tropical Medicine and Hygiene 1998, 58(1):90-95.
352. Rawlinson S.M., Pryor M.J., Wright P.J., Jans D.A. CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production. Journal of Biological Chemistry 2009, 284(23):15589-15597.
353. Ray S., Srivastava R., Tripathi K., Vaibhav V., Patankar S., Srivastava S. Serum proteome changes in dengue virus-infected patients from a dengue-endemic area of India: Towards new molecular targetsα. OMICS 2012, 16(10):527-536.
354. Reineke L.C., Lloyd R.E. Diversion of stress granules and P-bodies during viral infection. Virology 2013, 436(2):255-267.
355. Reyes-Del Valle J., Chavez-Salinas S., Medina F., Del Angel R.M. Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells. Journal of Virology 2005, 79(8):4557-4567.
356. Rodenhuis-Zybert I.A., van der Schaar H.M., da Silva Voorham J.M., van der Ende-Metselaar H., Lei H.Y., Wilschut J., et al. Immature dengue virus: A veiled pathogenα. PLoS Pathogens 2010, 6(1):e1000718.
357. Rodriguez M.C., Merino E.R., Pujol C.A., Damonte E.B., Cerezo A.S., Matulewicz M.C. Galactans from cystocarpic plants of the red seaweed Callophyllis variegata (Kallymeniaceae, Gigartinales). Carbohydrate Research 2005, 340(18):2742-2751.
358. Rodriguez-Madoz J.R., Belicha-Villanueva A., Bernal-Rubio D., Ashour J., Ayllon J., Fernandez-Sesma A. Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex. Journal of Virology 2010, 84(19):9760-9774.
359. Rodriguez-Madoz J.R., Bernal-Rubio D., Kaminski D., Boyd K., Fernandez-Sesma A. Dengue virus inhibits the production of type I interferon in primary human dendritic cells. Journal of Virology 2010, 84(9):4845-4850.
360. Romero T.A., Tumban E., Jun J., Lott W.B., Hanley K.A. Secondary structure of dengue virus type 4 3' untranslated region: Impact of deletion and substitution mutations. Journal of General Virology 2006, 87(Pt. 11):3291-3296.
361. Rothwell C., Lebreton A., Young Ng C., Lim J.Y., Liu W., Vasudevan S., et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology 2009, 389(1-2):8-19.
362. Rubinsztein D.C., Codogno P., Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nature Reviews Drug Discovery 2012, 11(9):709-730.
363. Ruggieri A., Dazert E., Metz P., Hofmann S., Bergeest J.P., Mazur J., et al. Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host & Microbe 2012, 12(1):71-85.
364. Sabchareon A., Wallace D., Sirivichayakul C., Limkittikul K., Chanthavanich P., Suvannadabba S., et al. Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: A randomised, controlled phase 2b trial. Lancet 2012, 380(9853):1559-1567.
365. Sabin A.B., Schlesinger R.W. Production of immunity to dengue with virus modified by propagation in mice. Science 1945, 101(2634):640-642.
366. Sachse C., Krausz E., Kronke A., Hannus M., Walsh A., Grabner A., et al. High-throughput RNA interference strategies for target discovery and validation by using synthetic short interfering RNAs: Functional genomics investigations of biological pathways. Methods in Enzymology 2005, 392:242-277.
367. Saka H.A., Valdivia R. Emerging roles for lipid droplets in immunity and host-pathogen interactions. Annual Review of Cell and Developmental Biology 2012, 28:411-437.
368. Sakoonwatanyoo P., Boonsanay V., Smith D.R. Growth and production of the dengue virus in C6/36 cells and identification of a laminin-binding protein as a candidate serotype 3 and 4 receptor protein. Intervirology 2006, 49(3):161-172.
369. Sakuntabhai A., Turbpaiboon C., Casademont I., Chuansumrit A., Lowhnoo T., Kajaste-Rudnitski A., et al. A variant in the CD209 promoter is associated with severity of dengue disease. Nature Genetics 2005, 37(5):507-513.
370. Salazar M.I., Richardson J.H., Sanchez-Vargas I., Olson K.E., Beaty B.J. Dengue virus type 2: Replication and tropisms in orally infected Aedes aegypti mosquitoes. BMC Microbiology 2007, 7:9.
371. Samsa M.M., Mondotte J.A., Caramelo J.J., Gamarnik A.V. Uncoupling cis-acting RNA elements from coding sequences revealed a requirement of the N-terminal region of dengue virus capsid protein in virus particle formation. Journal of Virology 2012, 86(2):1046-1058.
372. Samsa M.M., Mondotte J.A., Iglesias N.G., Assuncao-Miranda I., Barbosa-Lima G., Da Poian A.T., et al. Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathogens 2009, 5(10):e1000632.
373. Sangiambut S., Keelapang P., Aaskov J., Puttikhunt C., Kasinrerk W., Malasit P., et al. Multiple regions in dengue virus capsid protein contribute to nuclear localization during virus infection. Journal of General Virology 2008, 89(Pt. 5):1254-1264.
374. San Martin J.L., Brathwaite O., Zambrano B., Solorzano J.O., Bouckenooghe A., Dayan G.H., et al. The epidemiology of dengue in the Americas over the last three decades: A worrisome reality. American Journal of Tropical Medicine and Hygiene 2010, 82(1):128-135.
375. Sariol C.A., Munoz-Jordan J.L., Abel K., Rosado L.C., Pantoja P., Giavedoni L., et al. Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1. Clinical and Vaccine Immunology 2007, 14(6):756-766.
376. Sarrazin S., Lamanna W.C., Esko J.D. Heparan sulfate proteoglycans. Cold Spring Harbor Perspectives in Biology 2011, 3(7):a004952.
377. Schoggins J.W., Wilson S.J., Panis M., Murphy M.Y., Jones C.T., Bieniasz P., et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2011, 472(7344):481-485.
378. Schuessler A., Funk A., Lazear H.M., Cooper D.A., Torres S., Daffis S., et al. West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. Journal of Virology 2012, 86(10):5708-5718.
379. Schul W., Liu W., Xu H.Y., Flamand M., Vasudevan S.G. A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. Journal of Infectious Diseases 2007, 195(5):665-674.
380. Seijo A. Dengue 2009: Chronology of an epidemic. Archivos Argentinos de Pediatría 2009, 107(5):387-389.
381. Selisko B., Peyrane F.F., Canard B., Alvarez K., Decroly E. Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n). Journal of General Virology 2010, 91(Pt. 1):112-121.
382. Selisko B., Potisopon S., Agred R., Priet S., Varlet I., Thillier Y., et al. Molecular basis for nucleotide conservation at the ends of the dengue virus genome. PLoS Pathogens 2012, 8(9):e1002912.
383. Seneviratne S.L., Malavige G.N., de Silva H.J. Pathogenesis of liver involvement during dengue viral infections. Transactions of the Royal Society of Tropical Medicine and Hygiene 2006, 100(7):608-614.
384. Sessions O.M., Barrows N.J., Souza-Neto J.A., Robinson T.J., Hershey C.L., Rodgers M.A., et al. Discovery of insect and human dengue virus host factors. Nature 2009, 458(7241):1047-1050.
385. Se-Thoe S.Y., Ling A.E., Ng M.M. Alteration of virus entry mode: A neutralisation mechanism for dengue-2 virus. Journal of Medical Virology 2000, 62(3):364-376.
386. Shafee N., AbuBakar S. Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis. Journal of General Virology 2003, 84(Pt. 8):2191-2195.
387. Shresta S., Kyle J.L., Snider H.M., Basavapatna M., Beatty P.R., Harris E. Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical. Journal of Virology 2004, 78(6):2701-2710.
388. Shukla D., Liu J., Blaiklock P., Shworak N.W., Bai X., Esko J.D., et al. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell 1999, 99(1):13-22.
389. Shum D., Smith J.L., Hirsch A.J., Bhinder B., Radu C., Stein D.A., et al. High-content assay to identify inhibitors of dengue virus infection. Assay and Drug Development Technologies 2010, 8(5):553-570.
390. Sim S., Dimopoulos G. Dengue virus inhibits immune responses in Aedes aegypti cells. PLoS One 2010, 5(5):e10678.
391. Sim S., Ramirez J.L., Dimopoulos G. Dengue virus infection of the Aedes aegypti salivary gland and chemosensory apparatus induces genes that modulate infection and blood-feeding behavior. PLoS Pathogens 2012, 8(3):e1002631.
392. Simmons C.P., Popper S., Dolocek C., Chau T.N., Griffiths M., Dung N.T., et al. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. Journal of Infectious Diseases 2007, 195(8):1097-1107.
393. Sit S.T., Manser E. Rho GTPases and their role in organizing the actin cytoskeleton. Journal of Cell Science 2011, 124(Pt. 5):679-683.
394. Somnuke P., Hauhart R.E., Atkinson J.P., Diamond M.S., Avirutnan P. N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement. Virology 2011, 413(2):253-264.
395. Soto-Acosta R., Mosso C., Cervantes-Salazar M., Puerta-Guardo H., Medina F., Favari L., et al. The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity. Virology 2013, 442(2):132-147.
396. Stern O., Hung Y.F., Valdau O., Yaffe Y., Harris E., Hoffmann S., et al. An N-terminal amphipathic helix in dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication. Journal of Virology 2013, 87(7):4080-4085.
397. St John A.L., Abraham S.N., Gubler D.J. Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. Nature Reviews Microbiology 2013, 11(6):420-426.
398. Suksanpaisan L., Susantad T., Smith D.R. Characterization of dengue virus entry into HepG2 cells. Journal of Biomedical Science 2009, 16:17.
399. Sun P., Fernandez S., Marovich M.A., Palmer D.R., Celluzzi C.M., Boonnak K., et al. Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus. Virology 2009, 383(2):207-215.
400. Swiecki M., Omattage N.S., Brett T.J. BST-2/tetherin: Structural biology, viral antagonism, and immunobiology of a potent host antiviral factor. Molecular Immunology 2013, 54(2):132-139.
401. Szretter K.J., Brien J.D., Thackray L.B., Virgin H.W., Cresswell P., Diamond M.S. The interferon-inducible gene viperin restricts West Nile virus pathogenesis. Journal of Virology 2011, 85(22):11557-11566.
402. Tadano M., Makino Y., Fukunaga T., Okuno Y., Fukai K. Detection of dengue 4 virus core protein in the nucleus. I. A monoclonal antibody to dengue 4 virus reacts with the antigen in the nucleus and cytoplasm. Journal of General Virology 1989, 70(Pt. 6):1409-1415.
403. Tai A.W., Benita Y., Peng L.F., Kim S.S., Sakamoto N., Xavier R.J., et al. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host & Microbe 2009, 5(3):298-307.
404. Tajima S., Nukui Y., Takasaki T., Kurane I. Characterization of the variable region in the 3' non-translated region of dengue type 1 virus. Journal of General Virology 2007, 88(Pt. 8):2214-2222.
405. Tajima S., Takasaki T., Kurane I. Characterization of Asn130-to-Ala mutant of dengue type 1 virus NS1 protein. Virus Genes 2008, 36(2):323-329.
406. Tajima S., Takasaki T., Kurane I. Restoration of replication-defective dengue type 1 virus bearing mutations in the N-terminal cytoplasmic portion of NS4A by additional mutations in NS4B. Archives of Virology 2011, 156(1):63-69.
407. Takahashi H., Takahashi C., Moreland N.J., Chang Y.T., Sawasaki T., Ryo A., et al. Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors. Antiviral Research 2012, 96(3):305-314.
408. Talarico L.B., Damonte E.B. Interference in dengue virus adsorption and uncoating by carrageenans. Virology 2007, 363(2):473-485.
409. Talarico L.B., Duarte M.E., Zibetti R.G., Noseda M.D., Damonte E.B. An algal-derived dl-galactan hybrid is an efficient preventing agent for in vitro dengue virus infection. Planta Medica 2007, 73(14):1464-1468.
410. Talarico L.B., Noseda M.D., Ducatti D.R., Duarte M.E., Damonte E.B. Differential inhibition of dengue virus infection in mammalian and mosquito cells by iota-carrageenan. Journal of General Virology 2011, 92(Pt. 6):1332-1342.
411. Talarico L.B., Pujol C.A., Zibetti R.G., Faria P.C., Noseda M.D., Duarte M.E., et al. The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell. Antiviral Research 2005, 66(2-3):103-110.
412. Tan B.H., Fu J., Sugrue R.J., Yap E.H., Chan Y.C., Tan Y.H. Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity. Virology 1996, 216(2):317-325.
413. Tassaneetrithep B., Burgess T.H., Granelli-Piperno A., Trumpfheller C., Finke J., Sun W., et al. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. Journal of Experimental Medicine 2003, 197(7):823-829.
414. Tay M.Y., Fraser J.E., Chan K.K., Moreland N.J., Rathore A.P., Wang C., et al. Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin. Antiviral Research 2013, 99(3):301-306.
415. Teo K.F., Wright P.J. Internal proteolysis of the NS3 protein specified by dengue virus 2. Journal of General Virology 1997, 78(Pt. 2):337-341.
416. Teramoto T., Kohno Y., Mattoo P., Markoff L., Falgout B., Padmanabhan R. Genome 3'-end repair in dengue virus type 2. RNA 2008, 14(12):2645-2656.
417. Thepparit C., Phoolcharoen W., Suksanpaisan L., Smith D.R. Internalization and propagation of the dengue virus in human hepatoma (HepG2) cells. Intervirology 2004, 47(2):78-86.
418. Thepparit C., Smith D.R. Serotype-specific entry of dengue virus into liver cells: Identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor. Journal of Virology 2004, 78(22):12647-12656.
419. Tio P.H., Jong W.W., Cardosa M.J. Two dimensional VOPBA reveals laminin receptor (LAMR1) interaction with dengue virus serotypes 1, 2 and 3. Virology Journal 2005, 2:25.
420. Torres S., Hernandez J.C., Giraldo D., Arboleda M., Rojas M., Smit J.M., et al. Differential expression of toll-like receptors in dendritic cells of patients with dengue during early and late acute phases of the disease. PLoS Neglected Tropical Diseases 2013, 7(2):e2060.
421. Trauger S.A., Wu E., Bark S.J., Nemerow G.R., Siuzdak G. The identification of an adenovirus receptor by using affinity capture and mass spectrometry. Chembiochem 2004, 5(8):1095-1099.
422. Tsai Y.T., Chang S.Y., Lee C.N., Kao C.L. Human TLR3 recognizes dengue virus and modulates viral replication in vitro. Cellular Microbiology 2009, 11(4):604-615.
423. Ubol S., Masrinoul P., Chaijaruwanich J., Kalayanarooj S., Charoensirisuthikul T., Kasisith J. Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever. Journal of Infectious Diseases 2008, 197(10):1459-1467.
424. Umareddy I., Chao A., Sampath A., Gu F., Vasudevan S.G. Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. Journal of General Virology 2006, 87(Pt. 9):2605-2614.
425. Valle R.P., Falgout B. Mutagenesis of the NS3 protease of dengue virus type 2. Journal of Virology 1998, 72(1):624-632.
426. Vancini R., Kramer L.D., Ribeiro M., Hernandez R., Brown D. Flavivirus infection from mosquitoes in vitro reveals cell entry at the plasma membrane. Virology 2013, 435(2):406-414.
427. van der Schaar H.M., Rust M.J., Chen C., van der Ende-Metselaar H., Wilschut J., Zhuang X., et al. Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells. PLoS Pathogens 2008, 4(12):e1000244.
428. van der Schaar H.M., Rust M.J., Waarts B.L., van der Ende-Metselaar H., Kuhn R.J., Wilschut J., et al. Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. Journal of Virology 2007, 81(21):12019-12028.
429. van Vliet S.J., den Dunnen J., Gringhuis S.I., Geijtenbeek T.B., van Kooyk Y. Innate signaling and regulation of dendritic cell immunity. Current Opinion in Immunology 2007, 19(4):435-440.
430. Vasquez Ochoa M., Garcia Cordero J., Gutierrez Castaneda B., Santos Argumedo L., Villegas Sepulveda N., Cedillo Barron L. A clinical isolate of dengue virus and its proteins induce apoptosis in HMEC-1 cells: A possible implication in pathogenesis. Archives of Virology 2009, 154(6):919-928.
431. Vasudevan S.G., Johansson M., Brooks A.J., Llewellyn L.E., Jans D.A. Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets. Farmaco 2001, 56(1-2):33-36.
432. Vaughn D.W., Green S., Kalayanarooj S., Innis B.L., Nimmannitya S., Suntayakorn S., et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. Journal of Infectious Diseases 2000, 181(1):2-9.
433. Villordo S.M., Alvarez D.E., Gamarnik A.V. A balance between circular and linear forms of the dengue virus genome is crucial for viral replication. RNA 2010, 16(12):2325-2335.
434. Wagstaff K.M., Sivakumaran H., Heaton S.M., Harrich D., Jans D.A. Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochemical Journal 2012, 443(3):851-856.
435. Wang L., Chen R.F., Liu J.W., Lee I.K., Lee C.P., Kuo H.C., et al. DC-SIGN (CD209) promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation. PLoS Neglected Tropical Diseases 2011, 5(1):e934.
436. Wang S., He R., Anderson R. PrM- and cell-binding domains of the dengue virus E protein. Journal of Virology 1999, 73(3):2547-2551.
437. Wang C.C., Huang Z.S., Chiang P.L., Chen C.T., Wu H.N. Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein. FEBS Letters 2009, 583(4):691-696.
438. Wang J.P., Liu P., Latz E., Golenbock D.T., Finberg R.W., Libraty D.H. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. Journal of Immunology 2006, 177(10):7114-7121.
439. Wang S.H., Syu W.J., Huang K.J., Lei H.Y., Yao C.W., King C.C., et al. Intracellular localization and determination of a nuclear localization signal of the core protein of dengue virus. Journal of General Virology 2002, 83(Pt. 12):3093-3102.
440. Wang J.L., Zhang J.L., Chen W., Xu X.F., Gao N., Fan D.Y., et al. Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection. PLoS Neglected Tropical Diseases 2010, 4(8):e809.
441. Ward A.M., Bidet K., Yinglin A., Ler S.G., Hogue K., Blackstock W., et al. Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures. RNA Biology 2011, 8(6):1173-1186.
442. Warke R.V., Martin K.J., Giaya K., Shaw S.K., Rothman A.L., Bosch I. TRAIL is a novel antiviral protein against dengue virus. Journal of Virology 2008, 82(1):555-564.
443. Warke R.V., Xhaja K., Martin K.J., Fournier M.F., Shaw S.K., Brizuela N., et al. Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. Journal of Virology 2003, 77(21):11822-11832.
444. Watashi K., Hijikata M., Hosaka M., Yamaji M., Shimotohno K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003, 38(5):1282-1288.
445. Wati S., Soo M.L., Zilm P., Li P., Paton A.W., Burrell C.J., et al. Dengue virus infection induces upregulation of GRP78, which acts to chaperone viral antigen production. Journal of Virology 2009, 83(24):12871-12880.
446. Watterson D., Kobe B., Young P.R. Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. Journal of General Virology 2012, 93(Pt. 1):72-82.
447. Welsch S., Miller S., Romero-Brey I., Merz A., Bleck C.K., Walther P., et al. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host & Microbe 2009, 5(4):365-375.
448. Werme K., Wigerius M., Johansson M. Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling. Cellular Microbiology 2008, 10(3):696-712.
449. Westaway E.G., Mackenzie J.M., Khromykh A.A. Kunjin RNA replication and applications of Kunjin replicons. Advances in Virus Research 2003, 59:99-140.
450. Whitby K., Pierson T.C., Geiss B., Lane K., Engle M., Zhou Y., et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. Journal of Virology 2005, 79(14):8698-8706.
451. White J.P., Lloyd R.E. Regulation of stress granules in virus systems. Trends in Microbiology 2012, 20(4):175-183.
452. Whitehorn J., Simmons C.P. The pathogenesis of dengue. Vaccine 2011, 29(42):7221-7228.
453. Wichit S., Jittmittraphap A., Hidari K.I., Thaisomboonsuk B., Petmitr S., Ubol S., et al. Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells. Microbiology and Immunology 2011, 55(2):135-140.
454. Wilder-Smith A., Renhorn K.E., Tissera H., Abu Bakar S., Alphey L., Kittayapong P., et al. Dengue tools: Innovative tools and strategies for the surveillance and control of dengue. Global Health Action 2012, 5:17273.
455. Williams B.R. PKR; a sentinel kinase for cellular stress. Oncogene 1999, 18(45):6112-6120.
456. Winkler G., Maxwell S.E., Ruemmler C., Stollar V. Newly synthesized dengue-2 virus nonstructural protein NS1 is a soluble protein but becomes partially hydrophobic and membrane-associated after dimerization. Virology 1989, 171(1):302-305.
457. Winkler G., Randolph V.B., Cleaves G.R., Ryan T.E., Stollar V. Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer. Virology 1988, 162(1):187-196.
458. Wong S.S., Haqshenas G., Gowans E.J., Mackenzie J. The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers. FEBS Letters 2012, 586(7):1032-1037.
459. Wu S.J., Grouard-Vogel G., Sun W., Mascola J.R., Brachtel E., Putvatana R., et al. Human skin Langerhans cells are targets of dengue virus infection. Nature Medicine 2000, 6(7):816-820.
460. Wu S.F., Lee C.J., Liao C.L., Dwek R.A., Zitzmann N., Lin Y.L. Antiviral effects of an iminosugar derivative on flavivirus infections. Journal of Virology 2002, 76(8):3596-3604.
461. Xi Z., Ramirez J.L., Dimopoulos G. The Aedes aegypti toll pathway controls dengue virus infection. PLoS Pathogens 2008, 4(7):e1000098.
462. Xie X., Gayen S., Kang C., Yuan Z., Shi P.Y. Membrane topology and function of dengue virus NS2A protein. Journal of Virology 2013, 87(8):4609-4622.
463. Xu T., Sampath A., Chao A., Wen D., Nanao M., Chene P., et al. Structure of the dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4A. Journal of Virology 2005, 79(16):10278-10288.
464. Yap T.L., Xu T., Chen Y.L., Malet H., Egloff M.P., Canard B., et al. Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. Journal of Virology 2007, 81(9):4753-4765.
465. Ye J., Wang C., Sumpter R., Brown M.S., Goldstein J.L., Gale M. Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(26):15865-15870.
466. Yeung M.L., Houzet L., Yedavalli V.S., Jeang K.T. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Journal of Biological Chemistry 2009, 284(29):19463-19473.
467. Yocupicio-Monroy R.M., Medina F., Reyes-del Valle J., del Angel R.M. Cellular proteins from human monocytes bind to dengue 4 virus minus-strand 3' untranslated region RNA. Journal of Virology 2003, 77(5):3067-3076.
468. Yocupicio-Monroy M., Padmanabhan R., Medina F., del Angel R.M. Mosquito La protein binds to the 3' untranslated region of the positive and negative polarity dengue virus RNAs and relocates to the cytoplasm of infected cells. Virology 2007, 357(1):29-40.
469. Yon C., Teramoto T., Mueller N., Phelan J., Ganesh V.K., Murthy K.H., et al. Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase. Journal of Biological Chemistry 2005, 280(29):27412-27419.
470. You S., Falgout B., Markoff L., Padmanabhan R. In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure. Journal of Biological Chemistry 2001, 276(19):15581-15591.
471. You S., Padmanabhan R. A novel in vitro replication system for dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5'-and 3'-terminal complementary sequence motifs of the viral RNA. Journal of Biological Chemistry 1999, 274(47):33714-33722.
472. Yu C.Y., Chang T.H., Liang J.J., Chiang R.L., Lee Y.L., Liao C.L., et al. Dengue virus targets the adaptor protein MITA to subvert host innate immunity. PLoS Pathogens 2012, 8(6):e1002780.
473. Yu C.Y., Hsu Y.W., Liao C.L., Lin Y.L. Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. Journal of Virology 2006, 80(23):11868-11880.
474. Yu I.M., Zhang W., Holdaway H.A., Li L., Kostyuchenko V.A., Chipman P.R., et al. Structure of the immature dengue virus at low pH primes proteolytic maturation. Science 2008, 319(5871):1834-1837.
475. Yusof R., Clum S., Wetzel M., Murthy H.M., Padmanabhan R. Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro. Journal of Biological Chemistry 2000, 275(14):9963-9969.
476. Zaitseva E., Yang S.T., Melikov K., Pourmal S., Chernomordik L.V. Dengue virus ensures its fusion in late endosomes using compartment-specific lipids. PLoS Pathogens 2010, 6(10):e1001131.
477. Zeng L., Falgout B., Markoff L. Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replication. Journal of Virology 1998, 72(9):7510-7522.
478. Zhang W., Chipman P.R., Corver J., Johnson P.R., Zhang Y., Mukhopadhyay S., et al. Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Natural Structural Biology 2003, 10(11):907-912.
479. Zhang Y., Corver J., Chipman P.R., Zhang W., Pletnev S.V., Sedlak D., et al. Structures of immature flavivirus particles. EMBO Journal 2003, 22(11):2604-2613.
480. Zhang X., Ge P., Yu X., Brannan J.M., Bi G., Zhang Q., et al. Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Nature Structural & Molecular Biology 2013, 20(1):105-110.
481. Zhang Y., Kostyuchenko V.A., Rossmann M.G. Structural analysis of viral nucleocapsids by subtraction of partial projections. Journal of Structural Biology 2007, 157(2):356-364.
482. Zhang L., Mohan P.M., Padmanabhan R. Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. Journal of Virology 1992, 66(12):7549-7554.
483. Zhang X., Sheng J., Plevka P., Kuhn R.J., Diamond M.S., Rossmann M.G. Dengue structure differs at the temperatures of its human and mosquito hosts. Proceedings of the National Academy of Sciences of the United States of America 2013, 110(17):6795-6799.
484. Zhang J.L., Wang J.L., Gao N., Chen Z.T., Tian Y.P., An J. Up-regulated expression of beta3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells. Biochemical and Biophysical Research Communications 2007, 356(3):763-768.
485. Zhou H., Xu M., Huang Q., Gates A.T., Zhang X.D., Castle J.C., et al. Genome-scale RNAi screen for host factors required for HIV replication. Cell Host & Microbe 2008, 4(5):495-504.
486. Zhu W., Qin C., Chen S., Jiang T., Yu M., Yu X., et al. Attenuated dengue 2 viruses with deletions in capsid protein derived from an infectious full-length cDNA clone. Virus Research 2007, 126(1-2):226-232.
487. Zhu Z., Shi Z., Yan W., Wei J., Shao D., Deng X., et al. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One 2013, 8(2):e55920.
488. Zompi S., Harris E. Animal models of dengue virus infection. Viruses 2012, 4(1):62-82.
489. Zuo Z., Liew O.W., Chen G., Chong P.C., Lee S.H., Chen K., et al. Mechanism of NS2B-mediated activation of NS3pro in dengue virus: Molecular dynamics simulations and bioassays. Journal of Virology 2009, 83(2):1060-1070.
490. Zybert I.A., van der Ende-Metselaar H., Wilschut J., Smit J.M. Functional importance of dengue virus maturation: Infectious properties of immature virions. Journal of General Virology 2008, 89(Pt. 12):3047-3051.