A single amino acid in nonstructural protein NS4B Confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

Journal of Virology

Volumn 85, Issue 15, 2011, Pages 7775-7787

  Grant, Dixon ^a,b   Tan, Grace K ^c   Qing, Min ^a,d   Ng, Jowin K W ^c   Yip, Andy ^a   Zou, Gang ^a   Xie, Xuping ^a,d   Yuan, Zhiming ^a   Schreiber, J ^a   Schul, Wouter ^a   Shi, Pei Yong ^a   Alonso, Sylvie ^c  

^a Novartis Institute for Tropical Diseases   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d WUHAN INSTITUTE OF VIROLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; INTERFERON; LEUCINE; NONSTRUCTURAL PROTEIN 4B; PHENYLALANINE; STAT1 PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DENGUE VIRUS 2; HISTOPATHOLOGY; LIVER DYSFUNCTION; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA SYNTHESIS; SURVIVAL RATE; VIREMIA; VIRUS GENOME; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; VIRUS VIRULENCE;

AMINO ACIDS; ANIMALS; CELL LINE; DENGUE VIRUS; DNA, VIRAL; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE;

ANIMALIA; DENGUE VIRUS; MAMMALIA; MUS;

EID: 79960388759     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00665-11     Document Type: Article

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