α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum

Journal of Virology

Volumn 74, Issue 1, 2000, Pages 564-572

  Courageot, Marie Pierre ^a   Frenkiel, Marie Pascale ^a   Duarte Dos Santos, Claudia ^b   Deubel, Vincent ^a   Desprès, Philippe ^a  

^a INSTITUT PASTEUR   (France)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUCOSIDASE INHIBITOR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL COMPARTMENTALIZATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DENGUE VIRUS; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; GLYCOSYLATION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; VIRION; VIRUS ASSEMBLY; VIRUS MORPHOLOGY; VIRUS PARTICLE;

EID: 0033988280     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.1.564-572.2000     Document Type: Article

References (36)

1. Allison, S. L., K. Stadler, C. W. Mandl, C. Kunz, and F. X. Heinz. 1995. Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and paniculate form. J. Virol. 69:5816-5820.
2. Amberg, S. M., A. Nestorowicz, D. W. McCourt, and C. M. Rice. 1994. NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies. J. Virol. 68:3794-3802.
3. Block, T. M., X. Lu, A. Mehta, B. S. Blumberg, B. Tennant, M. Ebling, B. Korba, D. M. Lansky, G. S. Jacob, and R. A. Dwek. 1998. Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking. Nat. Med. 4:610-614.
4. Block, T. M., X. Lu, F. M. Platt, G. R. Foster, W. H. Gerlich, B. S. Blumberg, and R. A. Dwek. 1994. Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin. Proc. Natl. Acad. Sci. USA 91:2235-2239.
5. Chambers, T. J., C. S. Hahn, R. Galler, and C. M. Rice. 1990. Flavivirus genome organization, expression, and replication. Annu. Rev. Microbiol. 44:649-688.
6. Chang, G. J. 1997. Molecular biology of dengue viruses, p. 175-198. In D. J. Gubler and G. Kuno (ed.), Dengue and dengue hemorrhagic fever. CAB International, New York, N.Y.
7. Desprès, P., M. Flamand, P. E. Ceccaldi, and V. Deubel. 1996. Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells. J. Virol. 70:4090-4096.
8. Desprès, P., M. P. Frenkiel, P. E. Ceccaldi, C. Duarte Dos Santos, and V. Deubel. 1998. Apoptosis in the mouse central nervous system in response to infection with mouse-neurovirulent dengue viruses. J. Virol. 72:823-829.
9. Desprès, P., M. P. Frenkiel, and V. Deubel. 1993. Differences between cell membrane fusion activities of two dengue type-1 isolates reflect modifications of viral structure. Virology 196:209-219.
10. Desprès, P., J. W. Griffin, and D. E. Griffin. 1995. Effects of anti-E2 monoclonal antibody on Sindhis virus replication in AT3 cells expressing bcl-2. J. Virol. 69:7006-7014.
11. Fischer, P. B., M. Collin, G. B. Karlsson, W. James, T. D. Butters, S. J. Davis, S. Gordon, R. A. Dwek, and F. M. Platt. 1995. The α-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding. J. Virol. 69:5791-5797.
12. Fonseca, B. A., S. Pincus, R. E. Shope, E. Paoletti, and P. W. Mason. 1994. Recombinant vaccinia viruses co-expressing dengue-1 glycoproteins prM and E induce neutralizing antibodies in mice. Vaccine 12:279-285.
13. Hebert, D. N., B. Foellmer, and A. Helenius. 1995. Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum. Cell 81:425-433.
14. Hebert, D. N., B. Foellmer, and A. Helenius. 1996. Calnexin and calreticulin promote folding, delay oligomerization and suppress degradation of influenza hemagglutinin in microsomes. EMBO J. 15:2961-2968.
15. Heinz, F. X., G. Auer, K. Stiasny. H. Holzmann, C. Mandl, F. Guirakhoo, and C. Kunz. 1994. The interaction of the flavivirus envelope proteins: implications for virus entry and release. Arch. Virol. 9:339-348.
16. Helenius, A., E. S. Trombetta, D. N. Hebert, and J. F. Simons. 1997. Calnexin, calreticulin and the folding of glycoproteins. Trends Cell Biol. 7:193-210.
17. Johnson, A. J., F. Guirakhoo, and J. T. Roehrig. 1994. The envelope glycoproteins of dengue 1 and dengue 2 viruses grown in mosquito cells differ in their utilization of potential glycosylation sites. Virology 203:241-249.
18. Konishi, E., and P. W. Mason. 1993. Proper maturation of the Japanese encephalitis virus envelope glycoprotein requires cosynthesis with the premembrane protein. J. Virol. 67:1672-1675.
19. Lobigs, M. 1993. Flavivirus premembrane protein cleavage and spike heterodimer secretion require the function of the viral proteinase NS3. Proc. Natl. Acad. Sci. USA 90:6218-6222.
20. Lu, X., A. Mehta, M. Dadmarz, R. Dwek, B. S. Blumberg, and T. M. Block. 1997. Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited. Proc. Natl. Acad. Sci. USA 94:2380-2385.
21. Mehta, A., N. Zitzmann, P. M. Rudd, T. M. Block, and R. A. Dwek. 1998. α-Glucosidase inhibitors as potential broad based anti-viral agents. FEBS Lett. 430:17-22.
22. No, D., T. P. Yao, and R. M. Evans. 1996. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93:3346-3351.
23. Otteken, A., and B. Moss. 1996. Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin. J. Biol. Chem. 271:97-103.
24. Peterson, J. R., A. Ora, P. N. Van, and A. Helenius. 1995. Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins. Mol. Biol. Cell 6:1173-1184.
25. Rey, F. A., F. X. Heinz, C. Mandl, C. Kunz, and S. C. Harrison. 1995. The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution. Nature 375:291-298.
26. Rice, C. M. 1996. Flaviviridae: the viruses and their replication, p. 931-959. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
27. Stadler, K., S. L. Allison, J. Schalich, and F. X. Heinz. 1997. Proteolytic activation of tick-borne encephalitis virus by furin. J. Virol. 71:8475-8481.
28. Stocks, C. E., and M. Lobigs. 1995. Posttranslational signal peptidase cleavage at the flavivirus C-prM junction in vitro. J. Virol. 69:8123-8126.
29. Stocks, C. E., and M. Lobigs. 1998. Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM. J. Virol. 72:2141-2149.
30. Trombetta, E. S., and A. Helenius. 1998. Lectins as chaperones in glycoprotein folding. Curr. Opin. Struct. Biol. 8:587-592.
31. Wang, S., R. He, and R. Anderson. 1999. PrM- and cell-binding domains of dengue virus E protein. J. Virol. 73:2547-2551.
32. Werr, M., and R. Prange. 1998. Role for calnexin and N-linked glycosylation in the assembly and secretion of hepatitis B virus middle envelope protein particles. J. Virol. 72:778-782.
33. Yamshchikov, V. F., and R. W. Compans. 1995. Formation of the flavivirus envelope: role of the viral NS2B-NS3 protease. J. Virol. 69:1995-2003.
34. Yamshchikov, V. F., and R. W. Compans. 1993. Regulation of the late events in flavivirus protein processing and maturation. Virology 192:38-51.
35. Yamshchikov, V. F., D. W. Trent, and R. W. Compans. 1997. Upregulation of signalase processing and induction of prM-E secretion by the flavivirus NS2B-NS3 protease: roles of protease components. J. Virol. 71:4364-4371.
36. Zheng, Z., E. Maidji, S. Tugizov, and L. Pereira. 1996. Mutations in the carboxyl-terminal hydrophobic sequence of human cytomegalovirus glycoprotein B alter transport and protein chaperone binding. J. Virol. 70:8029-8040.