Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18817-18827

  Luo, Dahai ^a   Wei, Na ^b   Doan, Danny N ^b   Paradkar, Prasad N ^b   Chong, Yuwen ^b   Davidson, Andrew D ^c   Kotaka, Masayo ^a,e   Lescar, Julien ^a,d   Vasudevan, Subhash G ^b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d Centre National de la Recherche Scientifique   (France)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL SIGNIFICANCE; COFACTORS; DENGUE VIRUS; HELICASE ACTIVITIES; HELICASES; INCREASED FLEXIBILITY; INTER-DOMAIN; LINKER REGION; N-TERMINALS; OPTIMUM LENGTH; RNA HELICASES; RNA REPLICATION; SERINE PROTEASE; SUB-DOMAINS; VIRAL POLYPROTEIN; VIRAL RNA;

AMINO ACIDS; GRAIN BOUNDARIES; MANGANESE; MANGANESE COMPOUNDS; ORGANIC ACIDS; PHOSPHATASES; PROTEINS; RNA; VIRUSES;

CRYSTAL STRUCTURE;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; GLUTAMIC ACID; GLYCINE; HELICASE; LUCIFERASE; MANGANESE; NONSTRUCTURAL PROTEIN 3; PROLINE; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENGUE VIRUS; ENZYME ACTIVITY; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; REPLICON; REPORTER GENE; RNA REPLICATION; RNA SYNTHESIS;

ADENOSINE DIPHOSPHATE; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DNA HELICASES; GLYCINE; MANGANESE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE HYDROLASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS;

DENGUE VIRUS;

EID: 77953306294     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.090936     Document Type: Article

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